The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly.

abstract：:hnRNP A1 (34 kDa) is an RNA binding protein consisting of two tandemly arranged RNA binding domains C-terminally linked to a glycine-rich auxiliary domain (2 x RBD-Gly). A1 belongs to the set of polypeptides that bind nascent hnRNA in the nucleus to form the so called hnRNP complexes. These complexes seem to be involv...

journal_title：Journal of cell science

authors： Weighardt F,Biamonti G,Riva S

更新日期：1995-02-01 00:00:00

abstract：:Shape changes have been determined in human blood lymphocytes stimulated with OAG, diC8, PMA, colchicine or the hexapeptide fNLPNTL in short-term assays (30 min). Distinct types of shape-change responses were observed. Colchicine was active in generating a relatively small proportion of polarized lymphocytes (front-ta...

journal_title：Journal of cell science

authors： Keller HU,Niggli V,Zimmermann A

更新日期：1989-07-01 00:00:00

abstract：:Rac1 has a crucial role in epidermal growth factor (EGF)-induced membrane ruffling, lamellipodial protrusion, and cell migration. Several guanine nucleotide exchange factors (GEFs) including Sos1, Sos2, Tiam1 and Vav2 have been shown to transduce the growth signal from the EGF receptor to Rac1. To clarify the role of ...

journal_title：Journal of cell science

authors： Itoh RE,Kiyokawa E,Aoki K,Nishioka T,Akiyama T,Matsuda M

更新日期：2008-08-15 00:00:00

abstract：:Gene expression of malaria parasites is mediated by the apicomplexan Apetala2 (ApiAP2) transcription factor family. Different ApiAP2s control gene expression at distinct stages in the complex life cycle of the parasite, ensuring timely expression of stage-specific genes. ApiAP2s recognize short cis-regulatory elements...

journal_title：Journal of cell science

authors： Klug D,Kehrer J,Frischknecht F,Singer M

更新日期：2018-10-22 00:00:00

abstract：:The nimO predicted protein of Aspergillus nidulans is related structurally and functionally to Dbf4p, the regulatory subunit of Cdc7p kinase in budding yeast. nimOp and Dbf4p are most similar in their C-termini, which contain a PEST motif and a novel, short-looped Cys2-His2 zinc finger-like motif. DNA labelling and re...

journal_title：Journal of cell science

authors： James SW,Bullock KA,Gygax SE,Kraynack BA,Matura RA,MacLeod JA,McNeal KK,Prasauckas KA,Scacheri PC,Shenefiel HL,Tobin HM,Wade SD

更新日期：1999-05-01 00:00:00

abstract：:Fibrin deposits in tumor beds are an intriguing phenomenon. It has been suggested that fibrin plays a role as a provisional matrix in which the tumor grows and induces development of a vascular network. On the other hand fibrin possibly protects the tumor nodule from host defense mechanisms. We therefore investigate w...

journal_title：Journal of cell science

authors： Lichtenbeld HH,Muller AD,van Dam-Mieras MC,Blijham GH

更新日期：1993-10-01 00:00:00

abstract：:SARA, an early endosomal protein, plays a key role in TGFβ signalling, as it presents SMAD2 and SMAD3 for phosphorylation by the activated TGFβ receptors. Here, we show that ERBIN is a new SARA-interacting protein that can be recruited by SARA to early endosomes. ERBIN was recently shown to bind and segregate phosphor...

journal_title：Journal of cell science

authors： Sflomos G,Kostaras E,Panopoulou E,Pappas N,Kyrkou A,Politou AS,Fotsis T,Murphy C

更新日期：2011-10-01 00:00:00

abstract：:The conversion of the cellular prion protein (PrPc) into a pathogenic isoform (PrP(Sc)) is one of the underlying events in the pathogenesis of the fatal transmissible spongiform encephalopathies (TSEs). Numerous compounds have been described to inhibit prion replication and PrP(Sc) accumulation in cell culture. Among ...

journal_title：Journal of cell science

authors： Nunziante M,Kehler C,Maas E,Kassack MU,Groschup M,Schätzl HM

更新日期：2005-11-01 00:00:00

abstract：:Both at a basal level and after induction (especially in response to nutrient starvation), the function of autophagy is to allow cells to degrade and recycle damaged organelles, proteins and other biological constituents. Here, we focus on the role microtubules have in autophagosome formation, autophagosome transport ...

journal_title：Journal of cell science

authors： Mackeh R,Perdiz D,Lorin S,Codogno P,Poüs C

更新日期：2013-03-01 00:00:00

abstract：:Mutations to Pax3 and other Pax family genes in both mice and humans result in numerous tissue-specific morphological defects. Little is known, however, about the cellular and molecular mechanisms by which Pax genes regulate morphogenesis. We previously showed that Pax3 induces cell aggregation and a mesenchymal-to-ep...

