Single-particle tracking of murine polyoma virus-like particles on live cells and artificial membranes.

abstract：:Swiftlets are small insectivorous birds, many of which nest in caves and are known to echolocate. Due to a lack of distinguishing morphological characters, the taxonomy of swiftlets is primarily based on the presence or absence of echolocating ability, together with nest characters. To test the reliability of these be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee PL,Clayton DH,Griffiths R,Page RD

更新日期：1996-07-09 00:00:00

abstract：:In many plant species only a small proportion of buds yield branches. Both the timing and extent of bud activation are tightly regulated to produce specific branching architectures. For example, the primary shoot apex can inhibit the activation of lateral buds. This process is termed apical dominance and is dependent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prusinkiewicz P,Crawford S,Smith RS,Ljung K,Bennett T,Ongaro V,Leyser O

更新日期：2009-10-13 00:00:00

abstract：:Neutrophils are important effector cells in immunity to microorganisms, particularly bacteria. Here, we show that the process of neutrophil apoptosis is delayed in several inflammatory diseases, suggesting that this phenomenon may represent a general feature contributing to the development of neutrophilia, and, theref...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dibbert B,Weber M,Nikolaizik WH,Vogt P,Schöni MH,Blaser K,Simon HU

更新日期：1999-11-09 00:00:00

abstract：:Binding enhancement by tertiary interactions is a strategy that takes advantage of the higher order folding of functionally important RNAs to bind short nucleic acid-based compounds tightly and more specifically than possible by simple base pairing. For example, tertiary interactions enhance binding of specific hexame...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Testa SM,Gryaznov SM,Turner DH

更新日期：1999-03-16 00:00:00

abstract：:Antifreeze proteins (AFPs) are a diverse class of proteins that depress the kinetically observable freezing point of water. AFPs have been of scientific interest for decades, but the lack of an accurate model for predicting AFP activity has hindered the logical design of novel antifreeze systems. To address this, we p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kozuch DJ,Stillinger FH,Debenedetti PG

更新日期：2018-12-26 00:00:00

abstract：:Although Wingless (Wg)/Wnt signaling has been implicated in heart development of multiple organisms, conflicting results have been reported regarding the role of Wnt/beta-catenin pathway in cardiac myogenesis: Wg/armadillo signaling promotes heart development in Drosophila, whereas activation of Wnt/beta-catenin signa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naito AT,Shiojima I,Akazawa H,Hidaka K,Morisaki T,Kikuchi A,Komuro I

更新日期：2006-12-26 00:00:00

abstract：:We have identified a 10-kDa stress-inducible mitochondrial protein. The protein is synthesized at elevated rates in cultured rat hepatoma cells challenged with heat shock or amino acid analogues and, therefore, designated heat shock protein 10 (Hsp10). Hsp10 was purified to homogeneity from rat liver and found to exhi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hartman DJ,Hoogenraad NJ,Condron R,Høj PB

更新日期：1992-04-15 00:00:00

abstract：:Fuchs endothelial corneal dystrophy (FECD) is a leading cause of corneal endothelial (CE) degeneration resulting in impaired visual acuity. It is a genetically complex and age-related disorder, with higher incidence in females. In this study, we established a nongenetic FECD animal model based on the physiologic outco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Miyajima T,Melangath G,Miyai T,Vasanth S,Deshpande N,Kumar V,Ong Tone S,Gupta R,Zhu S,Vojnovic D,Chen Y,Rogan EG,Mondal B,Zahid M,Jurkunas UV

更新日期：2020-01-07 00:00:00

abstract：:Lambdoid phages form clear plaques and show reduced ability to establish immunity in strains of Escherichia coli that lack adenylate cyclase or catabolite activator protein. The absence of the activator protein or cyclic AMP reduces the frequency of lysogenization, but does not prevent steady-state repressor synthesis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grodzicker T,Arditti RR,Eisen H

更新日期：1972-02-01 00:00:00

abstract：:The probability of choosing an alternative in a long sequence of repeated choices is proportional to the total reward derived from that alternative, a phenomenon known as Herrnstein's matching law. This behavior is remarkably conserved across species and experimental conditions, but its underlying neural mechanisms st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loewenstein Y,Seung HS

