Pediatric Rhabdomyosarcoma in India: A Single-center Experience.

Abstract:

OBJECTIVE:Analyze the profile and outcome of children with rhabdomyosarcoma from a pediatric-oncology unit. DESIGN:Retrospective analysis of case records over 23 years (1990-2012). Setting:Government-run, tertiary-care, university hospital in Northern India. PARTICIPANTS:159 children (<12-years) with a diagnosis of rhabdomyosarcoma were enrolled. The median age was 4 years; 13% were infants. MAIN OUTCOME MEASURE:Five-year event free survival. RESULTS:The median symptom interval was 2-months. Head and neck region was the most frequent site (44%), followed by tumors in the extremity (15.7%). The majority (67%) of the tumors were located at 'unfavorable' sites; 68% were >5 cm in size. The most frequent (58%) pathological subtype was embryonal. Treatment was based on the 'Intergroup Rhabdomyosarcoma Study (IRS) Group' risk-stratification. 33% were 'low-risk' children, 11% were 'high-risk'. Treatment-refusal (18%) and abandonment (33%) were major impediments. The median ± SE five-year event free survival of those taking treatment was 43.6 ± 6%. Conclusion:Large sized tumors, tumors at unfavorable locations, and treatment refusal/abandonment contributed to inferior outcome in children with rhabdomyosarcoma.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Bansal D,Das A,Trehan A,Kapoor R,Panda NK,Srinivasan R,Panda NK,Srinivasan R,Kakkar N,Sodhi KS,Saxena AK,Narasimha Rao KL

doi

10.1007/s13312-017-1164-5

subject

Has Abstract

pub_date

2017-09-15 00:00:00

pages

735-738

issue

9

eissn

0019-6061

issn

0974-7559

journal_volume

54

pub_type

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