Abstract:
OBJECTIVE:To assess the glycometabolic function in chronically transfused patients of beta- thalassemia major in terms of glucose tolerance, insulin secretion, insulin resistance index, and beta cell function index and to determine their relationship with clinical and biochemical profile. METHODS:30 homozygous thalassemia major children (aged 8-15 years) receiving regular blood transfusion and 10 age and sex matched normal children attending a tertiary level hospital were subjected to glucose tolerance test, estimation of fasting plasma insulin level, insulin resistance index and beta cell function index. Liver enzymes, liver size and indicators of iron overload (serum ferritin, total units of blood transfused, splenic size) were recorded. RESULTS:There was no diabetes mellitus or impaired glucose tolerance test in either the cases or the controls. Fasting plasma insulin levels were significantly higher in cases than controls (P = 0.004), and correlated well with indicators of iron overload like total units of blood transfused (r = 0.41, P = 0.03), serum ferritin (r = 0.38, P = 0.038) and splenic size (r = 0.43, P = 0.03). Insulin resistance was higher in cases compared to controls (P = 0.01). It correlated well with age (r = 0.56, P = 0.006), fasting blood glucose (r = 0.8, P = 0.003), fasting plasma insulin (r = 0.95, P = 0.00001), total units of blood transfused (r = 0.52, P = 0.005), serum ferritin (r = 0.4, P = 0.02) and splenomegaly (r = 0.51, P = 0.004). Insulin resistance was higher in patients not on chelation therapy compared with those on chelation therapy (P = 0.003). The beta cell function index was higher in cases compared to the controls, but not of statistic significance (P = 0.077). It did not correlate well with total amount of blood transfused (r = -0.32, P = 0.08), serum ferritin (r = -0.138, P = 0.46), spleen size (r = 0.16, P = 0.36), or chelation therapy (P = 0.98). CONCLUSION:Diabetes mellitus or impaired glucose was not seen in chronically transfused patients of thalassemia major (between 8 and 15 years of age), in our study. Insulin resistance, compensated by hyperinsulinemia, sets in early even before the onset of frank diabetes mellitus and correlated well with age, chelation therapy and indicators of iron overload like total units of blood transfused, splenomegaly and serum ferritin.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Suvarna J,Ingle H,Deshmukh CTsubject
Has Abstractpub_date
2006-05-01 00:00:00pages
393-400issue
5eissn
0019-6061issn
0974-7559journal_volume
43pub_type
杂志文章abstract::The forced vital capacity, forced expiratory volume in one second, peak expiratory flow, mid-expiratory flow and maximum voluntary ventilation was measured in 632 healthy, normal children from Metropolitan city of Bombay using computerized spirometer. The children were between age range 6 years to 15 years and belong ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::Participation in research is important in producing doctors with an understanding of evidence-based medicine. Though a mandatory part in post-graduate medical course, research has largely been invisible from the under graduation medical course in India. Very few research opportunities are available at under graduate l...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-017-1104-4
更新日期:2017-05-15 00:00:00
abstract::A case control study was conducted in a referral and teaching hospital in North India on children aged 2 months to 5 years, to compare blood zinc levels in 50 cases of severe pneumonia and 50 age,sex and nutritional status matched controls. Mean blood Zinc levels in cases and controls was 376.1 ug/dL + 225.73 and 538....
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To assess the safety and reactogenecity of indigenously produced measles vaccine derived from EZ strain. DESIGN:A longitudinal clinical follow up after vaccination. SETTING:Hospital based and home follow up, as required. SUBJECTS:12,470 children, 9 to 15 months old, immunized with measles vaccine of EZ str...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::Growth monitoring (GM) in India is a strategy to detect early growth retardation, promote optimum growth, create awareness about growth among mothers, enhance delivery of primary health care, and identify those at risk of malnutrition. Anthropometric measures include weight, height, mid-upper arm circumference, chest ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract::Biliary atresia has been commonly reported with cytomegalovirus (CMV) infection. CMV positive patients may present with a later onset however long term outcome is similar to non-CMV patients. There are very few case reports of role of antivirals in CMV and biliary atresia. We treated a 2 month old girl with biliary at...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-012-0092-7
更新日期:2012-06-01 00:00:00
abstract:: ...
journal_title:Indian pediatrics
pub_type: 评论,社论
doi:
更新日期:2018-11-15 00:00:00
abstract::Fifty seven male children between ages of 10-16 years engaged in the brassware industry at Moradabad in Northern India were studied for occupational morbidity. The finding were compared with those obtained in the children (n = 29) engaged in other ancillary units which did not involve exposure to the metal fumes and d...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
abstract::This cross-sectional study was undertaken to compare WHO and Indian Academy of Pediatrics (IAP) recommended growth charts compiled by Agarwal. 2105 children aged less than 5 years, attending 132 Anganwadi centres in Mysore city, were included by simple random sampling method. Weight and height of all children were rec...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-012-0157-7
更新日期:2012-09-01 00:00:00
abstract::The morbidity pattern and nutritional profile was evaluated of school children who resided around Mosaboni Copper Mines and in surrounding villages of Ghatsila subdivision in Singhbhum district of Bihar State, India. A total of 1424 school children (816 boys and 608 girls) between 5-17 years old were studied. Children...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract::There is a large child work force in India reported to be about 40 million. Child labor is being regarded as a form of modern slavery, as children are forced to work or have no choice to refuse work. Children are employed in a variety of occupations, many of which are hazardous. Exposure to machinery, pesticides, dust...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2019-08-15 00:00:00
abstract::An outbreak of suspected pertussis occurred in Sarli circle of Kurung-kumey district of Arunachal Pradesh in 2007. We investigated this outbreak to confirm the etiology, estimate the magnitude and identify reasons for its occurrence. Twenty-six deaths were reported from the circle. We identified 72 case-patients meeti...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2009-11-01 00:00:00
abstract::Two hundred and forty four girls with different hemoglobin levels were selected, of which forty-one were non-anemic. The rest were graded as mildly, moderately or severely anemic and supplemented with 60 mg of iron daily or twice weekly for twelve weeks. There was no significant difference in the increase in hemoglobi...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::The phenotypic description of SHORT syndrome (OMIM- 269880) is expanding since its initial description in 1975. There have been 26 case reports till date but the genetic locus of this syndrome is elusive. Involvement of PITX2 gene initially envisaged is probably is not the only gene involved but has an important role ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-013-0099-8
更新日期:2013-04-01 00:00:00
abstract::Guillain-Barre syndrome is a post infectious polyradiculoneuropathy. It is equally prevalent in both the adult and the pediatric populations. Guillain-Barre syndrome following dengue fever is not a classically described entity and has not been reported in children. ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract::Three hundred and fifty stool samples from patients with acute diarrhea and 30 samples from normal healthy controls were examined for the presence of various parasitic and bacterial enteropathogens by conventional techniques. Cryptosporidium oocysts were detected in 15 out of 350 (4.3%) fecal samples. In 10 cases (2.9...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract::Ensuring quality in healthcare today has become extremely essential to ensure adequate utilization of healthcare services and improved outcomes. In addition to essential infrastructure in terms of safe and adequate space, knowledgeable and skilled health workers, and essential equipment and supply, the healthcare team...
