Upregulation and induction of surface antigens with special reference to MHC class II expression in microglia in postnatal rat brain following intravenous or intraperitoneal injections of lipopolysaccharide.

Abstract:

:The effects of bacterial lipopolysaccharide (LPS) on the expression of surface antigens including major histocompatibility complex (MHC) and complement type 3 (CR3) receptors on microglial cells in the corpus callosum in postnatal rat brain were investigated. When LPS was injected intravenously (i.v.) in 1-d-old rats, the immunostaining of callosal amoeboid microglial cells with OX-18 directed against MHC class I antigen was enhanced 24 h after the injection in comparison with the controls. The expression of MHC class II (Ia) antigen on the same cell type as shown by its immunoreactivity with OX-6 was also elicited especially after 2 intraperitoneal (i.p.) injections of LPS. Thus 7 d after a single i.p. injection of LPS into 1-d-old rats, only a few OX-6 positive cells showing a moderate staining reaction were observed in the corpus callosum. The immunoreactivity diminished 14 d after the injection. However, in rats receiving 2 successive i.p. injections of LPS at 1 and 4 d of age and killed 7 d after the 1st injection, a significant number of intensely stained OX-6 positive amoeboid microglial cells were observed in the corpus callosum. The expression of MHC class II antigens induced by 2 injections of LPS was sustained at least until d 14 when the callosal ramified microglial cells, known to be derived from gradual metamorphic transformation of amoeboid microglia, still exhibited intense immunoreactivity with OX-6. The effect of LPS on the expression of CR3 on amoeboid microglial cells was not obvious after a single injection, but the immunoreactivity with OX-42 was also augmented in rats given 2 i.p. administration of LPS into rats at 1 an 4 d of age. It is concluded from this study that the expression of MHC class I and class II antigens on amoeboid microglial cells in corpus callosum was upregulated and induced respectively after i.v. or i.p. injection of LPS into early postnatal rats. Although relatively fewer in number when compared with OX-18 and OX-42 positive cells, it is suggested that the OX-6 positive cells would have the potentiality to function in antigen presentation in the postnatal rat brain when challenged by the endotoxin.

journal_name

J Anat

journal_title

Journal of anatomy

authors

Xu J,Ling EA

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

285-96

eissn

0021-8782

issn

1469-7580

journal_volume

184 ( Pt 2)

pub_type

杂志文章
  • Lipid distribution, composition and uptake in bovine articular cartilage studied using Raman micro-spectrometry and confocal microscopy.

    abstract::The distribution and composition of endogenous lipids in articular cartilage and transport of exogenous fatty acids have been investigated on a microscopic scale in fresh bovine articular cartilage. To investigate the distribution and composition of the endogenous lipids, hyperspectral Raman maps were taken of chondro...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.12624

    authors: Mansfield JC,Winlove CP

    更新日期:2017-07-01 00:00:00

  • The ultrastructure of human abdominal mesothelium.

    abstract::Fresh specimens of human peritoneum collected from heart-beating cadaver organ donors have been examined by transmission electron microscopy. Samples were taken from the anterior abdominal wall and from the surfaces of the liver, stomach and diaphragm. The mesothelium consisted of a single layer of flattened cells gen...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Slater NJ,Raftery AT,Cope GH

    更新日期:1989-12-01 00:00:00

  • Two generations of the tongue and gustatory organs in the development of Hynobius dunni Tago.

    abstract::In the development of Hynobius dunni there are two consecutive generations of the tongue and two generations of gustatory organs (taste buds and taste disks). The anlage of the developing secondary tongue appears just in front of the free ending of the primary tongue beginning at the larval developmental stage 62. Fro...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1046/j.1469-7580.2002.00076.x

    authors: Zuwała K,Kato S,Jakubowski M

    更新日期:2002-07-01 00:00:00

  • Digital development and morphogenesis.

    abstract::Signalling interactions between the polarizing region, which produces SHH, and the apical ectodermal ridge, which produces FGFs, are essential for outgrowth and patterning of vertebrate limbs. However, mechanisms that mediate translation of early positional information of cells into anatomy remain largely unknown. In ...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1046/j.1469-7580.2003.00134.x

    authors: Sanz-Ezquerro JJ,Tickle C

    更新日期:2003-01-01 00:00:00

  • Allocation trade-offs impact organ size and muscle architecture in an invasive population of Xenopus laevis in Western France.

