Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis.

abstract：:Hereditary hemochromatosis (HH) is a disorder of iron metabolism caused by common mutations in the gene HFE. The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake. However, in vivo, HFE is strongly expressed by liver macropha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drakesmith H,Sweetland E,Schimanski L,Edwards J,Cowley D,Ashraf M,Bastin J,Townsend AR

更新日期：2002-11-26 00:00:00

abstract：:It is well documented that human modification of the hydrological cycle has profoundly affected the flow of liquid water across the Earth's land surface. Alteration of water vapor flows through land-use changes has received comparatively less attention, despite compelling evidence that such alteration can influence th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon LJ,Steffen W,Jönsson BF,Folke C,Falkenmark M,Johannessen A

更新日期：2005-05-24 00:00:00

abstract：:Immunoprecipitation of proteins extracted from metabolically labeled human glioblastoma and fibrosarcoma cells with antiserum to platelet-derived growth factor (PDGF) showed that these cells express and secrete proteins that are recognized specifically by the antiserum. The molecular masses of immunoprecipitated prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pantazis P,Pelicci PG,Dalla-Favera R,Antoniades HN

更新日期：1985-04-01 00:00:00

abstract：:Oil-in-water emulsions are potent human adjuvants used for effective pandemic influenza vaccines; however, their mechanism of action is still unknown. By combining microarray and immunofluorescence analysis, we monitored the effects of the adjuvants MF59 oil-in-water emulsion, CpG, and alum in the mouse muscle. MF59 i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosca F,Tritto E,Muzzi A,Monaci E,Bagnoli F,Iavarone C,O'Hagan D,Rappuoli R,De Gregorio E

更新日期：2008-07-29 00:00:00

abstract：:The small heat-shock protein (sHSP) from Methanococcus jannaschii (Mj HSP16.5) forms a homomeric complex of 24 subunits and has an overall structure of a multiwindowed hollow sphere with an external diameter of approximately 120 A and an internal diameter of approximately 65 A with six square "windows" of approximatel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim R,Lai L,Lee HH,Cheong GW,Kim KK,Wu Z,Yokota H,Marqusee S,Kim SH

更新日期：2003-07-08 00:00:00

abstract：:Hepatitis C virus (HCV) infects nearly 3% of the population of the world and is a major cause of liver disease. However, the mechanism whereby the virus targets the liver for infection remains unknown, because none of the putative cellular receptors for HCV are both expressed specifically in the liver and capable of b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gardner JP,Durso RJ,Arrigale RR,Donovan GP,Maddon PJ,Dragic T,Olson WC

更新日期：2003-04-15 00:00:00

abstract：:The influence of the rare initiation triplet AUU on mRNA translation was investigated by comparing the activity of two pairs of model mRNAs that differ in the length of Shine-Dalgarno and spacer sequences. Irrespective of the initiation triplet (AUG or AUU), all mRNAs had similar template activity in vitro, but transl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： La Teana A,Pon CL,Gualerzi CO

更新日期：1993-05-01 00:00:00

abstract：:Natural killer (NK) cells mediate vital control of cancer and viral infection. They rely on MHC class I (MHC I)-specific self-receptors to identify and lyse diseased cells without harming self-MHC I-bearing host cells. NK cells bearing inhibitory self-receptors for host MHC I also undergo education, referred to as lic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gamache A,Cronk JM,Nash WT,Puchalski P,Gillespie A,Wei H,Gray L,Hammarskjold ML,Xu W,Brown MG

更新日期：2019-12-16 00:00:00

abstract：:Thyroid cancer is a common endocrine malignancy that encompasses well-differentiated as well as dedifferentiated cancer types. The latter tumors have high mortality and lack effective therapies. Using a paired-end RNA-sequencing approach, we report the discovery of rearrangements involving the anaplastic lymphoma kina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly LM,Barila G,Liu P,Evdokimova VN,Trivedi S,Panebianco F,Gandhi M,Carty SE,Hodak SP,Luo J,Dacic S,Yu YP,Nikiforova MN,Ferris RL,Altschuler DL,Nikiforov YE

更新日期：2014-03-18 00:00:00

abstract：:An analysis of taxonomic longevity for species of the two Cenozoic radiations of Caribbean planktonic foraminifera shows strong similarity in longevity for extinct taxa, though extant species of the latter radiation are biased towards longer-lived forms. In this case, the present is not the key to the past. A simple o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levinton JS,Ginzburg L

