Abstract：
:Notch signalling is used throughout the animal kingdom to spatially and temporally regulate cell fate, proliferation and differentiation. Its importance is reflected in the dramatic effects produced on both development and health by small variations in the strength of the Notch signal. The Down-syndrome-associated kinase DYRK1A is coexpressed with Notch in various tissues during embryonic development. Here we show that DYRK1A moves to the nuclear transcription compartment where it interacts with the intracellular domain of Notch promoting its phosphorylation in the ankyrin domain and reducing its capacity to sustain transcription. DYRK1A attenuates Notch signalling in neural cells both in culture and in vivo, constituting a novel mechanism capable of modulating different developmental processes that can also contribute to the alterations observed during brain development in animal models of Down syndrome.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Fernandez-Martinez J,Vela EM,Tora-Ponsioen M,Ocaña OH,Nieto MA,Galceran Jdoi
10.1242/jcs.044354subject
Has Abstractpub_date
2009-05-15 00:00:00pages
1574-83issue
Pt 10eissn
0021-9533issn
1477-9137pii
jcs.044354journal_volume
122pub_type
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