Abstract：
OBJECTIVE:To assess the safety and immunogenicity of a quadrivalent meningococcal (groups A,C,Y,W) polysaccharide diphtheria toxoid conjugate vaccine (MenACYW-DT) in India. DESIGN:Open-label, descriptive, non-randomized study. SETTING:Three medical college hospitals, one each in New Delhi, Bengaluru and Mumbai, India. PARTICIPANTS:300 healthy, vaccine-naïve participants (100 children aged 2-11 years, 100 adolescents aged 12-17 years, and 100 adults aged 18-55 years). INTERVENTION:One dose (0.5 mL) of MenACYW-DT administered intramuscularly. MAIN OUTCOME MEASURES:Serum bactericidal antibody titers against A, C, Y, and W were measured before and after MenACWY-DT vaccination. Safety data were also collected. RESULTS:Thirty days post-vaccination, geometric mean titers rose across all serogroups. Most participants had protective titers >8 (1/dil) across the four serogroups. The percentage (95% CI) achieving >8 (1/dil) in the Adolescent Group was typical - A: 96.9% (91.2%; 99.4%); C: 96.9% (91.2%; 99.4%); Y:100% (96.3%; 100%); W:100% (96.3%; 100%). In general, solicited reactions were mild and short-lived. Unsolicited events were uncommon and unrelated to vaccination. CONCLUSIONS:MenACYW-DT was well tolerated and elicited a robust and protective immune response 30 days post-vaccination against meningococcal serogroups A, C, Y, and W-135 in the Indian study participants aged 2-55 years.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Yadav S,Manglani MV,Narayan DA,Sharma S,Ravish HS,Arora R,Castells VB,Arya S,Oster Pdoi
10.1007/s13312-014-0435-7subject
Has Abstractpub_date
2014-06-01 00:00:00pages
451-6issue
6eissn
0019-6061issn
0974-7559journal_volume
51pub_type
杂志文章,多中心研究abstract：:Youth violence is a growing problem worldwide. Research on adolescent violence in India is limited. Fifteen hundred high school students were investigated to study the prevalence and demographic characteristics of witnesses, victims and perpetrators of violence and to see the impact of violence exposure on their psych...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVE:To determine the incidence, risk factors and outcome of acute kidney injury (AKI) in hospitalized children with nephrotic syndrome. METHODS:All consecutive hospitalized children (aged 1-14 years) with diagnosis of nephrotic syndrome between February 2016 and February 2017 were enrolled for the study. Childre...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2019-02-15 00:00:00
abstract：OBJECTIVE:To estimate the prevalence of Iodine Deficiency Disorders, and household consumption of adequately iodized salt in Damoh district, Madhya Pradesh in 2016. METHODS:Cross-sectional study with cluster sampling method was used among school-going children. 30 clusters, each with 90 children were selected to acces...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2018-07-15 00:00:00
abstract：:A 3.5-month-old infant with undiagnosed underlying combined immunodeficiency presented with S. ceravisiae fungemia following treatment with S. boulardii containing probiotic preparation. This case highlights that the use of probiotics in sick patients may be fraught with danger. ...
journal_title：Indian pediatrics
pub_type： 信件
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更新日期：2019-11-15 00:00:00
abstract：OBJECTIVE:To find the effects of inhaled corticosteroids and the impact of different doses of inhaled corticosteroids on the isolation of nasopharyngeal flora in asthmatic children aged 1-15 years. METHODS:The study included 75 children with asthma and 25 age-matched controls. Nasopharyngeal swabs were obtained. Bacte...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2019-11-15 00:00:00
abstract：:In this study, 78 middle ear aspiration samples from 59 children between the ages of 2 14 who have undergone myringotomy under general anesthesia were included. The presence of DNA genome of Chlamydia trachomatis was analyzed with polymerase chain reaction in the aspiration material. The relationship between the natur...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2005-07-01 00:00:00
abstract：:We prospectively studied the effect of oral paracetamol in closing hemodynamically significant Patent ductus arteriosus in preterm infants (gestational age <32 weeks) where Ibuprofen was contraindicated. 29 of 40 neonates (72.5%) showed successful response while 11 (29.5%) failed to show any response. No major complic...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:To study the incidence and risk factors predisposing to retinopathy of prematurity (ROP) and to assess the outcome after laser photocoagulation. DESIGN:Prospective cohort observational study. SETTING:Infants admitted to a neonatal intensive care unit of a referral hospital between 2000-2006 and followed up ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Posterior reversible encephalopathy syndrome (PRES) is a benign disorder of reversible subcortical vasogenic cerebral edema. CASE CHARACTERISTICS:A 13-yr-old girl presented 4 days after complete recovery from diabetic ketoacidosis with symptoms of headache, altered sensorium, seizures, and visual loss. Ther...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2019-03-15 00:00:00
abstract：:Fifty eight (16%) of the 362 patients, who reported to Dermatology and STD Department with symptoms pertaining to their genitourinary system were below 14 years of age. Fifty four (93.1%) of these children belonged to families of lower socio-economic strata. All the children were slum dwellers and none of them had stu...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Streptococcus viridans is usually considered to be nonpathogenic in healthy patients. Some strains become penicillin-resistant and cause life-threatening infections in immuno-compromised patients. We report an immunocompetent boy who had community-acquired S. viridans pneumonia that was resistant to penicillin. Clinic...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2012-04-01 00:00:00
abstract：:We conducted this study to find out the incidence of extubation failure (EF) in ventilated neonates and associated clinical risk factors. Eighty two ventilated neonates were followed up to 48 hours post extubation to look for EF. Twenty two babies (26.8%) had EF. The common risk factors for EF were presence of patent ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2009-10-01 00:00:00
abstract：:Clinical and hematological data of 9 cases with factor XIII deficiency is highlighted. The age at first bleed ranged from 3 days of life to 1 year. Seven of these 9 cases had bleeding from the umbilicus, 3 had recurrent subcutaneous and muscle hematomas, while 4 cases had CNS bleeds of which 3 expired. Routine coagulo...
