Abstract：
OBJECTIVE:To evaluate the coagulation profile and its relation to steroid therapy, and the frequency of thromboembolic complications and its correlation with coagulation parameters in nephrotic syndrome (NS). SETTING:Hospital based. SUBJECTS AND METHODS:Forty children with NS were subdivided into four groups, namely, fresh cases, steroid dependent, remission after therapy and steroid resistant. An equal number of age and sex matched children served as controls. In all the study and control subjects, detailed clinical examination, liver function tests, renal function tests and detailed coagulation profile were done. Evaluation of renal veins and inferior vena cava for the presence of thrombosis was also done by abdominal ultrasonography. RESULTS:Thrombocytosis was detected in 57.5% and the degree of thrombocytosis was directly related to the amount of proteinuria. The mean prothrombin and thrombin times were within normal range in the study children. The activated partial thromboplastine time (APTT) was prolonged in six cases (15%) and three out of these six children had thromboembolic complications. Antithrombin-III level was significantly lower (p < 0.001) whereas protein C and S were significantly elevated (p < 0.001) as compared to controls. The levels became normal with remission of the disease. Steroid therapy significantly increased the levels of proteins C, protein S. AT-III and fibrinogen as compared to controls. Thromboembolic complications were seen in 3 cases (7.6%) and were associated with very low levels of AT-III and protein C and all three had serum albumin below 2 g/dl. CONCLUSIONS:The importance of coagulation profile in nephrotic syndrome is highlighted and a high index of suspicion for thromboembolic complications is warranted in patients with thrombocytosis, hyper fibrinogenemia, prolonged APTT and in children with low levels of AT-III, protein C and protein S.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Anand NK,Chand G,Talib VH,Chellani H,Pande Jsubject
Has Abstractpub_date
1996-12-01 00:00:00pages
1005-12issue
12eissn
0019-6061issn
0974-7559journal_volume
33pub_type
杂志文章abstract：:Thirty-two infants above one month of age admitted to a tertiary care hospital with signs of infection and presumptive diagnosis of sepsis were included. Cytokine levels of tumor necrosis factor alpha (TNFmu) and interleukin-6 (IL 6) were estimated at admission and after 48 to 72 hr, and their relationship examined to...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
abstract：:Congenital hypoparathyroidism, growth retardation and dysmorphism is a rare autosomal recessive syndrome among Arab population commonly known as Sanjad-Sakati syndrome(SSS).Several metabolic and septic complications are known to manifest in the neonatal age. We describe the first report of morbid pathological fracture...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-010-0066-6
更新日期：2010-05-01 00:00:00
abstract：UNLABELLED:Iron supplementation programs using pediatric tablets or drops have not been successful in the control of anemia amongst infants and children in India. Sprinkles is an innovative multi-micronutrient home fortification strategy to control iron deficiency and anemia. OBJECTIVE:We aimed to determine the hemato...
journal_title：Indian pediatrics
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2007-02-01 00:00:00
abstract：CONTEXT:Cryptosporidium spp. is a zoonotic infection, now being recognized as a significant cause of diarrhea in both immunocompetent and immunocompromised hosts. However, there still exist significant knowledge gaps in its estimated global burden, epidemiology, diagnosis and management. EVIDENCE ACQUISITION:A semi-sy...
journal_title：Indian pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s13312-017-1093-3
更新日期：2017-04-15 00:00:00
abstract：OBJECTIVE:To assess the safety and immunogenicity of a quadrivalent meningococcal (groups A,C,Y,W) polysaccharide diphtheria toxoid conjugate vaccine (MenACYW-DT) in India. DESIGN:Open-label, descriptive, non-randomized study. SETTING:Three medical college hospitals, one each in New Delhi, Bengaluru and Mumbai, India...
journal_title：Indian pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s13312-014-0435-7
更新日期：2014-06-01 00:00:00
abstract：:The prevalence of Attention deficit hyperactivity disorder was estimated in 500 adolescents using Conners' parents and teachers rating scales. Thirty six (7.2%) adolescents had positive scores on both the scales. The parents and teachers also completed a Diagnostic and Statistical Manual-IV based questionnaire which s...
