Abstract：
:The secreted Frizzled-related proteins (SFRPs) are a family of soluble proteins that are structurally related to Frizzled (Fz) proteins, the serpentine receptors that mediate the extensively used cell-cell communication pathway involving Wnt signalling. Because of their homology with the Wnt-binding domain on the Fz receptors, SFRPs were immediately characterised as antagonists that bind to Wnt proteins to prevent signal activation. Since these initial studies, interest in the family of SFRPs has grown progressively, offering new perspectives on their function and mechanism of action in both development and disease. These studies indicate that SFRPs are not merely Wnt-binding proteins, but can also antagonise one another's activity, bind to Fz receptors and influence axon guidance, interfere with BMP signalling by acting as proteinase inhibitors, and interact with other receptors or matrix molecules. Furthermore, their expression is altered in different types of cancers, bone pathologies, retinal degeneration and hypophosphatemic diseases, indicating that their activity is fundamental for tissue homeostasis. Here we review some of the debated aspects of SFRP-Wnt interactions and discuss the new and emerging roles of SFRPs.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Bovolenta P,Esteve P,Ruiz JM,Cisneros E,Lopez-Rios Jdoi
10.1242/jcs.026096subject
Has Abstractpub_date
2008-03-15 00:00:00pages
737-46issue
Pt 6eissn
0021-9533issn
1477-9137pii
121/6/737journal_volume
121pub_type
杂志文章,评审abstract：:Histone proteins are essential for chromatin formation, and histone gene expression is coupled to DNA synthesis. In metazoans, the histone RNA binding protein HBP/SLBP is involved in post-transcriptional control of histone gene expression. In vitro assays have demonstrated that human HBP/SLBP is involved in histone mR...
journal_title：Journal of cell science
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journal_title：Journal of cell science
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journal_title：Journal of cell science
pub_type： 杂志文章
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journal_title：Journal of cell science
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journal_title：Journal of cell science
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journal_title：Journal of cell science
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
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journal_title：Journal of cell science
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1977-02-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
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更新日期：2013-04-15 00:00:00
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pub_type： 杂志文章
doi：10.1242/jcs.02795
更新日期：2006-03-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：2002-05-15 00:00:00
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pub_type： 杂志文章
doi：10.1242/jcs.03418
更新日期：2007-04-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：10.1242/jcs.00234
更新日期：2003-01-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
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更新日期：2007-03-15 00:00:00
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pub_type： 杂志文章
doi：10.1242/jcs.094599
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doi：
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doi：
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