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:2018-09-15 00:00:00
abstract::We report a 6 year old female child, who presented with history of right sided recurrent headache for four months. On diagnostic nasal endoscopy, a metallic foreign body was seen impacted between superior turbinate, middle turbinate and nasal septum which was removed using pediatric nasal endoscope. Following removal,...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the frequency of non-autoimmune subclinical and overt hypothyroidism in children with idiopathic steroid-resistant nephrotic syndrome (SRNS). METHODS:This cross-sectional study recruited 30 children (age 1-18 y) with idiopathic SRNS; and 30 healthy controls. Serum T3, T4 and TSH were performed in...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-017-1183-2
更新日期:2017-11-15 00:00:00
abstract::Association of rotavirus gastroenteritis with histo-blood group antigens in children younger than 5 years admitted with diarrhea (n=389) was studied. Distribution of blood groups in rotavirus positive (n=96) and rotavirus negative (n=51) diarrhea gastroenteritis cases did not show any susceptibility to any blood group...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2016-07-08 00:00:00
abstract::A 6 month-old infant presenting with severe mitral regurgitation was found to have hepatosplenomegaly, corneal clouding, and Alder-Reilly granules in the leucocytes. Extremely low levels of beta glucuronidase confirmed the diagnosis of Sly disease (Mucopolysaccharidosis VII). This is the first case of MPS VII reported...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract::Shwachman-Diamond Syndrome (SDS) is a rare inherited disorder characterized by pancreatic insufficiency, bone marrow dysfunction and skeletal abnormalities. It is the most common cause of pancreatic insufficiency in children after cystic fibrosis. We report a child with classical SDS who presented to us predominantly ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-012-0138-x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To analyze variation in rotavirus-positivity using simple alternative statistical measures. METHODS:Hospital-based rotavirus surveillance among children admitted with acute gastroenteritis between 2005 and 2009. Prevalence, adjusted proportions and symmetrized index were calculated. RESULTS:Rotavirus preval...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-016-0898-9
更新日期:2016-07-08 00:00:00
abstract::Intravenously administered rehydration therapy was compared with orally administered rehydration therapy for treating children with diarrhea in a clinical study of 3000 children admitted to the Medical College Hospital, Kottayam, India. Oral rehydration was more effective and safer than intravenously administered flu...
journal_title:Indian pediatrics
pub_type: 临床试验,杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract:OBJECTIVE:To compare the mycobacteriological yield from gastric lavage (GL) and bronchoalveolar lavage (BAL), in children with pulmonary tuberculosis. METHODS:58 consecutive children with chest radiograph suggestive of tuberculosis and positive Mantoux test or a positive history of family contact with a case of tuberc...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of pre-exchange transfusion albumin priming in neonates with non-hemolytic hyperbilirubinemia. DESIGN:Single center, randomized controlled trial. SETTING:Level III Neonatal unit. PARTICIPANTS:Fifty healthy term and late preterm neonates with non-hemolytic hyperbilirubinemia requiri...
journal_title:Indian pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s13312-015-0713-z
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Outcome of pseudomonas enteric fever is unpredictable as multiple systemic lethal complications occur abruptly. CASE CHARACTERISTICS:A 9-month-old girl with multiple ileal perforations, leukocoria, ecthyma gangrenosum, hemiplegia and a perforated ulcer in the soft palate. Blood culture suggested Pseudomonas...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-015-0741-8
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:To find the relationship between Helicobacter pylori infection and iron deficiency anemia in school-aged children. METHODS:71 children with dyspepsia, epigastric and vague abdominal pain attending a tertiary medical center in Iran underwent upper gastrointestinal endoscopy and were investigated for H. Pylor...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2019-05-15 00:00:00
abstract::Hot water epilepsy (HWE) is a rare form of reflex epilepsy caused by bathing with hot water. In this paper, we describe three cases with hot water epilepsy. It occurs generally in children with normal psychomotor development and children continue to develop normally after seizure. HWE has usually a favorable prognosis...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To find out the degree of current undernutrition in rural reproductive age women. SETTING:49 villages of two adjoining rural blocks of Varanasi. METHODS:6130 non-pregnant and non-lactating rural women in the age group 18-45 year were studied for sociodemographic characteristics and anthropometry, i.e., weig...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00