Isoform B of myosin II heavy chain mediates actomyosin contractility during TNFalpha-induced apoptosis.

abstract：:Myofibrillar proteins assemble to form the highly ordered repetitive contractile structural unit known as a sarcomere. Studies of myogenesis in vertebrate cell culture and embryonic developmental systems have identified some of the processes involved during sarcomere formation. However, isoform changes during vertebra...

journal_title：Journal of cell science

authors： Nongthomba U,Clark S,Cummins M,Ansari M,Stark M,Sparrow JC

更新日期：2004-04-01 00:00:00

abstract：:ARVCF is a novel Armadillo repeat domain protein that is closely related to the catenin p120(ctn). Using new ARVCF monoclonal antibodies, we have found that ARVCF associates with E-cadherin and competes with p120 for interaction with the E-cadherin juxtamembrane domain. ARVCF also localized to the nucleus in some cell...

journal_title：Journal of cell science

authors： Mariner DJ,Wang J,Reynolds AB

更新日期：2000-04-01 00:00:00

abstract：:In 1993, a Commentary in this journal described how a simple mechanical model of cell structure based on tensegrity architecture can help to explain how cell shape, movement and cytoskeletal mechanics are controlled, as well as how cells sense and respond to mechanical forces (J. Cell Sci. 104, 613-627). The cellular ...

journal_title：Journal of cell science

authors： Ingber DE

更新日期：2003-04-01 00:00:00

abstract：:Rickettsia conorii, the causative agent of Mediterranean spotted fever, is able to attach to and invade a variety of cell types both in vitro and in vivo. Although previous studies show that entry of R. conorii into non-phagocytic cells relies on actin polymerization, little else is known about the molecular details g...

journal_title：Journal of cell science

authors： Martinez JJ,Cossart P

更新日期：2004-10-01 00:00:00

abstract：:Recently, we demonstrated in cultured endothelial cells and in vivo that deficiency of an isoform of intersectin-1, ITSN-1s, impairs caveolae and clathrin-mediated endocytosis and functionally upregulates compensatory pathways and their morphological carriers (i.e. enlarged endocytic structures, membranous rings or tu...

journal_title：Journal of cell science

authors： Bardita C,Predescu DN,Sha F,Patel M,Balaji G,Predescu SA

更新日期：2015-04-15 00:00:00

abstract：:Primary cilia are conserved organelles that play crucial roles as mechano- and chemosensors, as well as transducing signaling cascades. Consequently, ciliary dysfunction results in a broad range of phenotypes: the ciliopathies. Bardet-Biedl syndrome (BBS), a model ciliopathy, is caused by mutations in 16 known genes. ...

journal_title：Journal of cell science

authors： Gascue C,Tan PL,Cardenas-Rodriguez M,Libisch G,Fernandez-Calero T,Liu YP,Astrada S,Robello C,Naya H,Katsanis N,Badano JL

更新日期：2012-01-15 00:00:00

abstract：:ADP-ribosylation factors (Arfs) play central roles in the regulation of vesicular trafficking through the Golgi. Arfs are activated at the Golgi membrane by guanine-nucleotide-exchange factors (GEFs) that are recruited from cytosol. Here, we describe a novel mechanism for the regulation of recruitment and activity of ...

journal_title：Journal of cell science

authors： Quilty D,Gray F,Summerfeldt N,Cassel D,Melançon P

更新日期：2014-01-15 00:00:00

abstract：:Little is known about the molecular mechanisms that regulate the organization of vascular lumen. In this paper we show that lumen formation correlates with endothelial polarization. Adherens junctions (AJs) and VE-cadherin (VEC, encoded by CDH5) are required for endothelial apicobasal polarity in vitro and during embr...

journal_title：Journal of cell science

authors： Lampugnani MG,Orsenigo F,Rudini N,Maddaluno L,Boulday G,Chapon F,Dejana E

更新日期：2010-04-01 00:00:00

abstract：:The extracellular matrix (ECM) regulates cell behavior by influencing cell proliferation, survival, shape, migration and differentiation. Far from being a static structure, the ECM is constantly undergoing remodeling--i.e. assembly and degradation--particularly during the normal processes of development, differentiati...

journal_title：Journal of cell science

authors： Daley WP,Peters SB,Larsen M

更新日期：2008-02-01 00:00:00

abstract：:In the central nervous system, oligodendrocytes synthesize vast amounts of myelin, a multilamellar membrane wrapped around axons that dramatically enhances nerve transmission. A complex apparatus appears to coordinate trafficking of proteins and lipids during myelin synthesis, but the molecular interactions involved a...

