当前位置： SCI文献检索 > JOURNAL OF CLINICAL PERIODONTOLOGY期刊下所有文献 > Soluble beta-1,3/1,6-glucan from yeast inhibits experimental periodontal disease in Wistar rats.

Soluble beta-1,3/1,6-glucan from yeast inhibits experimental periodontal disease in Wistar rats.

Abstract：

OBJECTIVE:We have investigated whether a purified immunomodulatory water soluble beta-1,3/1,6-glucan isolated from the cell wall of Bakers yeast, Saccharomyces cerevisiae, would influence the progression of ligature-induced periodontal disease, and to modulate accompanying cytokine and hypothalamic-pituitary-adrenal (HPA) axis responses to a lipopolysaccharide (LPS) challenge. MATERIAL AND METHODS:beta-1,3/1,6-glucan (10 mg/kg/day) was given in the drinking water to Wistar rats during the entire experiment, starting 14 days before disease induction, while control rats were given tap water only. Periodontal disease was assessed when the ligatures had been in place for 35 days. RESULTS:Orally administered soluble beta-1,3/1,6-glucan significantly reduced periodontal bone loss as measured on digital X-rays (p=0,026). Glucan-treated rats also showed a significantly enhanced plasma level of the HPA axis-driven hormone corticosterone (p=0.047), and of the cytokine transforming growth factor-1beta (p=0.032), as well as a tendency to enhanced IL-10 (p=0.106), induced by intra-peritoneally administered LPS. CONCLUSION:Soluble beta-1,3/1,6-glucan administered by the oral route diminishes ligature-induced periodontal bone loss in this model. This effect may be attributable to the well documented ability of beta-1,3/1,6-glucan to stimulate macrophage phagocytosis and to skew the T helper (Th)1/Th2 balance towards Th1 and T regulatory responses. The HPA axis may play a significant role in beta-1,3/1,6-glucan induced immune modulation.

journal_name

J Clin Periodontol

journal_title

Journal of clinical periodontology

authors

Breivik T,Opstad PK,Engstad R,Gundersen G,Gjermo P,Preus H

doi

10.1111/j.1600-051X.2005.00672.x

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

347-52

issue

4

eissn

0303-6979

issn

1600-051X

pii

CPE672

journal_volume

32

pub_type

杂志文章

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