Abstract:
:Mesenchymal stem cells (MSCs) are among the most promising and suitable stem cell types for vascular tissue engineering. Substantial effort has been made to differentiate MSCs towards vascular cell phenotypes, including endothelial cells and smooth muscle cells (SMCs). The microenvironment of vascular cells not only contains biochemical factors that influence differentiation, but also exerts hemodynamic forces, such as shear stress and cyclic strain. Recent evidence has shown that these forces can influence the differentiation of MSCs into endothelial cells or SMCs. In this Commentary, we present the main findings in the area with the aim of summarizing the mechanisms by which shear stress and cyclic strain induce MSC differentiation. We will also discuss the interactions between these mechanical cues and other components of the microenvironment, and highlight how these insights could be used to maintain differentiation.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Dan P,Velot É,Decot V,Menu Pdoi
10.1242/jcs.167783subject
Has Abstractpub_date
2015-07-15 00:00:00pages
2415-22issue
14eissn
0021-9533issn
1477-9137pii
jcs.167783journal_volume
128pub_type
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journal_title:Journal of cell science
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journal_title:Journal of cell science
pub_type: 杂志文章
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
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journal_title:Journal of cell science
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doi:
更新日期:1998-10-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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doi:
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doi:
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doi:
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