Viral escape from endosomes and host detection at a glance.

abstract：:Putative protein synthesizing domains, called plaques, are characterized in the squid giant synapse and axon and in terminals of squid photoreceptor neurons. Plaques are oval-shaped formations of about 1 microm in size, which (1) generate signals that have spectroscopic electron energy loss characteristics of ribosome...

journal_title：Journal of cell science

authors： Martin R,Vaida B,Bleher R,Crispino M,Giuditta A

更新日期：1998-11-01 00:00:00

abstract：:The acidic carboxy-terminal regions of alpha- and beta-tubulin subunits are currently thought to be centrally involved in microtubule stability and in microtubule association with a variety of proteins (MAPs) such as MAP2 and tau proteins. Here, pure tubulin microtubules were exposed to subtilisin to produce polymers ...

journal_title：Journal of cell science

authors： Saoudi Y,Paintrand I,Multigner L,Job D

更新日期：1995-01-01 00:00:00

abstract：:Dynamins are a conserved family of proteins involved in membrane fusion and fission. Although mammalian dynamins are known to be involved in several membrane-trafficking events, the role of dynamin-1 in endocytosis is the best-characterised role of this protein family. Despite many similarities between endocytosis in ...

journal_title：Journal of cell science

authors： Smaczynska-de Rooij II,Allwood EG,Aghamohammadzadeh S,Hettema EH,Goldberg MW,Ayscough KR

更新日期：2010-10-15 00:00:00

abstract：:The plasma membrane of cells is composed of lateral heterogeneities, patches and microdomains. These membrane microdomains or lipid rafts are enriched in glycosphingolipids and cholesterol and have been implicated in cellular processes such as membrane sorting and signal transduction. In this study we investigated the...

journal_title：Journal of cell science

authors： Triantafilou M,Miyake K,Golenbock DT,Triantafilou K

更新日期：2002-06-15 00:00:00

abstract：:Myr 3, a member of the myosin-I family from rat, is shown in this study to be localized at adherens-type intercellular junctions in epithelial and nonepithelial tissues. Formation of intercellular junctions and the accompanying recruitment of myr 3 to these junctions involves signaling by the Rho subfamily of small GT...

journal_title：Journal of cell science

authors： Stöffler HE,Honnert U,Bauer CA,Höfer D,Schwarz H,Müller RT,Drenckhahn D,Bähler M

更新日期：1998-09-01 00:00:00

abstract：:A comparison of stained cytosolic proteins, in vivo 80 S ribosome translation products and in vitro translation products of poly(A)+ RNA from three species of Acetabularia was performed after characterization of their molecular weights and isoelectric points via two-dimensional electrophoresis. A total of 803 stained ...

journal_title：Journal of cell science

authors： Shoeman RL,Neuhaus G,Schweiger HG

更新日期：1983-03-01 00:00:00

abstract：:Fas ligand (FasL), a potent mediator of apoptosis expressed by CTL and NK cells, is sorted into the inner vesicles of secretory lysosomes for release via exosome-like vesicles. Previous studies identified a proline-rich domain in the cytoplasmic tail required for sorting FasL to secretory lysosomes, but the mechanisms...

journal_title：Journal of cell science

authors： Zuccato E,Blott EJ,Holt O,Sigismund S,Shaw M,Bossi G,Griffiths GM

更新日期：2007-01-01 00:00:00

abstract：:A cDNA encoding Xlamin B1 was cloned from a whole ovary mRNA by RT-PCR. GST-lamin fusion constructs were generated from this cDNA by first creating convenient restriction sites within the Xlamin B1 coding sequence, using PCR directed mutagenesis, and then sub-cloning relevant sequences into pGEX-4T-3. Two expression c...

journal_title：Journal of cell science

authors： Ellis DJ,Jenkins H,Whitfield WG,Hutchison CJ

更新日期：1997-10-01 00:00:00

abstract：:3-Phosphoinositide-dependent protein kinase-1 (PDK1) and phospholipase C (PLC)γ1 are two key enzymes in signal transduction that control several intracellular processes. Despite the fact that PLCγ1 has been investigated for several years, the mechanisms of activation of this enzyme are still not completely clear. Simi...

journal_title：Journal of cell science

authors： Raimondi C,Chikh A,Wheeler AP,Maffucci T,Falasca M

更新日期：2012-07-01 00:00:00

abstract：:Plectin, a cytolinker protein greater than 500 kDa in size, has an important role as a mechanical stabiliser of cells. It interlinks the various cytoskeletal filament systems and anchors intermediate filaments to peripheral junctional complexes. In addition, there is increasing evidence that plectin acts as a scaffold...

journal_title：Journal of cell science

authors： Gregor M,Zeöld A,Oehler S,Marobela KA,Fuchs P,Weigel G,Hardie DG,Wiche G

