Centriolar cycle of fused cells.

abstract：:The monoclonal antibody Bx63 recognizes a centrosomal antigen of Drosophila melanogaster by indirect immunofluorescence and identifies two proteins, with apparent molecular weights of 185 x 10(3) and 66 x 10(3), on Western blots. We have used this antibody to isolate five clones (lambda cs1, -2, -3, -4 and lambda j63)...

journal_title：Journal of cell science

authors： Whitfield WG,Millar SE,Saumweber H,Frasch M,Glover DM

更新日期：1988-04-01 00:00:00

abstract：:The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and modulates the progression of chronic inflammatory disease through activation of the receptor CCR2. Here, we show that co-activation of the P2Y₆ purinergic receptor (encoded by P2RY₆) occurs when...

journal_title：Journal of cell science

authors： Campwala H,Sexton DW,Crossman DC,Fountain SJ

更新日期：2014-11-15 00:00:00

abstract：:We have identified a novel autoantibody specificity in scleroderma that we term anti-chromo. These antibodies recognize several chromosomal antigens with apparent molecular mass of between 23 and 25 kDa, as determined by immunoblots. Anti-chromo autoantibodies occur in 10-15% of sera from patients with anti-centromere...

journal_title：Journal of cell science

authors： Saunders WS,Chue C,Goebl M,Craig C,Clark RF,Powers JA,Eissenberg JC,Elgin SC,Rothfield NF,Earnshaw WC

更新日期：1993-02-01 00:00:00

abstract：:Little is known of the molecular basis for the diversity of microtubule structure and function found within the eukaryotic flagellum. Antibodies that discriminate between tyrosinated alpha tubulin and post-translationally detyrosinated alpha tubulin were used to localize these complementary tubulin isoforms in flagell...

journal_title：Journal of cell science

authors： Johnson KA

更新日期：1998-02-01 00:00:00

abstract：:During development, general body plan information must be translated into distinct morphologies of individual cells. Shaping cells is thought to involve cortical cytoskeletal components and Bin-Amphiphysin-Rvs167 (BAR) superfamily proteins. We therefore conducted comprehensive side-by-side loss-of-function studies of ...

journal_title：Journal of cell science

authors： Schüler S,Hauptmann J,Perner B,Kessels MM,Englert C,Qualmann B

更新日期：2013-01-01 00:00:00

abstract：:Pieces of small intestine from newborn, I- and 6-day-old piglets were incubated in vitro and ligated segments were incubated in vivo with polycationic ferritin (PCF) to determine the distribution and possible role in protein uptake of anionic sites on membranes at the luminal surfaces of the epithelial cells. Most PCF...

journal_title：Journal of cell science

authors： Chase CC,Munn EA

更新日期：1980-12-01 00:00:00

abstract：:One of the hallmarks of cancer is the ability of tumor cells to invade surrounding tissues and metastasize. During metastasis, cancer cells degrade the extracellular matrix, which acts as a physical barrier, by developing specialized actin-rich membrane protrusion structures called invadopodia. The formation of invado...

journal_title：Journal of cell science

authors： Goicoechea SM,Zinn A,Awadia SS,Snyder K,Garcia-Mata R

更新日期：2017-03-15 00:00:00

abstract：:Cytoplasm of Paramecium caudatum syngen 3 in the period of sexual immaturity was effective in inducing immaturity when injected into mating-reactive cells of other syngens of P. caudatum. When immature cytoplasm of P. caudatum was injected into mature cells of P. multimicronucleatum, immaturity was also induced in the...

journal_title：Journal of cell science

authors： Miwa I

更新日期：1979-04-01 00:00:00

abstract：:During spermatogenesis in mammals, the transcripts of transition protein 1 (TP 1) and protamine 1 (Prm 1) are under translational regulation. Following their transcription in round spermatids, the mRNAs for TP 1 and Prm 1 are stored in the cytoplasm from 3-7 days before being translated towards the end of spermatogene...

journal_title：Journal of cell science

authors： Morales CR,Kwon YK,Hecht NB

更新日期：1991-09-01 00:00:00

abstract：:Activation and invasion of the vascular endothelium by Staphylococcus aureus is a major cause of sepsis and endocarditis. For endothelial cell invasion, S. aureus triggers actin polymerization through Cdc42, N-WASp (also known as WASL) and the Arp2/3 complex to assemble a phagocytic cup-like structure. Here, we show t...

journal_title：Journal of cell science

authors： Rauch L,Hennings K,Trasak C,Röder A,Schröder B,Koch-Nolte F,Rivera-Molina F,Toomre D,Aepfelbacher M

