Education, intelligence and Alzheimer's disease: evidence from a multivariable two-sample Mendelian randomization study.

Abstract:

OBJECTIVES:To examine whether educational attainment and intelligence have causal effects on risk of Alzheimer's disease (AD), independently of each other. DESIGN:Two-sample univariable and multivariable Mendelian randomization (MR) to estimate the causal effects of education on intelligence and vice versa, and the total and independent causal effects of both education and intelligence on AD risk. PARTICIPANTS:17 008 AD cases and 37 154 controls from the International Genomics of Alzheimer's Project (IGAP) consortium. MAIN OUTCOME MEASURE:Odds ratio (OR) of AD per standardized deviation increase in years of schooling (SD = 3.6 years) and intelligence (SD = 15 points on intelligence test). RESULTS:There was strong evidence of a causal, bidirectional relationship between intelligence and educational attainment, with the magnitude of effect being similar in both directions [OR for intelligence on education = 0.51 SD units, 95% confidence interval (CI): 0.49, 0.54; OR for education on intelligence = 0.57 SD units, 95% CI: 0.48, 0.66]. Similar overall effects were observed for both educational attainment and intelligence on AD risk in the univariable MR analysis; with each SD increase in years of schooling and intelligence, odds of AD were, on average, 37% (95% CI: 23-49%) and 35% (95% CI: 25-43%) lower, respectively. There was little evidence from the multivariable MR analysis that educational attainment affected AD risk once intelligence was taken into account (OR = 1.15, 95% CI: 0.68-1.93), but intelligence affected AD risk independently of educational attainment to a similar magnitude observed in the univariate analysis (OR = 0.69, 95% CI: 0.44-0.88). CONCLUSIONS:There is robust evidence for an independent, causal effect of intelligence in lowering AD risk. The causal effect of educational attainment on AD risk is likely to be mediated by intelligence.

journal_name

Int J Epidemiol

authors

Anderson EL,Howe LD,Wade KH,Ben-Shlomo Y,Hill WD,Deary IJ,Sanderson EC,Zheng J,Korologou-Linden R,Stergiakouli E,Davey Smith G,Davies NM,Hemani G

doi

10.1093/ije/dyz280

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

1163-1172

issue

4

eissn

0300-5771

issn

1464-3685

pii

5719343

journal_volume

49

pub_type

杂志文章
  • Using operational research modelling to improve the provision of health services: the case of DNA technology.

    abstract::Operational research (OR) analysis provides information and systems to support decision making. In health care there are examples of OR being used to support decisions surrounding both the organization of health services and the treatment of individual patients. However, its uptake is currently low in spite of the inc...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/24.supplement_1.s90

    authors: Beech R

    更新日期:1995-01-01 00:00:00

  • It is just a game: lack of association between watching football matches and the risk of acute cardiovascular events.

    abstract:BACKGROUND:The role of trigger factors in acute cardiovascular events has been much studied in the past few years. A recent study analysed changes in the rates of cardiac emergencies in Bavaria (Germany) during the last Football World Cup. The authors reported a 2.7-fold increase in the incidence of cardiac emergencies...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyq007

    authors: Barone-Adesi F,Vizzini L,Merletti F,Richiardi L

    更新日期:2010-08-01 00:00:00

  • Food insecurity, food choices, and body mass index in adults: nutrition transition in Trinidad and Tobago.

    abstract:BACKGROUND:This study evaluated whether food insecurity and obesity were associated in a population sample in Trinidad. METHODS:A sample was drawn of 15 clusters of households, in north central Trinidad. Resident adults were enumerated. A questionnaire was administered including the short form Household Food Security ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyg100

    authors: Gulliford MC,Mahabir D,Rocke B

    更新日期:2003-08-01 00:00:00

  • Prevalence and control of hypertension in a large cohort of occupationally-active Israelis examined during 1985-1987: the Cordis Study.

    abstract::In view of the many changes in the approach to the detection and management of hypertension that have occurred, the paucity of current data on this subject in Israel limits the possibilities of making international comparisons or evaluating trends. This study contributes recent information on the occupationally-active...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/21.4.676

    authors: Green MS,Peled I

    更新日期:1992-08-01 00:00:00

  • Cohort profile: the Themba Lethu Clinical Cohort, Johannesburg, South Africa.

    abstract::The Themba Lethu Clinical Cohort was established in 2004 to allow large patient-level analyses from a single HIV treatment site to evaluate National Treatment Guidelines, answer questions of national and international policy relevance and to combine an economic and epidemiologic focus on HIV research. The current obje...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dys029

    authors: Fox MP,Maskew M,MacPhail AP,Long L,Brennan AT,Westreich D,MacLeod WB,Majuba P,Sanne IM

