Micro-environmental control of cell migration--myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics.

abstract：:CDC14 was originally identified by L. Hartwell in his famous screen for genes that regulate the budding yeast cell cycle. Subsequent work showed that Cdc14 belongs to a family of highly conserved dual-specificity phosphatases that are present in a wide range of organisms from yeast to human. Human CDC14B is even able ...

journal_title：Journal of cell science

authors： Mocciaro A,Schiebel E

更新日期：2010-09-01 00:00:00

abstract：:As previously described, a cell surface-associated adhesive factor (AF) was separated from differentiated rat ascites hepatoma AH136B cells (forming cell islands in vivo) and highly purified by chromatography. AF synthesis by the cells was investigated by means of ultrastructural immunoperoxidase cytochemistry. Its sy...

journal_title：Journal of cell science

authors： Hattori R,Ishimaru Y,Kurano R,Hayashi H

更新日期：1984-10-01 00:00:00

abstract：:When cultured cerebellar macroneurons develop attached to a laminin-containing substrate or after the acute addition of laminin to the tissue culture medium, there is an acceleration in the rate and extent of axonal elongation. Furthermore, laminin is capable of inducing axonal formation and microtubule stabilization ...

journal_title：Journal of cell science

authors： DiTella MC,Feiguin F,Carri N,Kosik KS,Cáceres A

更新日期：1996-02-01 00:00:00

abstract：:Desmocollin 3 (Dsc3) is a transmembrane glycoprotein that belongs to the cadherin family of cell adhesion receptors. Together with desmoglein(s), it forms the transmembrane core of desmosomes, a multiprotein complex involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. Previous ...

journal_title：Journal of cell science

authors： Den Z,Cheng X,Merched-Sauvage M,Koch PJ

更新日期：2006-02-01 00:00:00

abstract：:Recently, we demonstrated in cultured endothelial cells and in vivo that deficiency of an isoform of intersectin-1, ITSN-1s, impairs caveolae and clathrin-mediated endocytosis and functionally upregulates compensatory pathways and their morphological carriers (i.e. enlarged endocytic structures, membranous rings or tu...

journal_title：Journal of cell science

authors： Bardita C,Predescu DN,Sha F,Patel M,Balaji G,Predescu SA

更新日期：2015-04-15 00:00:00

abstract：:When HeLa cells are lysed in solutions containing a non-ionic detergent and 2 M-NaCl, structures are released that retain many of the morphological features of nuclei. These nucleoids contain all the nuclear RNA and DNA but few of the proteins characteristic of chromatin. Their DNA is supercoiled and so intact. Using ...

journal_title：Journal of cell science

authors： Levin JM,Cook PR

更新日期：1981-08-01 00:00:00

abstract：:Prions are proteins that access self-templating amyloid forms, which confer phenotypic changes that can spread from individual to individual within or between species. These infectious phenotypes can be beneficial, as with yeast prions, or deleterious, as with mammalian prions that transmit spongiform encephalopathies...

journal_title：Journal of cell science

authors： Cushman M,Johnson BS,King OD,Gitler AD,Shorter J

更新日期：2010-04-15 00:00:00

abstract：:The semaphorin family comprises soluble and membrane-bound proteins originally identified as axonal guidance cues that function during neuronal development. Emerging evidence suggests that a subset of semaphorins, called 'immune semaphorins', function in the immune system. The class IV semaphorins Sema4D/CD100 and Sem...

journal_title：Journal of cell science

authors： Kumanogoh A,Kikutani H

更新日期：2003-09-01 00:00:00

abstract：:p63 (also known as TP63) is a transcription factor of the p53 family, along with p73. Multiple isoforms of p63 have been discovered and these have diverse functions encompassing a wide array of cell biology. p63 isoforms are implicated in lineage specification, proliferative potential, differentiation, cell death and ...

journal_title：Journal of cell science

authors： Fisher ML,Balinth S,Mills AA

更新日期：2020-09-11 00:00:00

abstract：:ADP-ribosylation factors (Arfs) and ADP-ribosylation factor-like proteins (Arls) are highly conserved small GTPases that function as main regulators of vesicular trafficking and cytoskeletal reorganization. Arl1, the first identified member of the large Arl family, is an important regulator of Golgi complex structure ...

journal_title：Journal of cell science

authors： Yu CJ,Lee FJ

更新日期：2017-05-15 00:00:00

abstract：:The p53 tumor suppressor protein is a key regulator of cellular functions including responses to numerous stress signals, and triggers apoptosis in many cell types, including neurons. The major mechanisms known to regulate p53 stabilization and activation include phosphorylation and ubiquitin ligase-mediated proteasom...

