Abstract:
:Alix is a cytosolic protein in mammalian cells that was originally identified on the basis of its association with pro-apoptotic signaling. More recent evidence has established that Alix has a hand in regulating other cellular mechanisms, including endocytic membrane trafficking and cell adhesion. Although Alix appears to participate directly in these various activities, the role it plays in each process has largely been inferred from the functions of proteins with which it interacts. For example, recruitment of Alix to endosomes is mediated by its N-terminal Bro1 domain, the structure of which was recently solved for its yeast orthologue, Bro1. The diversity of Alix functions is due to its proline-rich C-terminus, which provides multiple protein-binding sites. With this blueprint in hand, we can now ask whether Alix acts simply as an adaptor that links different proteins into networks or, instead, contributes a specific function to distinct molecular machineries.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Odorizzi Gdoi
10.1242/jcs.03072subject
Has Abstractpub_date
2006-08-01 00:00:00pages
3025-32issue
Pt 15eissn
0021-9533issn
1477-9137pii
119/15/3025journal_volume
119pub_type
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