更新日期：2006-05-01 00:00:00

abstract：:Notch signalling is used throughout the animal kingdom to spatially and temporally regulate cell fate, proliferation and differentiation. Its importance is reflected in the dramatic effects produced on both development and health by small variations in the strength of the Notch signal. The Down-syndrome-associated kin...

journal_title：Journal of cell science

authors： Fernandez-Martinez J,Vela EM,Tora-Ponsioen M,Ocaña OH,Nieto MA,Galceran J

更新日期：2009-05-15 00:00:00

abstract：:Hepatocyte growth factor, also known as scatter factor, is a pleiotropic cytokine, which stimulates cell motility, invasion, proliferation, survival and morphogenesis, and induces the expression of specific genes by activating its receptor tyrosine kinase. In this work we have isolated, characterized and used as agoni...

journal_title：Journal of cell science

authors： Prat M,Crepaldi T,Pennacchietti S,Bussolino F,Comoglio PM

更新日期：1998-01-01 00:00:00

abstract：:Ligand-dependent nuclear import is crucial for the function of the androgen receptor (AR) in both health and disease. The unliganded AR is retained in the cytoplasm but, on binding 5alpha-dihydrotestosterone, it translocates into the nucleus and alters transcription of its target genes. Nuclear import of AR is mediate...

journal_title：Journal of cell science

authors： Cutress ML,Whitaker HC,Mills IG,Stewart M,Neal DE

更新日期：2008-04-01 00:00:00

abstract：:Members of the PKC superfamily have been implicated in various migratory models and in particular in spatially restricted processes. However, defining the precise local events that underlie the PKC-dependent processes is constrained by the unspecific nature of interventions. Here we address this problem in relation to...

journal_title：Journal of cell science

authors： Boeckeler K,Rosse C,Howell M,Parker PJ

更新日期：2010-08-15 00:00:00

abstract：:It is now becoming clear that additional transmembrane components can modify integrin-mediated adhesion. Syndecan-4 is a transmembrane heparan sulfate proteoglycan whose external glycosaminoglycan chains can bind extracellular matrix ligands and whose core protein cytoplasmic domain can signal during adhesion. Two pap...

journal_title：Journal of cell science

authors： Couchman JR,Woods A

更新日期：1999-10-01 00:00:00

abstract：:The mechanism responsible for spermatid translocation in the mammalian seminiferous epithelium was proposed to be the microtubule-based transport of specialized junction plaques (ectoplasmic specializations) that occur in Sertoli cell regions attached to spermatid heads. These plaques each consist of a cistern of endo...

journal_title：Journal of cell science

authors： Guttman JA,Kimel GH,Vogl AW

更新日期：2000-06-01 00:00:00

abstract：:Assembly of the nuclear envelope (NE) in telophase is essential for higher eukaryotic cells to re-establish a functional nucleus. Time-lapse, FRAP and FRET analyses in human cells showed that barrier-to-autointegration factor (BAF), a DNA-binding protein, assembled first at the distinct ;core' region of the telophase ...

journal_title：Journal of cell science

authors： Haraguchi T,Kojidani T,Koujin T,Shimi T,Osakada H,Mori C,Yamamoto A,Hiraoka Y

更新日期：2008-08-01 00:00:00

abstract：:Rapid endocytosis of lipoprotein receptors involves NPxY signals contained in their cytoplasmic tails. Several proteins, including ARH and Dab2, can bind these sequences, but their importance for endocytosis may vary in different cell types. The lipoprotein receptor megalin is expressed in the visceral endoderm (VE), ...

journal_title：Journal of cell science

authors： Maurer ME,Cooper JA

更新日期：2005-11-15 00:00:00

abstract：:Laminins are heterotrimeric glycoproteins of the extracellular matrix that are secreted by epithelial cells and which are crucial for the normal structure and function of the basement membrane. We have generated a mouse harboring a conditional knockout of α3 laminin (Lama3(fl/fl)), one of the main laminin subunits in ...

journal_title：Journal of cell science

authors： Urich D,Eisenberg JL,Hamill KJ,Takawira D,Chiarella SE,Soberanes S,Gonzalez A,Koentgen F,Manghi T,Hopkinson SB,Misharin AV,Perlman H,Mutlu GM,Budinger GR,Jones JC

更新日期：2011-09-01 00:00:00

abstract：:Motile eukaryotic flagella beat through coordinated activity of dynein motor proteins; however, the mechanisms of dynein coordination and regulation are incompletely understood. The inner dynein arm (IDA) f complex (also known as the I1 complex), and the tether and tether head (T/TH) complex are thought to be key regu...

journal_title：Journal of cell science

authors： Beneke T,Banecki K,Fochler S,Gluenz E

更新日期：2020-01-23 00:00:00

abstract：:Plasmid DNA or artificial mRNA injected intramuscularly into skeletal muscle via a 27 g needle expressed transgenes at relatively efficient levels in skeletal myofibers and cardiac cells. In the present study, several approaches were used to determine the mechanism of cellular uptake. After exposure of naked plasmid D...

