E-cadherin mediates adherens junction organization through protein kinase C.

abstract：:Brain-derived neurotrophic factor (BDNF) is known to be a crucial regulator of neuronal survival and synaptic plasticity in the mammalian brain. Furthermore, BDNF positively influences differentiation of embryonic neural precursors, as well as that of neural stem cells from adult neurogenic niches. To study the impact...

journal_title：Journal of cell science

authors： Leschik J,Eckenstaler R,Nieweg K,Lichtenecker P,Brigadski T,Gottmann K,Lessmann V,Lutz B

更新日期：2013-11-01 00:00:00

abstract：:Isoamyl alcohol (IAA) induces a phenotype that resembles pseudohyphae in the budding yeast Saccharomyces cerevisiae. We show here that IAA causes the rapid formation of linear chains of anucleate buds, each of which is accompanied by the formation of a septin ring at its neck. This process requires the activity of Swe...

journal_title：Journal of cell science

authors： Martinez-Anaya C,Dickinson JR,Sudbery PE

更新日期：2003-08-15 00:00:00

abstract：:MOR1, the Arabidopsis thaliana homologue of the Xenopus microtubule-associated protein MAP215, is required for spatial organization of the acentrosomal microtubule arrays of plant cells. To determine how loss of MOR1 function affects microtubule dynamics, we compared various parameters of microtubule dynamics in the t...

journal_title：Journal of cell science

authors： Kawamura E,Wasteneys GO

更新日期：2008-12-15 00:00:00

abstract：:Vascular endothelial (VE)-cadherin is the endothelium-specific member of the cadherin family of homotypic cell adhesion molecules. VE-cadherin, but not the cell adhesion molecule platelet/endothelial cell adhesion molecule (PECAM-1), markedly colocalizes with actin stress fibers at cell-cell junctions between human um...

journal_title：Journal of cell science

authors： Hordijk PL,Anthony E,Mul FP,Rientsma R,Oomen LC,Roos D

更新日期：1999-06-01 00:00:00

abstract：:The karyo-cytoskeleton of cells cultured in vitro was investigated employing resinless section immunogold electron microscopy. Cells were entrapped in low-melting agarose, sequentially extracted with various buffers and digested with nucleases to obtain karyo-cytoskeletal frameworks and reacted with specific primary a...

journal_title：Journal of cell science

authors： Wang X,Traub P

更新日期：1991-01-01 00:00:00

abstract：:The extracellular signal-regulated protein kinase ERK1/2 is a crucial effector linking extracellular stimuli to cellular responses: upon phosphorylation ERK [also known as mitogen-activated protein kinase P42/P44 (MAPK)] concentrates in the nucleus where it activates specific programs of gene expression. Notwithstandi...

journal_title：Journal of cell science

authors： Costa M,Marchi M,Cardarelli F,Roy A,Beltram F,Maffei L,Ratto GM

更新日期：2006-12-01 00:00:00

abstract：:The main neuropathological features of Parkinson's disease are dopaminergic nigrostriatal neuron degeneration, and intraneuronal and intraneuritic proteinaceous inclusions named Lewy bodies and Lewy neurites, respectively, which mainly contain α-synuclein (α-syn, also known as SNCA). The neuronal phosphoprotein synaps...

journal_title：Journal of cell science

authors： Zaltieri M,Grigoletto J,Longhena F,Navarria L,Favero G,Castrezzati S,Colivicchi MA,Della Corte L,Rezzani R,Pizzi M,Benfenati F,Spillantini MG,Missale C,Spano P,Bellucci A

更新日期：2015-07-01 00:00:00

abstract：:During meiosis, cohesion between sister chromatids is required for normal levels of homologous recombination, maintenance of chiasmata and accurate chromosome segregation during both divisions. In Drosophila, null mutations in the ord gene abolish meiotic cohesion, although how ORD protein promotes cohesion has remain...

journal_title：Journal of cell science

authors： Khetani RS,Bickel SE

更新日期：2007-09-01 00:00:00

abstract：:The scaffold attachment factor SAFB1 and its recently discovered homologue SAFB2 might provide an important link between pre-mRNA splicing, intracellular signalling and transcription. Using novel mono-specific antisera, we found endogenous SAFB2 protein has a different spatial distribution from SAFB1 within the nucleu...

journal_title：Journal of cell science

authors： Sergeant KA,Bourgeois CF,Dalgliesh C,Venables JP,Stevenin J,Elliott DJ

更新日期：2007-01-15 00:00:00

abstract：:Atomic force microscopy (AFM) was used to probe topology, conformational changes and initial substrate-carrier interactions of Na+-glucose co-transporter (SGLT1) in living cells on a single-molecule level. By scanning SGLT1-transfected Chinese hamster ovary (CHO) cells with AFM tips carrying an epitope-specific antibo...

