Insertional inactivation of dsbA produces sensitivity to cadmium and zinc in Escherichia coli.

Abstract:

:In a search for genes that produce hypersensitivity to cadmium salts in Escherichia coli, random transposon mutagenesis with TnphoA was used. One of the mutant strains obtained was sensitive to Cd2+ and Zn2+. Sequence analysis showed that the TnphoA insertion was located in the dsbA gene coding for a periplasmic protein required for disulfide bond formation.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Rensing C,Mitra B,Rosen BP

doi

10.1128/jb.179.8.2769-2771.1997

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

2769-71

issue

8

eissn

0021-9193

issn

1098-5530

journal_volume

179

pub_type

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