A comparison of triclosan and stannous fluoride toothpastes for inhibition of plaque regrowth. A crossover study designed to assess carry over.


:Some triclosan and stannous fluoride toothpastes have been shown effective in reducing plaque and more particularly gingivitis in home use studies. There have been few comparisons of such products for their chemical plaque inhibitory action divorced from the indeterminate variable of toothbrushing. This study was a randomised, single-blind, cross-over comparison of 4 products, in a 4-day plaque regrowth design, balanced for residual effects and involving 12 healthy dentate subjects. The test agents were a stannous fluoride toothpaste, a triclosan/copolymer toothpaste, a triclosan/zinc citrate toothpaste and water. On day 1 of each study period, subjects were rendered plaque free. For the following 4 days, each subject suspended normal toothcleaning and rinsed 2 x daily with the allocated treatment for 60 s under supervision. On day 5, plaque was scored by index. Washout periods of 2 1/2 days brushing with water alone, followed each treatment period. Pseudo treatment periods of 4 days, involving 2 x daily rinsing with water in the absence of toothbrushing, followed the normal washouts after the stannous fluoride and triclosan/zinc citrate treatments, giving a total of 6 treatment periods. This design permitted analyses for 1st-order-carry-over. Intention to treat analyses revealed all toothpastes were more effective than water but that there were no differences between the active treatments. Per protocol analysis gave essentially similar findings except that the difference in plaque in favour of the triclosan/zinc citrate toothpaste over water did not reach significance. There was no evidence of 1st-order-carry-over effects for the stannous fluoride or triclosan/zinc citrate toothpastes. Consistent with other studies it appears that stannous fluoride and triclosan can be formulated into toothpaste vehicles to provide plaque inhibitory effects.


J Clin Periodontol


Binney A,Addy M,Owens J,Faulkner J




Has Abstract


1997-03-01 00:00:00












  • In-dental-office screening for diabetes mellitus using gingival crevicular blood.

    abstract:BACKGROUND:Diabetes mellitus (DM) is undiagnosed in approximately 1/2 of the patients actually suffering from the disease. In addition, the prevalence of DM is more than 2x as high in patients with periodontitis when compared to periodontally healthy subjects. Thus, a high number of patients with periodontitis may have...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Beikler T,Kuczek A,Petersilka G,Flemmig TF

    更新日期:2002-03-01 00:00:00

  • Dramatic osteonecrosis of the jaw associated with oral bisphosphonates, periodontitis, and dental implant removal.

    abstract:INTRODUCTION:Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these medications, osteonecrosis of the jaw is a significant complication in a subset of patients receiving these drug...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Fernández Ayora A,Herion F,Rompen E,Reginster JY,Magremanne M,Lambert F

    更新日期:2015-02-01 00:00:00

  • The effect of periodontal status and occlusal support on masticatory performance: the Suita study.

    abstract:AIM:In this study, we investigated the effect of differences in periodontal status in the masticatory performance of dentate subjects with the same occlusal supporting area. MATERIALS AND METHODS:The subjects of the analysis were classified into those of Eichner A1-3 (n = 1094) and Eichner B1-4 (n = 529). Subjects' pe...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Kosaka T,Ono T,Yoshimuta Y,Kida M,Kikui M,Nokubi T,Maeda Y,Kokubo Y,Watanabe M,Miyamoto Y

    更新日期:2014-05-01 00:00:00

  • Levels of salivary IgA antibodies reactive with bacteria from dental plaque are associated with susceptibility to experimental gingivitis.

    abstract::Serum IgG, IgA and IgM and salivary IgA antibody levels reactive with extracts from Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Eubacterium saburreum and Streptococcus mutans, were measured by enzyme-linked immunosorbent assay in samples from 12 persons before, during and after experimental gingivi...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Schenck K,Poppelsdorf D,Denis C,Tollefsen T

    更新日期:1993-07-01 00:00:00

  • A radiographic survey of periodontal conditions in Greece.

    abstract::The present study used radiographic assessments to evaluate the pattern of destructive periodontal disease ina rural and an urban sample of 25-64 year old Greek adults. The rural sample (A) comprised 190 subjects and the urban sample (B) 400 subjects. 13% of the subjects in sample A and 8% in sample B were edentulous....

