Localization of neuropeptide Y and atrial natriuretic peptide in the endothelial cells of human umbilical blood vessels.

Abstract:

:The localization of neuropeptide Y (NPY) and atrial natriuretic peptide (ANP) in the endothelial cells of human umbilical blood vessels was studied using the pre-embedding peroxidase-antiperoxidase (PAP) technique for electron microscopy and avidin-biotin-complex (ABC) immunostaining for endothelial cells cultured from umbilical vein. Subpopulations of NPY- and ANP-immunoreactive endothelial cells were present in term umbilical vein and artery. The umbilical vein contained more positive cells than the artery. The percentage of NPY- and ANP-immunoreactive umbilical vein cells in culture was 32% and 44%, respectively, out of a total of 3013 cells examined. The possibility that these potent vasoactive substances located in the endothelial cells of the non-innervated umbilical vessels are involved in the local regulation of blood flow is discussed.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Cai WQ,Bodin P,Sexton A,Loesch A,Burnstock G

doi

10.1007/BF00323584

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

175-81

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

272

pub_type

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