journal_title：Journal of cell science

authors： Puntheeranurak T,Wildling L,Gruber HJ,Kinne RK,Hinterdorfer P

更新日期：2006-07-15 00:00:00

abstract：:Reorganization of the actin cytoskeleton is essential to numerous cellular processes including cell locomotion and cytokinesis. This actin remodeling is regulated in part by Rho family GTPases. Previous studies implicated Trio, a Dbl-homology guanine nucleotide exchange factor with two exchange factor domains, in regu...

journal_title：Journal of cell science

authors： Seipel K,O'Brien SP,Iannotti E,Medley QG,Streuli M

更新日期：2001-01-01 00:00:00

abstract：:We previously reported that, among the three connexins expressed in chick lens, overexpression of connexin (Cx) 45.6, not Cx43 or Cx56, stimulates lens cell differentiation; however, the underlying mechanism responsible for this effect is unclear. Here, we took advantage of naturally occurring loss-of-gap-junction fun...

journal_title：Journal of cell science

authors： Banks EA,Yu XS,Shi Q,Jiang JX

更新日期：2007-10-15 00:00:00

abstract：:We have identified a liver-regulating protein involved in cell contact-mediated regulation of Sertoli cell function by primary spermatocytes in rat testis. Liver-regulating protein was studied using monoclonal antibody L8 prepared from rat primitive biliary epithelial cells. This molecule was located in vivo at the in...

journal_title：Journal of cell science

authors： Gérard N,Corlu A,Kneip B,Kercret H,Rissel M,Guguen-Guillouzo C,Jégou B

更新日期：1995-03-01 00:00:00

abstract：:Prion diseases are fatal transmissible neurodegenerative disorders characterized by the accumulation of an abnormally folded isoform of the cellular prion protein (PrP(C)) denoted PrP(Sc). Recently, wild-type and pathogenic PrP mutants have been shown to be degraded by the endoplasmic reticulum-associated degradation ...

journal_title：Journal of cell science

authors： Mangé A,Crozet C,Lehmann S,Béranger F

更新日期：2004-05-01 00:00:00

abstract：:The tissue concentration of an endogenous beta-galactoside-specific lectin is developmentally regulated in rabbit tissues during foetal and neonatal development. Immunoassay data and localization studies both indicate that the lectin is particularly associated with late embryonic and early postnatal development. No le...

journal_title：Journal of cell science

authors： Catt JW,Harrison FL,Carleton JS

更新日期：1987-06-01 00:00:00

abstract：:PACSIN2, a membrane-sculpting BAR domain protein, localizes to caveolae. Here, we found that protein kinase C (PKC) phosphorylates PACSIN2 at serine 313, thereby decreasing its membrane binding and tubulation capacities. Concomitantly, phosphorylation decreased the time span for which caveolae could be tracked at the ...

journal_title：Journal of cell science

authors： Senju Y,Rosenbaum E,Shah C,Hamada-Nakahara S,Itoh Y,Yamamoto K,Hanawa-Suetsugu K,Daumke O,Suetsugu S

更新日期：2015-08-01 00:00:00

abstract：:Using a polyclonal antibody against purified zymogen granule membrane components from rat pancreas a cDNA coding for the 29 kDa protein (ZG29p) was identified by immunoscreening of a hormonally stimulated pancreas cDNA library. Western blot analysis suggests that ZG29p is a pancreas-specific protein and immunofluoresc...

journal_title：Journal of cell science

authors： Kleene R,Zdzieblo J,Wege K,Kern HF

更新日期：1999-08-01 00:00:00

abstract：:Nearly all intermediate filament (IF) proteins share two sequence motifs located at the N- and the C-terminal ends of their helical rod domain ('coil 1a' and 'coil 2b', respectively). To examine the structural role of the coil 2b motif, we have performed in vitro assembly studies and in vivo microinjection experiments...

journal_title：Journal of cell science

authors： Kouklis PD,Traub P,Georgatos SD

更新日期：1992-05-01 00:00:00

abstract：:The post-translational modifications of the G protein of vesicular stomatitis virus, described in the preceding paper, indicate that its transport is arrested by carbonylcyanide m-chlorophenylhydrazone (CCCP) in or near the trans-Golgi. Immunofluorescence microscopy of BHK-21 cells infected with vesicular stomatitis v...

journal_title：Journal of cell science

authors： Burkhardt JK,Hester S,Argon Y

更新日期：1989-04-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) of peritoneal mesothelial cells is a pathological process that occurs during peritoneal dialysis. EMT leads to peritoneal fibrosis, ultrafiltration failure and eventually to the discontinuation of therapy. Signaling pathways involved in mesothelial EMT are thus of great inter...

journal_title：Journal of cell science

authors： Strippoli R,Benedicto I,Foronda M,Perez-Lozano ML,Sánchez-Perales S,López-Cabrera M,Del Pozo MÁ

