Integrin expression and differentiation in transformed human epidermal cells is regulated by fibroblasts.

abstract：:In Drosophila, telomere-capping proteins have the remarkable capacity to recognize chromosome ends in a sequence-independent manner. This epigenetic protection is essential to prevent catastrophic ligations of chromosome extremities. Interestingly, capping proteins occupy a large telomere chromatin domain of several k...

journal_title：Journal of cell science

authors： Dubruille R,Loppin B

更新日期：2015-05-15 00:00:00

abstract：:The nuclear division of Oxyrrhis marina is a very distinct one among the mitoses of dinoflagellates that have been studies. Using synchronized populations, we have investigated the ultrastructural changes in this nuclear division. In interphase, nuclei can be classified into two groups on the basis of the shapes of th...

journal_title：Journal of cell science

authors： Gao XP,Li JY

更新日期：1986-09-01 00:00:00

abstract：:Spindle pole bodies in the fission yeast Schizosaccharomyces pombe are required during meiosis, not only for spindle formation but also for the assembly of forespore membranes. The spo15 mutant is defective in the formation of forespore membranes, which develop into spore envelopes. The spo15(+)gene encodes a protein ...

journal_title：Journal of cell science

authors： Ikemoto S,Nakamura T,Kubo M,Shimoda C

更新日期：2000-02-01 00:00:00

abstract：:Nodal signaling induces the formation of the endoderm and mesoderm during gastrulation. Nodal expression persists until the definitive endoderm progenitor has completely formed, and disappears thereafter. A tightly regulated Nodal expression system is essential for the differentiation of embryonic stem (ES) cells into...

journal_title：Journal of cell science

authors： Takenaga M,Fukumoto M,Hori Y

更新日期：2007-06-15 00:00:00

abstract：:Centaurin-alpha(1) is a phosphatidylinositol 3,4,5-trisphosphate binding protein as well as a GTPase activating protein (GAP) for the ADP-ribosylation factor (ARF) family of small GTPases. To further understand its cellular function, we screened a rat brain cDNA library using centaurin-alpha(1) as bait to identify cen...

journal_title：Journal of cell science

authors： Venkateswarlu K,Hanada T,Chishti AH

更新日期：2005-06-01 00:00:00

abstract：:Iron (Fe(2+), Fe(3+)) homeostasis is a tightly regulated process, involving precise control of iron influx and egress from cells. Although the mechanisms of its import into cells by iron carrier molecules are well characterized, iron export remains poorly understood. The current paradigm envisages unique functions ass...

journal_title：Journal of cell science

authors： Sheokand N,Malhotra H,Kumar S,Tillu VA,Chauhan AS,Raje CI,Raje M

更新日期：2014-10-01 00:00:00

abstract：:A temperature-sensitive mutant tsBN63 cell line was isolated by the fluorodeoxyuridine method from the BHK21/13 cell line after mutagenesis with nitrosoguanidine. When cultures of tsBN63 cells growing asynchronously at 33.5 degrees C were shifted to 39.5 degrees C, a nonpermissive temperature, the ability for protein ...

journal_title：Journal of cell science

authors： Watanabe M,Furuno N,Goebl M,Go M,Miyauchi K,Sekiguchi T,Basilico C,Nishimito T

更新日期：1991-09-01 00:00:00

abstract：:In Rat-1 fibroblasts, v-Src causes a profound remodelling of cortical actin cytoskeleton. This transformation includes membrane ruffling, a hallmark of the leading edge in migrating cells, and results from activation of phosphoinositide 3-kinase (PI 3-kinase), phospholipase C (PLC) and phospholipase D (PLD). We theref...

journal_title：Journal of cell science

authors： Platek A,Mettlen M,Camby I,Kiss R,Amyere M,Courtoy PJ

更新日期：2004-09-15 00:00:00

abstract：:The function of DAXX, a highly conserved mammalian gene, has remained controversial; this is due, in part, to its identification in a variety of yeast two-hybrid screens. Targeted deletion in the mouse revealed that DAXX is essential for embryonic development. Furthermore, the increased levels of apoptosis observed in...

journal_title：Journal of cell science

authors： Michaelson JS,Leder P

更新日期：2003-01-15 00:00:00

abstract：:Endothelial cells are known to undergo transitions in cell shape during long-term culture. Thus, the assumption that the separate phenotypes of microvascular endothelial cells (MVEC) recently isolated from bovine corpus luteum represent constitutively different cell strains cannot automatically be made. For this reaso...