更新日期：1984-09-01 00:00:00

abstract：:Recent advances indicate that, in various chronic inflammatory disorders, the activation of the immune system is triggered locally rather than in lymphoid organs. In this study, we have evaluated whether the humoral alloimmune response involved in chronic rejection is elicited within the graft. We used the rat aortic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thaunat O,Field AC,Dai J,Louedec L,Patey N,Bloch MF,Mandet C,Belair MF,Bruneval P,Meilhac O,Bellon B,Joly E,Michel JB,Nicoletti A

更新日期：2005-10-11 00:00:00

abstract：:Depending on the cellular context, BCL2-like proteins promote mitochondrial fusion or fission. What determines which of these two opposing processes they promote has so far been unknown. Furthermore, the mechanisms through which BCL2-like proteins affect mitochondrial dynamics remain to be fully understood. The BCL2-l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Y,Rolland SG,Conradt B

更新日期：2011-10-11 00:00:00

abstract：:Using a novel technique of modulated photo-dissociation of carbon monoxide from hemoglobin, we have obtained the rates for conversion between the two quaternary states, R, and T, at 3-fold ligation. Our measurements at pH 7 and 22 degrees give rates of 780 +/- 40 sec-1 for going from R to T, and 2500 +/- 200 sec-1 fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrone FA,Hopfield JJ

更新日期：1976-12-01 00:00:00

abstract：:Quantitative immunohistochemical analysis of the sphenopalatine ganglion in normal cats revealed that virtually all ganglion cells (98.5%) were immunoreactive to vasoactive intestinal polypeptide (VIP). After surgical removal of this ganglion, the content of both VIP and choline acetyltransferase (acetyl-CoA:choline O...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lundberg JM,Anggård A,Emson P,Fahrenkrug J,Hökfelt T

更新日期：1981-08-01 00:00:00

abstract：:neurogenin2 (ngn2) encodes a basic helix-loop-helix transcription factor and plays an important role in neurogenesis from migratory neural crest cells. Its role in retinal development is poorly understood. We observed that in the developing chick retina, ngn2 was expressed in a subpopulation of proliferating progenito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan RT,Ma WX,Wang SZ

更新日期：2001-12-18 00:00:00

abstract：:Cryopreservation is widely used to maintain backups of cells as it enables the semipermanent storage of cells. During the freezing process, ice crystals that are generated inside and outside the cells can lethally damage the cells. All conventional cryopreservation methods use at least one cryoprotective agent (CPA) t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akiyama Y,Shinose M,Watanabe H,Yamada S,Kanda Y

更新日期：2019-04-16 00:00:00

abstract：:The modern concept of neurogenesis in the adult brain is predicated on the premise that multipotent glial cells give rise to new neurons throughout life. Although extensive evidence exists indicating that this is the case, the transition from glial to neuronal phenotype remains poorly understood. A unique monolayer ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheffler B,Walton NM,Lin DD,Goetz AK,Enikolopov G,Roper SN,Steindler DA

更新日期：2005-06-28 00:00:00

abstract：:Interactions between two excitatory monosynaptic inputs to hippocampal neurons of the CA1 region were examined in the in vitro slice. By adjusting the strengths of the electrical stimuli delivered to the two input pathways, one was made to generate a weak and the other a strong synaptic response. Simultaneous tetanic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrionuevo G,Brown TH

更新日期：1983-12-01 00:00:00

abstract：:Osteonectin is a prominent noncollagenous protein of developing bone. A 2150-base-pair cDNA coding for osteonectin, isolated from a bovine bone cell lambda gt11 expression library, was sequenced and identified by comparison with protein sequence data. The nucleotide sequence predicts that osteonectin contains 304 amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bolander ME,Young MF,Fisher LW,Yamada Y,Termine JD

更新日期：1988-05-01 00:00:00

abstract：:Mechanotransduction in the mammalian auditory system depends on mechanosensitive channels in the hair bundles that project from the apical surface of the sensory hair cells. Individual stereocilia within each bundle contain a core of tightly packed actin filaments, whose length is dynamically regulated during developm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furness DN,Johnson SL,Manor U,Rüttiger L,Tocchetti A,Offenhauser N,Olt J,Goodyear RJ,Vijayakumar S,Dai Y,Hackney CM,Franz C,Di Fiore PP,Masetto S,Jones SM,Knipper M,Holley MC,Richardson GP,Kachar B,Marcotti W

