Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes.

abstract：:The CCAAT/enhancer-binding protein beta (C/EBPbeta, also known as CEBPB) was first identified as a regulator of differentiation and inflammatory processes in adipose tissue and liver. Although C/EBPbeta was initially implicated in synaptic plasticity, its function in the brain remains largely unknown. We have previous...

journal_title：Journal of cell science

authors： Cortes-Canteli M,Luna-Medina R,Sanz-Sancristobal M,Alvarez-Barrientos A,Santos A,Perez-Castillo A

更新日期：2008-04-15 00:00:00

abstract：:Failure to form proper synapses in mechanosensory hair cells, the sensory cells responsible for hearing and balance, leads to deafness and balance disorders. Ribbons are electron-dense structures that tether synaptic vesicles to the presynaptic zone of mechanosensory hair cells where they are juxtaposed with the post-...

journal_title：Journal of cell science

authors： Suli A,Pujol R,Cunningham DE,Hailey DW,Prendergast A,Rubel EW,Raible DW

更新日期：2016-06-01 00:00:00

abstract：:TAR DNA-binding protein (TDP-43, also known as TARDBP) is the major pathological protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Large TDP-43 aggregates that are decorated with degradation adaptor proteins are seen in the cytoplasm of remaining neurons in ALS and FTD patients post mor...

journal_title：Journal of cell science

authors： Scotter EL,Vance C,Nishimura AL,Lee YB,Chen HJ,Urwin H,Sardone V,Mitchell JC,Rogelj B,Rubinsztein DC,Shaw CE

更新日期：2014-03-15 00:00:00

abstract：:Elementary Ca(2+) signals, such as "Ca(2+) puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca(2+) signalling. We characterized Ca(2+) puffs in six cell types that expressed differing ratios of the three inositol 1,4,5-trisphosphate receptor is...

journal_title：Journal of cell science

authors： Tovey SC,de Smet P,Lipp P,Thomas D,Young KW,Missiaen L,De Smedt H,Parys JB,Berridge MJ,Thuring J,Holmes A,Bootman MD

更新日期：2001-11-01 00:00:00

abstract：:The translationally controlled tumor protein (TCTP; also known as TPT1 in mammals) is highly conserved and ubiquitously expressed in eukaryotes. It is involved in growth and development, cell cycle progression, protection against cellular stresses and apoptosis, indicating the multifunctional role of the protein. Here...

journal_title：Journal of cell science

authors： Jojic B,Amodeo S,Bregy I,Ochsenreiter T

更新日期：2018-05-10 00:00:00

abstract：:How vesicle trafficking components actively contribute to regulation of paracrine signaling is unclear. We genetically uncovered a requirement for α-soluble NSF attachment protein (α-Snap) in the activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway during Drosophila egg de...

journal_title：Journal of cell science

authors： Saadin A,Starz-Gaiano M

更新日期：2018-11-30 00:00:00

abstract：:Promyelocytic leukemia nuclear bodies (PML-NBs) are mobile subnuclear organelles formed by PML and Sp100 protein. They have been reported to have a role in transcription, DNA replication and repair, telomere lengthening, cell cycle control and tumor suppression. We have conducted high-resolution 4Pi fluorescence laser...

journal_title：Journal of cell science

authors： Lang M,Jegou T,Chung I,Richter K,Münch S,Udvarhelyi A,Cremer C,Hemmerich P,Engelhardt J,Hell SW,Rippe K

更新日期：2010-02-01 00:00:00

abstract：:In fission yeast, Mid1p, a major determinant for division plane position, defines a medial cortical compartment where it recruits myosin II at the onset of mitosis to initiate contractile ring assembly. How Mid1p is restricted to the medial cortex is unknown. We report here that in a pom1 polarity mutant, which displa...

journal_title：Journal of cell science

authors： Celton-Morizur S,Racine V,Sibarita JB,Paoletti A

更新日期：2006-11-15 00:00:00

abstract：:Evidence from various systems suggests that either asters or the midzone of the mitotic spindle are the predominant determinants of cleavage plane position. Disrupting spindle midzone formation in the one-cell Caenorhabditis elegans embryo, such as by using mutants of the centralspindlin component ZEN-4, prevents comp...

journal_title：Journal of cell science

authors： Verbrugghe KJ,White JG

更新日期：2007-05-15 00:00:00

abstract：:Expression of a dominant negative fragment of the spectrin family member Syne-1 causes an accumulation of binucleate cells, suggesting a role for this protein in cytokinesis. An association of this fragment with the C-terminal tail domain of the kinesin II subunit KIF3B was identified by yeast two-hybrid and co-precip...