journal_title：Journal of cell science

authors： Anitei M,Ifrim M,Ewart MA,Cowan AE,Carson JH,Bansal R,Pfeiffer SE

更新日期：2006-03-01 00:00:00

abstract：:Using epitope mapping we have demonstrated that a high molecular weight protein (Mr approximately 115 x 10(3)) present in brain and spinal cord is a member of the tau family of microtubule-associated proteins. Antibodies directed against the amino-terminal, middle and carboxyl-terminal portions of tau recognize this p...

journal_title：Journal of cell science

authors： Georgieff IS,Liem RK,Mellado W,Nunez J,Shelanski ML

更新日期：1991-09-01 00:00:00

abstract：:Macroautophagy is morphologically characterized by autophagosome formation. Autophagosomes are double-membraned vesicles that sequester cytoplasmic components for further degradation in the lysosome. Basal autophagy is paramount for intracellular quality control in post-mitotic cells but, surprisingly, the number of a...

journal_title：Journal of cell science

authors： Fernandez-Fernandez MR,Ruiz-Garcia D,Martin-Solana E,Chichon FJ,Carrascosa JL,Fernandez JJ

更新日期：2017-01-01 00:00:00

abstract：:Gene expression of malaria parasites is mediated by the apicomplexan Apetala2 (ApiAP2) transcription factor family. Different ApiAP2s control gene expression at distinct stages in the complex life cycle of the parasite, ensuring timely expression of stage-specific genes. ApiAP2s recognize short cis-regulatory elements...

journal_title：Journal of cell science

authors： Klug D,Kehrer J,Frischknecht F,Singer M

更新日期：2018-10-22 00:00:00

abstract：:MACF1 (microtubule actin crosslinking factor), also called ACF7 (actin crosslinking family 7) is a cytoskeletal linker protein that can associate with both actin filaments and microtubules. We have identified a novel alternatively spliced isoform of MACF1. We named this isoform MACF1b and renamed the original isoform ...

journal_title：Journal of cell science

authors： Lin CM,Chen HJ,Leung CL,Parry DA,Liem RK

更新日期：2005-08-15 00:00:00

abstract：:Members of the ezrin-radixin-moesin (ERM) family of proteins are involved in multiple aspects of cell migration by acting both as crosslinkers between the membrane, receptors and the actin cytoskeleton, and as regulators of signalling molecules that are implicated in cell adhesion, cell polarity and migration. Increas...

journal_title：Journal of cell science

authors： Clucas J,Valderrama F

更新日期：2014-01-15 00:00:00

abstract：:PML nuclear bodies (NBs) are involved in the regulation of key nuclear pathways but their biochemical function in nuclear metabolism is unknown. In this study PML NB assembly dynamics were assessed by live cell imaging and mathematic modeling of its major component parts. We show that all six nuclear PML isoforms exhi...

journal_title：Journal of cell science

authors： Weidtkamp-Peters S,Lenser T,Negorev D,Gerstner N,Hofmann TG,Schwanitz G,Hoischen C,Maul G,Dittrich P,Hemmerich P

更新日期：2008-08-15 00:00:00

abstract：:A mutation in the alpha 1-tubulin gene of Chlamydomonas reinhardtii was isolated by using the amiprophos-methyl-resistant mutation apm1-18 as a background to select new mutants that showed increased resistance to the drug. The upA12 mutation caused twofold resistance to amiprophos-methyl and oryzalin, and twofold hype...

journal_title：Journal of cell science

authors： James SW,Silflow CD,Stroom P,Lefebvre PA

更新日期：1993-09-01 00:00:00

abstract：:The mechanism responsible for spermatid translocation in the mammalian seminiferous epithelium was proposed to be the microtubule-based transport of specialized junction plaques (ectoplasmic specializations) that occur in Sertoli cell regions attached to spermatid heads. These plaques each consist of a cistern of endo...

journal_title：Journal of cell science

authors： Guttman JA,Kimel GH,Vogl AW

更新日期：2000-06-01 00:00:00

abstract：:Syntaxin 1C (STX1C), produced by alternative splicing of the stx1A gene, is a soluble syntaxin lacking a SNARE domain and a transmembrane domain. It is unclear how soluble syntaxin can control intracellular membrane trafficking. We found that STX1C affected microtubule (MT) dynamics through its tubulin-binding domain ...

journal_title：Journal of cell science

authors： Nakayama T,Kamiguchi H,Akagawa K

更新日期：2012-02-15 00:00:00

abstract：:A line of null mice has been produced which fails to express the transmembrane chondroitin sulfate proteoglycan NG2. Homozygous NG2 null mice do not exhibit gross phenotypic differences from wild-type mice, suggesting that detailed analyses are required to detect subtle alterations caused by the absence of NG2. Accord...

journal_title：Journal of cell science

authors： Grako KA,Ochiya T,Barritt D,Nishiyama A,Stallcup WB

更新日期：1999-03-01 00:00:00

abstract：:The Tec kinases represent the second largest family of mammalian non-receptor tyrosine kinases and are distinguished by the presence of distinct proline-rich regions and pleckstrin homology domains that are required for proper regulation and activation. Best studied in lymphocyte and mast cells, these kinases are crit...