更新日期：2006-10-10 00:00:00

abstract：:Specific rearrangement of internal chromosomal regions occurs during development of the somatic macronucleus in Tetrahymena thermophila and results in elimination of germ-line (micronuclear) DNA sequences. The timing and mechanism of genome rearrangement within one particular 9.3-kilobase region, which contains three ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austerberry CF,Allis CD,Yao MC

更新日期：1984-12-01 00:00:00

abstract：:PDZ domains are abundant protein interaction modules and typically recognize a short motif at the C terminus of their ligands, with a few residues in the motif endowing the binding specificity. The sequence-based rules, however, cannot fully account for the specificity between the vast number of PDZ domains and ligand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pascoe HG,Gutowski S,Chen H,Brautigam CA,Chen Z,Sternweis PC,Zhang X

更新日期：2015-12-01 00:00:00

abstract：:CCR5 encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for HIV-type 1 (HIV-1). Varied HIV-1 susceptibility and time to progression to AIDS have been associated with polymorphisms in CCR5. Many of these polymorphisms are located in the 5' cis-regulatory region of CCR5...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bamshad MJ,Mummidi S,Gonzalez E,Ahuja SS,Dunn DM,Watkins WS,Wooding S,Stone AC,Jorde LB,Weiss RB,Ahuja SK

更新日期：2002-08-06 00:00:00

abstract：:Glioblastoma is the most common primary malignant brain tumor of adults and one of the most lethal of all cancers. Patients with this disease have a median survival of 15 months from the time of diagnosis despite surgery, radiation, and chemotherapy. New treatment approaches are needed. Recent works suggest that gliob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horvath S,Zhang B,Carlson M,Lu KV,Zhu S,Felciano RM,Laurance MF,Zhao W,Qi S,Chen Z,Lee Y,Scheck AC,Liau LM,Wu H,Geschwind DH,Febbo PG,Kornblum HI,Cloughesy TF,Nelson SF,Mischel PS

更新日期：2006-11-14 00:00:00

abstract：:Degassing of planetary interiors through surface volcanism plays an important role in the evolution of planetary bodies and atmospheres. On Earth, carbon dioxide and water are the primary volatile species in magmas. However, little is known about the speciation and degassing of carbon in magmas formed on other planets...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wetzel DT,Rutherford MJ,Jacobsen SD,Hauri EH,Saal AE

更新日期：2013-05-14 00:00:00

abstract：:The "parallel-up" packing in cellulose Ialpha and Ibeta unit cells was experimentally demonstrated by a combination of direct-staining the reducing ends of cellulose chains and microdiffraction-tilting electron crystallographic analysis. Microdiffraction investigation of nascent bacterial cellulose microfibrils showed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koyama M,Helbert W,Imai T,Sugiyama J,Henrissat B

更新日期：1997-08-19 00:00:00

abstract：:Climate change is expected to alter the distribution and abundance of many species. Predictions of climate-induced population extinctions are supported by geographic range shifts that correspond to climatic warming, but few extinctions have been linked mechanistically to climate change. Here we show that extinctions o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McLaughlin JF,Hellmann JJ,Boggs CL,Ehrlich PR

更新日期：2002-04-30 00:00:00

abstract：:Multiple cues, across multiple sensory modalities, are involved in mate choice in a wide range of animal taxa. This multiplicity leads to the prediction that, in adaptive radiations, sexual isolation results from divergence in multiple dimensions. However, difficulties in directly measuring preferences and detecting m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hohenlohe PA,Arnold SJ

更新日期：2010-09-21 00:00:00

abstract：:The Schiff base adducts of glyceraldehyde with hemoglobin undergo Amadori rearrangement to form stable ketoamine structures; this reaction is similar to the nonenzymic glucosylation of proteins. In the present studies the analogous rearrangement of the Schiff base adducts of glycolaldehyde with proteins has been demon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acharya AS,Manning JM

更新日期：1983-06-01 00:00:00

abstract：:Netrin-1 is critical for axonal pathfinding which shares similarities with formation of vascular network. Here we report that netrin-1 induction of angiogenesis is mediated by an increase in endothelial nitric oxide (NO*) production, which occurs via a DCC-dependent, ERK1/2-eNOS feed-forward mechanism. Exposure of mat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nguyen A,Cai H

更新日期：2006-04-25 00:00:00

abstract：:The type II cell of the alveolar epithelium of adult rats has been studied by electron microscopy to determine its ability to endocytose electron-dense tracers of differing molecular charge and size. The tracers studied were native (anionic) ferritin, cationic ferritin, 70-kilodalton dextran, and colloidal carbon. Alv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams MC