journal_title：Journal of cell science

authors： Fan J,Beck KA

更新日期：2004-02-01 00:00:00

abstract：:Stem cell regeneration is crucial for both cell turnover and tissue healing in multicellular organisms. In Arabidopsis roots, a reduced group of cells known as the quiescent center (QC) act as a cell reservoir for surrounding stem cells during both normal growth and in response to external damage. Although cells of th...

journal_title：Journal of cell science

authors： Lozano-Elena F,Planas-Riverola A,Vilarrasa-Blasi J,Schwab R,Caño-Delgado AI

更新日期：2018-01-29 00:00:00

abstract：:Quantitative information about the range of influence of extracellular signaling molecules is critical for understanding their effects, but is difficult to determine in the complex and dynamic three-dimensional environment of a living embryo. Drosophila germ cells migrate during embryogenesis and use spatial informati...

journal_title：Journal of cell science

authors： Mukherjee A,Neher RA,Renault AD

更新日期：2013-12-01 00:00:00

abstract：:It has been suggested by many studies that Ca2+ signaling plays an important role in regulating key steps in cell division. In order to study the down stream components of calcium signaling, we have fused the gene of calmodulin (CaM) with that of green fluorescent protein (GFP) and expressed it in HeLa cells. The GFP-...

journal_title：Journal of cell science

authors： Li CJ,Heim R,Lu P,Pu Y,Tsien RY,Chang DC

更新日期：1999-05-01 00:00:00

abstract：:Cardiac fibrosis is linked to fibroblast-to-myofibroblast phenoconversion and proliferation but the mechanisms underlying this are poorly understood. Ski is a negative regulator of TGF-β-Smad signaling in myofibroblasts, and might redirect the myofibroblast phenotype back to fibroblasts. Meox2 could alter TGF-β-mediat...

journal_title：Journal of cell science

authors： Cunnington RH,Northcott JM,Ghavami S,Filomeno KL,Jahan F,Kavosh MS,Davies JJ,Wigle JT,Dixon IM

更新日期：2014-01-01 00:00:00

abstract：:KLP61F in Drosophila and other BimC kinesins are essential for spindle bipolarity across species; loss of BimC function generates high frequencies of monopolar spindles. Concomitant loss of Kar3 kinesin function increases the frequency of bipolar spindles although the underlying mechanism is not known. Recent studies ...

journal_title：Journal of cell science

authors： Wilson PG,Simmons R,Saighal S

更新日期：2004-10-01 00:00:00

abstract：:The protein import machinery of the peroxisome consists of many proteins, collectively called the peroxins. By applying the split-ubiquitin technique we systematically tested the pair-wise interactions between the Nub- and Cub-labeled peroxins for the first time in the living cells of the yeast Saccharomyces cerevisia...

journal_title：Journal of cell science

authors： Eckert JH,Johnsson N

更新日期：2003-09-01 00:00:00

abstract：:Skeletal and heart muscle-specific variant of the α subunit of nascent polypeptide associated complex (skNAC; encoded by NACA) is exclusively found in striated muscle cells. Its function, however, is largely unknown. Previous reports have demonstrated that skNAC binds to m-Bop/Smyd1, a multi-functional protein that re...

journal_title：Journal of cell science

authors： Berkholz J,Michalick L,Munz B

更新日期：2014-09-01 00:00:00

abstract：:The ribonucleoprotein enzyme RNase P catalyzes the 5' processing of pre-transfer RNA, and has also recently been implicated in pre-ribosomal RNA processing. In the present investigation, in situ hybridization revealed that RNase P RNA is present throughout the nucleus of mammalian cells. However, rhodamine-labeled hum...

journal_title：Journal of cell science

authors： Jacobson MR,Cao LG,Taneja K,Singer RH,Wang YL,Pederson T

更新日期：1997-04-01 00:00:00

abstract：:The centrosome organizes microtubules by controlling nucleation and anchoring processes. In mammalian cells, subdistal appendages of the mother centriole are major microtubule-anchoring structures of the centrosome. It is not known how newly nucleated microtubules are anchored to these appendages. We show here that ni...

journal_title：Journal of cell science

authors： Delgehyr N,Sillibourne J,Bornens M

更新日期：2005-04-15 00:00:00

abstract：:In animals and yeast, CLASP proteins are microtubule plus-end tracking proteins (+TIPS) involved in the regulation of microtubule plus-end dynamics and stabilization. Here we show that mutations in the Arabidopsis CLASP homolog result in various plant growth reductions, cell form defects and reduced mitotic activity. ...