    更新日期:2013-04-01 00:00:00

  • Different demographic and sexual correlates for chlamydial infection and gonorrhoea in Rotterdam.

    abstract:BACKGROUND:The objective of the study was to estimate the prevalence of gonorrhoea and chlamydial infections and to determine sexual and demographic correlates for these sexually transmitted diseases (STD) among visitors of an STD clinic. METHODS:In 1994, a cross-sectional study was carried out among 2984 consecutive ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/26.6.1373

    authors: Van Duynhoven YT,van de Laar MJ,Schop WA,Mouton JW,van der Meijden WI,Sprenger MJ

    更新日期:1997-12-01 00:00:00

  • Morbidity profile and its relationship with disability and psychological distress among elderly people in Northern India.

    abstract:BACKGROUND:Morbidity among elderly people has an important influence on their physical functioning and psychological well-being. Evaluation of the morbidity profile and its determinants, which have implications for elderly people, are not available. The objective of this study is to assess morbidity, co-morbidity, and ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyg204

    authors: Joshi K,Kumar R,Avasthi A

    更新日期:2003-12-01 00:00:00

  • Interrupted time series regression for the evaluation of public health interventions: a tutorial.

    abstract::Interrupted time series (ITS) analysis is a valuable study design for evaluating the effectiveness of population-level health interventions that have been implemented at a clearly defined point in time. It is increasingly being used to evaluate the effectiveness of interventions ranging from clinical therapy to nation...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyw098

    authors: Bernal JL,Cummins S,Gasparrini A

    更新日期:2017-02-01 00:00:00

  • Latin American critical ('Social') epidemiology: new settings for an old dream.

    abstract:BACKGROUND:Epidemiology's role as the 'diagnostic' arm of public health has submitted epidemiological reasoning and practice to the crossfire of oppositional social values and demands. In Latin America, the visible signs of extreme social and political authoritarianism and inequity, as well as the growing unfairness of...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyn135

    authors: Breilh J

    更新日期:2008-08-01 00:00:00

  • Size at birth as a predictor of mortality in adulthood: a follow-up of 350 000 person-years.

    abstract:BACKGROUND:Small body size at birth, as a marker of an adverse intrauterine environment, has recently emerged as an important risk factor for death from cardiovascular disease. Our aim was to study the relationship between small size at birth and all-cause and non-cardiovascular mortality, which has been poorly documen...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyi048

    authors: Kajantie E,Osmond C,Barker DJ,Forsén T,Phillips DI,Eriksson JG

    更新日期:2005-06-01 00:00:00

  • The EURODEM collaborative re-analysis of case-control studies of Alzheimer's disease: implications for clinical research and practice.

    abstract::The EURODEM re-analyses of 11 case-control studies of Alzheimer's disease imply that familial aggregation of dementia, Down's syndrome, and parkinsonism occurs more frequently in Alzheimer's disease than in matched controls. Prior history of head trauma, hypothyroidism, and depression also occurs in higher frequency a...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/20.supplement_2.s65

    authors: Kokmen E

    更新日期:1991-01-01 00:00:00

  • Antibodies to human herpes virus type 8 (HHV8) in general population and in individuals at risk for sexually transmitted diseases in Western Sicily.

    abstract:BACKGROUND:Human herpes virus 8 (HHV8) appears to be the primary aetiologic agent of Kaposi sarcoma (KS). To study the distribution of HHV8, a seroepidemiological study was carried out in western Sicily, where a high incidence rate of classical KS is well documented. METHODS:A total of 970 sera of healthy human immuno...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/29.1.175

    authors: Perna AM,Bonura F,Vitale F,Viviano E,Di Benedetto MA,Ajello F,Villafrate MR,Prestileo T,Mancuso S,Goedert JJ,Romano N

    更新日期:2000-02-01 00:00:00

  • Long-term antioxidant supplementation has no effect on health-related quality of life: the randomized, double-blind, placebo-controlled, primary prevention SU.VI.MAX trial.

    abstract:BACKGROUND:The effect of antioxidant vitamin and mineral supplementation on health is one of the most controversial issues in human nutrition. Our objective was to investigate the effect of nutritional doses of a combination of antioxidant vitamins and minerals on health-related quality of life (HRQoL) in a sample of h...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ije/dyr161

    authors: Briançon S,Boini S,Bertrais S,Guillemin F,Galan P,Hercberg S

    更新日期:2011-12-01 00:00:00

  • An international case-control study of adult glioma and meningioma: the role of head trauma.

