Abstract:
BACKGROUND:Child feeding recommendations include breastfeeding beyond 12 months, however, some researchers have reported increased rates of malnutrition in breastfed toddlers. A negative association between growth and breast-feeding may reflect reverse causality; that is, the outcome (growth) is a determinant of the predictor (breastfeeding), and not vice versa. We examined this question with data from 134 Peruvian toddlers. METHODS:A linear regression analysis predicted length at the age of 15 months by length at 12 months, study interval, and 12-14.9-month breastfeeding, complementary food intake, and diarrhoeal incidence. This analysis defined the association between breastfeeding and linear growth. To elucidate the direction of the effect between breastfeeding and linear growth, logistic regression was used to predict the probability of weaning by the end of 14 months. Determinants included weight-for-age (W/A) at 12 months, complementary food intake at 9-11.9 months, and change in diarrhoeal incidence between 9 and 14.9 months. RESULTS:There was a significant (P < 0.01) interaction of breastfeeding, diarrhoeal incidence, and complementary food intake on length at 15 months. Increased breastfeeding was associated with a 1.0 cm decrease in length gain when dietary intake was low and diarrhoeal morbidity was high, implying that breastfeeding is harmful. The logistic analysis, however, demonstrated that the risk of weaning decreased only when W/A and dietary intake were low and diarrhoeal morbidity was high. CONCLUSIONS:The negative association between breastfeeding and linear growth reflected reverse causality. Increased breastfeeding did not lead to poor growth; children's poor growth and health led to increased breastfeeding. Children's health must be considered when evaluating the association of breastfeeding with anthropometric outcomes. :There has been a perplexing finding, in many developing countries, of increased rates of stunting and growth faltering in breast-fed toddlers receiving complementary foods relative to their non-breast-fed counterparts. Longitudinal data on 134 children 12-15 months of age from Lima, Peru, were used to investigate the hypothesis that the negative association between growth and breast feeding reflects reverse causality. The toddlers were participants in a broader persistent diarrhea surveillance survey conducted during 1985-87. 72.9% of children were breast-fed beyond 12 months (median duration, 16.8 months). Anthropometric measurements revealed stunting in 19.4% of toddlers at 12 months and in 29.1% at 15 months. Linear growth between 12 and 15 months had a complex relationship with breast feeding, diarrhea, and dietary factors. Increased breast feeding was associated with a 1.0 cm decrease in length gain between 12 and 15 months when dietary intake was low and diarrheal morbidity was high. However, logistic analysis demonstrated that mothers whose children had low dietary intakes, low weight-for-age, and increased incidence of diarrhea were less likely to wean their infants at 12 and 14 months. This finding that mothers modified their children's feeding practices according to the child's health and growth status supports a reverse causality process in which poor growth is a determinant rather than a result of breast feeding.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Marquis GS,Habicht JP,Lanata CF,Black RE,Rasmussen KMdoi
10.1093/ije/26.2.349subject
Has Abstractpub_date
1997-04-01 00:00:00pages
349-56issue
2eissn
0300-5771issn
1464-3685journal_volume
26pub_type
杂志文章abstract:OBJECTIVE:The BED assay was developed to estimate the proportion of recent HIV infections in a population. We used the BED assay as a proxy for acute infection to quantify the associated risk of mother-to-child-transmission (MTCT) during pregnancy and delivery. Design A total of 3773 HIV-1 sero-positive women were test...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章
doi:10.1093/ije/dyr055
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:This is a study of the associations of adult leg and trunk length with early life height and weight, diet, socioeconomic circumstances, and health, and parental height, divorce and death. METHOD:The data used were collected in a longitudinal study of the health, development and ageing of a British national ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:2002-04-01 00:00:00
abstract::Serum triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and thyroid autoantibodies (TAA) to either microsome or thyroglobulin were measured in 1251 samples from the general population, 546 males and 705 females, aged 40 or over in Hisayama, a Japanese rural town. TAA was positive in 7.7% of men ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.4.545
更新日期:1987-12-01 00:00:00
abstract:Background:To assess the worldwide variation of amyotrophic lateral sclerosis (ALS) incidence, we performed a systematic review and meta-analysis of population-based data published to date. Methods:We reviewed Medline and Embase up to June 2015 and included all population-based studies of newly diagnosed ALS cases, us...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyw061
