Abstract:
OBJECTIVE:To compare the efficacy of phenobarbitone and phenytoin for treatment of neonatal seizures in term and near-term neonates. DESIGN:Open labeled randomized controlled trial. SETTING:Neonatal intensive care unit of a level II unit from India, from November 2008 to September 2009. PARTICIPANTS:All term and late pre-term neonates admitted with clinically apparent seizures and not having any transient metabolic disorders (hypoglycemia or hypocalcemia) were randomly assigned. INTERVENTION:Phenobarbitone (n=54) or phenytoin (n=55) intravenously 20 mg/kg/dose over 20-30 min. Neonates whose seizures were not controlled by the assigned drug were then crossed over to be treated with other drug in same dose. PRIMARY OUTCOME VARIABLE:Clinical control of seizures (seizure free period of 24 hours after giving anticonvulsant). RESULTS:Baseline characteristics including mean birthweight, gestation age and sex were comparable in both groups. Seizures were controlled in 8 of the 55 (14.5%) neonates who received phenytoin, as compared to 39 of 54 (72.2%) neonates who received phenobarbitone (P <0.001). In babies not responding to assigned drugs, after cross-over to the other drug, seizure control was achieved in 44/55 (80%) of the neonates assigned to receive phenytoin first as compared to 49/54 (91%) of those assigned to receive phenobarbitone first (P=0.014). After maximum dose of phenobarbitone seizures were controlled in 49/55(89%) in phenytoin group and 52/54 (96%) in phenobarbitone group (P<0.05). CONCLUSIONS:Phenobarbitone is more efficacious than phenytoin in control of clinical seizures in term or near-term neonates, irrespective of etiology. To evaluate serum vascular endothelial growth factor (VEGF) levels in children with acute lymphoblastic leukemia (ALL) during the induction phase of chemotherapy.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Pathak G,Upadhyay A,Pathak U,Chawla D,Goel SPdoi
10.1007/s13312-013-0218-6subject
Has Abstractpub_date
2013-08-01 00:00:00pages
753-7issue
8eissn
0019-6061issn
0974-7559pii
SO97475591200051journal_volume
50pub_type
杂志文章,随机对照试验abstract::We conducted this study to ascertain whether health workers can routinely administer verbal autopsy (VA) to determine the cause of death in their area. The health workers were trained to administer verbal autopsy tool on the deaths occurring in the population under them. All the verbal autopsies of under-five deaths b...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2003-08-01 00:00:00
abstract::Clinical and hematological data of 9 cases with factor XIII deficiency is highlighted. The age at first bleed ranged from 3 days of life to 1 year. Seven of these 9 cases had bleeding from the umbilicus, 3 had recurrent subcutaneous and muscle hematomas, while 4 cases had CNS bleeds of which 3 expired. Routine coagulo...
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1992-07-01 00:00:00
abstract::Biliary atresia has been commonly reported with cytomegalovirus (CMV) infection. CMV positive patients may present with a later onset however long term outcome is similar to non-CMV patients. There are very few case reports of role of antivirals in CMV and biliary atresia. We treated a 2 month old girl with biliary at...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-012-0092-7
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the coagulation profile and its relation to steroid therapy, and the frequency of thromboembolic complications and its correlation with coagulation parameters in nephrotic syndrome (NS). SETTING:Hospital based. SUBJECTS AND METHODS:Forty children with NS were subdivided into four groups, namely,...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::A 3 year old child was brought with fever, left parotid swelling and altered sensorium. Cultures from blood, pus and throat swab grew Burkholderia pseudomallei. A diagnosis of septicemic melioidosis with encephalopathy was made. She recovered following treatment with parenteral ceftazidime for 14 days, and 6 months of...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-010-0106-2
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To provide tribe- specific child mortality rates and health indicators from selected states in India. METHODS:We used Census 2011 data and Coale Demney methodology to estimate the infant mortality rate (IMR), under-five mortality rate (U5MR) and expectation of life at birth (LEB) for 123 tribes of selected s...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2021-01-15 00:00:00
abstract:OBJECTIVE:To evaluate the effect of vitamin D and calcium supplementation for osteoprotection in thalassemia. METHODS:29 children (age 2-12 y) were supplemented with oral vitamin D (1000 IU/d) and calcium (500 mg/d) for 1 year. The dual energy X-ray absorptiometry (DXA) was done to assess bone mineral content at basel...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2019-04-15 00:00:00
abstract:OBJECTIVE:To determine the role of intravenous administration of human albumin prior to blood exchange in term neonates for reduction of total serum bilirubin (TSB). DESIGN:Randomized controlled trial. SETTING:Neonatal Unit of Nemazee Hospital, affiliated with Shiraz University of Medical Sciences, southern Iran. PA...