    abstract::Invasive species are a global scourge and often negatively impact native species. Understanding the expansion and dispersal limits of these species is essential. As previous studies have demonstrated increased locomotor performance for populations at the edge of the range of expanding populations, studies of locomotio...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.13063

    authors: Padilla P,Courant J,Herrel A

    更新日期:2019-12-01 00:00:00

  • Neutron diffraction studies of lumbar vertebrae.

    abstract::Neutron diffraction measurements of the orientation of the apatite crystals show a significant preference of their c-axes for the vertical direction. This preference increases from bottom to top of each vertebral body and is substantially greater for the second than for the fifth lumbar vertebrae. This is in line with...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Bacon GE,Bacon PJ,Griffiths RK

    更新日期:1979-03-01 00:00:00

  • Investigating the potential value of individual parameters of histological grading systems in a sheep model of cartilage damage: the Modified Mankin method.

    abstract::A total histological grade does not necessarily distinguish between different manifestations of cartilage damage or degeneration. An accurate and reliable histological assessment method is required to separate normal and pathological tissue within a joint during treatment of degenerative joint conditions and to sub-cl...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/j.1469-7580.2012.01513.x

    authors: Moody HR,Heard BJ,Frank CB,Shrive NG,Oloyede AO

    更新日期:2012-07-01 00:00:00

  • The rete testis of birds.

    abstract::The rete testis in the domestic fowl (Gallus gallus domesticus), Japanese quail (Coturnix coturnix japonica), guinea-fowl (Numida meleagris galeata) and drake (Anas platyrhynchos) was studied histologically and with both the scanning and transmission electron microscopes. All the birds have rete epithelial cells varyi...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Aire TA

    更新日期:1982-08-01 00:00:00

  • Tissue distribution of cells derived from the area opaca in heterospecific quail-chick blastodermal chimeras.

    abstract::The objective of the current study was to determine the tissue distribution of cells derived from the area opaca in heterospecific quail-chick blastodermal chimeras. Quail-chick chimeras were constructed by transferring dissociated cells from the area opaca of the stage X-XII (EG&K) quail embryo into the subgerminal c...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/j.1469-7580.2009.01168.x

    authors: Karagenç L,Sandikci M

    更新日期:2010-01-01 00:00:00

  • The distribution and relative sized of fibre types in the extensor digitorum longus and soleus muscles of the adult rat.

    abstract::Histochemical fibre types classified in sections stained for succinic dehydrogenase (sdh) and myosin ATPase at pH 9.4, were found to be distributed in a consistent manner within the extensor digitorum longus (EDL) and 4 soleus muscles of the adult rat. Simple morphometric techniques applied to complete transverse sect...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Pullen AH

    更新日期:1977-04-01 00:00:00

  • Long bone histology of the stem salamander Kokartus honorarius (Amphibia: Caudata) from the Middle Jurassic of Kyrgyzstan.

    abstract::Kokartus honorarius from the Middle Jurassic (Bathonian) of Kyrgyzstan is one of the oldest salamanders in the fossil record, characterized by a mixture of plesiomorphic morphological features and characters shared with crown-group salamanders. Here we present a detailed histological analysis of its long bones. The an...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.12281

    authors: Skutschas P,Stein K

    更新日期:2015-04-01 00:00:00

  • Instructive niches: environmental instructions that confound NG2 proteoglycan expression and the fate-restriction of CNS progenitors.

    abstract::Cellullar deficits are replenished within the central nervous system (CNS) by progenitors to maintain integrity and recover function after injury. NG2 proteoglycan-expressing progenitors replenish oligodendrocyte populations, but the nature of NG2 proteoglycan may not indicate a restricted population of progenitors. A...

    journal_title:Journal of anatomy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1469-7580.2005.00480.x

    authors: Sellers DL,Horner PJ

    更新日期:2005-12-01 00:00:00

  • The differentiation of granulated metrial gland cells in chimeric mice and the effect of uterine shielding during irradiation.

    abstract::The differentiation of granulated metrial gland (GMG) cells has been investigated during deciduomata formation in radiation-induced chimeric mice reconstituted with rat or mouse bone marrow. The extent of the decidual reaction was apparently normal in regions of the uterine horns shielded from the irradiation but was ...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Peel S,Stewart I