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Increasing evidence links chronic infections, especially burden of several infections, with increased risk for cardiovascular diseases (CVD). We studied joint immune response against two major periodontal pathogens and herpes simplex virus (HSV) in relation to established risk factors of CVD. METHODS:Serum ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyl166
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To study the associations of lifestyle factors with waist circumference 'Action Levels', hip circumference and body mass index. DESIGN:Cross-sectional study in a random sample of 5887 men and 7018 women aged 20-59 years, selected from the civil registries of Amsterdam, Maastricht and Doetinchem, The Netherla...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.3.422
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:Bundling, which consists of wrapping an infant for prolonged periods in a sheepskin cover after dried cow dung is applied, is a common and apparently unique practice limited to the rural, mountainous regions of Northern Pakistan. The practice is initiated at various ages during the neonatal period. Its poten...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.4.879
更新日期:1996-08-01 00:00:00
abstract::A prediction of the end-stage renal disease (ESRD) population in Japan from 1980 to 2000 was made using a system dynamics model based on previously published estimates. It is estimated that the ESRD population will be 145,750 (1111 per million population (pmp)) by the year 2000, if renal transplantation gradually incr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.4.1032
更新日期:1991-12-01 00:00:00
abstract:AIM AND METHODS:To discuss evidence for and against genetic 'causes' of type 2 diabetes, illustrated by standardized study of glucose intolerance and high blood pressure in four representative African origin populations. Comparison of two genetically closer sites: rural (site 1) and urban Cameroon (2); then Jamaica (3)...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.1.111
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:Methodological issues in the design and interpretation of cross-sectional interview surveys of the prevalence of acute respiratory infections (ARI) were assessed among young children. METHODS:A cross-sectional survey was conducted in approximately 20,000 children in the north of Ghana. Approximately half we...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.3.608
更新日期:1994-06-01 00:00:00
abstract::Quantitative bias analysis serves several objectives in epidemiological research. First, it provides a quantitative estimate of the direction, magnitude and uncertainty arising from systematic errors. Second, the acts of identifying sources of systematic error, writing down models to quantify them, assigning values to...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyu149
更新日期:2014-12-01 00:00:00
abstract::One hundred consecutive patients with histologically confirmed colorectal cancer and an equal number of age- and sex-matched orthopaedic patients as hospital controls were interviewed about demographic, socioeconomic, biometric and medical variables. Cholecystectomy was significantly more frequent among cases than con...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/13.2.155
更新日期:1984-06-01 00:00:00
abstract:BACKGROUND:In studies of health behaviour exploring factors associated with differences and changes in eating patterns of populations, diet is often measured with short food frequency questionnaires (FFQ). This study examines the validity of a short FFQ by comparing frequencies of food intake from the FFQ to informatio...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.5.1023
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to analyse misclassification of height, weight and body mass index (BMI), derived from mail questionnaires, and its dependency on socioeconomic factors. METHODS:A random sample of 4442 adults aged 18-84 years, living in Stockholm county, Sweden, were in 1984-1985 asked about th...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.4.860
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Urbanization in developing countries is usually accompanied by migration to cities, making it a challenge to unpack the independent relationships between migration, urbanization and health, particularly in the presence of health-selective migration. Since 1978, unprecedented planned urbanization has taken pl...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyz031
更新日期:2019-08-01 00:00:00
abstract:Background:Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC) to examine racial/ethnic differences...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyx252
更新日期:2018-04-01 00:00:00
abstract::Spontaneous losses between the 5th and 27th weeks of pregnancy were measured in a prospective study of 32 123 women whose contraceptive history around the time of conception was known. Diaphragm use prior to conception was associated with a significant reduction in second-trimester losses, after taking into account th...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/9.1.49
更新日期:1980-03-01 00:00:00