journal_title：Journal of cell science

authors： Kirik V,Herrmann U,Parupalli C,Sedbrook JC,Ehrhardt DW,Hülskamp M

更新日期：2007-12-15 00:00:00

abstract：:Triton X-100-treated sperms were injected into non-nucleate egg fragments of Xenopus laevis to determine whether the structure of the injected sperm nucleus is affected by the cyclic activity of the cytoplasm. Swollen vesicular nuclei were very frequently observed when the sperms were injected and incubated during the...

journal_title：Journal of cell science

authors： Sakai M,Shinagawa A

更新日期：1983-09-01 00:00:00

abstract：:Homophilic binding of E-cadherins through their ectodomains is fundamental to epithelial cell-cell adhesion. Despite this, E-cadherin ectodomains have evolved differently in the vertebrate and insect lineages. Of the five rod-like, tandemly aligned extracellular cadherin domains of vertebrate E-cadherin, the tip extra...

journal_title：Journal of cell science

authors： Nishiguchi S,Yagi A,Sakai N,Oda H

更新日期：2016-09-01 00:00:00

abstract：:Using a reconstituted complex of profilin and skeletal muscle actin as an antigen, we generated a monoclonal mouse antibody against actin, termed 2G2. As revealed by immunoblots of proteolytic actin fragments and by pepscan analysis, the antibody recognises a nonsequential epitope on actin which is located within thre...

journal_title：Journal of cell science

authors： Gonsior SM,Platz S,Buchmeier S,Scheer U,Jockusch BM,Hinssen H

更新日期：1999-03-01 00:00:00

abstract：:The synaptonemal complex is an elaborate meiosis-specific supramolecular protein assembly that promotes chromosome synapsis and meiotic recombination. We inactivated the meiosis-specific gene Tex12 and found that TEX12 is essential for progression of meiosis in both male and female germ cells. Structural analysis of t...

journal_title：Journal of cell science

authors： Hamer G,Wang H,Bolcun-Filas E,Cooke HJ,Benavente R,Höög C

更新日期：2008-08-01 00:00:00

abstract：:Notch signaling is a conserved signaling pathway implicated in embryogenesis and adult tissue maintenance. Notch signaling strength is strictly regulated, notably by maintaining a controlled pool of functional receptor at the cell surface. Mammalian non-activated Notch receptor is internalized, ubiquitylated by the It...

journal_title：Journal of cell science

authors： Puca L,Chastagner P,Meas-Yedid V,Israël A,Brou C

更新日期：2013-10-01 00:00:00

abstract：:During meiotic prophase in the ciliate Tetrahymena thermophila micronuclei dramatically elongate and form thread-like crescents. The arrangement of the chromosomes within the crescent as well as the timing of chromosome pairing and recombination with respect to the elongation process have been subjects of ongoing deba...

journal_title：Journal of cell science

authors： Loidl J,Scherthan H

更新日期：2004-11-15 00:00:00

abstract：:Transcriptional activation of the major histocompatibility complex (MHC) by IFNgamma is a key step in cell-mediated immunity. At an early stage of IFNgamma induction, chromatin carrying the entire MHC locus loops out from the chromosome 6 territory. We show here that JAK/STAT signalling triggers this higher-order chro...

journal_title：Journal of cell science

authors： Christova R,Jones T,Wu PJ,Bolzer A,Costa-Pereira AP,Watling D,Kerr IM,Sheer D

更新日期：2007-09-15 00:00:00

abstract：:After birth the proliferation of cardiac cells declines, and further growth of the heart occurs by hypertrophic cell growth. In the present study the cell proliferation capacity of mouse embryonic stem (ES) cells versus neonatal cardiomyocytes and the effects of reactive oxygen species (ROS) on cardiomyogenesis and ca...

journal_title：Journal of cell science

authors： Buggisch M,Ateghang B,Ruhe C,Strobel C,Lange S,Wartenberg M,Sauer H

更新日期：2007-03-01 00:00:00

abstract：:The production, transport, and disposition of material labelled with [3H]mannose were studied in microsurgically enucleated and control amoebae. Cells were injected with the precursor and samples were prepared for electron-microscope radioautography at intervals, up to 24 h later. Control cells showed heavy labelling ...

journal_title：Journal of cell science

authors： Flickinger CJ

更新日期：1984-06-01 00:00:00

abstract：:Mucin expression was analysed, in relation to cell growth, in parental HT-29 cells and in two populations of mucus-secreting HT-29 cells selected by adaptation to methotrexate (HT29-MTX) or 5-fluorouracil (HT29-FU). These two populations express mature mucins that differ in their immunoreactivity to antibodies against...

journal_title：Journal of cell science

authors： Lesuffleur T,Porchet N,Aubert JP,Swallow D,Gum JR,Kim YS,Real FX,Zweibaum A

更新日期：1993-11-01 00:00:00