Is periodontal disease a risk indicator for colorectal cancer? A systematic review and meta-analysis.

Abstract:

AIMS:Existing epidemiological studies have suggested that periodontal disease (PD) may be a risk indicator for colorectal cancer (CRC). However, no formal systematic review and meta-analysis have been performed. Therefore, we aimed to evaluate the association between PD and CRC risk in this study. MATERIALS AND METHODS:We used the PubMed, EMBASE, Cochrane Library and Web of Science to search for related articles published from 1 January 1966 to 16 July 2020. Stata (Version 15) software was used to calculate the total risk ratio (RR) and 95% confidence interval (CI) of the included studies through the random-effects model to assess the association between PD and CRC risk. RESULTS:Nine studies were included in the narrative synthesis, and seven studies were included in the meta-analysis. Results showed that PD significantly increased the risk of CRC by 44% (RR, 1.44; 95% CI, 1.18-1.76; I2 , 55.2%). CONCLUSION:We found an association between PD and CRC. PD can be a potential risk indicator for the occurrence and development of CRC, and further studies are needed to assess causality. Hence, effective periodontal treatment could be a valuable preventive measure for CRC.

journal_name

J Clin Periodontol

authors

Li W,Xu J,Zhang R,Li Y,Wang J,Zhang X,Lin L

doi

10.1111/jcpe.13402

subject

Has Abstract

pub_date

2020-11-11 00:00:00

eissn

0303-6979

issn

1600-051X

pub_type

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