journal_title：Journal of cell science

authors： Lee JH,Kim HS,Lee SJ,Kim KT

更新日期：2007-07-01 00:00:00

abstract：:Talin binds to β-integrin tails to activate integrins, regulating cell migration, invasion and metastasis. There are two talin genes, TLN1 and TLN2, encoding talin1 and talin2, respectively. Talin1 regulates focal adhesion dynamics, cell migration and invasion, whereas the biological function of talin2 is not clear an...

journal_title：Journal of cell science

authors： Qi L,Jafari N,Li X,Chen Z,Li L,Hytönen VP,Goult BT,Zhan CG,Huang C

更新日期：2016-10-01 00:00:00

abstract：:The mitochondrial influx and efflux of Ca(2+) play a relevant role in cytosolic and mitochondrial Ca(2+) homeostasis, and contribute to the regulation of mitochondrial functions in neurons. The mitochondrial Na(+)/Ca(2+) exchanger, which was first postulated in 1974, has been primarily investigated only from a functio...

journal_title：Journal of cell science

authors： Scorziello A,Savoia C,Sisalli MJ,Adornetto A,Secondo A,Boscia F,Esposito A,Polishchuk EV,Polishchuk RS,Molinaro P,Carlucci A,Lignitto L,Di Renzo G,Feliciello A,Annunziato L

更新日期：2013-12-15 00:00:00

abstract：:DNA replication in the polytene chromosomes of larval salivary glands of Drosophila hydei has been examined under normal physiological conditions, with or without puromycin, by an autoradiographic procedure using [3H]thymidine. It has been demonstrated that puromycin induces new labelling patterns that can be identifi...

journal_title：Journal of cell science

authors： Mukherjee AS,Chatterjee C

更新日期：1984-01-01 00:00:00

abstract：:Identification of the cell surface glycoproteins is an essential requirement for elucidating the mechanisms that mediate intercellular adhesion and cell migration in gastrulating amphibian embryos. In our experiments the glycoproteins present at the surface of isolated cells at blastula and gastrula stages were labell...

journal_title：Journal of cell science

authors： Riou JF,Darribère T,Boucaut JC

更新日期：1986-06-01 00:00:00

abstract：:Syntaxins are thought to participate in the specific interactions between vesicles and acceptor membranes in intracellular protein trafficking. VAM3 of Saccharomyces cerevisiae encodes a 33 kDa protein (Vam3p) with a hydrophobic transmembrane segment at its C terminus. Vam3p has structural similarities to syntaxins of...

journal_title：Journal of cell science

authors： Wada Y,Nakamura N,Ohsumi Y,Hirata A

更新日期：1997-06-01 00:00:00

abstract：:Isoamyl alcohol (IAA) induces a phenotype that resembles pseudohyphae in the budding yeast Saccharomyces cerevisiae. We show here that IAA causes the rapid formation of linear chains of anucleate buds, each of which is accompanied by the formation of a septin ring at its neck. This process requires the activity of Swe...

journal_title：Journal of cell science

authors： Martinez-Anaya C,Dickinson JR,Sudbery PE

更新日期：2003-08-15 00:00:00

abstract：:Tumor necrosis factor alpha-converting enzyme (TACE/ADAM17) has been implicated in the inducible shedding of numerous cell surface proteins. In light of this, the regulation of TACE catalytic activation and protein maturation has recently received considerable interest in the context of extracellular signal-regulated ...

journal_title：Journal of cell science

authors： Soond SM,Everson B,Riches DW,Murphy G

更新日期：2005-06-01 00:00:00

abstract：:The nimO predicted protein of Aspergillus nidulans is related structurally and functionally to Dbf4p, the regulatory subunit of Cdc7p kinase in budding yeast. nimOp and Dbf4p are most similar in their C-termini, which contain a PEST motif and a novel, short-looped Cys2-His2 zinc finger-like motif. DNA labelling and re...

journal_title：Journal of cell science

authors： James SW,Bullock KA,Gygax SE,Kraynack BA,Matura RA,MacLeod JA,McNeal KK,Prasauckas KA,Scacheri PC,Shenefiel HL,Tobin HM,Wade SD

更新日期：1999-05-01 00:00:00

abstract：:The lepidopteran-specific P1 delta-endotoxin of Bacillus thuringiensis var. kurstaki HD-1 was activated in vitro using insect gut proteases and found to be highly specific for the lepidopteran cell line Choristoneura fumiferana CF1 among a wide range of lepidopteran and dipteran cell lines tested. The toxicity of P1 a...

