Regulation of meiotic cohesion and chromosome core morphogenesis during pachytene in Drosophila oocytes.

abstract：:Mitotic progression is timely regulated by the accumulation and degradation of A- and B-type cyclins. In plants, there are three classes of A-, and two classes of B-type cyclins, but their specific roles are not known. We have generated transgenic tobacco plants in which the ectopic expression of a plant cyclin B2 gen...

journal_title：Journal of cell science

authors： Weingartner M,Pelayo HR,Binarova P,Zwerger K,Melikant B,de la Torre C,Heberle-Bors E,Bögre L

更新日期：2003-02-01 00:00:00

abstract：:During development, axons migrate long distances in responses to attractive or repulsive signals that are detected by their growth cones. One of these signals is mediated by netrin-1, a diffusible laminin-related molecule that both attracts and repels growth cones via interaction with its receptor DCC (deleted in colo...

journal_title：Journal of cell science

authors： Hérincs Z,Corset V,Cahuzac N,Furne C,Castellani V,Hueber AO,Mehlen P

更新日期：2005-04-15 00:00:00

abstract：:Recruitment of secretory vesicles to the cell surface is essential for the sustained secretion of insulin in response to glucose. At present, the molecular motors involved in this movement, and the mechanisms whereby they may be regulated, are undefined. To investigate the role of kinesin family members, we labelled d...

journal_title：Journal of cell science

authors： Varadi A,Ainscow EK,Allan VJ,Rutter GA

更新日期：2002-11-01 00:00:00

abstract：:Ovarian follicles are the basic functional units of female reproduction in the mammalian ovary. We show here that the protein a disintegrin and metalloproteinase domain 10 (ADAM10), a cell surface sheddase, plays an indispensable role in controlling primordial follicle formation by regulating the recruitment of follic...

journal_title：Journal of cell science

authors： Feng L,Wang Y,Cai H,Sun G,Niu W,Xin Q,Tang X,Zhang J,Wang C,Zhang H,Xia G

更新日期：2016-06-01 00:00:00

abstract：:Eukaryotic plasma membranes assemble actin filaments within seconds of activation of many receptors, especially during chemotaxis. Here, serum or sphingosine-1-phosphate stimulation of J774 and RAW macrophages released ADP within seconds into the extracellular medium, along with an adenylate kinase activity that conve...

journal_title：Journal of cell science

authors： Kuehnel MP,Reiss M,Anand PK,Treede I,Holzer D,Hoffmann E,Klapperstueck M,Steinberg TH,Markwardt F,Griffiths G

更新日期：2009-02-15 00:00:00

abstract：:Normal human foreskin keratinocytes (HFKs) and transformed HFKs (FEPE1L-8 cells) generated by the introduction of cloned human papillomavirus type 16 sequences were compared for the expression and function of a family of adhesion receptors termed integrins. Initially, cells were examined in conventional monolayer cult...

journal_title：Journal of cell science

authors： Kaur P,Carter WG

更新日期：1992-11-01 00:00:00

abstract：:Structures retaining many of the morphological features of nuclei may be released by gently lysing human cells in solutions containing non-ionic detergents and high concentrations of salt. These nucleoids contain superhelical DNA. Using a double-labelling procedure we have compared, at different salt concentrations, t...

journal_title：Journal of cell science

authors： Levin JM,Jost E,Cook PR

更新日期：1978-02-01 00:00:00

abstract：:Gp78 (also known as AMFR and RNF45) is an E3 ubiquitin ligase that targets proteins for proteasomal degradation through endoplasmic reticulum (ER)-associated degradation (ERAD). In this study, we showed that gp78-mediated ubiquitylation is initiated in the peripheral ER. Substrate monoubiquitylation and gp78 CUE domai...

journal_title：Journal of cell science

authors： St-Pierre P,Dang T,Joshi B,Nabi IR

更新日期：2012-04-01 00:00:00

abstract：:Barrier junctions prevent pathogen invasion and restrict paracellular leakage across epithelial sheets. To understand how one barrier junction, the septate junction (SJ), is regulated in vivo, we used fluorescence recovery after photobleaching (FRAP) to examine SJ protein dynamics in Drosophila. Most SJ-associated pro...

journal_title：Journal of cell science

authors： Oshima K,Fehon RG

更新日期：2011-08-15 00:00:00

abstract：:The mAb RK7, previously shown to recognize keratin 19, was also found to cross-react with a biologically unrelated 102 kDa protein, which becomes associated with the poles of the mitotic apparatus. This newly identified protein, called cytocentrin, is a stable cellular component, may be at least in part phosphorylated...

