Studies of the familial aggregation of chronic bronchitis and obstructive airways disease.

Abstract:

:The familial aggregation of chronic bronchitis and obstructive airways disease was investigated in a propositus population of 430 persons aged 45-54 years and 1340 of their first (1 degree), second (2degrees) and third (3 degrees ) order relatives. All subjects were screened in their homes using a modified British MRC respiratory disease questionnaire and a portable spirometer. 1 degree relatives of propositi with either chronic bronchitis or obstructive airways disease demonstrated up to a two-fold excess prevalence of chronic bronchitis when compared to 1 degree relatives of non-affected propositi. This excess prevalence of chronic bronchitis was independent of sex, cigarette smoking patterns, respiratory illness history, residence in a common household, geographical distribution within the study community and the presence of alpha1-antitrypsin Pi variants. The prevalence of chronic bronchitis in 1 degree relatives of diseased propositi was also greater than in 2 degrees relatives of diseased propositi, in whom the prevalence approximated that of the general population.

journal_name

Int J Epidemiol

authors

Tager I,Tishler PV,Rosner B,Speizer FE,Litt M

doi

10.1093/ije/7.1.55

subject

Has Abstract

pub_date

1978-03-01 00:00:00

pages

55-62

issue

1

eissn

0300-5771

issn

1464-3685

journal_volume

7

pub_type

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