journal_title：Indian pediatrics
pub_type： 杂志文章,评审
doi：
更新日期：1992-07-01 00:00:00
abstract：:Fifty two mother-infant pairs were studied. Twenty six of these were delivered by the normal vaginal route (NVD group) and twenty six by Cesarean section (CS group). The NVD babies were roomed in with their mothers soon after birth whereas the CS babies had a mean separation of 2.8 +/- 1.0 days. The mother baby intera...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
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journal_title：Indian pediatrics
pub_type： 杂志文章,实务指引
doi：
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:Antiphospholipid syndrome is a multisystem auto-immune disorder characterized by arterial or venous thrombosis in children. CASE CHARACTERISTICS:11-year-old child with pneumococcal meningitis also had cerebral sinus vein thrombosis and pulmonary artery segmental thrombosis. OBSERVATION:Pro-thrombotic evalu...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2018-05-15 00:00:00
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journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-013-0034-z
更新日期：2013-01-08 00:00:00
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journal_title：Indian pediatrics
pub_type： 信件
doi：10.1007/s13312-014-0477-x
更新日期：2014-08-01 00:00:00
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journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:To study the clinical and biochemical spectrum of Gaucher disease. DESIGN:Assay of beta glucosidase enzyme in leucocytes in patients with splenomegaly, and in chorionic villi for prenatal diagnosis. SETTING:Hospital-based. SUBJECTS:Of 13 cases of Gaucher disease, aged 1-6 years, 9 were identified at Delhi ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:This study was conducted to standardize a clinical test to assess cognitive functions in children between 3-14 years and to evaluate its use in patients with encephalopathy. We included 50 children in Group A with non-neurological illness. Another 50 children were included in Group B with encephalopathy due to varied ...
journal_title：Indian pediatrics
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：:Decline in malnutrition levels has been dismal since the 1990s. We ascertained decadal trend in childhood nutritional status between 1997 and 2007 in Chandigarh, India and assessed impact of Integrated Child Development Services (ICDS) on childhood undernutrition. A total of 803 under-five children, 547 children betwe...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-011-0058-1
更新日期：2011-04-01 00:00:00
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journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
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journal_title：Indian pediatrics
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doi：
更新日期：2008-06-01 00:00:00
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journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:To determine the clinical profile of children with Henoch-Schonlein purpura (HSP). DESIGN:Hospital based descriptive follow-up study. SUBJECTS:45 patients attending the Pediatric Rheumatology and Immunology clinic over the last 4 years. RESULTS:The patients were aged between 2.5-12 years with a male to fem...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Mevalonate kinase deficiency (MKD) is a rare autosomal recessive autoinflammatory disease caused by mutations in MVK. We report two siblings with MKD, presenting with recurrent febrile illnesses, detected to have compound heterozygous variants in MVK. MKD mimics common pediatric conditions and should be considered as ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2020-02-15 00:00:00
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journal_title：Indian pediatrics
pub_type： 杂志文章,实务指引
doi：10.1007/s13312-012-0216-0
更新日期：2012-11-01 00:00:00
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journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
abstract：:A case of idiopathic hypereosinophilic syndrome who had an unusual presentation in the form of pericardial effusion is being presented here. The child initially responded to corticosteroids but could not maintain normal eosinophil counts on tapering of steroids. Therefore he was put on hydroxyurea and low dose of ster...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
