Pom1 kinase links division plane position to cell polarity by regulating Mid1p cortical distribution.

abstract：:The human Ras superfamily of small GTPases controls essential cellular processes such as gene expression and cell proliferation. As their deregulation is widely associated with human cancer, small GTPases and their regulatory proteins have become increasingly attractive for the development of novel therapeutics. Class...

journal_title：Journal of cell science

authors： Koraïchi F,Gence R,Bouchenot C,Grosjean S,Lajoie-Mazenc I,Favre G,Cabantous S

更新日期：2018-01-08 00:00:00

abstract：:Distribution of mitochondria as well as other intracellular organelles in mammalian cells is regulated by interphase microtubules. Here, we demonstrate a role of microtubules in the mitochondrial biogenesis using various microtubule-active drugs and human osteosarcoma cell line 143B cells and rat liver-derived RL-34 c...

journal_title：Journal of cell science

authors： Karbowski M,Spodnik JH,Teranishi M,Wozniak M,Nishizawa Y,Usukura J,Wakabayashi T

更新日期：2001-01-01 00:00:00

abstract：:Rabbit muscle is a major source of material for biochemical experiments and spin labelling studies of contraction, and so it is important to establish how closely this material resembles the frog and fish muscles usually used for structural studies. Previous studies have shown that relaxed rabbit muscle thick filament...

journal_title：Journal of cell science

authors： Kensler RW,Stewart M

更新日期：1993-07-01 00:00:00

abstract：:We have explored the biological function of a surface glycoprotein (GP72) of Trypanosoma cruzi by studying a null mutant parasite, generated by targeted gene deletion. GP72 deletion affected parasite morphology in several stages of the life cycle. Insect midgut (epimastigote) forms had a detached flagellum (apomastigo...

journal_title：Journal of cell science

authors： de Jesus AR,Cooper R,Espinosa M,Gomes JE,Garcia ES,Paul S,Cross GA

更新日期：1993-12-01 00:00:00

abstract：:Wnts are glycan- and lipid-modified morphogens that are important for cellular responses, but how Wnts are secreted in polarized epithelial cells remains unclear. Although Wntless (Wls) has been shown to interact with Wnts and support their secretion, the role of Wls in the sorting of Wnts to the final destination in ...

journal_title：Journal of cell science

authors： Yamamoto H,Awada C,Hanaki H,Sakane H,Tsujimoto I,Takahashi Y,Takao T,Kikuchi A

更新日期：2013-07-01 00:00:00

abstract：:The development or maturation of intercellular adhesions following their initiation has received very little attention even though this is an area of significance for a variety of in vivo processes. Using Ca2(+)-induced desmosome formation in MDCK cells as a study system it is shown that, following its initiation, des...

journal_title：Journal of cell science

authors： Mattey DL,Burdge G,Garrod DR

更新日期：1990-12-01 00:00:00

abstract：:C-CAM is a Ca(2+)-independent cell adhesion molecule (CAM) that mediates intercellular adhesion of isolated rat hepatocytes. It is widely distributed in epithelia, where its presence both at lateral cell borders and on apical cell surfaces suggests that it may have diverse biological functions. Two major isoforms, C-C...

journal_title：Journal of cell science

authors： Hunter I,Lindh M,Obrink B

更新日期：1994-05-01 00:00:00

abstract：:Myosin-X (Myo10) is an unconventional myosin with MyTH4-FERM domains that is best known for its striking localization to the tips of filopodia and its ability to induce filopodia. Although the head domain of Myo10 enables it to function as an actin-based motor, its tail contains binding sites for several molecules wit...

journal_title：Journal of cell science

authors： Kerber ML,Cheney RE

更新日期：2011-11-15 00:00:00

abstract：:A mutation in the alpha 1-tubulin gene of Chlamydomonas reinhardtii was isolated by using the amiprophos-methyl-resistant mutation apm1-18 as a background to select new mutants that showed increased resistance to the drug. The upA12 mutation caused twofold resistance to amiprophos-methyl and oryzalin, and twofold hype...

journal_title：Journal of cell science

authors： James SW,Silflow CD,Stroom P,Lefebvre PA

更新日期：1993-09-01 00:00:00

abstract：:Yeast Reb1 and its mammalian ortholog TTF1 are conserved Myb-type DNA-binding proteins that bind to specific sites near the 3'-end of rRNA genes (rDNA). Here, they participate in the termination of transcription driven by RNA polymerase I and block DNA replication forks approaching in the opposite direction. We found ...

journal_title：Journal of cell science

authors： Rodríguez-Sánchez L,Rodríguez-López M,García Z,Tenorio-Gómez M,Schvartzman JB,Krimer DB,Hernández P

