Abstract:
:The effects of bacterial lipopolysaccharide (LPS) on the expression of surface antigens including major histocompatibility complex (MHC) and complement type 3 (CR3) receptors on microglial cells in the corpus callosum in postnatal rat brain were investigated. When LPS was injected intravenously (i.v.) in 1-d-old rats, the immunostaining of callosal amoeboid microglial cells with OX-18 directed against MHC class I antigen was enhanced 24 h after the injection in comparison with the controls. The expression of MHC class II (Ia) antigen on the same cell type as shown by its immunoreactivity with OX-6 was also elicited especially after 2 intraperitoneal (i.p.) injections of LPS. Thus 7 d after a single i.p. injection of LPS into 1-d-old rats, only a few OX-6 positive cells showing a moderate staining reaction were observed in the corpus callosum. The immunoreactivity diminished 14 d after the injection. However, in rats receiving 2 successive i.p. injections of LPS at 1 and 4 d of age and killed 7 d after the 1st injection, a significant number of intensely stained OX-6 positive amoeboid microglial cells were observed in the corpus callosum. The expression of MHC class II antigens induced by 2 injections of LPS was sustained at least until d 14 when the callosal ramified microglial cells, known to be derived from gradual metamorphic transformation of amoeboid microglia, still exhibited intense immunoreactivity with OX-6. The effect of LPS on the expression of CR3 on amoeboid microglial cells was not obvious after a single injection, but the immunoreactivity with OX-42 was also augmented in rats given 2 i.p. administration of LPS into rats at 1 an 4 d of age. It is concluded from this study that the expression of MHC class I and class II antigens on amoeboid microglial cells in corpus callosum was upregulated and induced respectively after i.v. or i.p. injection of LPS into early postnatal rats. Although relatively fewer in number when compared with OX-18 and OX-42 positive cells, it is suggested that the OX-6 positive cells would have the potentiality to function in antigen presentation in the postnatal rat brain when challenged by the endotoxin.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Xu J,Ling EAsubject
Has Abstractpub_date
1994-04-01 00:00:00pages
285-96eissn
0021-8782issn
1469-7580journal_volume
184 ( Pt 2)pub_type
杂志文章abstract::The distribution and composition of endogenous lipids in articular cartilage and transport of exogenous fatty acids have been investigated on a microscopic scale in fresh bovine articular cartilage. To investigate the distribution and composition of the endogenous lipids, hyperspectral Raman maps were taken of chondro...
journal_title:Journal of anatomy
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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journal_title:Journal of anatomy
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pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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journal_title:Journal of anatomy
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journal_title:Journal of anatomy
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Journal of anatomy
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doi:
更新日期:1977-04-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2012.01519.x
更新日期:2012-08-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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journal_title:Journal of anatomy
pub_type: 杂志文章
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journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:
更新日期:1995-08-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章,评审
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更新日期:2015-10-01 00:00:00
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journal_title:Journal of anatomy
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