Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells.

abstract：:Eukaryotic cells replicate and partition their organelles between the mother cell and the daughter cell at cytokinesis. Polarized cells, notably the budding yeast Saccharomyces cerevisiae, are well suited for the study of organelle inheritance, as they facilitate an experimental dissection of organelle transport and r...

journal_title：Journal of cell science

authors： Knoblach B,Rachubinski RA

更新日期：2015-02-15 00:00:00

abstract：:The family of integrin transmembrane receptors is essential for the normal function of multicellular organisms by facilitating cell-extracellular matrix adhesion. The vitronectin-binding integrin αVβ5 localizes to focal adhesions (FAs) as well as poorly characterized flat clathrin lattices (FCLs). Here, we show that, ...

journal_title：Journal of cell science

authors： Zuidema A,Wang W,Kreft M,Te Molder L,Hoekman L,Bleijerveld OB,Nahidiazar L,Janssen H,Sonnenberg A

更新日期：2018-11-05 00:00:00

abstract：:Rothmund-Thomson syndrome (RTS) is a human genetic disorder characterized by genome instability, cancer susceptibility and premature aging. The gene defective in a subset of RTS cases, RECQL4, encodes a member of the RecQ family of DNA helicases. To better define the function of the RECQL4 protein, we have determined ...

journal_title：Journal of cell science

authors： Petkovic M,Dietschy T,Freire R,Jiao R,Stagljar I

更新日期：2005-09-15 00:00:00

abstract：:We have previously shown that chymotrypsin-cleaved soluble uPAR (D2D3(88-274)) elicits migration of monocytic cells through interaction with FPRL-1, a G protein-coupled receptor that is homologous to the fMLP receptor. Here, we report that D2D3(88-274) also modulates the ability of monocytes to migrate in response to ...

journal_title：Journal of cell science

authors： Furlan F,Orlando S,Laudanna C,Resnati M,Basso V,Blasi F,Mondino A

更新日期：2004-06-15 00:00:00

abstract：:Notch signalling is used throughout the animal kingdom to spatially and temporally regulate cell fate, proliferation and differentiation. Its importance is reflected in the dramatic effects produced on both development and health by small variations in the strength of the Notch signal. The Down-syndrome-associated kin...

journal_title：Journal of cell science

authors： Fernandez-Martinez J,Vela EM,Tora-Ponsioen M,Ocaña OH,Nieto MA,Galceran J

更新日期：2009-05-15 00:00:00

abstract：:The growth of two human diploid skin fibroblast cell lines, originally grown in medium supplemented with foetal bovine serum and later adapted to medium supplemented with newborn bovine, bovine calf or horse serum, has been studied. Prolonged generation times increased cell volumes and decreased plating efficiencies w...

journal_title：Journal of cell science

authors： Zamansky GB,Arundel C,Nagasawa H,Little JB

更新日期：1983-05-01 00:00:00

abstract：:Dynamin, a microtubule-activated GTPase, has recently been identified as the product of the shibire gene in Drosophila. shi(ts) mutants are defective in synaptic vesicle recycling, which leads to rapid and reversible temperature-sensitive paralysis. In the present study, results from RNase protection assays and analys...

journal_title：Journal of cell science

authors： Chen MS,Burgess CC,Vallee RB,Wadsworth SC

更新日期：1992-11-01 00:00:00

abstract：:Addition of lysophosphatidic acid (LPA) to serum-deprived N1E-115 neuronal cells results in rapid f-actin assembly accompanied by neurite retraction and rounding of the cell body due to contraction of the cortical actin cytoskeleton. LPA action is mimicked by activated RhoA, while it is blocked by dominant-negative Rh...

journal_title：Journal of cell science

authors： Kranenburg O,Poland M,Gebbink M,Oomen L,Moolenaar WH

更新日期：1997-10-01 00:00:00

abstract：:Autophagy requires the formation of membrane vesicles, known as autophagosomes, that engulf cellular cargoes and subsequently recruit lysosomal hydrolases for the degradation of their contents. A number of autophagy-related proteins act to mediate the de novo biogenesis of autophagosomes and vesicular trafficking even...

journal_title：Journal of cell science

authors： Gammoh N

更新日期：2020-10-30 00:00:00

abstract：:The JAK/STAT pathway is an essential signalling cascade required for multiple processes during development and for adult homeostasis. A key question in understanding this pathway is how it is regulated in different cell contexts. Here, we have examined how endocytic processing contributes to signalling by the single c...