    更新日期:1984-12-01 00:00:00

  • Endocytotic activity of kitten odontoblasts in early dentinogenesis. 1. Thin section and freeze-fracture study.

    abstract::The morphological features of odontoblast processes in young kitten odontoblasts were studied by thin section and freeze-fracture electron microscopy. Freeze-fracture replication revealed depressions with particles on the plasma membranes of the proximal parts of odontoblast processes. Comparison with thin sections su...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Sasaki T,Tominaga H,Higashi S

    更新日期:1984-05-01 00:00:00

  • The topography of root fibres within the sciatic nerve trunk of the dog.

    abstract::The architecture of the fibres in the sciatic nerve of the dog has been analysed by following the degeneration of fibres resulting from division of the individual spinal nerves which contribute to the sciatic nerve. A pattern has been demonstrated which varies in part with the size of the contribution to the sciatic n...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Ueyama T

    更新日期:1978-10-01 00:00:00

  • Homologies of the meningeal-orbital arteries of humans: a reappraisal.

    abstract::Two arteries connect the anterior branch of the middle meningeal artery to the lacrimal artery. One vessel, the sphenoidal artery, passes through the superior orbital fissure. The other vessel, the meningolacrimal artery, passes through the cranio-orbital foramen. An analysis of data derived from embryology, comparati...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Diamond MK

    更新日期:1991-10-01 00:00:00

  • Reorganization after pre- and perinatal brain lesions.

    abstract::The developing human brain can compensate for pre- and perinatally acquired focal lesions more effectively than the adult brain. The mechanisms by which this effective reorganization is achieved vary considerably between different functional systems, reflecting differences in the normal maturation of these systems. In...

    journal_title:Journal of anatomy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1469-7580.2010.01262.x

    authors: Staudt M

    更新日期:2010-10-01 00:00:00

  • Ontogeny of the cranial system in Laonastes aenigmamus.

    abstract::Rodents, together with bats, are among the ecologically most diverse and most speciose groups of mammals. Moreover, rodents show elaborate specializations of the feeding apparatus in response to the predominantly fore-aft movements of the lower jaw. The Laotian rock rat Laonastes aenigmamus was recently discovered and...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/j.1469-7580.2012.01519.x

    authors: Herrel A,Fabre AC,Hugot JP,Keovichit K,Adriaens D,Brabant L,Van Hoorebeke L,Cornette R

    更新日期:2012-08-01 00:00:00

  • Innervation of the palpebral conjunctiva and the superior tarsal muscle in the cynomolgous monkey: a retrograde fluorescent tracing study.

    abstract::Retrograde fluorescent transport of Fast Blue (FB) and Diamidino Yellow (DY) was used to study the localisation of neurons that innervate the palpebral conjunctiva and the superior tarsal muscle in the cynomolgous monkey. Labelled cell bodies of sensory neurons including a few double labelled cell bodies were found in...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: van der Werf F,Baljet B,Prins M,Ruskell GL,Otto JA

    更新日期:1996-10-01 00:00:00

  • Magnetic resonance imaging of semicircular canals.

    abstract::The present paper reports the results of the first investigation of the semicircular canals in a living, small animal by means of high spatial resolution magnetic resonance imaging. This procedure is noninvasive and allows identification of the endolymphatic and perilymphatic spaces yielding a morphology quite consist...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Sbarbati A,Leclercq F,Zancanaro C,Antonakis K

    更新日期:1992-04-01 00:00:00

  • Comparative skeletal anatomy of neonatal ursids and the extreme altriciality of the giant panda.

    abstract::Mammalian neonates are born at a wide range of maturity levels. Altricial newborns are born with limited sensory agency and require extensive parental care. In contrast, precocial neonates are relatively mature physically and often capable of independent function shortly after birth. In extant mammals, placental newbo...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.13127

    authors: Li P,Smith KK

    更新日期:2020-04-01 00:00:00

  • Embryonic skull development in the gecko, Tarentola annularis (Squamata: Gekkota: Phyllodactylidae).