journal_title：Journal of cell science

authors： Paul EC,Quaroni A

更新日期：1993-11-01 00:00:00

abstract：:TGFβ binding to the TGFβ receptor (TβR) activates R-Smad-dependent pathways, such as Smad2/3, and R-Smad-independent pathways, such as ERK1/2. The mechanism of the TGFβ-TβRII-TβRI-Smad2/3 pathway is established; however, it is not known how TGFβ activates ERK1/2. We show here that although TGFβ equally activated Smad2...

journal_title：Journal of cell science

authors： Bandyopadhyay B,Han A,Dai J,Fan J,Li Y,Chen M,Woodley DT,Li W

更新日期：2011-01-01 00:00:00

abstract：:Programmed cell death comprises several subtypes, as revealed by electron microscopy. Apoptosis or type I programmed cell death is characterized by condensation of cytoplasm and preservation of organelles, essentially without autophagic degradation. Autophagic cell death or type II programmed cell death exhibits exten...

journal_title：Journal of cell science

authors： Bursch W,Hochegger K,Torok L,Marian B,Ellinger A,Hermann RS

更新日期：2000-04-01 00:00:00

abstract：:Splice variants of certain genes impact on genetic biodiversity in mammals. The tumor suppressor TP53 gene (encoding p53) plays an important role in the regulation of tumorigenesis in hepatocellular carcinoma (HCC). Δ40p53α is a naturally occurring p53 isoform that lacks the N-terminal transactivation domain, yet litt...

journal_title：Journal of cell science

authors： Ota A,Nakao H,Sawada Y,Karnan S,Wahiduzzaman M,Inoue T,Kobayashi Y,Yamamoto T,Ishii N,Ohashi T,Nakade Y,Sato K,Itoh K,Konishi H,Hosokawa Y,Yoneda M

更新日期：2017-02-01 00:00:00

abstract：:Myosin VI is an actin-based retrograde motor protein that plays a crucial role in both endocytic and secretory membrane trafficking pathways. Myosin VI's targeting to and function in these intracellular pathways is mediated by a number of specific binding partners. In this paper we have identified a new myosin-VI-bind...

journal_title：Journal of cell science

authors： Chibalina MV,Seaman MN,Miller CC,Kendrick-Jones J,Buss F

更新日期：2007-12-15 00:00:00

abstract：:BCL6 is a potent transcriptional repressor that plays important roles in germinal center formation, T helper cell differentiation and lymphomagenesis and regulates expression of several chemokine genes in macrophages. In a further investigation of its role in macrophages, we show that BCL6 inactivation in primary bone...

journal_title：Journal of cell science

authors： Pixley FJ,Xiong Y,Yu RY,Sahai EA,Stanley ER,Ye BH

更新日期：2005-05-01 00:00:00

abstract：:The cell surface delivery of extracellular matrix (ECM) and integrins is fundamental for cell migration in wound healing and during cancer cell metastasis. This process is not only driven by several soluble NSF attachment protein (SNAP) receptor (SNARE) proteins, which are key players in vesicle transport at the cell ...

journal_title：Journal of cell science

authors： Enrich C,Rentero C,Hierro A,Grewal T

更新日期：2015-03-15 00:00:00

abstract：:Most secretory proteins travel through a well-documented conventional secretion pathway involving the endoplasmic reticulum (ER) and the Golgi complex. However, recently, it has been shown that a significant number of proteins reach the plasma membrane or extracellular space via unconventional routes. Unconventional p...

journal_title：Journal of cell science

authors： Kim J,Gee HY,Lee MG

更新日期：2018-06-25 00:00:00

abstract：:Microinjected GTP gamma S revealed three distinct steps in the exocytic transport of the temperature sensitive glycoprotein of vesicular stomatitis virus (ts-O45-G) from the ER to the cell surface in intact Vero cells. While COPII dependent export of ts-O45-G from the ER is blocked in cells injected with recombinant p...

journal_title：Journal of cell science

authors： Pepperkok R,Lowe M,Burke B,Kreis TE

更新日期：1998-07-01 00:00:00

abstract：:Tie2-promoter-mediated loss of peroxisome proliferator-activated receptor gamma (PPARγ, also known as PPARG) in mice leads to osteopetrosis and pulmonary arterial hypertension. Vascular disease is associated with loss of PPARγ in pulmonary microvascular endothelial cells (PMVEC); we evaluated the role of PPARγ in PMVE...

journal_title：Journal of cell science

authors： Vattulainen-Collanus S,Akinrinade O,Li M,Koskenvuo M,Li CG,Rao SP,de Jesus Perez V,Yuan K,Sawada H,Koskenvuo JW,Alvira C,Rabinovitch M,Alastalo TP

更新日期：2016-02-15 00:00:00

abstract：:Insulin granule trafficking is a key step of glucose-stimulated insulin secretion from pancreatic beta cells. Using quantitative live cell imaging, we examined insulin granule movements within the reserve pool upon secretory stimulation in betaTC3 cells. For this study, we developed a custom image analysis program tha...