更新日期：2010-12-15 00:00:00

abstract：:Cell migration and invasion play a crucial role during normal and pathological development. The expression of several members of the Ets family of transcription factors has been shown to correlate with the occurrence of these processes. In the present study, we investigated the effect of the expression of Ets1-DB, the...

journal_title：Journal of cell science

authors： Delannoy-Courdent A,Mattot V,Fafeur V,Fauquette W,Pollet I,Calmels T,Vercamer C,Boilly B,Vandenbunder B,Desbiens X

更新日期：1998-06-01 00:00:00

abstract：:In animals and yeast, CLASP proteins are microtubule plus-end tracking proteins (+TIPS) involved in the regulation of microtubule plus-end dynamics and stabilization. Here we show that mutations in the Arabidopsis CLASP homolog result in various plant growth reductions, cell form defects and reduced mitotic activity. ...

journal_title：Journal of cell science

authors： Kirik V,Herrmann U,Parupalli C,Sedbrook JC,Ehrhardt DW,Hülskamp M

更新日期：2007-12-15 00:00:00

abstract：:The postnatal mouse ovary is rich in quiescent and early-growing oocytes, each one surrounded by a layer of somatic granulosa cells (GCs) on a basal lamina. As oocytes start to grow the GCs change shape from flattened to cuboidal, increase their proliferation and form multiple layers, providing a unique model for stud...

journal_title：Journal of cell science

authors： Da Silva-Buttkus P,Jayasooriya GS,Mora JM,Mobberley M,Ryder TA,Baithun M,Stark J,Franks S,Hardy K

更新日期：2008-12-01 00:00:00

abstract：:Several cell motility processes including cytokinesis and cell locomotion are dependent on the interplay of the microtubule and actomyosin cytoskeletons. However, because such processes are essentially visual phenomena, interactions between the two cytoskeletal systems have been difficult to study quantitatively. To o...

journal_title：Journal of cell science

authors： Canman JC,Bement WM

更新日期：1997-08-01 00:00:00

abstract：:Endocytosis is a regulated physiological process by which membrane receptors and their extracellular ligands are internalized. After internalization, they enter the endosomal trafficking pathway for sorting and processing. Amphiphysins consist of a family of proteins conserved throughout evolution that are crucial ele...

journal_title：Journal of cell science

authors： Leprince C,Le Scolan E,Meunier B,Fraisier V,Brandon N,De Gunzburg J,Camonis J

更新日期：2003-05-15 00:00:00

abstract：:The small GTPase Rac contributes to regulation of cytoskeletal rearrangement during chemokine-induced lymphocyte adhesion and migration in a multi-step process that is very precisely coordinated. Chimaerins are Rac1-specific GTPase-activating proteins of unknown biological function, which have a canonical diacylglycer...

journal_title：Journal of cell science

authors： Siliceo M,García-Bernal D,Carrasco S,Díaz-Flores E,Coluccio Leskow F,Teixidó J,Kazanietz MG,Mérida I

更新日期：2006-01-01 00:00:00

abstract：:The essential function of the T cell receptor (TCR) is to translate the engagement of peptides on the major histocompatibility complex (pMHC) into appropriate intracellular signals through the associated cluster of differentiation 3 (CD3) complex. The spatial organization of the TCR-CD3 complex in the membrane is thou...

journal_title：Journal of cell science

authors： Goyette J,Nieves DJ,Ma Y,Gaus K

更新日期：2019-02-11 00:00:00

abstract：:Vertebrate nuclear lamins form a multigene family with developmentally controlled expression. In contrast, invertebrates have long been thought to contain only a single lamin, which in Drosophila is the well-characterized lamin Dm0. Recently, however, a Drosophila cDNA clone (pG-IF) has been identified that codes for ...

journal_title：Journal of cell science

authors： Riemer D,Stuurman N,Berrios M,Hunter C,Fisher PA,Weber K

更新日期：1995-10-01 00:00:00

abstract：:Maturation of nociceptive neurons depends on changes in transcription factors, ion channels and neuropeptides. Mature nociceptors initiate pain in part by drastically reducing the activation threshold via intracellular sensitization signaling. Whether sensitization signaling also changes during development and aging r...

journal_title：Journal of cell science

authors： Isensee J,Schild C,Schwede F,Hucho T

更新日期：2017-07-01 00:00:00

abstract：:The adaptor protein Miranda plays a pivotal role in the asymmetric cell division of neuroblasts by asymmetrically segregating key differentiation factors. Miranda localization requires Myosin VI and Myosin II. The apical-then-basal localization pattern of Miranda detected in fixed tissue, and the localization defects ...

journal_title：Journal of cell science

authors： Erben V,Waldhuber M,Langer D,Fetka I,Jansen RP,Petritsch C

更新日期：2008-05-01 00:00:00