更新日期：2013-08-20 00:00:00

abstract：:The coupling of calcium transport to ATP hydrolysis in rabbit muscle sarcoplasmic reticulum vesicles was determined under steady-state conditions in the presence of 5 mM oxalate and using various concentrations of vesicles to modulate the concentration of free Ca2+ in the medium. This experimental approach takes advan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gafni A,Boyer PD

更新日期：1985-01-01 00:00:00

abstract：:Cadherin/catenin-based adhesions coordinate cellular growth, survival, migration, and differentiation within a tissue by mechanically anchoring cells to their neighbors. They also intersect with diverse signaling pathways in development and cancer. Although the adhesive functions of adherens junction proteins are well...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livshits G,Kobielak A,Fuchs E

更新日期：2012-03-27 00:00:00

abstract：:In feeding, aphids inject saliva into plant tissues, gaining access to phloem sap and eliciting (and sometimes overcoming) plant responses. We are examining the involvement, in this aphid-plant interaction, of individual aphid proteins and enzymes, as identified in a salivary gland cDNA library. Here, we focus on a sa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mutti NS,Louis J,Pappan LK,Pappan K,Begum K,Chen MS,Park Y,Dittmer N,Marshall J,Reese JC,Reeck GR

更新日期：2008-07-22 00:00:00

abstract：:This study presents, to our knowledge, the first on-line measurement of acetylcholinesterase (AcChoEase) release from brain tissue. It is now well established that a soluble form of the enzyme is released from central nervous system neurons, and it has been proposed on indirect grounds that such release may occur not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Llinás RR,Greenfield SA

更新日期：1987-05-01 00:00:00

abstract：:Hepatitis E virus is responsible for both sporadic and epidemic hepatitis in developing countries. The nonenveloped virus is 27-34 nm in diameter and has been shown to contain a single-strand, positive-sense, polyadenylylated RNA genome of approximately 7.5 kilobases. The nucleotide sequence of the Burma strain of hep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaur M,Hyams KC,Purdy MA,Krawczynski K,Ching WM,Fry KE,Reyes GR,Bradley DW,Carl M

更新日期：1992-05-01 00:00:00

abstract：:Double-positive (DP) thymocytes respond to intrathymic T-cell receptor (TCR) signals by undergoing positive selection and lineage differentiation into single-positive (SP) mature cells. Concomitant with these well-characterized events is the acquisition of a mature T-cell gene expression program characterized by the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi LZ,Saravia J,Zeng H,Kalupahana NS,Guy CS,Neale G,Chi H

更新日期：2017-01-03 00:00:00

abstract：:HUMAN LIVER ALCOHOL DEHYDROGENASE (ALCOHOL: NAD(+) oxidoreductase, EC 1.1.1.1), homogeneous by physicochemical criteria, has been available in quantity only recently [Lange, L. G. & Vallee, B. L. (1976) Biochemistry 15, 4681-4686]. Until now, the biochemical basis of human alcohol metabolism had to be extrapolated fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li TK,Bosron WF,Dafeldecker WP,Lange LG,Vallee BL

更新日期：1977-10-01 00:00:00

abstract：:Neonatal ablation of the suprachiasmatic nucleus in the rat has two important consequences. First, the direct projection from the retina to the suprachiasmatic nucleus fails to develop and no other retinal projection to any hypothalamic nucleus is formed. Second, circadian rhythms in drinking and spontaneous locomotor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosko S,Moore RY

更新日期：1978-12-01 00:00:00

abstract：:The proton markers located in the minor groove of the d(C-G-C-G-A-A-T-T-C-G-C-G) duplex and its netropsin complex have been assigned from measurements of intramolecular nuclear Overhauser effects (NOEs) between exchangeable imino protons and nonexchangeable base protons on the same and adjacent base pairs. Several poi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel DJ

更新日期：1982-11-01 00:00:00

abstract：:How do regions acquire the knowledge they need to diversify their economic activities? How does the migration of workers among firms and industries contribute to the diffusion of that knowledge? Here we measure the industry-, occupation-, and location-specific knowledge carried by workers from one establishment to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jara-Figueroa C,Jun B,Glaeser EL,Hidalgo CA

更新日期：2018-12-11 00:00:00