journal_title：Indian pediatrics
pub_type： 信件
doi：10.1007/s13312-014-0350-y
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:Gaucher disease in India has been reported only in a few case reports from India. The aim of the study was to assess the response to enzyme replacement therapy in Indian patients with Gaucher disease. DESIGN:Retrospective analysis of patients receiving CHO-derived recombinant macrophage-targetted glucocorebr...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-011-0128-4
更新日期：2011-10-01 00:00:00
abstract：:Streptococcus viridans is usually considered to be nonpathogenic in healthy patients. Some strains become penicillin-resistant and cause life-threatening infections in immuno-compromised patients. We report an immunocompetent boy who had community-acquired S. viridans pneumonia that was resistant to penicillin. Clinic...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2012-04-01 00:00:00
abstract：:A case of idiopathic hypereosinophilic syndrome who had an unusual presentation in the form of pericardial effusion is being presented here. The child initially responded to corticosteroids but could not maintain normal eosinophil counts on tapering of steroids. Therefore he was put on hydroxyurea and low dose of ster...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:We report a case of primary hyperparathyroidism associated with prolonged hungry syndrome (HBS) after parathyroid adenomectomy in a 10-year-old girl. Bone mineral density (BMD) revealed severe loss of cancellous BMD. Overt bone disease, high alkaline phosphatase, decreased cancellous BMD and a large adenoma can be use...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2009-02-01 00:00:00
abstract：:The discussion section explains the meaning of results to the readers, and addresses the implications of the findings emanating from the particular study. Authors should compare their results with previous reports, and attempt to explain similarities and differences. It is useful to outline the limitations and strengt...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0955-4
更新日期：2016-10-08 00:00:00
abstract：:A quadrivalent MMRV (measles-mumps-rubella-varicella) combination vaccine has recently been launched in India. This vaccine is highly immunogenic, with seroconversion rates against all antigens reaching 96.6-100% at 42 to 56 days after the second vaccine dose in unvaccinated children or in those previously vaccinated ...
journal_title：Indian pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s13312-017-1209-9
更新日期：2017-12-15 00:00:00
abstract：:This cross-sectional study was undertaken to compare WHO and Indian Academy of Pediatrics (IAP) recommended growth charts compiled by Agarwal. 2105 children aged less than 5 years, attending 132 Anganwadi centres in Mysore city, were included by simple random sampling method. Weight and height of all children were rec...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-012-0157-7
更新日期：2012-09-01 00:00:00
abstract：:Atypical celiac disease (ACD) presenting in childhood has rarely been documented from India. The present retrospective study analyzed features of atypical celiac disease over a 5-year period. Patients were diagnosed to have Celiac Disease (CD) as per the standard ESPGHAN criteria. The biochemical and hematological par...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Auxiliary partial orthotopic liver transplantation is a technique where part of diseased native liver is removed and replaced with healthy donor liver so that, the left behind native liver could later regenerate. CASE CHARACTERISTICS:2 year 6 month old girl with acute liver failure due to Hepatitis A. She u...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0795-2
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the current spectrum of hepatobiliary disorders in children in Northern India. SETTING:Tertiary level referral hospital. METHODS:All children with hepatobiliary disorders presenting between January 1992 through July 1995 were evaluated by clinical assessment, liver function tests, viral and auto...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:Sixty children with acute bacterial meningitis (ABM) were prospectively studied for their serum sodium values and cerebrospinal fluid (CSF), serum and urinary osmolality. The results have been compared with 20 age and nutritionally matched controls. Even though mean serum osmolality (283.2 +/- 13.84 mOsm/kg) and serum...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:Delayed diagnosis of undescended testes is a major problem. A retrospective review of 298 testes units was performed to assess the age at referral, age at operation, complications and final outcome. The mean age at referral was 57 months. Only 24% of cases were operated below 2 years. A similar pattern of delayed orch...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2008-06-01 00:00:00
abstract：:Many children report chronic abdominal pain that is severe and disruptive to normal lifestyle and schooling. Assessment and management depends on indentifying those with underlying organic disease, such as chronic infection, celiac disease or inflammatory bowel disease, but avoiding unnecessary invasive investigations...