journal_title：Journal of cell science

authors： Fenyves AM,Behrens J,Spanel-Borowski K

更新日期：1993-11-01 00:00:00

abstract：:Cells are internally organized into compartmentalized organelles that execute specialized functions. To understand the functions of individual organelles and their regulations, it is critical to resolve the compositions of individual organelles, which relies on a rapid and efficient isolation method for specific organ...

journal_title：Journal of cell science

authors： Xiong J,He J,Xie WP,Hinojosa E,Ambati CSR,Putluri N,Kim HE,Zhu MX,Du G

更新日期：2019-12-13 00:00:00

abstract：:The biosynthetic machinery in the melanotrope cells of the Xenopus intermediate pituitary is primarily dedicated to the generation of proopiomelanocortin (POMC)-derived, melanophore-stimulating peptides. Transfer of the animal to a black background stimulates the production of these peptides and causes a dramatic incr...

journal_title：Journal of cell science

authors： Holthuis JC,Jansen EJ,van Riel MC,Martens GJ

更新日期：1995-10-01 00:00:00

abstract：:Using a series of chimeric and truncated N-acetylglucosaminyltransferase I (NAGT I) molecules we have shown that part of the lumenal stalk region is both necessary and sufficient for kin recognition of mannosidase II and retention in the Golgi stack. The membrane-spanning domain was not required for retention, but rep...

journal_title：Journal of cell science

authors： Nilsson T,Rabouille C,Hui N,Watson R,Warren G

更新日期：1996-07-01 00:00:00

abstract：:In chicken oocytes, proteins of the K/J family or their analogs, such as are known to be involved in mRNA processing in humans, are closely associated with nascent C-rich RNA transcripts on the loops of lampbrush chromosomes. Using labelled single stranded nucleotide probes and an antibody to protein K, these C-rich t...

journal_title：Journal of cell science

authors： Solovei I,Macgregor H,Gaginskaya E

更新日期：1995-04-01 00:00:00

abstract：:In skeletal muscle, the triad is a structure comprising a transverse (T)-tubule and sarcoplasmic reticulum (SR) cisternae. Triads constitute the basis of excitation-contraction coupling as the cradle of the Ca2+ release complex. We have shown previously that triadin, a member of this complex, has shaping properties on...

journal_title：Journal of cell science

authors： Osseni A,Sébastien M,Sarrault O,Baudet M,Couté Y,Fauré J,Fourest-Lieuvin A,Marty I

更新日期：2016-10-15 00:00:00

abstract：:In many cells, the endoplasmic reticulum (ER) contains segregated smooth and rough domains, but the mechanism of this segregation is unclear. Here, we used a HeLa cell line, inducibly expressing a GFP fusion protein [GFP-b(5)tail] anchored to the ER membrane, as a tool to investigate factors influencing ER organisatio...

journal_title：Journal of cell science

authors： Sprocati T,Ronchi P,Raimondi A,Francolini M,Borgese N

更新日期：2006-08-01 00:00:00

abstract：:Interaction of cationized ferritin with the anionic groups on the cell surface of Naegleria was studied using transmission electron microscopy in conjunction with fluorescence microscopy. Most of the experiments involved the use of fluorescein-labelled cationized ferritin (FITC-CF) incubated with living amoebae. Initi...

journal_title：Journal of cell science

authors： King CA,Preston TM

更新日期：1977-12-01 00:00:00

abstract：:The process of cell migration is initiated by protrusion at the leading edge of the cell, the formation of peripheral adhesions, the exertion of force on these adhesions, and finally the release of the adhesions at the rear of the cell. Focal adhesion kinase (FAK) is intimately involved in the regulation of this proce...

journal_title：Journal of cell science

authors： Tilghman RW,Slack-Davis JK,Sergina N,Martin KH,Iwanicki M,Hershey ED,Beggs HE,Reichardt LF,Parsons JT

更新日期：2005-06-15 00:00:00

abstract：:Cell-free extracts of Xenopus eggs support nuclear assembly and DNA replication in vitro. Extracts supplemented with the protein phosphatase inhibitor microcystin-LR displayed various inhibitory effects at different concentrations of the toxin. In the presence of cycloheximide, additions of microcystin did not induce ...

journal_title：Journal of cell science

authors： Murphy J,Crompton CM,Hainey S,Codd GA,Hutchison CJ

更新日期：1995-01-01 00:00:00

abstract：:The coordinated cellular responses to physiological stress are known to be effected in part by the activation of heat-shock factor 1, a transcriptional activator protein capable of binding to, and inducing transcription from genes containing heat shock elements. Other stress responsive signal transduction pathways als...