更新日期：1984-10-01 00:00:00

abstract：:Activation of p53 tumor suppressor by antagonizing its negative regulator murine double minute (MDM)2 has been considered an attractive strategy for cancer therapy and several classes of p53-MDM2 binding inhibitors have been developed. However, these compounds do not inhibit the p53-MDMX interaction, and their effecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves B,Thompson T,Xia M,Janson C,Lukacs C,Deo D,Di Lello P,Fry D,Garvie C,Huang KS,Gao L,Tovar C,Lovey A,Wanner J,Vassilev LT

更新日期：2012-07-17 00:00:00

abstract：:Two adjacent, divergently transcribed, developmentally regulated genes of the maize chloroplast chromosome have different superhelical density/transcriptional activation profiles when transcribed in vitro by the homologous DNA-dependent RNA polymerase. Promoter-specific transcription of the gene for the beta and epsil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stirdivant SM,Crossland LD,Bogorad L

更新日期：1985-08-01 00:00:00

abstract：:Transfer RNA (tRNA) is essential for decoding the genome sequence into proteins. In Archaea, previous studies have revealed unique multiple intron-containing tRNAs and tRNAs that are encoded on 2 separate genes, so-called split tRNAs. Here, we discovered 10 fragmented tRNA genes in the complete genome of the hyperther...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujishima K,Sugahara J,Kikuta K,Hirano R,Sato A,Tomita M,Kanai A

更新日期：2009-02-24 00:00:00

abstract：:We have recently shown that p-terphenyl-3,5,3',5'-tetracarboxylic acid adsorbed on graphite self-assembles into a two-dimensional rhombus random tiling. This tiling is close to ideal, displaying long-range correlations punctuated by sparse localized tiling defects. In this article we explore the analogy between dynami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garrahan JP,Stannard A,Blunt MO,Beton PH

更新日期：2009-09-08 00:00:00

abstract：:Thirty percent of the 189 tumors studied to date express DNA polymerase beta variants. One of these variants was identified in a prostate carcinoma and is altered from isoleucine to methionine at position 260, within the hydrophobic hinge region of the protein. Another variant was identified in a colon carcinoma and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sweasy JB,Lang T,Starcevic D,Sun KW,Lai CC,Dimaio D,Dalal S

更新日期：2005-10-04 00:00:00

abstract：:Pain is a major health concern even though numerous analgesic agents are available. Side effects and lack of wide-spectrum efficacy of current drugs justify efforts to better understand pain mechanisms. Stabilization of natural epoxy-fatty acids (EFAs) through inhibition of the soluble epoxide hydrolase (sEH) reduces ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inceoglu B,Wagner K,Schebb NH,Morisseau C,Jinks SL,Ulu A,Hegedus C,Rose T,Brosnan R,Hammock BD

更新日期：2011-03-22 00:00:00

abstract：:Double-stranded oligodeoxynucleotides that represent protein binding sites in the regulatory regions of the mouse genes encoding transthyretin (TTR) and alpha 1-antitrypsin (alpha 1-AT) bound a nuclear protein factor(s) found mainly in hepatocytes. A site in the regulatory region of the gene encoding rat serum albumin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Costa RH,Grayson DR,Xanthopoulos KG,Darnell JE Jr

更新日期：1988-06-01 00:00:00

abstract：:Aryloxyphenoxypropionates, inhibitors of the plastid acetyl-CoA carboxylase (ACC) of grasses, also inhibit Toxoplasma gondii ACC. Clodinafop, the most effective of the herbicides tested, inhibits growth of T. gondii in human fibroblasts by 70% at 10 microM in 2 days and effectively eliminates the parasite in 2-4 days ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuther E,Johnson JJ,Haselkorn R,McLeod R,Gornicki P

更新日期：1999-11-09 00:00:00

abstract：:The inhibitory protein that binds calmodulin and thus prevents activation of several Ca2+-dependent enzymes by calmodulin is shown to also bind four Ca2+ per mol of protein with high affinity (Kd less than or equal to 10(-6) M). On the basis of its Ca2+- binding properties and its localization to nervous tissue, the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klee CB,Crouch TH,Krinks MH

更新日期：1979-12-01 00:00:00