abstract::The characteristics of 673 mothers of twins were compared to those of a matched sample of mothers of singletons. Both groups of mothers were interviewed just after delivery, and births in each group were matched for time and place. Of the characteristics studied, the use of oral contraceptives (OC) displayed a signifi...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/10.4.319
更新日期:1981-12-01 00:00:00
abstract:BACKGROUND:Child mortality rates have been declining in most developing countries. We studied child and maternal mortality risk factors for child mortality in Beira city in July 1993, after a decade of conflict in Mozambique. METHODS:A community-based cluster sample survey of 4609 women of childbearing age was conduct...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.2.349
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVES:To examine whether educational attainment and intelligence have causal effects on risk of Alzheimer's disease (AD), independently of each other. DESIGN:Two-sample univariable and multivariable Mendelian randomization (MR) to estimate the causal effects of education on intelligence and vice versa, and the to...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyz280
更新日期:2020-08-01 00:00:00
abstract::The familial aggregation of chronic bronchitis and obstructive airways disease was investigated in a propositus population of 430 persons aged 45-54 years and 1340 of their first (1 degree), second (2degrees) and third (3 degrees ) order relatives. All subjects were screened in their homes using a modified British MRC...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/7.1.55
更新日期:1978-03-01 00:00:00
abstract:BACKGROUND:Previous studies have shown an inconsistency in the association between maternal education and child nutritional status across socioeconomic levels. This may be because the beneficial effects of education are only significant when resources are sufficient but not abundant. METHODS:Associations were examined...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.3.585
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Violent criminality is at least moderately heritable, but the mechanisms behind this remain largely unexplained. Height, a highly heritable trait, may be involved but no study has estimated the effect of height on crime while simultaneously accounting for important demographic, biological and other heritable...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt274
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The aim of this research was to determine the hepatitis B surface antigen (HBsAg) carrier prevalence among cases of hepatocellular carcinoma (HCC), and the population attributable risk of HBsAg carriage for HCC, by ethnicity in New Zealand. METHODS:The hospital notes of HCC cases registered with the New Zea...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/28.2.204
更新日期:1999-04-01 00:00:00
abstract::In recent years, the residential exposure to radon daughters has become a cause for concern as a contributing factor for lung cancer. In order to evaluate the population's risk consequences of different interpretations of the results of epidemiological studies in cohorts of uranium miners, a simulation model has been ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.supplement_1.s73
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Early-life social environment has been suggested to play an important role during the development of Helicobacter pylori-related gastric diseases. We aimed to assess the association of sibship size with H. pylori infection and chronic atrophic gastritis (CAG) in a population-based study from Germany. METHOD...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyp250
更新日期:2010-02-01 00:00:00
abstract::Selection bias remains a more difficult bias to understand than confounding or measurement error. Past definitions have not always been illuminating and a simple method (such as the change-in-estimate method for confounding) has not been available to determine its presence and magnitude in the study sample. A better u...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy138
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Epidemiology's role as the 'diagnostic' arm of public health has submitted epidemiological reasoning and practice to the crossfire of oppositional social values and demands. In Latin America, the visible signs of extreme social and political authoritarianism and inequity, as well as the growing unfairness of...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyn135
更新日期:2008-08-01 00:00:00
abstract::Rapid changes in national rates, with little evidence of cohort effects, must substantially reflect changes in incidence rates due to socioeconomic and behavioral influences, operating with a rather short incubation period. Every newly-rich society usually experiences its epidemic of coronary heart disease. Rate chang...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::In an effort to search for causes of malnutrition in the urban environment to guide intervention efforts, a study of more than 2000 mother/child pairs was conducted in Kinshasa, Zaire. Under the auspices of the Zairian National Nutrition Planning Center a representative sample of a large lower class urban population w...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.3.556
更新日期:1988-09-01 00:00:00