Abstract:
:The familial aggregation of chronic bronchitis and obstructive airways disease was investigated in a propositus population of 430 persons aged 45-54 years and 1340 of their first (1 degree), second (2degrees) and third (3 degrees ) order relatives. All subjects were screened in their homes using a modified British MRC respiratory disease questionnaire and a portable spirometer. 1 degree relatives of propositi with either chronic bronchitis or obstructive airways disease demonstrated up to a two-fold excess prevalence of chronic bronchitis when compared to 1 degree relatives of non-affected propositi. This excess prevalence of chronic bronchitis was independent of sex, cigarette smoking patterns, respiratory illness history, residence in a common household, geographical distribution within the study community and the presence of alpha1-antitrypsin Pi variants. The prevalence of chronic bronchitis in 1 degree relatives of diseased propositi was also greater than in 2 degrees relatives of diseased propositi, in whom the prevalence approximated that of the general population.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Tager I,Tishler PV,Rosner B,Speizer FE,Litt Mdoi
10.1093/ije/7.1.55subject
Has Abstractpub_date
1978-03-01 00:00:00pages
55-62issue
1eissn
0300-5771issn
1464-3685journal_volume
7pub_type
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