Targeting of the myosin-I myr 3 to intercellular adherens type junctions induced by dominant active Cdc42 in HeLa cells.

abstract：:The conformation and biological activities of fibronectin (FN) and vitronectin (VN) coated on different plastic surfaces were investigated using cell adhesion and a panel of domain-specific monoclonal antibodies (mAbs). The adhesion of BHK fibroblasts was markedly better on FN coated on hydrophilic tissue culture poly...

journal_title：Journal of cell science

authors： Underwood PA,Steele JG,Dalton BA

更新日期：1993-03-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are among the most promising and suitable stem cell types for vascular tissue engineering. Substantial effort has been made to differentiate MSCs towards vascular cell phenotypes, including endothelial cells and smooth muscle cells (SMCs). The microenvironment of vascular cells not only c...

journal_title：Journal of cell science

authors： Dan P,Velot É,Decot V,Menu P

更新日期：2015-07-15 00:00:00

abstract：:How cell fate becomes restricted during somatic cell differentiation is a long-lasting question in biology. Epigenetic mechanisms not present in pluripotent cells and acquired during embryonic development are expected to stabilize the differentiated state of somatic cells and thereby restrict their ability to convert ...

journal_title：Journal of cell science

authors： Pasque V,Radzisheuskaya A,Gillich A,Halley-Stott RP,Panamarova M,Zernicka-Goetz M,Surani MA,Silva JC

更新日期：2012-12-15 00:00:00

abstract：:Meiosis is characterized by two chromosome segregation rounds (meiosis I and II), which follow a single round of DNA replication, resulting in haploid genome formation. Chromosome reduction occurs at meiosis I. It relies on key structures, such as chiasmata, which are formed by repair of double-strand breaks (DSBs) be...

journal_title：Journal of cell science

authors： Meyer RE,Algazeery A,Capri M,Brazier H,Ferry C,Aït-Ahmed O

更新日期：2014-11-01 00:00:00

abstract：:In mammalian cells, Rho GTPases control the reorganisation of the actin cytoskeleton in response to growth factors. In the cytoplasm, the polymerisation of actin filaments and their organisation into complex architectures is orchestrated by numerous proteins which act either directly, by interacting with actin, or by ...

journal_title：Journal of cell science

authors： Dutartre H,Davoust J,Gorvel JP,Chavrier P

更新日期：1996-02-01 00:00:00

abstract：:Fatty acids constitute an important energy source for various tissues. The mechanisms that mediate and control uptake of free fatty acids from the circulation, however, are poorly understood. Here we show that efficient fatty-acid uptake by yeast cells requires the protein kinase Ypk1, the orthologue of the human seru...

journal_title：Journal of cell science

authors： Jacquier N,Schneiter R

更新日期：2010-07-01 00:00:00

abstract：:p63 (also known as TP63) is a transcription factor of the p53 family, along with p73. Multiple isoforms of p63 have been discovered and these have diverse functions encompassing a wide array of cell biology. p63 isoforms are implicated in lineage specification, proliferative potential, differentiation, cell death and ...

journal_title：Journal of cell science

authors： Fisher ML,Balinth S,Mills AA

更新日期：2020-09-11 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is encoded by multiple mRNA variants whose differential subcellular distribution constitutes a 'spatial code' for local translation of BDNF and selective morphological remodeling of dendrites. Here, we investigated where BDNF translation takes place and what are the signaling p...

journal_title：Journal of cell science

authors： Baj G,Pinhero V,Vaghi V,Tongiorgi E

更新日期：2016-07-15 00:00:00

abstract：:After birth the proliferation of cardiac cells declines, and further growth of the heart occurs by hypertrophic cell growth. In the present study the cell proliferation capacity of mouse embryonic stem (ES) cells versus neonatal cardiomyocytes and the effects of reactive oxygen species (ROS) on cardiomyogenesis and ca...

journal_title：Journal of cell science

authors： Buggisch M,Ateghang B,Ruhe C,Strobel C,Lange S,Wartenberg M,Sauer H

更新日期：2007-03-01 00:00:00

abstract：:Human SW-13 cells express the intermediate filament protein vimentin in a mosaic pattern (Hedberg, K. K. and Chen, L. B. (1986). Exp. Cell Res. 163, 509-517). We have isolated SW-13 clones that do (vim+) or do not (vim-) synthesize vimentin as analyzed using anti-intermediate filament immunofluorescence, electron micr...

journal_title：Journal of cell science

authors： Sarria AJ,Lieber JG,Nordeen SK,Evans RM

更新日期：1994-06-01 00:00:00

abstract：:A fundamental prediction of the hypothesis that critical events in tumour formation are rare is that the tumours develop by clonal expansion. This prediction has been tested by establishing the isozyme content of tumours induced in mosaic animals whose normal tissues contain two distinguishable isozyme activities. The...