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Diamanti-Kipioti A,Afentoulidis N,Moraitaki-Tsami A,Lindhe J,Mitsis F,Papapanou PN

    更新日期:1995-05-01 00:00:00

  • The osteoclast and periodontitis.

    abstract::The osteoclast may play an important rŏle in the variable rate of osseous destruction seen in periodontitis. Current understanding of various aspects of the osteoclast may help explain this fact. This review paper will first look at two theories of cell origin of the osteoclast: the multipotential osteoprogenitor cell...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Sterrett JD

    更新日期:1986-04-01 00:00:00

  • Analysis of changes in gingival contour from three-dimensional co-ordinate data in subjects with drug-induced gingival overgrowth.

    abstract:OBJECTIVES:This aim of this study was to develop and assess a technique that could be used to assess accurately the gingival volume changes seen in drug-induced gingival overgrowth by the analysis of data obtained from an entire gingival surface by means of three-dimensional imaging. MATERIAL AND METHODS:Stone dental ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Thomason JM,Ellis JS,Jovanovski V,Corson M,Lynch E,Seymour RA

    更新日期:2005-10-01 00:00:00

  • Risk variables in the association between frequency of alcohol consumption and periodontitis.

    abstract:OBJECTIVE:Investigate the association between the frequency of alcohol consumption and periodontitis. Moreover, evaluate the influence of biological, behavioural, and social risk variables in this association. METHODS:Sample was comprised by 542 subjects of both genders, 35-55 years of age, who underwent a complete pe...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Lages EJ,Costa FO,Lages EM,Cota LO,Cortelli SC,Nobre-Franco GC,Cyrino RM,Cortelli JR

    更新日期:2012-02-01 00:00:00

  • Subgingival instrumentation for treatment of periodontitis. A systematic review.

    abstract:OBJECTIVES:To evaluate the efficacy of subgingival instrumentation (PICOS-1), sonic/ultrasonic/hand instruments (PICOS-2) and different subgingival instrumentation delivery protocols (PICOS-3) to treat periodontitis. METHODS:Systematic electronic search (CENTRAL/MEDLINE/EMBASE/SCOPUS/LILACS) to March 2019 was conducte...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Suvan J,Leira Y,Moreno Sancho FM,Graziani F,Derks J,Tomasi C

    更新日期:2020-07-01 00:00:00

  • Effects of smoking and gingival inflammation on salivary antioxidant capacity.

    abstract:AIM:This study evaluated possible effects of smoking and gingival inflammation on salivary antioxidants in gingivitis patients. METHODS:Twenty otherwise healthy gingivitis patients (10 self-reported smokers) and 20 periodontally and systemically healthy volunteer subjects were enrolled in the study. Whole saliva sampl...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Buduneli N,Kardeşler L,Işik H,Willis CS 3rd,Hawkins SI,Kinane DF,Scott DA

    更新日期:2006-03-01 00:00:00

  • The recovery efficiency of various materials for sampling enzymes and polymorphonuclear leukocytes from gingival crevices.

    abstract::The present investigation was designed to assess the effects of strips made of different materials on the recovery of enzymes in gingival crevicular fluid (GCF) (Experiment 1), and to examine a possible relationship between lysosomal enzyme activities and number of crevicular polymorphonuclear leukocytes (PMNs) (Exper...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Nakashima K,Demeurisse C,Cimasoni G

    更新日期:1994-08-01 00:00:00

  • Predictors of tooth loss during long-term periodontal maintenance: a systematic review of observational studies.

    abstract:OBJECTIVE:To systematically assess the factors influencing tooth loss during long-term periodontal maintenance (PM). METHODS:CENTRAL, MEDLINE and EMBASE were searched up to and including September 2009. Studies limited to patients with periodontitis who underwent periodontal therapy and followed a maintenance care pro...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,评审


    authors: Chambrone L,Chambrone D,Lima LA,Chambrone LA

    更新日期:2010-07-01 00:00:00

  • Effect of mHealth in improving oral hygiene: A systematic review with meta-analysis.

    abstract:AIM:To evaluate the effectiveness of mobile applications and text messages, compared with conventional oral hygiene instructions, for improving oral health knowledge and/or reducing gingival inflammation, when delivered to adolescents, adults and mothers of young children. METHODS:Randomized clinical trials evaluating...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,meta分析,评审


    authors: Toniazzo MP,Nodari D,Muniz FWMG,Weidlich P

    更新日期:2019-03-01 00:00:00

  • Does the nature of the solvent affect the anti-inflammatory capacity of triclosan? An experimental study.