journal_title：Journal of cell science

authors： Takesono A,Finkelstein LD,Schwartzberg PL

更新日期：2002-08-01 00:00:00

abstract：:Sox7, Sox17 and Sox18 constitute group F of the Sox family of HMG box transcription factor genes. Dominant-negative mutations in Sox18 underlie the cardiovascular defects observed in ragged mutant mice. By contrast, Sox18(-/-) mice are viable and fertile, and display no appreciable anomaly in their vasculature, sugges...

journal_title：Journal of cell science

authors： Matsui T,Kanai-Azuma M,Hara K,Matoba S,Hiramatsu R,Kawakami H,Kurohmaru M,Koopman P,Kanai Y

更新日期：2006-09-01 00:00:00

abstract：:Prox1 is a master regulator for the development of lymphatic vasculature and the induction of lymphangiogenesis. In this study, we identified Prox1 as a new target for small ubiquitin-like modifier 1 (SUMO-1). Lysine 556 (K556) was found to be the major sumoylation site for Prox1 in vitro and in vivo. Mutation of this...

journal_title：Journal of cell science

authors： Pan MR,Chang TM,Chang HC,Su JL,Wang HW,Hung WC

更新日期：2009-09-15 00:00:00

abstract：:Niemann-Pick disease type C (NPC) is an inherited lipid storage disorder caused by mutations in NPC1 or NPC2. NPC1 is a polytopic glycoprotein that contains a sterol-sensing domain, whereas NPC2 is a soluble protein that contains an MD-2-like lipid-recognition domain. In the current study, we addressed the hypothesis ...

journal_title：Journal of cell science

authors： Ohsaki Y,Sugimoto Y,Suzuki M,Hosokawa H,Yoshimori T,Davies JP,Ioannou YA,Vanier MT,Ohno K,Ninomiya H

更新日期：2006-07-01 00:00:00

abstract：:The HB2 cell line, developed from luminal epithelial cells cultured from milk, forms ball-like structures in collagen gels which show a uniform branching response to hepatocyte growth factor. The alpha2beta1 integrin is the major integrin expressed by luminal epithelial cells, and the role of this integrin in mammary ...

journal_title：Journal of cell science

authors： Alford D,Baeckström D,Geyp M,Pitha P,Taylor-Papadimitriou J

更新日期：1998-02-01 00:00:00

abstract：:We reported previously that Ca2+ depletion of Dictyostelium discoideum cells severely inhibits extracellular cyclic nucleotide phosphodiesterase (PD) synthesis at a post-transcriptional step. In this study, further experiments were performed to learn more about the nature of this phenomenon. Examination of the polysom...

journal_title：Journal of cell science

authors： Coukell MB,Cameron AM,Adames NR

更新日期：1992-10-01 00:00:00

abstract：:The CCAAT/enhancer-binding protein beta (C/EBPbeta, also known as CEBPB) was first identified as a regulator of differentiation and inflammatory processes in adipose tissue and liver. Although C/EBPbeta was initially implicated in synaptic plasticity, its function in the brain remains largely unknown. We have previous...

journal_title：Journal of cell science

authors： Cortes-Canteli M,Luna-Medina R,Sanz-Sancristobal M,Alvarez-Barrientos A,Santos A,Perez-Castillo A

更新日期：2008-04-15 00:00:00

abstract：:Recent evidence suggests that organization of the extracellular matrix (ECM) into aligned fibrils or fibril-like ECM topographies promotes rapid migration in fibroblasts. However, the mechanisms of cell migration that are altered by these changes in micro-environmental topography remain unknown. Here, using 1D fibrill...

journal_title：Journal of cell science

authors： Doyle AD,Kutys ML,Conti MA,Matsumoto K,Adelstein RS,Yamada KM

更新日期：2012-05-01 00:00:00

abstract：:A complex network of interactions between the stroma, the extracellular matrix and the epithelium drives mammary gland development and function. Two main assumptions in chemical carcinogenesis of the mammary gland have been that carcinogens induce neoplasia by causing mutations in the DNA of the epithelial cells and t...

journal_title：Journal of cell science

authors： Maffini MV,Soto AM,Calabro JM,Ucci AA,Sonnenschein C

更新日期：2004-03-15 00:00:00

abstract：:Triton X-100-treated sperms were injected into non-nucleate egg fragments of Xenopus laevis to determine whether the structure of the injected sperm nucleus is affected by the cyclic activity of the cytoplasm. Swollen vesicular nuclei were very frequently observed when the sperms were injected and incubated during the...

journal_title：Journal of cell science

authors： Sakai M,Shinagawa A

更新日期：1983-09-01 00:00:00