journal_title：Journal of cell science

authors： Deamant FD,Iannaccone PM

更新日期：1987-10-01 00:00:00

abstract：:The secreted Frizzled-related proteins (SFRPs) are a family of soluble proteins that are structurally related to Frizzled (Fz) proteins, the serpentine receptors that mediate the extensively used cell-cell communication pathway involving Wnt signalling. Because of their homology with the Wnt-binding domain on the Fz r...

journal_title：Journal of cell science

authors： Bovolenta P,Esteve P,Ruiz JM,Cisneros E,Lopez-Rios J

更新日期：2008-03-15 00:00:00

abstract：:Distributions of ErbB receptors on membranes of SKBR3 breast cancer cells were mapped by immunoelectron microscopy. The most abundant receptor, ErbB2, is phosphorylated, clustered and active. Kinase inhibitors ablate ErbB2 phosphorylation without dispersing clusters. Modest co-clustering of ErbB2 and EGFR, even after ...

journal_title：Journal of cell science

authors： Yang S,Raymond-Stintz MA,Ying W,Zhang J,Lidke DS,Steinberg SL,Williams L,Oliver JM,Wilson BS

更新日期：2007-08-15 00:00:00

abstract：:During development, general body plan information must be translated into distinct morphologies of individual cells. Shaping cells is thought to involve cortical cytoskeletal components and Bin-Amphiphysin-Rvs167 (BAR) superfamily proteins. We therefore conducted comprehensive side-by-side loss-of-function studies of ...

journal_title：Journal of cell science

authors： Schüler S,Hauptmann J,Perner B,Kessels MM,Englert C,Qualmann B

更新日期：2013-01-01 00:00:00

abstract：:Mdm2 is a nucleoplasmic and nucleolar protein interacting with p53 and alternative reading frame (ARF) tumor suppressor proteins. Here we demonstrate relocalization and novel interactions of Mdm2 with the promyelocytic leukemia (PML) protein following cellular stress and DNA damage. We show that Mdm2 and PML interact ...

journal_title：Journal of cell science

authors： Kurki S,Latonen L,Laiho M

更新日期：2003-10-01 00:00:00

abstract：:Crumbs (Crb) is an evolutionarily conserved transmembrane protein localised to the apical membrane of epithelial cells. Loss or mislocalisation of Crb is often associated with disruption of apicobasal cell polarity. crb mRNA is also apically enriched in epithelial cells, and, as shown here, accumulates in the oocyte o...

journal_title：Journal of cell science

authors： Bhagavatula S,Knust E

更新日期：2021-01-25 00:00:00

abstract：:DNA replication in the polytene chromosomes of larval salivary glands of Drosophila hydei has been examined under normal physiological conditions, with or without puromycin, by an autoradiographic procedure using [3H]thymidine. It has been demonstrated that puromycin induces new labelling patterns that can be identifi...

journal_title：Journal of cell science

authors： Mukherjee AS,Chatterjee C

更新日期：1984-01-01 00:00:00

abstract：:Occludin plays an important role in maintaining tight junction barrier function in many types of epithelia. We previously reported that activation of transient receptor potential vanilloid subtype 1 (TRPV1) in rabbit submandibular gland promoted salivary secretion, partly by an increase in paracellular permeability. W...

journal_title：Journal of cell science

authors： Cong X,Zhang Y,Yang NY,Li J,Ding C,Ding QW,Su YC,Mei M,Guo XH,Wu LL,Yu GY

更新日期：2013-03-01 00:00:00

abstract：:An important aspect of wound healing is the recruitment of neutrophils to the site of infection or tissue injury. Lumican, an extracellular matrix component belonging to the small leucine rich proteoglycan (SLRP) family, is one of the major keratan sulfate proteoglycans (KSPGs) within the corneal stroma. Increasing ev...

journal_title：Journal of cell science

authors： Hayashi Y,Call MK,Chikama T,Liu H,Carlson EC,Sun Y,Pearlman E,Funderburgh JL,Babcock G,Liu CY,Ohashi Y,Kao WW

更新日期：2010-09-01 00:00:00

abstract：:The novel NSP gene was previously shown to encode, among a variety of neuroendocrine cell types, two 3'-overlapping transcripts, a 3.4 kb one for NSP-A (776 amino acids) and a 1.8 kb one for NSP-C (208 amino acids). The deduced proteins, which were predicted to possess distinct amino-terminal regions, appeared to exhi...

