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Effects of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing.

Abstract：

:This paper examines the effects of smoking on the treatment outcomes of two nonsurgical therapies: (1) scaling and root planing alone (SRP) or (2) controlled-release of subgingivally delivered doxycycline hyclate in a polylactic acid based polymer gel. Subjects from 2 9-month multicenter studies were classified as nonsmokers (never smoked: 100 subjects), former smokers (137 subjects), and current smokers (> or = 10 cigarettes/day: 121 subjects). Clinical parameters were analyzed for treated sites with baseline probing depths > or = 5 mm and for a subset of treated sites with baseline probing depths of > or = 7 mm. Clinical parameters (plaque levels, clinical attachment levels, pocket depths, and bleeding on probing) were analyzed at baseline, 4, 6, and 9 months. In the doxycycline treated group in general, there were neither marked significant differences in clinical attachment gain nor differences in probing depth reduction among the 3 smoking groups. On the other hand, in the scaling and root planing treated group in general, there were significant differences in clinical attachment gain and pocket depth reduction, with non-smokers responding better than former smokers and current smokers at 6 and 9 months. These differences in clinical response between scaling and root planing alone versus controlled-release of locally-delivered doxycycline hyclate among these 3 smoking groups are discussed in relation to treatment implications for smokers.

journal_name

J Clin Periodontol

journal_title

Journal of clinical periodontology

authors

Ryder MI,Pons B,Adams D,Beiswanger B,Blanco V,Bogle G,Donly K,Hallmon W,Hancock EB,Hanes P,Hawley C,Johnson L,Wang HL,Wolinsky L,Yukna R,Polson A,Carron G,Garrett S

doi

10.1034/j.1600-051x.1999.261008.x

keywords:

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

683-91

issue

10

eissn

0303-6979

issn

1600-051X

journal_volume

26

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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