更新日期：2011-01-01 00:00:00

abstract：:The median cell cycle of synchronized NHIK3025 cells grown in Eagle's MEM with 10% foetal calf serum was 23.6 h, compared to 18 h observed earlier in Puck's E2a medium with 30% serum (20% human and 10% horse). This difference is due to prolongation of both G1 and G2 in the MEM type medium. Testosterone and 4-androsten...

journal_title：Journal of cell science

authors： Ostgaard K,Wibe E,Lindmo T,Eik-Nes KB

更新日期：1981-04-01 00:00:00

abstract：:Agrin, a 200 kDa extracellular matrix protein, participates in the maturation of the postsynaptic target at the neuromuscular junction. Although agrin has also been detected in central neurons, little is known about its role in the formation of their synapses. In the present study, the pattern of expression, localizat...

journal_title：Journal of cell science

authors： Ferreira A

更新日期：1999-12-01 00:00:00

abstract：:Myofibroblasts, characterised by high expression of alpha-smooth muscle actin (alpha-SMA), are important and transient cells in normal wound healing but are found in increased number in various pathological conditions of the lung including asthma and pulmonary fibrosis. The mechanisms that regulate the myofibroblast p...

journal_title：Journal of cell science

authors： Scaffidi AK,Moodley YP,Weichselbaum M,Thompson PJ,Knight DA

更新日期：2001-10-01 00:00:00

abstract：:Two of the best understood somatic cell mRNA cytoplasmic trafficking elements are those governing localization of beta-actin and myelin basic protein mRNAs. These cis-acting elements bind the trans-acting factors fibroblast ZBP-1 and hnRNP A2, respectively. It is not known whether these elements fulfil other roles in ...

journal_title：Journal of cell science

authors： Snee M,Kidd GJ,Munro TP,Smith R

更新日期：2002-12-01 00:00:00

abstract：:Cellular senescence suppresses cancer by arresting cells at risk of malignant tumorigenesis. However, senescent cells also secrete molecules that can stimulate premalignant cells to proliferate and form tumors, suggesting the senescence response is antagonistically pleiotropic. We show that premalignant mammary epithe...

journal_title：Journal of cell science

authors： Parrinello S,Coppe JP,Krtolica A,Campisi J

更新日期：2005-02-01 00:00:00

abstract：:The cell types responsible for osteolysis associated with skeletal metastasis of solid malignancies are unclear. Tumour infiltrating macrophages (TIMs) isolated from primary mammary carcinomas of C3H/Avy mice were cultured on bone slices to assess their ability to resorb bone. After 14 days in co-culture with murine m...

journal_title：Journal of cell science

authors： Quinn JM,Athanasou NA

更新日期：1992-03-01 00:00:00

abstract：:How cell fate becomes restricted during somatic cell differentiation is a long-lasting question in biology. Epigenetic mechanisms not present in pluripotent cells and acquired during embryonic development are expected to stabilize the differentiated state of somatic cells and thereby restrict their ability to convert ...

journal_title：Journal of cell science

authors： Pasque V,Radzisheuskaya A,Gillich A,Halley-Stott RP,Panamarova M,Zernicka-Goetz M,Surani MA,Silva JC

更新日期：2012-12-15 00:00:00

abstract：:Megalin is a receptor expressed by embryonic epithelia that mediates endocytosis of numerous ligands, including sonic hedgehog (Shh) and retinol, the precursor to retinoic acid (RA). The importance of Shh and RA signaling in neurodevelopment, combined with the fact that megalin-deficient mice show profound neurodevelo...

journal_title：Journal of cell science

authors： McCarthy RA,Argraves WS

更新日期：2003-03-15 00:00:00

abstract：:Cofilin has emerged as a key regulator of actin dynamics at the leading edge of motile cells. Through its actin-severing activity, it creates new actin barbed ends for polymerization and also depolymerizes old actin filaments. Its function is tightly regulated in the cell. Spatially, its activity is restricted by othe...

journal_title：Journal of cell science

authors： DesMarais V,Ghosh M,Eddy R,Condeelis J

更新日期：2005-01-01 00:00:00

abstract：:The effect of a synthetic peptide consisting of Arg-Gly-Asp-Ser (RGDS), the amino acid sequence representing the fibroblast attachment site in fibronectin (FN), was tested on migrating newt epidermal cells. In one approach, skin explants were placed on the bottom of plastic dishes coated with human FN, human fibrinoge...