journal_title：Journal of cell science

authors： Moore R,Vogt K,Acosta-Martin AE,Shire P,Zeidler M,Smythe E

更新日期：2020-10-12 00:00:00

abstract：:The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) defines a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF). Here, we describe a LEM protein annotated in databases as 'Ankyrin r...

journal_title：Journal of cell science

authors： Brachner A,Braun J,Ghodgaonkar M,Castor D,Zlopasa L,Ehrlich V,Jiricny J,Gotzmann J,Knasmüller S,Foisner R

更新日期：2012-02-15 00:00:00

abstract：:The mAb RK7, previously shown to recognize keratin 19, was also found to cross-react with a biologically unrelated 102 kDa protein, which becomes associated with the poles of the mitotic apparatus. This newly identified protein, called cytocentrin, is a stable cellular component, may be at least in part phosphorylated...

journal_title：Journal of cell science

authors： Paul EC,Quaroni A

更新日期：1993-11-01 00:00:00

abstract：:Cadherins and integrins are intrinsically linked through the actin cytoskeleton and share common signaling molecules. Although mechanosensing by the integrin-actin axis has long been appreciated, a growing body of literature now demonstrates that cadherins also transduce and respond to mechanical forces. Mounting evid...

journal_title：Journal of cell science

authors： Mui KL,Chen CS,Assoian RK

更新日期：2016-03-15 00:00:00

abstract：:Cancer cells thrive when challenged with proteotoxic stress by inducing components of the protein folding, proteasome, autophagy and unfolded protein response (UPR) pathways. Consequently, specific molecular chaperones have been validated as targets for anti-cancer therapies. For example, inhibition of Hsp70 family pr...

journal_title：Journal of cell science

authors： Sannino S,Guerriero CJ,Sabnis AJ,Stolz DB,Wallace CT,Wipf P,Watkins SC,Bivona TG,Brodsky JL

更新日期：2018-09-05 00:00:00

abstract：:Autophagy is fundamental for cell and organismal health. Two types of autophagy are conserved in eukaryotes: macroautophagy and microautophagy. During macroautophagy, autophagosomes deliver cytoplasmic constituents to endosomes or lysosomes, whereas during microautophagy lytic organelles take up cytoplasm directly. Wh...

journal_title：Journal of cell science

authors： Schuck S

更新日期：2020-09-09 00:00:00

abstract：:Tau is a group of neuronal microtubule-associated proteins that are formed by alternative mRNA splicing and accumulate in neurofibrillary tangles in Alzheimer's disease (AD) brain. Tau plays a key role in regulating microtubule dynamics, axonal transport and neurite outgrowth, and all these functions of tau are modula...

journal_title：Journal of cell science

authors： Johnson GV,Stoothoff WH

更新日期：2004-11-15 00:00:00

abstract：:During spermatogenesis, the first morphological indication of spermatogonia differentiation is incomplete cytokinesis, followed by the assembly of stable intercellular cytoplasmic communications. This distinctive feature of differentiating male germ cells has been highly conserved during evolution, suggesting that reg...

journal_title：Journal of cell science

authors： Cunto FD,Imarisio S,Camera P,Boitani C,Altruda F,Silengo L

更新日期：2002-12-15 00:00:00

abstract：:During meiosis, cohesion between sister chromatids is required for normal levels of homologous recombination, maintenance of chiasmata and accurate chromosome segregation during both divisions. In Drosophila, null mutations in the ord gene abolish meiotic cohesion, although how ORD protein promotes cohesion has remain...

journal_title：Journal of cell science

authors： Khetani RS,Bickel SE

更新日期：2007-09-01 00:00:00

abstract：:The adapter protein CD2-associated protein (CD2AP) functions in various signaling and vesicle trafficking pathways, including endosomal sorting and/or trafficking and degradation pathways. Here, we investigated the role of CD2AP in insulin-dependent glucose transporter 4 (Glut4, also known as SLC2A4) trafficking and g...

journal_title：Journal of cell science

authors： Tolvanen TA,Dash SN,Polianskyte-Prause Z,Dumont V,Lehtonen S

更新日期：2015-12-15 00:00:00

abstract：:The presence of gap junctions in stratified epithelia has now been extensively documented, but there have been few attempts to quantify them. In the present report, samples of hamster cheek pouch mucosa were processed for electron microscopy and electron micrographs from defined basal, spinous and granular layers were...

journal_title：Journal of cell science

authors： White FH,Thompson DA,Gohari K

更新日期：1984-07-01 00:00:00

abstract：:Members of the ezrin-radixin-moesin (ERM) family of proteins are involved in multiple aspects of cell migration by acting both as crosslinkers between the membrane, receptors and the actin cytoskeleton, and as regulators of signalling molecules that are implicated in cell adhesion, cell polarity and migration. Increas...