journal_title：Journal of cell science

authors： Wiggan O,Hamel PA

更新日期：2002-02-01 00:00:00

abstract：:Cytoplasm of Paramecium caudatum syngen 3 in the period of sexual immaturity was effective in inducing immaturity when injected into mating-reactive cells of other syngens of P. caudatum. When immature cytoplasm of P. caudatum was injected into mature cells of P. multimicronucleatum, immaturity was also induced in the...

journal_title：Journal of cell science

authors： Miwa I

更新日期：1979-04-01 00:00:00

abstract：:Previously, we showed that an integral component of stored mRNP particles in Xenopus oocytes, Xp54, is a DEAD-box RNA helicase with ATP-dependent RNA-unwinding activity. Xp54 belongs to small family of helicases (DDX6) that associate with mRNA molecules encoding proteins required for progress through meiosis. Here we ...

journal_title：Journal of cell science

authors： Smillie DA,Sommerville J

更新日期：2002-01-15 00:00:00

abstract：:Fibroblast migration is an integral component of biological processes such as wound healing and embryogenesis. Previous experiments examining fibroblast locomotion from tissue explants have shown that migrating fibroblasts lack, or contain only transient, focal adhesions (focal contacts). Focal adhesions are specializ...

journal_title：Journal of cell science

authors： Dunlevy JR,Couchman JR

更新日期：1993-06-01 00:00:00

abstract：:Mammalian homologs of the Drosophila TRP protein have been shown to form cation-permeable channels in the plasma membrane but very little is known about the mechanisms that control their cell surface localization. Recently it has been demonstrated that the last three C-terminal amino acids (TRL) of TRPC4 comprise a PD...

journal_title：Journal of cell science

authors： Mery L,Strauss B,Dufour JF,Krause KH,Hoth M

更新日期：2002-09-01 00:00:00

abstract：:Polarization of early embryos provides a foundation to execute essential patterning and morphogenetic events. In Caenorhabditis elegans, cell contacts polarize early embryos along their radial axis by excluding the cortical polarity protein PAR-6 from sites of cell contact, thereby restricting PAR-6 to contact-free ce...

journal_title：Journal of cell science

authors： Chan E,Nance J

更新日期：2013-04-01 00:00:00

abstract：:Cell migration and invasion play a crucial role during normal and pathological development. The expression of several members of the Ets family of transcription factors has been shown to correlate with the occurrence of these processes. In the present study, we investigated the effect of the expression of Ets1-DB, the...

journal_title：Journal of cell science

authors： Delannoy-Courdent A,Mattot V,Fafeur V,Fauquette W,Pollet I,Calmels T,Vercamer C,Boilly B,Vandenbunder B,Desbiens X

更新日期：1998-06-01 00:00:00

abstract：:Many of the cilia- and flagella-specific integral membrane proteins identified to date function to sense the extracellular milieu, and there is considerable interest in defining pathways for targeting such proteins to these sensory organelles. The flagellar glucose transporter of Leishmania mexicana, LmxGT1, is target...

journal_title：Journal of cell science

authors： Tran KD,Rodriguez-Contreras D,Shinde U,Landfear SM

更新日期：2012-07-15 00:00:00

abstract：:Dynamin-related GTPase proteins (DRPs) are main players in membrane remodelling. Conserved DRPs called mitofusins (Mfn1/Mfn2/Fzo1) mediate the fusion of mitochondrial outer membranes (OM). OM fusion depends on self-assembly and GTPase activity of mitofusins as well as on two other proteins, Ugo1 and Mdm30. Here, we de...

journal_title：Journal of cell science

authors： Anton F,Fres JM,Schauss A,Pinson B,Praefcke GJ,Langer T,Escobar-Henriques M

更新日期：2011-04-01 00:00:00

abstract：:NF-kappaB plays a central role in mediating pathogen and cytokine-stimulated gene transcription. NF-kappaB repressing factor (NRF) has been shown to interact with specific negative regulatory DNA elements (NRE) to mediate transcriptional repression by inhibition of the NF-kappaB activity at certain promoters. mRNA abl...

journal_title：Journal of cell science

authors： Niedick I,Froese N,Oumard A,Mueller PP,Nourbakhsh M,Hauser H,Köster M

更新日期：2004-07-15 00:00:00

abstract：:During meiosis, cohesion between sister chromatids is required for normal levels of homologous recombination, maintenance of chiasmata and accurate chromosome segregation during both divisions. In Drosophila, null mutations in the ord gene abolish meiotic cohesion, although how ORD protein promotes cohesion has remain...