journal_title：Journal of cell science

authors： Head MW,Hurwitz L,Goldman JE

更新日期：1996-05-01 00:00:00

abstract：:Organelles such as neuropeptide-containing dense-core vesicles (DCVs) and mitochondria travel down axons to supply synaptic boutons. DCV distribution among en passant boutons in small axonal arbors is mediated by circulation with bidirectional capture. However, it is not known how organelles are distributed in extensi...

journal_title：Journal of cell science

authors： Tao J,Bulgari D,Deitcher DL,Levitan ES

更新日期：2017-08-01 00:00:00

abstract：:By differential screening of a Xenopus laevis egg cDNA library, we have isolated a 2,111 bp cDNA which corresponds to a maternal mRNA specifically deadenylated after fertilisation. This cDNA, called Eg2, encodes a 407 amino acid protein kinase. The pEg2 sequence shows significant identity with members of a new protein...

journal_title：Journal of cell science

authors： Roghi C,Giet R,Uzbekov R,Morin N,Chartrain I,Le Guellec R,Couturier A,Dorée M,Philippe M,Prigent C

更新日期：1998-03-01 00:00:00

abstract：:Changes in the cytoskeletal structure of cultured A10 smooth muscle cells induced by calyculin-A (CL-A), a potent inhibitor of types 1 and 2A protein phosphatases, were analyzed using indirect fluorescence techniques. In the presence of 1 x 10(-7) M CL-A the cells became round and subsequently detached from the substr...

journal_title：Journal of cell science

authors： Hosoya N,Mitsui M,Yazama F,Ishihara H,Ozaki H,Karaki H,Hartshorne DJ,Mohri H

更新日期：1993-08-01 00:00:00

abstract：:The GGGGCC (G4C2) repeat expansion mutation in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Transcription of the repeat and formation of nuclear RNA foci, which sequester specific RNA-binding proteins, is one of the possible pathological me...

journal_title：Journal of cell science

authors： Bajc Česnik A,Darovic S,Prpar Mihevc S,Štalekar M,Malnar M,Motaln H,Lee YB,Mazej J,Pohleven J,Grosch M,Modic M,Fonovič M,Turk B,Drukker M,Shaw CE,Rogelj B

更新日期：2019-03-07 00:00:00

abstract：:In order to determine whether fibronexus morphogenesis is involved in the establishment of more normal cellular morphology and substrate adhesion patterns in Nil/HSV transformed fibroblasts induced by treatment with exogenous fibronectin (FN), this system was studied with electron microscopy (EM), immunocytochemistry,...

journal_title：Journal of cell science

authors： Singer II

更新日期：1982-08-01 00:00:00

abstract：:The attachment of polymorphonuclear leukocytes (PMN) to the endothelial lining of blood vessels is an important initial event in the acute inflammatory reaction. Experiments were carried out to examine some of the parameters of this adhesive interaction and the extent to which the substrate (endothelium) plays a role ...

journal_title：Journal of cell science

authors： Hoover RL,Folger R,Haering WA,Ware BR,Karnovsky MJ

更新日期：1980-10-01 00:00:00

abstract：:Syndecan-4 is a ubiquitously expressed transmembrane heparan sulphate proteoglycan acting in concert with integrins in the formation of focal adhesions and stress fibres. Signalling events studied thus far suggest the formation of a ternary complex between syndecan-4, phosphatidylinositol 4,5-bisphosphate and protein ...

journal_title：Journal of cell science

authors： Dovas A,Yoneda A,Couchman JR

更新日期：2006-07-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic human disease, with around 12.5 million people affected worldwide. ADPKD results from mutations in either PKD1 or PKD2, which encode the atypical G-protein coupled receptor polycystin-1 (PC1) and the transient receptor potential channel ...

journal_title：Journal of cell science

authors： Tilley FC,Gallon M,Luo C,Danson CM,Zhou J,Cullen PJ

更新日期：2018-06-06 00:00:00

abstract：:The transbilayer dynamics of lipids in the plasma membrane of mammalian sperm cells is crucial for the fertilization process. Here, the transbilayer movement and distribution of phospholipids in the plasma membrane of fresh, ejaculated and cryopreserved ram spermatozoa was studied by labeling cells with fluorescent an...

journal_title：Journal of cell science

authors： Müller K,Pomorski T,Müller P,Herrmann A

更新日期：1999-01-01 00:00:00

abstract：:At the onset of development, the single cells of the eukaryotic micro-organism Dictyostelium discoideum secrete proteolytic activity which can be assayed using the insoluble substrate remazolbrilliant blue hide. The activity is not secreted by exponentially growing cells, but does appear extracellularly at the onset o...

journal_title：Journal of cell science

authors： Rossomando EF,Maldonado B,Crean EV,Kollar EJ

更新日期：1978-04-01 00:00:00