journal_title：Journal of cell science

authors： Clucas J,Valderrama F

更新日期：2014-01-15 00:00:00

abstract：:The canonical Wnt/β-catenin signaling pathway regulates cell proliferation in development and adult tissue homeostasis. Dysregulated signaling contributes to human diseases, in particular cancer. Growing evidence suggests a role for clathrin and/or endocytosis in the regulation of this pathway, but conflicting results...

journal_title：Journal of cell science

authors： Munthe E,Raiborg C,Stenmark H,Wenzel EM

更新日期：2020-07-09 00:00:00

abstract：:Splice variants of certain genes impact on genetic biodiversity in mammals. The tumor suppressor TP53 gene (encoding p53) plays an important role in the regulation of tumorigenesis in hepatocellular carcinoma (HCC). Δ40p53α is a naturally occurring p53 isoform that lacks the N-terminal transactivation domain, yet litt...

journal_title：Journal of cell science

authors： Ota A,Nakao H,Sawada Y,Karnan S,Wahiduzzaman M,Inoue T,Kobayashi Y,Yamamoto T,Ishii N,Ohashi T,Nakade Y,Sato K,Itoh K,Konishi H,Hosokawa Y,Yoneda M

更新日期：2017-02-01 00:00:00

abstract：:The mucolipin (TRPML) subfamily of transient receptor potential (TRP) cation channels consists of three members that play various roles in the regulation of membrane and protein sorting along endo-lysosomal pathways. Loss-of-function mutations in TRPML1 cause the neurodegenerative lysosomal storage disorder, mucolipid...

journal_title：Journal of cell science

authors： Zeevi DA,Lev S,Frumkin A,Minke B,Bach G

更新日期：2010-09-15 00:00:00

abstract：:The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and modulates the progression of chronic inflammatory disease through activation of the receptor CCR2. Here, we show that co-activation of the P2Y₆ purinergic receptor (encoded by P2RY₆) occurs when...

journal_title：Journal of cell science

authors： Campwala H,Sexton DW,Crossman DC,Fountain SJ

更新日期：2014-11-15 00:00:00

abstract：:Reorganization of the actin cytoskeleton is essential to numerous cellular processes including cell locomotion and cytokinesis. This actin remodeling is regulated in part by Rho family GTPases. Previous studies implicated Trio, a Dbl-homology guanine nucleotide exchange factor with two exchange factor domains, in regu...

journal_title：Journal of cell science

authors： Seipel K,O'Brien SP,Iannotti E,Medley QG,Streuli M

更新日期：2001-01-01 00:00:00

abstract：:BMP-dependent patterning in the Drosophila melanogaster wing imaginal disc serves as a paradigm to understand how morphogens specify cell fates. The observed profile of the transcriptional response to the graded signal of BMP relies upon two counter-active gradients of pMad and Brinker (Brk). This patterning model is ...

journal_title：Journal of cell science

authors： Ziv O,Finkelstein R,Suissa Y,Dinur T,Deshpande G,Gerlitz O

更新日期：2012-12-01 00:00:00

abstract：:Moving the nucleus to a specific position within the cell is an important event during many cell and developmental processes. Several different molecular mechanisms exist to position nuclei in various cell types. In this Commentary, we review the recent progress made in elucidating mechanisms of nuclear migration in a...

journal_title：Journal of cell science

authors： Bone CR,Starr DA

更新日期：2016-05-15 00:00:00

abstract：:Glutathione (GSH) levels progressively decline during aging and in neurodegenerative disorders. However, the contribution of such event in mediating neuronal cell death is still uncertain. In this report, we show that, in neuroblastoma cells as well as in primary mouse cortical neurons, GSH decrease, induced by buthio...

journal_title：Journal of cell science

authors： Aquilano K,Baldelli S,Cardaci S,Rotilio G,Ciriolo MR

更新日期：2011-04-01 00:00:00

abstract：:The type II transmembrane protein CD98, best known as the heavy chain of the heterodimeric amino acid transporters (HAT), is required for the surface expression and basolateral localization of this transporter complex in polarized epithelial cells. CD98 also interacts with beta1 integrins resulting in an increase in t...

journal_title：Journal of cell science

authors： Cai S,Bulus N,Fonseca-Siesser PM,Chen D,Hanks SK,Pozzi A,Zent R

更新日期：2005-03-01 00:00:00