    abstract::Tarentola annularis is a climbing gecko with a wide distribution in Africa north of the equator. In the present paper, we describe the development of the osteocranium of this lizard, from the first appearance of the cranial elements up to the point of hatching. This is based on a combination of histology and cleared a...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/joa.13213

    authors: Khannoon ER,Evans SE

    更新日期:2020-09-01 00:00:00

  • The effects of ageing on cutaneous wound healing in mammals.

    abstract::The dogma that cutaneous wound healing is impaired as a function of age is largely unsubstantiated. This can be attributed to poor experimental design of human studies, the lack of subject characterisation with the exclusion of disease processes, and the study of inappropriate animal models. Structural and functional ...

    journal_title:Journal of anatomy

    pub_type: 杂志文章,评审

    doi:

    authors: Ashcroft GS,Horan MA,Ferguson MW

    更新日期:1995-08-01 00:00:00

  • Histochemistry of the striated musculature in the opossum and human oesophagus.

    abstract::The striated muscle component of the opossum oesophagus has been studied for fibre type as revealed by histochemical stains for succinic acid dehydrogenase, adenosine triphosphatase, nicotinamide adenine dinucleotide dehydrogenase and after staining with the periodic acid-Schiff reagent. The reactions were compared to...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Shedlofsky-Deschamps G,Krause WJ,Cutts JH,Hansen S

    更新日期:1982-03-01 00:00:00

  • Ultrastructure of the mouse spinal cord ependyma.

    abstract::This study was done in order to investigate the normal ultrastructure of well-preserved mouse spinal canal ependyma using light, scanning and transmission electron microscopy. The ependymal lining was found to consist of a simple, cuboidal epithelium essentially similar to the unspecialized cuboidal ependyma of the br...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Bjugn R,Haugland HK,Flood PR

    更新日期:1988-10-01 00:00:00

  • The internal cranial morphology of an armoured dinosaur Euoplocephalus corroborated by X-ray computed tomographic reconstruction.

    abstract::Internal cranial anatomy is a challenging area to study in fossilized skulls because of small sample sizes and varied post-mortem preservational alterations. This difficulty has led to the lack of correspondence between results obtained from direct osteological observation and from more indirect reconstruction methods...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:10.1111/j.1469-7580.2011.01427.x

    authors: Miyashita T,Arbour VM,Witmer LM,Currie PJ

    更新日期:2011-12-01 00:00:00

  • Non-myelinated nerve fibres and their terminals in the sub-odontoblastic plexus of the feline dental pulp.

    abstract::Serial thin sections of the coronal dental pulp of the cat's canine tooth were cut. Parts of the sub-odontoblastic neural plexus were photographed from 100 of the sections. The plexus consists of many slender, predominantly unmyelinated nerve fibres. Many axons are incompletely sheathed by their Schwann cell. Some axo...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Holland GR

    更新日期:1980-05-01 00:00:00

  • The renal veins in the human cadaveric fetus: their importance as contributors to collateral flow.

    abstract::The venous collateral flow emanating from and around the renal veins was investigated in the human cadaveric fetus. Experimental venous occlusion was performed along several venous pathways under the sphere of influence of the renal veins in 11 fetuses. Radiological techniques were used to investigate renal venous col...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Satyapal KS,Kalideen JM

    更新日期:1995-04-01 00:00:00

  • An enhanced role and expanded developmental origins for gamma-aminobutyric acidergic interneurons in the human cerebral cortex.

    abstract::Human beings have considerably expanded cognitive abilities compared with all other species and they also have a relatively larger cerebral cortex compared with their body size. But is a bigger brain the only reason for higher cognition or have other features evolved in parallel? Humans have more and different types o...

    journal_title:Journal of anatomy

    pub_type: 杂志文章,评审

    doi:10.1111/joa.12198

    authors: Clowry GJ

    更新日期:2015-10-01 00:00:00

  • Histochemical characteristics and contractile properties of the spinotrapezius muscle in the rat and the mouse.

    abstract::In the spinotrapezius muscle of the rat and the mouse approximately equal proportions of A,B and C fibres are present. The spinotrapezius therefore contains a lower proportion of B fibres than are known to be present in soleus, but a higher proportion than in tibialis anterior. These results are consistent with the fu...

    journal_title:Journal of anatomy

    pub_type: 杂志文章

    doi:

    authors: Taylor K,Calvey TN

    更新日期:1977-02-01 00:00:00