更新日期：2016-08-01 00:00:00

abstract：:Although endocytosis and exocytosis have been extensively studied in budding yeast, there have been relatively few investigations of these complex processes in the fission yeast Schizosaccharomyces pombe. Here we identify and characterize fission yeast Mug33, a novel Tea1-interacting protein, and show that Mug33 is in...

journal_title：Journal of cell science

authors： Snaith HA,Thompson J,Yates JR 3rd,Sawin KE

更新日期：2011-07-01 00:00:00

abstract：:Polarization of early embryos provides a foundation to execute essential patterning and morphogenetic events. In Caenorhabditis elegans, cell contacts polarize early embryos along their radial axis by excluding the cortical polarity protein PAR-6 from sites of cell contact, thereby restricting PAR-6 to contact-free ce...

journal_title：Journal of cell science

authors： Chan E,Nance J

更新日期：2013-04-01 00:00:00

abstract：:Adaptive immunity, a vertebrate specialization, adds memory and exquisite specificity to the basic innate immune responses present in invertebrates while conserving metabolic resources. In adaptive immunity, antigenic challenge requires extremely rapid proliferation of rare antigen-specific lymphocytes to produce larg...

journal_title：Journal of cell science

authors： Cantor JM,Ginsberg MH

更新日期：2012-03-15 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are among the most promising and suitable stem cell types for vascular tissue engineering. Substantial effort has been made to differentiate MSCs towards vascular cell phenotypes, including endothelial cells and smooth muscle cells (SMCs). The microenvironment of vascular cells not only c...

journal_title：Journal of cell science

authors： Dan P,Velot É,Decot V,Menu P

更新日期：2015-07-15 00:00:00

abstract：:Nedd1 is a new member of the gamma-tubulin ring complex (gammaTuRC) and targets the gammaTuRC to the centrosomes for microtubule nucleation and spindle assembly in mitosis. Although its role is known, its functional regulation mechanism remains unclear. Here we report that the function of Nedd1 is regulated by Cdk1 an...

journal_title：Journal of cell science

authors： Zhang X,Chen Q,Feng J,Hou J,Yang F,Liu J,Jiang Q,Zhang C

更新日期：2009-07-01 00:00:00

abstract：:The adapter protein CD2-associated protein (CD2AP) functions in various signaling and vesicle trafficking pathways, including endosomal sorting and/or trafficking and degradation pathways. Here, we investigated the role of CD2AP in insulin-dependent glucose transporter 4 (Glut4, also known as SLC2A4) trafficking and g...

journal_title：Journal of cell science

authors： Tolvanen TA,Dash SN,Polianskyte-Prause Z,Dumont V,Lehtonen S

更新日期：2015-12-15 00:00:00

abstract：:Both at a basal level and after induction (especially in response to nutrient starvation), the function of autophagy is to allow cells to degrade and recycle damaged organelles, proteins and other biological constituents. Here, we focus on the role microtubules have in autophagosome formation, autophagosome transport ...

journal_title：Journal of cell science

authors： Mackeh R,Perdiz D,Lorin S,Codogno P,Poüs C

更新日期：2013-03-01 00:00:00

abstract：:Integrin alpha1beta1 is a collagen receptor predominantly found in mesenchymal tissues. Mice lacking this receptor are viable. We have previously suggested that alpha1beta1 might participate in the down-regulation of collagen gene expression observed in cells suspended inside collagen gels. The results presented here ...

journal_title：Journal of cell science

authors： Gardner H,Broberg A,Pozzi A,Laato M,Heino J

更新日期：1999-02-01 00:00:00

abstract：:The Arp2/3 complex is important for morphogenesis in various developmental systems, but specific in vivo roles for this complex in cells that move during morphogenesis are not well understood. We have examined cellular roles for Arp2/3 in the Caenorhabditis elegans embryo. In C. elegans, the first morphogenetic moveme...

journal_title：Journal of cell science

authors： Roh-Johnson M,Goldstein B

更新日期：2009-11-01 00:00:00

abstract：:Galectin-3 is a member of a closely related family of beta-galactoside-binding soluble proteins found in many vertebrate epithelial and myeloid cell types. The developmentally regulated presence of galectin-3 in tissues, for example kidney, and an affinity for many cell-surface and matrix glycoproteins indicate its im...

journal_title：Journal of cell science

authors： Bao Q,Hughes RC

更新日期：1995-08-01 00:00:00

abstract：:We report the first direct analysis of the endogenous β-catenin phosphorylation activity in colon cancer SW480 cells. By comparing parental SW480 cells that harbor a typical truncated adenomatous polyposis coli (APC) form, cells expressing full-length APC and APC-depleted cells, we provide the formal demonstration tha...