    abstract:BACKGROUND:Increased brain tumour risk after head trauma suggested by case reports and clinical series has been previously studied epidemiologically with mixed results. An international multicentre case-control study investigated the role of head trauma from injury or sports participation in adult brain tumour risk. M...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ije/27.4.579

    authors: Preston-Martin S,Pogoda JM,Schlehofer B,Blettner M,Howe GR,Ryan P,Menegoz F,Giles GG,Rodvall Y,Choi NW,Little J,Arslan A

    更新日期:1998-08-01 00:00:00

  • Joint modelling of repeated measurement and time-to-event data: an introductory tutorial.

    abstract:BACKGOUND:The term 'joint modelling' is used in the statistical literature to refer to methods for simultaneously analysing longitudinal measurement outcomes, also called repeated measurement data, and time-to-event outcomes, also called survival data. A typical example from nephrology is a study in which the data from...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/ije/dyu262

    authors: Asar Ö,Ritchie J,Kalra PA,Diggle PJ

    更新日期:2015-02-01 00:00:00

  • How well does LiST capture mortality by wealth quintile? A comparison of measured versus modelled mortality rates among children under-five in Bangladesh.

    abstract:BACKGROUND:In the absence of planned efforts to target the poor, child survival programs often favour the rich. Further evidence is needed urgently about which interventions and programme approaches are most effective in addressing inequities. The Lives Saved Tool (LiST) is available and can be used to model mortality ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyq034

    authors: Amouzou A,Richard SA,Friberg IK,Bryce J,Baqui AH,El Arifeen S,Walker N

    更新日期:2010-04-01 00:00:00

  • Pigmentary traits, family history of melanoma and the risk of endometriosis: a cohort study of US women.

    abstract:BACKGROUND:Endometriosis has been associated with a higher risk of cutaneous melanoma, but the mechanisms underlying this association are unknown.Some constitutional factors known to influence melanoma risk have been associated with endometriosis in some retrospective studies. However, prospective data are scarce, and ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyt235

    authors: Kvaskoff M,Han J,Qureshi AA,Missmer SA

    更新日期:2014-02-01 00:00:00

  • Software Application Profile: The Anchored Multiplier calculator-a Bayesian tool to synthesize population size estimates.

    abstract::Estimating the number of people in hidden populations is needed for public health research, yet available methods produce highly variable and uncertain results. The Anchored Multiplier calculator uses a Bayesian framework to synthesize multiple population size estimates to generate a consensus estimate. Users submit p...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyz101

    authors: Wesson PD,McFarland W,Qin CC,Mirzazadeh A

    更新日期:2019-12-01 00:00:00

  • Increasing mortality during the expansions of the US economy, 1900-1996.

    abstract:BACKGROUND:In Western countries mortality dropped throughout the 20th century, but over and above the long-term falling trend, the death rate has oscillated over time. It has been postulated that these short-term oscillations may be related to changes in the economy. METHODS:To ascertain if these short-term oscillatio...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyi141

    authors: Tapia Granados JA

    更新日期:2005-12-01 00:00:00

  • Educational attainment and cigarette smoking: a causal association?

    abstract:BACKGROUND:Despite abundant evidence that lower education is associated with a higher risk of smoking, whether the association is causal has not been convincingly established. METHODS:We investigated the association between education and lifetime smoking patterns in a birth cohort established in 1959 and followed thro...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dym250

    authors: Gilman SE,Martin LT,Abrams DB,Kawachi I,Kubzansky L,Loucks EB,Rende R,Rudd R,Buka SL

    更新日期:2008-06-01 00:00:00

  • Albuminuria as a marker of the risk of developing type 2 diabetes in non-diabetic Aboriginal Australians.

    abstract:BACKGROUND:Aboriginal Australians experience a higher risk of diabetes than the general Australian population. In this paper, we conducted a nested case-control study to determine whether the presence of microalbuminuria and macroalbuminuria is associated with the development of diabetes among diabetes-free Aboriginal ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyl115

    authors: Wang Z,Hoy WE

    更新日期:2006-10-01 00:00:00

  • DataSHIELD: taking the analysis to the data, not the data to the analysis.

    abstract:BACKGROUND:Research in modern biomedicine and social science requires sample sizes so large that they can often only be achieved through a pooled co-analysis of data from several studies. But the pooling of information from individuals in a central database that may be queried by researchers raises important ethico-leg...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyu188

    authors: Gaye A,Marcon Y,Isaeva J,LaFlamme P,Turner A,Jones EM,Minion J,Boyd AW,Newby CJ,Nuotio ML,Wilson R,Butters O,Murtagh B,Demir I,Doiron D,Giepmans L,Wallace SE,Budin-Ljøsne I,Oliver Schmidt C,Boffetta P,Boniol M,B

