Abstract：
:p190 RhoGAP is a tyrosine phosphorylated protein that contains an N-terminal GTP binding domain, a middle domain (MD) that mediates interaction with p120 RasGAP and a C-terminal GTPase-activating protein (GAP) domain that is specific for the &Rgr; family of small GTPases. Evidence is accumulating to suggest that p190 participates in actin cytoskeleton rearrangements that occur following transformation by v-Src or stimulation by growth factors, and that tyrosine phosphorylation of p190 by Src influences these processes. The current study was performed to establish whether p190RhoGAP directly participates in epidermal growth factor-induced actin stress fiber disassembly and how c-Src is involved in this process. Our results support a model in which the p190 MD negatively regulates the activity of the GAP domain and that c-Src phosphorylation of Y1105 is necessary, but insufficient on its own, for actin stress fiber disassembly.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Haskell MD,Nickles AL,Agati JM,Su L,Dukes BD,Parsons SJkeywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
1699-708issue
Pt 9eissn
0021-9533issn
1477-9137journal_volume
114pub_type
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journal_title：Journal of cell science
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journal_title：Journal of cell science
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journal_title：Journal of cell science
pub_type： 杂志文章
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journal_title：Journal of cell science
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更新日期：1976-05-01 00:00:00
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journal_title：Journal of cell science
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journal_title：Journal of cell science
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doi：
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journal_title：Journal of cell science
pub_type： 杂志文章
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更新日期：2009-09-15 00:00:00
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更新日期：2003-11-15 00:00:00
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journal_title：Journal of cell science
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更新日期：1999-09-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：10.1242/jcs.03035
更新日期：2006-07-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：10.1242/jcs.243303
更新日期：2020-08-11 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
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更新日期：2008-05-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：10.1242/jcs.203455
更新日期：2017-08-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：10.1242/jcs.02380
更新日期：2005-06-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1979-10-01 00:00:00
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journal_title：Journal of cell science
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doi：
更新日期：2002-07-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
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更新日期：2006-03-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-01-15 00:00:00
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journal_title：Journal of cell science
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更新日期：2009-08-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
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更新日期：2019-09-23 00:00:00
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更新日期：2004-10-01 00:00:00
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更新日期：2017-09-01 00:00:00
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更新日期：2004-02-01 00:00:00
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journal_title：Journal of cell science
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更新日期：2007-09-01 00:00:00