journal_title：Journal of cell science

authors： Wang L,Liu X,Gusev E,Wang C,Fagotto F

更新日期：2014-04-15 00:00:00

abstract：:Recently isolated trophoblasts express nitric oxide synthase 2 (NOS-2) and cyclooxygenase 2 (COX-2), decreasing the levels of the corresponding mRNAs when the cells were maintained in culture. The sustained expression of COX-2 and NOS-2 in trophoblasts was dependent on the activation of nuclear factor kappaB (NF-kappa...

journal_title：Journal of cell science

authors： Callejas NA,Casado M,Boscá L,Martín-Sanz P

更新日期：1999-09-01 00:00:00

abstract：:We have recently shown that leukotriene D(4) (LTD(4)) increases cell survival in intestinal epithelial cells. Here we report and explore the complementary finding that LTD(4) also enhances proliferation in these cells. This proliferative response was approximately half of that induced by epidermal growth factor (EGF) ...

journal_title：Journal of cell science

authors： Paruchuri S,Hallberg B,Juhas M,Larsson C,Sjölander A

更新日期：2002-05-01 00:00:00

abstract：:Molecular mechanisms of chemotactic response are highly conserved among many eukaryotic cells including human leukocytes and Dictyostelium discoideum cells. The cells can sense the differences in chemoattractant concentration across the cell body and respond by extending pseudopods from the cell side facing to a highe...

journal_title：Journal of cell science

authors： Matsuoka S,Iijima M,Watanabe TM,Kuwayama H,Yanagida T,Devreotes PN,Ueda M

更新日期：2006-03-15 00:00:00

abstract：:Cells depend on a highly ordered organisation of their content and must develop strategies to maintain the anisotropic distribution of organelles during periods of nutrient shortage. One of these strategies is to solidify the cytoplasm, which was observed in bacteria and yeast cells with acutely interrupted energy pro...

journal_title：Journal of cell science

authors： Heimlicher MB,Bächler M,Liu M,Ibeneche-Nnewihe C,Florin EL,Hoenger A,Brunner D

更新日期：2019-11-08 00:00:00

abstract：:Integrin and receptor tyrosine kinase signalling networks cooperate to regulate various biological functions. The molecular details underlying the integration of both signalling networks remain largely uncharacterized. Here we identify a signalling module composed of a fibronectin-α5β1-integrin-integrin-linked-kinase ...

journal_title：Journal of cell science

authors： Azimifar SB,Böttcher RT,Zanivan S,Grashoff C,Krüger M,Legate KR,Mann M,Fässler R

更新日期：2012-01-15 00:00:00

abstract：:We have used MPM-2, a monoclonal antibody raised against mitotic HeLa cells, to stain a Drosophila cell line, whole mounts of Drosophila embryos, and sectioned tissue from embryonic and larval stages of development. MPM-2 recognizes a major phosphoprotein of approximately 125 X 10(3) Mr in Drosophila tissue culture ce...

journal_title：Journal of cell science

authors： Millar SE,Freeman M,Glover DM

更新日期：1987-02-01 00:00:00

abstract：:What forces drive chromosome segregation remains one of the most challenging questions in cell division. Even though the duration of anaphase is short, it is of utmost importance for genome fidelity that no mistakes are made. Seminal studies in model organisms have revealed different mechanisms operating during chromo...

journal_title：Journal of cell science

authors： Vukušić K,Buđa R,Tolić IM

更新日期：2019-09-16 00:00:00

abstract：:Previously, we showed that an integral component of stored mRNP particles in Xenopus oocytes, Xp54, is a DEAD-box RNA helicase with ATP-dependent RNA-unwinding activity. Xp54 belongs to small family of helicases (DDX6) that associate with mRNA molecules encoding proteins required for progress through meiosis. Here we ...

journal_title：Journal of cell science

authors： Smillie DA,Sommerville J

更新日期：2002-01-15 00:00:00

abstract：:Chick embryo fibroblasts cultivated in vitro and Ehrlich ascites tumor cells (in vivo or in vitro) have been treated with amphotericin B. Cell multiplication is strongly inhibited. Large clear zones appear in the fibroblast nucleoi (phase-contrast and electron-microscope observations). Many treated fibroblasts and tum...

journal_title：Journal of cell science

authors： De Paermentier F,Bassleer R,Lepoint A,Desaive C,Goessens G,Lhoest-Gauthier MP

更新日期：1975-08-01 00:00:00