    更新日期:2014-12-01 00:00:00

  • Trends and determinants of CHD mortality: changes in risk factors and their effects.

    abstract::Cardiovascular disease risk factor and mortality data collected since the 1978 Conference on the Decline in Coronary Heart Disease Mortality were reviewed. Risk factor and disease trends were generally parallel and compatible with current hypotheses of cause and prevention. A few discrepancies between risk factors and...

    journal_title:International journal of epidemiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Blackburn H

    更新日期:1989-01-01 00:00:00

  • Universal COVID-19 screening of 4040 health care workers in a resource-limited setting: an Egyptian pilot model in a university with 12 public hospitals and medical centers.

    abstract:BACKGROUND:The scale of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among health care workers (HCWs), particularly in resource-limited settings, remains unclear. To address this concern, universal (non-symptom-based) screening of HCWs was piloted to determine the proportion of SARS-CoV-2 infe...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyaa173

    authors: Mostafa A,Kandil S,El-Sayed MH,Girgis S,Hafez H,Yosef M,Saber S,Ezzelarab H,Ramadan M,Afifi I,Hassan F,Elsayed S,Reda A,Fattuh D,Mahmoud A,Mansour A,Sabry M,Habeb P,Ebeid FS,Saleh A,Mansour O,Omar A,El-Meteini

    更新日期:2020-10-23 00:00:00

  • Thyroid disorders in the general population of Hisayama Japan, with special reference to prevalence and sex differences.

    abstract::Serum triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and thyroid autoantibodies (TAA) to either microsome or thyroglobulin were measured in 1251 samples from the general population, 546 males and 705 females, aged 40 or over in Hisayama, a Japanese rural town. TAA was positive in 7.7% of men ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/16.4.545

    authors: Okamura K,Nakashima T,Ueda K,Inoue K,Omae T,Fujishima M

    更新日期:1987-12-01 00:00:00

  • Socioeconomic differences in cardiovascular risk factors in China.

    abstract::Socioeconomic conditions are important in explaining variation in cardiovascular morbidity in advanced societies. To analyse whether cardiovascular risk factors vary according to socioeconomic status in a developing country, and more specifically, in an urban area of China, we compared data from structured interviews ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/19.4.905

    authors: Siegrist J,Bernhardt R,Feng ZC,Schettler G

    更新日期:1990-12-01 00:00:00

  • HDSS Profile: The Kersa Health and Demographic Surveillance System.

    abstract::Kersa HDSS was established in 12 sub-districts of Kersa district, Eastern Hararge, Oromia Region, Ethiopia. The site is principally rural with two small towns (Kersa and Weter). The baseline census was conducted in 2007 and since then has been updated every 6 months, with registration of demographic and health events....

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyv284

    authors: Assefa N,Oljira L,Baraki N,Demena M,Zelalem D,Ashenafi W,Dedefo M

    更新日期:2016-02-01 00:00:00

  • Hypertension and sources of blood pressure variability among Mexican-Americans in Starr County, Texas.

    abstract::Previous investigations have established that the Mexican-American community of south Texas has a three- to five-fold elevated risk for non-insulin dependent diabetes mellitus when compared to the US population as a whole. In addition, evidence points to similarly increased risks of the related disorders, hypertension...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/14.2.231

    authors: Hanis CL,Ferrell RE,Schull WJ

    更新日期:1985-06-01 00:00:00

  • Cardiovascular risk factor distribution above the age of 75 years in a Belgian community.

    abstract::An elderly Belgian population group anno 1986 consisting of 53 men and 110 women above the age of 75 years with a mean age of 80 and 81 years, respectively, is characterized by relative obesity and low diastolic blood pressure, both in men and women. The SBP/DBP ratio is 1.91 in men and 1.88 in women. HDL-cholesterol ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/17.3.520

    authors: Kesteloot H,Heyrman J,Geboers J,De Lepeleire J,Lissens W

    更新日期:1988-09-01 00:00:00

  • The prevalence of dementia in Europe: a collaborative study of 1980-1990 findings. Eurodem Prevalence Research Group.

    abstract::To obtain age- and gender-specific estimates of the prevalence of dementia in Europe and to study differences in prevalence across countries, we pooled and re-analysed original data of prevalence studies of dementia carried out in some European countries between 1980 and 1990. The study followed these steps: census of...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/20.3.736

    authors: Hofman A,Rocca WA,Brayne C,Breteler MM,Clarke M,Cooper B,Copeland JR,Dartigues JF,da Silva Droux A,Hagnell O

    更新日期:1991-09-01 00:00:00