    abstract::The anti-inflammatory properties of triclosan have been revealed in several recent studies, including an effect on histamine-induced inflammation. In other studies, the nature of the solvent has been shown to be of importance for the plaque inhibiting as well as the antibacterial potential of triclosan. This study was...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Skaare AB,Kjaerheim V,Barkvoll P,Rölla G

    更新日期:1997-02-01 00:00:00

  • Soft tissue volume augmentation at dental implant sites using a volume stable three-dimensional collagen matrix - histological outcomes of a preclinical study.

    abstract:AIM:The aim of this study was to test whether or not soft tissue augmentation with a collagen matrix (VCMX) leads to a similar increase in ridge width around dental implants compared to the use of an autogenous subepithelial connective tissue graft (SCTG). MATERIALS AND METHODS:In 12 dogs, immediate dental implants we...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Thoma DS,Naenni N,Benic GI,Hämmerle CH,Jung RE

    更新日期:2017-02-01 00:00:00

  • Entire papilla preservation technique in the regenerative treatment of deep intrabony defects: 1-Year results.

    abstract:AIM:This study evaluates the clinical outcomes of a novel tunnel-like surgical technique in the treatment of isolated deep intrabony defects. MATERIAL AND METHODS:Twelve patients presenting with at least one isolated deep intrabony defect received regenerative periodontal treatment with "entire papilla preservation (E...

    journal_title:Journal of clinical periodontology



    authors: Aslan S,Buduneli N,Cortellini P

    更新日期:2017-09-01 00:00:00

  • Supportive periodontal therapy of furcation sites: non-surgical instrumentation with or without topical doxycycline.

    abstract:OBJECTIVES:Evaluation of the clinical effect of topical subgingival application of doxycycline gel adjunctively to scaling and root planing (SRP) at furcation sites during supportive periodontal therapy (SPT). MATERIAL AND METHODS:In 39 SPT patients exhibiting at least four pockets > or m with bleeding on probing, SRP...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章,随机对照试验


    authors: Dannewitz B,Lippert K,Lang NP,Tonetti MS,Eickholz P

    更新日期:2009-06-01 00:00:00

  • Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2.

    abstract:AIM:To test the hypothesis that a synthetic hydroxyapatite/β-tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins-2 (rhBMP-2) enhances new bone formation compared with bone morphogenetic proteins-2 (BMP-2) delivered using the HA...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Gruber RM,Krohn S,Mauth C,Dard M,Molenberg A,Lange K,Perske C,Schliephake H

    更新日期:2014-08-01 00:00:00

  • No detrimental effect of fibrin glue on the regeneration of intrabony defects. A controlled clinical trial.

    abstract::This controlled clinical trial evaluated the potential of fibrin glue as a biological carrier to locally deliver guided tissue regeneration (GTR) modulators, 2 controlateral, morphologically similar defects were selected in each of 11 patients and randomly assigned to the test (teflon membrane and fibrin glue) and the...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cortellini P,Pini Prato GP,Tonetti MS

    更新日期:1995-09-01 00:00:00

  • Cell-seeding of periodontal ligament fibroblasts. A novel technique to create new attachment. A pilot study.

    abstract::This study was undertaken to test the hypothesis that seeded periodontal ligament cells are able to create new attachment. In one beagle dog, a premolar was removed and scrapings of the ligament were cultured. Artificial periodontal defects were made and the cultured ligament cells were seeded on the planed root surfa...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: van Dijk LJ,Schakenraad JM,van der Voort HM,Herkströter FM,Busscher HJ

    更新日期:1991-03-01 00:00:00

  • Risk factors for gingival overgrowth in patients medicated with ciclosporin in the absence of calcium channel blockers.

    abstract:OBJECTIVES:This study investigates the effect of a range of potential risk factors on the severity of gingival overgrowth in transplant patients medicated with ciclosporin in the absence of any calcium channel blockers. MATERIALS AND METHODS:One hundred dentate solid organ transplants medicated with ciclosporin (but n...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Thomason JM,Seymour RA,Ellis JS

    更新日期:2005-03-01 00:00:00

  • The prospective study of autotransplanted severely impacted developing premolars: periodontal status and the long-term outcome.

    abstract:AIMS:To determine the periodontal status and long-term outcomes of the surgical treatment of severely impacted developing premolars. MATERIALS AND METHODS:Nine impacted and adversely angulated second premolars (four maxillary and five mandibular) were autotransplanted from their initial position to the ideal position ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Plakwicz P,Czochrowska EM