journal_title：Journal of cell science

authors： Wolff JA,Dowty ME,Jiao S,Repetto G,Berg RK,Ludtke JJ,Williams P,Slautterback DB

更新日期：1992-12-01 00:00:00

abstract：:The migration of neutrophils from blood vessels to peripheral tissues is a key step of inflammation. This requires the formation of transient gaps between endothelial cells with concomitant leucocyte squeezing through these narrow apertures and immediate restoration of endothelium continuity. It is currently considere...

journal_title：Journal of cell science

authors： Kaplanski G,Farnarier C,Benoliel AM,Foa C,Kaplanski S,Bongrand P

更新日期：1994-09-01 00:00:00

abstract：:Two variants (74AD and 74FL) established from rat ascites hepatoma AH7974 were examined for the production of glycosaminoglycans in culture. There was no difference between the adhesive (74AD) and the floating (74FL) variants in quantity of glycosaminoglycans produced by their cultivation in minimum essential medium s...

journal_title：Journal of cell science

authors： Kimura A,Kawaguchi T,Ono T,Sakuma A,Yokoya Y,Kochi H,Nakamura K

更新日期：1988-08-01 00:00:00

abstract：:The progression of cells from metaphase to anaphase is thought to be regulated by a checkpoint that delays entry into anaphase until all chromosomes reach a stable bi-polar attachment at the metaphase plate. Previous work has suggested that the 3F3/2 kinetochore phosphoepitopes are involved in this checkpoint system. ...

journal_title：Journal of cell science

authors： Bousbaa H,Correia L,Gorbsky GJ,Sunkel CE

更新日期：1997-09-01 00:00:00

abstract：:Accumulation of adipocytes and collagen type-I-producing cells (fibrosis) is observed in muscular dystrophies. The origin of these cells had been largely unknown, but recently we identified mesenchymal progenitors positive for platelet-derived growth factor receptor alpha (PDGFRα) as the origin of adipocytes in skelet...

journal_title：Journal of cell science

authors： Uezumi A,Ito T,Morikawa D,Shimizu N,Yoneda T,Segawa M,Yamaguchi M,Ogawa R,Matev MM,Miyagoe-Suzuki Y,Takeda S,Tsujikawa K,Tsuchida K,Yamamoto H,Fukada S

更新日期：2011-11-01 00:00:00

abstract：:How ion channels localize and distribute on the cell membrane remains incompletely understood. We show that interventions that vary cell adhesion proteins and cell size also affect the membrane current density of inward-rectifier K+ channels (Kir2.1; encoded by KCNJ2) and profoundly alter the action potential shape of...

journal_title：Journal of cell science

authors： Sengupta S,Rothenberg KE,Li H,Hoffman BD,Bursac N

更新日期：2019-09-02 00:00:00

abstract：:Phosphorylation regulates assembly and disassembly of proteins during endocytosis. In yeast, Prk1 and Ark1 phosphorylate factors after vesicle internalization leading to coat disassembly. Scd5, a protein phosphatase-1 (PP1)-targeting subunit, is proposed to regulate dephosphorylation of Prk1/Ark1 substrates to promote...

journal_title：Journal of cell science

authors： Chi RJ,Torres OT,Segarra VA,Lansley T,Chang JS,Newpher TM,Lemmon SK

更新日期：2012-10-15 00:00:00

abstract：:Chick embryo fibroblasts cultivated in vitro and Ehrlich ascites tumor cells (in vivo or in vitro) have been treated with amphotericin B. Cell multiplication is strongly inhibited. Large clear zones appear in the fibroblast nucleoi (phase-contrast and electron-microscope observations). Many treated fibroblasts and tum...

journal_title：Journal of cell science

authors： De Paermentier F,Bassleer R,Lepoint A,Desaive C,Goessens G,Lhoest-Gauthier MP

更新日期：1975-08-01 00:00:00

abstract：:Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases play a critical role in various cellular pathways, including but not limited to protein trafficking, subcellular localization, innate immune response, viral infections, DNA damage responses and apoptosis. To date, 28 HECT E3 ubiquitin ligases have been identifi...

journal_title：Journal of cell science

authors： Wang Y,Argiles-Castillo D,Kane EI,Zhou A,Spratt DE

更新日期：2020-04-07 00:00:00

abstract：:Anionic phospholipids PI(4,5)P2 and phosphatidylserine (PS) are enriched in the cytosolic leaflet of the plasma membrane where endocytic sites form. In this study, we investigated the roles of PI(4,5)P2 and PS in clathrin-mediated endocytosis (CME) site initiation and vesicle formation in Saccharomyces cerevisiae. Liv...

journal_title：Journal of cell science

authors： Sun Y,Drubin DG

更新日期：2012-12-15 00:00:00