journal_title：Journal of cell science

authors： Knowles BH,Ellar DJ

更新日期：1986-07-01 00:00:00

abstract：:Actin functions in a multitude of cellular processes owing to its ability to polymerize into filaments, which can be further organized into higher-order structures by an array of actin-binding and regulatory proteins. Therefore, research on actin and actin-related functions relies on the visualization of actin structu...

journal_title：Journal of cell science

authors： Melak M,Plessner M,Grosse R

更新日期：2017-02-01 00:00:00

abstract：:The Wnt-5a gene encodes a secreted protein that controls several normal processes during embryogenesis and development of adult tissues by as yet unknown mechanisms. Endogenous expression of Wnt-5a mRNA is known to occur in both mouse and human mammary cell lines. To investigate the biological role of Wnt-5a in the hu...

journal_title：Journal of cell science

authors： Jönsson M,Andersson T

更新日期：2001-06-01 00:00:00

abstract：:Keratin 8 is a type II intermediate filament protein found in simple epithelia. We have introduced a 12 kb DNA fragment of the human K8 locus into the germ line of mice. The transgene, containing 1.1 kb of 5' flanking sequences, 7.7 kb corresponding to the body of the gene and 3.2 kb of 3' flanking sequences, was expr...

journal_title：Journal of cell science

authors： Casanova L,Bravo A,Were F,Ramírez A,Jorcano JJ,Vidal M

更新日期：1995-02-01 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) are conserved regulators of proliferation, differentiation and adaptation in eukaryotic cells. Their activity often involves changes in their subcellular localization, indicating an important role for these spatio-temporal dynamics in signal transmission. A striking model illu...

journal_title：Journal of cell science

authors： Serrano A,Illgen J,Brandt U,Thieme N,Letz A,Lichius A,Read ND,Fleißner A

更新日期：2018-05-04 00:00:00

abstract：:Cells synthesize ceramides in the endoplasmic reticulum (ER) as precursors for sphingolipids to form an impermeable plasma membrane. As ceramides are engaged in apoptotic pathways, cells would need to monitor their levels closely to avoid killing themselves during sphingolipid biosynthesis. How this is accomplished re...

journal_title：Journal of cell science

authors： Tafesse FG,Vacaru AM,Bosma EF,Hermansson M,Jain A,Hilderink A,Somerharju P,Holthuis JC

更新日期：2014-01-15 00:00:00

abstract：:Activator of G-protein signaling 3 (AGS3, also known as GPSM1) regulates the trans-Golgi network. The AGS3 GoLoco motif binds to Gαi and thereby regulates the transport of proteins to the plasma membrane. Compaction of early embryos is based on the accumulation of E-cadherin (Cdh1) at cell-contacted membranes. However...

journal_title：Journal of cell science

authors： Nie ZW,Niu YJ,Zhou W,Zhou DJ,Kim JY,Cui XS

更新日期：2020-12-07 00:00:00

abstract：:In vitro experimental evidences suggest that the proteolytic degradation of the extracellular matrix (ECM) by activation of the urokinase-type plasminogen activator (uPA)/plasmin system may affect growth factor activity and bioavailability. However, no direct in vivo observations were available to support this hypothe...

journal_title：Journal of cell science

authors： Ribatti D,Leali D,Vacca A,Giuliani R,Gualandris A,Roncali L,Nolli ML,Presta M

更新日期：1999-12-01 00:00:00

abstract：:Neutrophil migration is vital for immunity and precedes effector functions such as pathogen killing. Here, we report that this process is regulated by the Rab27a GTPase, a protein known to control granule exocytosis. Rab27a-deficient (Rab27a KO) neutrophils exhibit migration defects in vitro and in vivo, and live-cell...

journal_title：Journal of cell science

authors： Singh RK,Liao W,Tracey-White D,Recchi C,Tolmachova T,Rankin SM,Hume AN,Seabra MC

更新日期：2012-04-01 00:00:00

abstract：:We have previously shown that Xenopus oocytes, eggs, and early embryos contain lamins LII and LIII, and that portions of each are associated with distinct egg vesicle populations. We now report that a lamin similar or identical to the B-type lamin LI is also present in oocyte nuclei and in egg extracts. We have quanti...

journal_title：Journal of cell science

authors： Lourim D,Kempf A,Krohne G

更新日期：1996-07-01 00:00:00

abstract：:The nature, intracellular distribution, and role of proteins synthesized during meiotic maturation of mouse oocytes in vitro have been examined. Proteins synthesized during the initial stages of maturation are concentrated within the nucleus (germinal vesicle) and become intimately associated with the condensing chrom...

journal_title：Journal of cell science

authors： Wassarman PM,Letourneau GE

更新日期：1976-05-01 00:00:00