journal_title：Journal of cell science

authors： Khetani RS,Bickel SE

更新日期：2007-09-01 00:00:00

abstract：:Notch signaling is pivotal for the morphogenesis and homeostasis of many tissues. We found that aberrant Notch activation in mouse neural-crest-derived periocular mesenchymal cells (POMCs), which contribute to the formation of corneal and eyelid stroma, results in blepharophimosis. Compound transgenic mice overexpress...

journal_title：Journal of cell science

authors： Zhang Y,Kao WW,Pelosi E,Schlessinger D,Liu CY

更新日期：2011-08-01 00:00:00

abstract：:Tissues fixed in osmium tetroxide or in combined osmium and glutaraldehyde (Hinde), embedded in Spurr's medium, cut at 0-5-I mum and mounted in Farrants' gum medium containing ethyl gallate, show good staining of lipid-contaning structures (droplets of triglyceride, membranes, mitochondria, etc.) in the light microsco...

journal_title：Journal of cell science

authors： Wigglesworth VB

更新日期：1975-12-01 00:00:00

abstract：:Cultured endothelial cells isolated from fenestrated capillaries express many properties characteristic of their in vivo differentiated phenotype, including the formation of a limited number of fenestrae. In this study, we have investigated whether physiological factors that control cell differentiation might regulate...

journal_title：Journal of cell science

authors： Lombardi T,Montesano R,Furie MB,Silverstein SC,Orci L

更新日期：1988-10-01 00:00:00

abstract：:Drosophila bristle cells form enormous extensions that are supported by equally impressive scaffolds of modular, polarized and crosslinked actin filament bundles. As the cell matures and support is taken over by the secreted cuticle, the actin scaffold is completely removed. This removal begins during cell elongation ...

journal_title：Journal of cell science

authors： Guild GM,Connelly PS,Vranich KA,Shaw MK,Tilney LG

更新日期：2002-02-01 00:00:00

abstract：:Protrusion formation is the first step that precedes cell movement of motile cells. Spatial control of actin polymerization is necessary to achieve directional protrusion during cell migration. Here we show that the spatial coordinators p190RhoGEF and p190RhoGAP regulate actin polymerization during leading edge protru...

journal_title：Journal of cell science

authors： Bravo-Cordero JJ,Sharma VP,Roh-Johnson M,Chen X,Eddy R,Condeelis J,Hodgson L

更新日期：2013-08-01 00:00:00

abstract：:Assembly of the nuclear envelope (NE) in telophase is essential for higher eukaryotic cells to re-establish a functional nucleus. Time-lapse, FRAP and FRET analyses in human cells showed that barrier-to-autointegration factor (BAF), a DNA-binding protein, assembled first at the distinct ;core' region of the telophase ...

journal_title：Journal of cell science

authors： Haraguchi T,Kojidani T,Koujin T,Shimi T,Osakada H,Mori C,Yamamoto A,Hiraoka Y

更新日期：2008-08-01 00:00:00

abstract：:p97 (CDC-48 in Caenorhabditis elegans) is a ubiquitin-selective AAA (ATPases associated with diverse cellular activities) chaperone and its key function is to disassemble protein complexes. p97 functions in diverse cellular processes including endoplasmic reticulum (ER)-associated degradation, membrane fusion, and mei...

journal_title：Journal of cell science

authors： Sasagawa Y,Otani M,Higashitani N,Higashitani A,Sato K,Ogura T,Yamanaka K

更新日期：2009-10-15 00:00:00

abstract：:Asymmetric cell division can produce daughter cells with different developmental fates and is often accompanied by a difference in cell size. A number of recent genetic and in vivo imaging studies in Drosophila and Caenorhabditis elegans have begun to elucidate the mechanisms underlying the rearrangements of the cytos...

journal_title：Journal of cell science

authors： Kaltschmidt JA,Brand AH

更新日期：2002-06-01 00:00:00

abstract：:During pre-mRNA splicing, introns are removed and exons are ligated to form an mRNA. Exon choice is determined by different nuclear protein concentrations varying among tissues and cell types or by developmental stage. These can be altered by different cellular circumstances such as physiological stimuli, environmenta...

journal_title：Journal of cell science

authors： Shomron N,Alberstein M,Reznik M,Ast G

更新日期：2005-03-15 00:00:00

abstract：:To understand the molecular mechanisms underlying sorting of apical and basolateral membrane components in human intestinal epithelial cells, we have cloned the human homolog of rat syntaxin 3 and looked for its subcellular localization. Endogenous human syntaxin 3 was found to be localized at the apical membrane of c...

journal_title：Journal of cell science

authors： Delgrossi MH,Breuza L,Mirre C,Chavrier P,Le Bivic A

更新日期：1997-09-01 00:00:00