    更新日期:2014-05-01 00:00:00

  • Actinobacillus actinomycetemcomitans in Chinese adults. Serotype distribution and analysis of the leukotoxin gene promoter locus.

    abstract::The aim of the present study was to examine the Actinobacillus actinomycetemcomitans carrier rate in Chinese subjects, and to determine serotype distribution, presence of the leukotoxin gene lktA and the structure of the lktA-promoter region. Subgingival microbiological samples were obtained from 31 Chinese subjects w...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Mombelli A,Gmür R,Lang NP,Corbert E,Frey J

    更新日期:1999-08-01 00:00:00

  • A method to study sustained antimicrobial activity of rinse and dentifrice components on biofilm viability in vivo.

    abstract:AIM:To develop an improved method for quantitative assessment of antimicrobial efficacy and substantivity of mouth rinses and dentifrices on in vivo treated plaque. MATERIAL AND METHODS:Nine- and 72-h-old plaques were formed in volunteers carrying out standardized hygiene using NaF-containing dentifrice. Plaques were ...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: van der Mei HC,White DJ,Atema-Smit J,van de Belt-Gritter E,Busscher HJ

    更新日期:2006-01-01 00:00:00

  • Cleaning effectiveness of chewing sticks among Tanzanian schoolchildren.

    abstract::The oral hygiene of habitual chewing stick and toothbrush users who participated in an oral health education (OHE) programme in schools was evaluated. The study comprised all chewing stick users (n = 45) in standard 4 in 8 randomly selected experimental schools and all chewing stick users (n = 17) in standard 4 in 4 r...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: van Palenstein Helderman WH,Munck L,Mushendwa S,Mrema FG

    更新日期:1992-08-01 00:00:00

  • The gingival biotype: measurement of soft and hard tissue dimensions - a radiographic morphometric study.

    abstract:BACKGROUND:Gingival biotypes have been reported to influence the outcome of restorative therapies. The aim of this study was to evaluate the correlation of different morphometric parameters with the thickness of the buccal gingiva and alveolar bone at different apico-coronal levels. METHODS:In 60 periodontally healthy...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Stein JM,Lintel-Höping N,Hammächer C,Kasaj A,Tamm M,Hanisch O

    更新日期:2013-12-01 00:00:00

  • Factors associated with different responses to periodontal therapy.

    abstract::In a study of the efficacy of modified Widman flap surgery and scaling and root planning accompanied by 1 of 4 systemic adjunctive agents, Augmentin, tetracycline, ibuprofen or placebo, it was observed that subjects differed in their response to therapy. The difference was only partially accounted for by the adjunctiv...

    journal_title:Journal of clinical periodontology

    pub_type: 临床试验,杂志文章


    authors: Haffajee AD,Dibart S,Kent RL Jr,Socransky SS

    更新日期:1995-08-01 00:00:00

  • A biomechanical assessment of the relation between the oral implant stability at insertion and subjective bone quality assessment.

    abstract:AIM:The study was set to evaluate the validity of subjective jaw bone quality assessment. MATERIALS AND METHODS:A total of 298 patients (198 females, mean age 56.4) were treated with oral implants at the Periodontology Department at the University Hospital of KUL. A total of 761 TiUnite implants have been installed. S...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Alsaadi G,Quirynen M,Michiels K,Jacobs R,van Steenberghe D

    更新日期:2007-04-01 00:00:00

  • A "case control" study on the rôle of HLA DR4 in severe periodontitis and rapidly progressive periodontitis. Identification of types and subtypes using molecular biology (PCR.SSO).

    abstract::HLA DR4 antigens have been considered as a risk factor in periodontal disease. The aim of this "case control" study was to verify and to provide fuller clarification of such data. "Cases" or patients had to be aged between 20 and 48 years. They presented at least 5 sites spread over several teeth with an attachment lo...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Bonfil JJ,Dillier FL,Mercier P,Reviron D,Foti B,Sambuc R,Brodeur JM,Sedarat C

    更新日期:1999-02-01 00:00:00

  • Predictive power of various models for longitudinal attachment level change.

    abstract::Several statistical models that have been suggested in the periodontal literature for describing longitudinal attachment level changes, such as the gradual loss, single-burst, multiple-burst, and random walk models as well as other models introduced in this paper are compared by their power to predict future attachmen...

    journal_title:Journal of clinical periodontology

    pub_type: 杂志文章


    authors: Yang MC,Marks RG,Clark WB,Magnusson I

    更新日期:1992-02-01 00:00:00