Abstract:
:The main pathology of cystic fibrosis results from obstruction of ducts in several organs by mucous secretions. The cause of this obstruction remains unclear. We have examined expression of the cystic fibrosis transmembrane conductance regulator (CFTR) and of the major pancreatic mucin, MUC1, in primary pancreatic duct and vas deferens epithelial cells, and in pancreatic duct cell lines. MUC1 is expressed at a high level in the primary ductal epithelial cells and at variable levels in different pancreatic adenocarcinoma cell lines. However, although the pancreatic duct is one of the sites in vivo where CFTR transcription is at its highest level, the majority of cell lines examined no longer express CFTR. Only one pancreatic duct cell line, Capan 1, expresses CFTR at a significant level; further, the level of expression is dependent on confluency. We have shown that salt stress alone is not sufficient to account for the build-up of mucous secretions in CF ducts.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Chambers JA,Harris Asubject
Has Abstractpub_date
1993-06-01 00:00:00pages
417-22eissn
0021-9533issn
1477-9137journal_volume
105 ( Pt 2)pub_type
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journal_title:Journal of cell science
pub_type: 杂志文章
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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journal_title:Journal of cell science
pub_type: 杂志文章
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journal_title:Journal of cell science
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更新日期:2007-03-15 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2007-07-15 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2003-05-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2014-01-15 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
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journal_title:Journal of cell science
pub_type: 杂志文章
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
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journal_title:Journal of cell science
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2015-04-15 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:1978-02-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:1986-07-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2016-07-15 00:00:00
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journal_title:Journal of cell science
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更新日期:2006-05-15 00:00:00
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journal_title:Journal of cell science
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