journal_title：Journal of cell science

authors： van de Velde HJ,Roebroek AJ,Senden NH,Ramaekers FC,Van de Ven WJ

更新日期：1994-09-01 00:00:00

abstract：:Quantitative experimental data from studies of intracellular processing and transport of secretory and membrane proteins are only rarely evaluated using kinetic modelling. Instead, the analysis of such data is usually limited to calculating either the apparent half-life or the transit time. Neither of these parameters...

journal_title：Journal of cell science

authors： Noe DA,Delenick JC

更新日期：1989-03-01 00:00:00

abstract：:Glycosylphosphatidylinositol-anchored proteins on the egg surface have been proposed to play a role in gamete fusion on the basis of in vitro experiments. We tested this hypothesis by asking if oocyte GPI-anchored proteins are required for fertilization in vivo. Oocyte-specific knockout mice were created using the Cre...

journal_title：Journal of cell science

authors： Alfieri JA,Martin AD,Takeda J,Kondoh G,Myles DG,Primakoff P

更新日期：2003-06-01 00:00:00

abstract：:Proper cellular functioning requires that cellular machinery behave in a spatiotemporally regulated manner in response to global changes in nutrient availability. Mounting evidence suggests that one way this is achieved is through the establishment of physically defined gradients of O-GlcNAcylation (O-linked addition ...

journal_title：Journal of cell science

authors： Harwood KR,Hanover JA

更新日期：2014-05-01 00:00:00

abstract：:Although it is well established that embryonic stem (ES) cells have the potential to differentiate into dopamine neurons, the molecular basis of this process, particularly the role of microRNAs (miRNAs), remains largely unknown. Here we report that miR-132 plays a key role in the differentiation of dopamine neurons by...

journal_title：Journal of cell science

authors： Yang D,Li T,Wang Y,Tang Y,Cui H,Tang Y,Zhang X,Chen D,Shen N,Le W

更新日期：2012-04-01 00:00:00

abstract：:Using a novel PCR approach, we have cloned a cDNA encoding the entire high molecular weight tau molecule from rat dorsal root ganglia. The resulting 2080 bp cDNA differs from low molecular weight rat brain tau by the insertion of a novel 762 bp region (exon 4a) between exons 4 and 5. This cDNA clone is identical in se...

journal_title：Journal of cell science

authors： Georgieff IS,Liem RK,Couchie D,Mavilia C,Nunez J,Shelanski ML

更新日期：1993-07-01 00:00:00

abstract：:Protein kinases AKT and PKBR1 of Dictyostelium belong to the AGC protein kinase superfamily. AKT and PKBR1 are phosphorylated at similar sites by phosphoinositide-dependent kinase 1 (PDK1) and TORC2 kinases; however, they have different subcellular localizing domains. AKT has a phosphoinositide 3-kinase (PI3K)/phospha...

journal_title：Journal of cell science

authors： Liao XH,Buggey J,Kimmel AR

更新日期：2010-03-15 00:00:00

abstract：:How vesicle trafficking components actively contribute to regulation of paracrine signaling is unclear. We genetically uncovered a requirement for α-soluble NSF attachment protein (α-Snap) in the activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway during Drosophila egg de...

journal_title：Journal of cell science

authors： Saadin A,Starz-Gaiano M

更新日期：2018-11-30 00:00:00

abstract：:The GGGGCC (G4C2) repeat expansion mutation in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Transcription of the repeat and formation of nuclear RNA foci, which sequester specific RNA-binding proteins, is one of the possible pathological me...

journal_title：Journal of cell science

authors： Bajc Česnik A,Darovic S,Prpar Mihevc S,Štalekar M,Malnar M,Motaln H,Lee YB,Mazej J,Pohleven J,Grosch M,Modic M,Fonovič M,Turk B,Drukker M,Shaw CE,Rogelj B

更新日期：2019-03-07 00:00:00

abstract：:Kalirin, one of the few Rho guanine nucleotide exchange factors (GEFs) that contains spectrin-like repeats, plays a critical role in axon extension and maintenance of dendritic spines. PC12 cells were used to determine whether Cdk5, a critical participant in both processes, regulates the action of Kalirin. Expression ...

journal_title：Journal of cell science

authors： Xin X,Wang Y,Ma XM,Rompolas P,Keutmann HT,Mains RE,Eipper BA

更新日期：2008-08-01 00:00:00

abstract：:We previously demonstrated that activation of v-ABL protein tyrosine kinase resulted in suppression of apoptosis following interleukin-3 removal using an interleukin-3-dependent haemopoietic cell line transfected with a temperature-sensitive mutant of the v-abl oncoprotein (IC.DP). Cellular signalling events associate...

journal_title：Journal of cell science

authors： Evans CA,Lord JM,Owen-Lynch PJ,Johnson G,Dive C,Whetton AD

更新日期：1995-07-01 00:00:00