Abstract：
:Megalin is a receptor expressed by embryonic epithelia that mediates endocytosis of numerous ligands, including sonic hedgehog (Shh) and retinol, the precursor to retinoic acid (RA). The importance of Shh and RA signaling in neurodevelopment, combined with the fact that megalin-deficient mice show profound neurodevelopmental abnormalities, has raised questions as to the possible role of megalin in Shh and RA signaling. Several mechanisms could explain how megalin influences Shh and RA signaling in the context of neurodevelopment. These include the involvement of megalin in the transport of Shh and retinol within neuroepithelia, as well as direct signal transduction as a response to binding of Shh and retinol to megalin.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
McCarthy RA,Argraves WSdoi
10.1242/jcs.00313keywords:
subject
Has Abstractpub_date
2003-03-15 00:00:00pages
955-60issue
Pt 6eissn
0021-9533issn
1477-9137journal_volume
116pub_type
杂志文章,评审abstract：:Although telomere formation occurs through a different mechanism in Drosophila compared with other organisms, telomere associations result from mutations in homologous genes, indicating the involvement of similar pathways in chromosome end protection. We report here that mutations of the Drosophila melanogaster gene C...
journal_title：Journal of cell science
pub_type： 杂志文章
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abstract：:Normal human foreskin keratinocytes (HFKs) and transformed HFKs (FEPE1L-8 cells) generated by the introduction of cloned human papillomavirus type 16 sequences were compared for the expression and function of a family of adhesion receptors termed integrins. Initially, cells were examined in conventional monolayer cult...
journal_title：Journal of cell science
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pub_type： 杂志文章
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journal_title：Journal of cell science
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doi：10.1242/jcs.019729
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journal_title：Journal of cell science
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doi：
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journal_title：Journal of cell science
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journal_title：Journal of cell science
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更新日期：2013-03-15 00:00:00
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journal_title：Journal of cell science
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doi：
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journal_title：Journal of cell science
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更新日期：2006-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-01-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：10.1242/jcs.157503
更新日期：2015-05-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1981-10-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：10.1242/jcs.214379
更新日期：2018-06-11 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章,评审
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更新日期：2011-11-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章,评审
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更新日期：2006-02-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
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更新日期：2006-06-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
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journal_title：Journal of cell science
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1978-06-01 00:00:00
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journal_title：Journal of cell science
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更新日期：2008-06-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
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更新日期：2020-12-30 00:00:00
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journal_title：Journal of cell science
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journal_title：Journal of cell science
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更新日期：1993-08-01 00:00:00
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