journal_title：Journal of cell science

authors： Donaldson DJ,Mahan JT,Smith GN Jr

更新日期：1987-05-01 00:00:00

abstract：:PINCH1 is composed of 5 LIM domains, binds integrin-linked kinase (ILK) and locates to integrin-mediated adhesion sites. In order to investigate PINCH1 function we generated mice and embryonic stem (ES) cell-derived embryoid bodies (EBs) lacking the PINCH1 gene. Similar to mice lacking beta1 integrin or Ilk, loss of P...

journal_title：Journal of cell science

authors： Li S,Bordoy R,Stanchi F,Moser M,Braun A,Kudlacek O,Wewer UM,Yurchenco PD,Fässler R

更新日期：2005-07-01 00:00:00

abstract：:Enterotoxigenic Bacteroides fragilis - organisms that live in the colon - secrete a metalloprotease toxin, B. fragilis toxin. This toxin binds to a specific intestinal epithelial cell receptor and stimulates cell proliferation, which is dependent, in part, on E-cadherin degradation and beta-catenin-T-cell-factor nucle...

journal_title：Journal of cell science

authors： Wu S,Rhee KJ,Zhang M,Franco A,Sears CL

更新日期：2007-06-01 00:00:00

abstract：:Bone erosion both demands that the osteoclast resorbs bone matrix and moves over the bone surface. It is widely accepted that these two activities alternate, because they are considered mutually exclusive since resorption is believed to involve an immobilizing seal to the bone surface. However, clear real-time observa...

journal_title：Journal of cell science

authors： Søe K,Delaissé JM

更新日期：2017-06-15 00:00:00

abstract：:A glass neodymium laser was modified to make it possible to produce small lesions of 1-2 micron size with a quantitatively known amount of energy. The 1-06-micron radiation of this laser is sufficiently absorbed by water to work without the additions of dyes. Ciliary arrest in Phragmatopoma gills was produced by an am...

journal_title：Journal of cell science

authors： Rikmenspoel R,Orris SE,O'Day P

更新日期：1977-04-01 00:00:00

abstract：:Polarization of early embryos provides a foundation to execute essential patterning and morphogenetic events. In Caenorhabditis elegans, cell contacts polarize early embryos along their radial axis by excluding the cortical polarity protein PAR-6 from sites of cell contact, thereby restricting PAR-6 to contact-free ce...

journal_title：Journal of cell science

authors： Chan E,Nance J

更新日期：2013-04-01 00:00:00

abstract：:The outer nuclear membrane proteins nesprin-1 and nesprin-2 are retained at the nuclear envelope through an interaction of their klarsicht/ANC-1/syne homology (KASH) domain with Sun proteins present at the inner nuclear membrane. We investigated the requirements for the localization of nesprin-3alpha at the outer nucl...

journal_title：Journal of cell science

authors： Ketema M,Wilhelmsen K,Kuikman I,Janssen H,Hodzic D,Sonnenberg A

更新日期：2007-10-01 00:00:00

abstract：:The early adhesive interaction of living cells with substrates was examined. L1210 cells were allowed to interact with collagen or glass in serum-containing medium (time of cell-substrate interaction, tint, under stationary conditions, was within 2-25 min) or in serum-free medium (tint was 5 s-15 min). The relative nu...

journal_title：Journal of cell science

authors： Kowalczyńska HM,Nowak M

更新日期：1984-03-01 00:00:00

abstract：:Cdc6 and Cdt1 initiate DNA replication licensing when cells exit mitosis. In cycling cells, Cdc6 is efficiently degraded from anaphase onwards as a result of APC/C-Cdh1 activity. When APC/C-Cdh1 is switched off again, at the end of G1 phase, Cdc6 could thus re-accumulate, risking the re-licensing of DNA as long as Cdt...

journal_title：Journal of cell science

authors： Clijsters L,Wolthuis R

更新日期：2014-03-15 00:00:00

abstract：:Loss-of-function mutations in the genes encoding PINK1 and Parkin (also known as PARK2) are the most common causes of recessive Parkinson's disease. Both together mediate the selective degradation of mitochondrial proteins and whole organelles via the proteasome and the autophagy-lysosome pathway (mitophagy). The mito...

journal_title：Journal of cell science

authors： Fiesel FC,Moussaud-Lamodière EL,Ando M,Springer W

更新日期：2014-08-15 00:00:00

abstract：:The mammalian retromer complex is a multi-protein complex that regulates retrograde transport of the cation-independent mannose 6-phosphate receptor (CI-MPR) from early endosomes to the trans Golgi network (TGN). It consists of two subcomplexes: a membrane-bound coat comprising sorting nexin-1 (SNX1) and possibly sort...

journal_title：Journal of cell science

authors： Bujny MV,Popoff V,Johannes L,Cullen PJ

更新日期：2007-06-15 00:00:00