Reactogenecity of indigenously produced measles vaccine.

Abstract:

OBJECTIVE:To assess the safety and reactogenecity of indigenously produced measles vaccine derived from EZ strain. DESIGN:A longitudinal clinical follow up after vaccination. SETTING:Hospital based and home follow up, as required. SUBJECTS:12,470 children, 9 to 15 months old, immunized with measles vaccine of EZ strain, in accordance with the National Immunization Schedule, at five centers. METHODS:A clinical follow up of children at 1 day, 1 week, 2 weeks, 3 weeks and 6 weeks after measles vaccination. A detailed clinical neurological examination in children showing side effects. RESULTS:Mild side effects were documented in 31%. Of these, 90% were seen in the first two weeks, out of which two thirds were seen during the first week. Commonest side effects were coryza (10%), fever (9.8%), cough (3.2%) and diarrhea (3.2%). Convulsions, with no later sequelae were documented in 2 cases only. CONCLUSIONS:Measles vaccine manufactured in India, using EZ strain is a safe vaccine. It has a level of reactogenecity including neurological aspects, lower than that reported in India with the Schwarz strain vaccine.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Bhargava I,Chhaparwal BC,Phadke MA,Irani SF,Chakladhar BK,Maheshwari CP

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

827-31

issue

10

eissn

0019-6061

issn

0974-7559

journal_volume

33

pub_type

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