journal_title：Journal of cell science

authors： Hao M,Li X,Rizzo MA,Rocheleau JV,Dawant BM,Piston DW

更新日期：2005-12-15 00:00:00

abstract：:Dystrophin has been proposed to associate with the skeletal muscle membrane by way of a glycoprotein complex that interacts with its C-terminal domains. Transfection of mdx mouse myotubes in culture or myofibres in vivo with recombinant genes encoding human dystrophin deletion mutants shows, however, that not only the...

journal_title：Journal of cell science

authors： Dunckley MG,Wells KE,Piper TA,Wells DJ,Dickson G

更新日期：1994-06-01 00:00:00

abstract：:Cytidine triphosphate synthase (CTPS) and inosine monophosphate dehydrogenase (IMPDH) (both of which have two isoforms) can form fiber-like subcellular structures termed 'cytoophidia' under certain circumstances in mammalian cells. Although it has been shown that filamentation of CTPS downregulates its activity by dis...

journal_title：Journal of cell science

authors： Chang CC,Lin WC,Pai LM,Lee HS,Wu SC,Ding ST,Liu JL,Sung LY

更新日期：2015-10-01 00:00:00

abstract：:Diploid yeast, like most eukaryotes, can undergo meiotic differentiation to form haploid gametes. Meiotic differentiation and cell growth (proliferation) are mutually exclusive programs, and in yeast the switch between growth and meiosis is controlled by nutritional signals. The signaling pathways that mediate nutriti...

journal_title：Journal of cell science

authors： Honigberg SM,Purnapatre K

更新日期：2003-06-01 00:00:00

abstract：:Cell migration is essential for normal development and many pathological processes. Rho-family small GTPases play important roles in this event. In particular, Rac regulates lamellipodia formation at the leading edge during migration. The small GTPase RhoG activates Rac through its effector ELMO and the ELMO-binding p...

journal_title：Journal of cell science

authors： Katoh H,Hiramoto K,Negishi M

更新日期：2006-01-01 00:00:00

abstract：:In chondrocytes, PTHrP maintains them in a proliferative state and prevents premature hypertrophy. The mechanism by which PTHrP does this is not fully understood. Both Runx2 and Runx3 are required for chondrocyte maturation. We recently demonstrated that cyclin D1 induces Runx2 protein phosphorylation and degradation....

journal_title：Journal of cell science

authors： Zhang M,Xie R,Hou W,Wang B,Shen R,Wang X,Wang Q,Zhu T,Jonason JH,Chen D

更新日期：2009-05-01 00:00:00

abstract：:Ultrastructure of centrioles of fused cells containing heterophasic interphase nuclei, premature chromosome condensation, and a telophase-like nucleus were studied. The study indicated that the heterophasic cellular environments contributed by the different cell partners exert a mutually opposite effect on the structu...

journal_title：Journal of cell science

authors： Manandhar G,Onishchenko GE

更新日期：1995-02-01 00:00:00

abstract：:During pre-mRNA splicing, introns are removed and exons are ligated to form an mRNA. Exon choice is determined by different nuclear protein concentrations varying among tissues and cell types or by developmental stage. These can be altered by different cellular circumstances such as physiological stimuli, environmenta...

journal_title：Journal of cell science

authors： Shomron N,Alberstein M,Reznik M,Ast G

更新日期：2005-03-15 00:00:00

abstract：:MIP and MP70 are putative gap junction components in the plasma membranes of the mammalian lens fibre cells. We show now that MP70 can be solubilized separately from MIP in mild detergent solutions, and that this treatment results in the dissociation of the fibre gap junctions. Solubilized MP70 was isolated as 16.9 S ...

journal_title：Journal of cell science

authors： Kistler J,Bullivant S

更新日期：1988-11-01 00:00:00

abstract：:Protein kinases AKT and PKBR1 of Dictyostelium belong to the AGC protein kinase superfamily. AKT and PKBR1 are phosphorylated at similar sites by phosphoinositide-dependent kinase 1 (PDK1) and TORC2 kinases; however, they have different subcellular localizing domains. AKT has a phosphoinositide 3-kinase (PI3K)/phospha...

journal_title：Journal of cell science

authors： Liao XH,Buggey J,Kimmel AR

更新日期：2010-03-15 00:00:00

abstract：:The neural cell adhesion molecule NCAM plays an important role during neural development and in the adult brain. To study the intracellular trafficking of NCAM in neurons, two major isoforms, NCAM140 or NCAM180, were expressed in primary cortical neurons and in the rat B35 neuroblastoma cell line. NCAM was endocytosed...

journal_title：Journal of cell science

authors： Diestel S,Schaefer D,Cremer H,Schmitz B

更新日期：2007-11-15 00:00:00