journal_title:Indian pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s13312-010-0046-x
更新日期:2010-03-01 00:00:00
abstract::This prospective study was conducted in a teaching hospital to identify and analyze medical errors in pediatric practice. All admitted children underwent surveillance for medical errors. Of 457 errors identified in 1286 children, medication errors were 313 (68.5%), those related to treatment procedures were 62 (13.6%)...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
abstract::The discussion section explains the meaning of results to the readers, and addresses the implications of the findings emanating from the particular study. Authors should compare their results with previous reports, and attempt to explain similarities and differences. It is useful to outline the limitations and strengt...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-016-0955-4
更新日期:2016-10-08 00:00:00
abstract::We performed a retrospective study of hospital records of children younger than 14 years with ocular trauma seen at our center in Sao Paulo, Brazil, between 2011 and 2012. From the total number of cases, 224 (89.2%) could be easily avoided. Accidents occurred with 5 children under 1 year of age; with one baby as young...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2020-12-26 00:00:00
abstract::A random urine calcium/creatinine ratio (UCa/Cr) is of practical use in screening for hypercalciuria. However, due to worldwide variations, reference values for the pediatric population are not yet well established. Furthermore, no study has been conducted to establish normal UCa/Cr values in Turkish children. The obj...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Calcinosis cutis is usually seen in long standing and untreated cases of juvenile dermatomyositis. CASE CHARACTERISTICS:7-year-old girl with severe calcinosis cutis who developed cutaneous ulceration, rash and myopathy. OBSERVATION:Myopathic changes in EMG, muscle edema in MRI, elevated muscle enzymes and ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-014-0531-8
更新日期:2014-11-01 00:00:00
abstract::The prevalence of vitamin A deficiency was estimated in 366 rural children in the age group of 1 to 15 years. In a systematically selected subsample of 90 children, the dietary intake of vitamin A was assessed. The prevalence of vitamin A deficiency signs ranged from 24.1 to 34.8%. The adequacy of dietary intake of vi...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::In an earlier study usefulness and validity of calf circumference in the identification of low birth weight (LBW) infants was reported. To evolve a simple indicator in identifying LBW in community, comparative evaluation of three simple measurements, i.e., circumferences of calf (CC), thigh (TC) and arm (AC) was done ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Eighteen cyanotic congenital heart disease (CCHD) and 17 acyanotic congenital heart disease (ACHD) patients in the age range of 2 months to 10 years along with their age and nutrition matched controls were studied for bactericidal, chemotactic and phagocytic functions. Bactericidal and phagocytic functions were signif...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract::A modified technique for umbilical artery catheterization was assessed in babies in whom conventional method failed or if the cord was dry. Success rate attained with the modified technique was 90% (19/21). This modified technique could provide an easier and faster method for successful umbilical arterial catheterizat...
journal_title:Indian pediatrics
pub_type: 信件
doi:10.1007/s13312-014-0477-x
更新日期:2014-08-01 00:00:00
abstract::The distribution of supplementary nutrition (SN) to beneficiaries is an issue of debate in the Integrated Child Development Services (ICDS) program, discussed in almost all fora in which the scheme is on the agenda. ICDS program managers rightly decided in 1975 to make SN a program component, and it should remain so....
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1998-03-01 00:00:00
abstract::Increasing availability of DNA based tests in clinical practice has lead to widespread debate on the ethical issues involved. The wider usage of these tests in children has raised many questions regarding the ethics, validity of the request and its effects on childs psychosocial well-being. Though there have been much...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-013-0228-4
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To compare the mycobacteriological yield from gastric lavage (GL) and bronchoalveolar lavage (BAL), in children with pulmonary tuberculosis. METHODS:58 consecutive children with chest radiograph suggestive of tuberculosis and positive Mantoux test or a positive history of family contact with a case of tuberc...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To estimate the prevalence of rotavirus diarrhea among hospitalized children less than 5 years of age in Kerala State and to determine the circulating strains of rotavirus in Kerala. DESIGN:Multicenter, cross-sectional study. SETTING:Eight representative hospitals in Kunnathunadu Thaluk, Ernakulam district,...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-014-0329-8
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To document effects of intrapartum risk factors for early onset sepsis (EOS) on CRP levels in neonates and to assess the suitability of this test in diagnosing EOS. DESIGN:Cohort study. SETTING:Labour and post natal wards in a tertiary level teaching hospital in India. SUBJECTS:250 neonates at risk of deve...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract::There is a paucity of data on the incidence of sporadic viral hepatitis in Indian children. Clinical, biochemical and etiological profile of 54 patients with acute viral hepatitis was evaluated. Of these, 32 (59.25%) patients had Hepatitis A, 18 (33.33%) had NANB, 2 (3.7%) had Hepatitis B and 2 (3.7%) concurrent Hepat...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract::There are well defined therapeutic protocols for childhood nephrotic syndrome. Appropriate therapy helps in minimizing side effects besides decreasing referrals to tertiary care centres. We have analysed the appropriateness of therapy of primary care physicians in 111 children with nephrotic syndrome referred to our I...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Fetal growth restriction and abnormal Doppler flow studies are commonly associated. Neonatal outcomes are not well known particularly in developing countries, where the burden of the disease is the highest. OBJECTIVE:To determine outcomes of preterm infants with history of absent/reversed end-diastolic umbi...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-013-0235-5
更新日期:2013-09-01 00:00:00
abstract::There is little published literature from the third World countries that described the factors influencing survival of babies with esophageal atresia. We analysed 25 consecutive neonates treated for esophageal atresia. The overall survival rate was 36%. All 4 babies in Waterston Group A, 37.5% in Group B, and 15.4% in...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::We enrolled 75 consecutive infants presenting with history of first seizure at a tertiary care hospital in New Delhi, India. Clinical and biochemical work-up for etiology, and electroencephalography were performed in all infants. Developmental assessment was done 3-month after discharge. 72% had generalized seizures, ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2016-10-08 00:00:00
abstract:BACKGROUND:Despite a reduction in disease burden of vaccine preventable diseases through childhood immunization, considerable progress needs to be made in terms of ensuring efficiency and equity of vaccination coverage. OBJECTIVE:To conduct a systematic review to identify and explore factors associated with inequities...
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s13312-012-0063-z
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To describe a novel wrist deformity in b-thalassemia major patients, and their radiographic and magnetic resonance imaging findings. METHODS:30 patients with b-thalassemia major who were noticed to have ulnar deviation at wrist joint were evaluated for previous history of medications, serum ferritin levels, ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2019-01-15 00:00:00
abstract:: ...
journal_title:Indian pediatrics
pub_type: 评论,信件
doi:
更新日期:2018-11-15 00:00:00