journal_title：Indian pediatrics
pub_type： 杂志文章,评审
doi：
更新日期：2009-05-01 00:00:00
abstract：:In Kumbakonam, Tamil Nadu State in India, 384 final-year female students attending the Government College for Women completed a questionnaire so the researcher could assess their knowledge of prenatal and childhood immunizations, breast feeding, weaning, oral rehydration solution (ORS), and feeding during diarrhea. 5...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:This retrospective analysis documents the usefulness of fiberoptic bronchoscopy in finding the etiology of 56 cases of unresolved atelectasis in infancy, over a two year period (June 2005 to May 2007). Fiberoptic bronchoscopy identified the etiology leading to a revised diagnosis and change in management strategy in 3...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-010-0134-y
更新日期：2010-07-01 00:00:00
abstract：:In this study, 78 middle ear aspiration samples from 59 children between the ages of 2 14 who have undergone myringotomy under general anesthesia were included. The presence of DNA genome of Chlamydia trachomatis was analyzed with polymerase chain reaction in the aspiration material. The relationship between the natur...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2005-07-01 00:00:00
abstract：OBJECTIVE:To evaluate recovery and survival of severely wasted children without community management of acute malnutrition programme. DESIGN:Single time point follow-up (24th December 2013 - 2nd April, 2014) of severely wasted children identified in a community-based cross-sectional survey (September 2012 - October 20...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-017-1142-y
更新日期：2017-10-15 00:00:00
abstract：BACKGROUND:Mediastinal pancreatic pseudocyst is a rare complication of pancreatitis. CASE CHARACTERISTICS:An 8-year-old boy with chest pain and shortness of breath. Computed tomography of chest showed a cystic mass in the mediastinum. The cyst aspirate revealed high amylase and lipase levels, suggestive of pancreatic ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2018-03-15 00:00:00
abstract：:This paper explores the relationships between maternal weight, height and poor pregnancy outcome using a data set from a case-control study of low birth weight (LBW) and perinatal mortality in Ahmedabad, India. Maternal height and weights were compared between mothers of 611 perinatal deaths, 644 preterm-LBW, and 1465...
journal_title：Indian pediatrics
pub_type： 杂志文章,多中心研究
doi：
更新日期：1994-10-01 00:00:00
abstract：:Hot water epilepsy (HWE) is a rare form of reflex epilepsy caused by bathing with hot water. In this paper, we describe three cases with hot water epilepsy. It occurs generally in children with normal psychomotor development and children continue to develop normally after seizure. HWE has usually a favorable prognosis...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:In Karnataka state, perinatal mortality rate is almost equal to infant mortality rate. This preliminary study was conducted in two districts of Karnataka to study potential problems to start of perinatal death audit. METHODS:Hospitals providing maternal and child health care services, which met study inclusi...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2020-11-15 00:00:00
abstract：:Shwachman-Diamond Syndrome (SDS) is a rare inherited disorder characterized by pancreatic insufficiency, bone marrow dysfunction and skeletal abnormalities. It is the most common cause of pancreatic insufficiency in children after cystic fibrosis. We report a child with classical SDS who presented to us predominantly ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-012-0138-x
更新日期：2012-09-01 00:00:00
abstract：:This prospective study was conducted in a teaching hospital to identify and analyze medical errors in pediatric practice. All admitted children underwent surveillance for medical errors. Of 457 errors identified in 1286 children, medication errors were 313 (68.5%), those related to treatment procedures were 62 (13.6%)...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:High bilirubin level is toxic to developing brain and auditory system but the current debate surrounds the toxicity of bilirubin in healthy term infants. METHODS:Longitudinal observational study to find BERA abnormalities in term newborns with isolated hyperbilirubinemia of 20 mg/dL and more and to follow u...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-014-0346-7
更新日期：2014-02-01 00:00:00
