Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation.

abstract：:In culture, cell confluence generates signals that commit actively growing keratinocytes to exit the cell cycle and differentiate to form a stratified epithelium. Using a comparative proteomic approach, we studied this 'confluence switch' and identified a new pathway triggered by cell confluence that regulates basemen...

journal_title：Journal of cell science

authors： Botta A,Delteil F,Mettouchi A,Vieira A,Estrach S,Négroni L,Stefani C,Lemichez E,Meneguzzi G,Gagnoux-Palacios L

更新日期：2012-09-15 00:00:00

abstract：:Cartilage oligomeric matrix protein (COMP) is an abundant component in the extracellular matrix (ECM) of load-bearing tissues such as tendons and cartilage. It provides adaptor functions by bridging different ECM structures. We have previously shown that COMP is also a constitutive component of healthy human skin and ...

journal_title：Journal of cell science

authors： Schulz JN,Nüchel J,Niehoff A,Bloch W,Schönborn K,Hayashi S,Kamper M,Brinckmann J,Plomann M,Paulsson M,Krieg T,Zaucke F,Eckes B

更新日期：2016-02-15 00:00:00

abstract：:The production, transport, and disposition of material labelled with [3H]mannose were studied in microsurgically enucleated and control amoebae. Cells were injected with the precursor and samples were prepared for electron-microscope radioautography at intervals, up to 24 h later. Control cells showed heavy labelling ...

journal_title：Journal of cell science

authors： Flickinger CJ

更新日期：1984-06-01 00:00:00

abstract：:Mitotic progression is timely regulated by the accumulation and degradation of A- and B-type cyclins. In plants, there are three classes of A-, and two classes of B-type cyclins, but their specific roles are not known. We have generated transgenic tobacco plants in which the ectopic expression of a plant cyclin B2 gen...

journal_title：Journal of cell science

authors： Weingartner M,Pelayo HR,Binarova P,Zwerger K,Melikant B,de la Torre C,Heberle-Bors E,Bögre L

更新日期：2003-02-01 00:00:00

abstract：:A universal feature of mitosis is that all chromosomes become aligned at the spindle equator--the halfway point between the two spindle poles--prior to anaphase onset. This migratory event is called congression, and is powered by centromere-bound protein machines called kinetochores. This Commentary aims to document r...

journal_title：Journal of cell science

authors： Auckland P,McAinsh AD

更新日期：2015-09-15 00:00:00

abstract：:Meiotic cell cycles differ from mitotic cell cycles in that the former lack S-phase in the interphase between meiosis I and meiosis II. To obtain clues for mechanisms involved in the cell cycle regulation unique to meiosis, we have examined changes in chromosomal morphology and H1 kinase activity during a meiotic peri...

journal_title：Journal of cell science

authors： Ohsumi K,Sawada W,Kishimoto T

更新日期：1994-11-01 00:00:00

abstract：:Autophagy is a pivotal cytoprotective process that secures cellular homeostasis, fulfills essential roles in development, immunity and defence against pathogens, and determines the lifespan of eukaryotic organisms. However, autophagy also crucially contributes to the development of age-related human pathologies, inclu...

journal_title：Journal of cell science

authors： Proikas-Cezanne T,Takacs Z,Dönnes P,Kohlbacher O

更新日期：2015-01-15 00:00:00

abstract：:Alpha4 integrins are used by leukocytes and neural crest derivatives for adhesion and migration during embryogenesis, immune responses and tumour invasion. The pro-migratory activity of alpha4 integrin is mediated in part through the direct binding of the cytoplasmic domain to paxillin. Here, using intermolecular FRET...

journal_title：Journal of cell science

authors： Deakin NO,Bass MD,Warwood S,Schoelermann J,Mostafavi-Pour Z,Knight D,Ballestrem C,Humphries MJ

更新日期：2009-05-15 00:00:00

abstract：:The acidic carboxy-terminal regions of alpha- and beta-tubulin subunits are currently thought to be centrally involved in microtubule stability and in microtubule association with a variety of proteins (MAPs) such as MAP2 and tau proteins. Here, pure tubulin microtubules were exposed to subtilisin to produce polymers ...

journal_title：Journal of cell science

authors： Saoudi Y,Paintrand I,Multigner L,Job D

更新日期：1995-01-01 00:00:00

abstract：:Diploid yeast, like most eukaryotes, can undergo meiotic differentiation to form haploid gametes. Meiotic differentiation and cell growth (proliferation) are mutually exclusive programs, and in yeast the switch between growth and meiosis is controlled by nutritional signals. The signaling pathways that mediate nutriti...

journal_title：Journal of cell science

authors： Honigberg SM,Purnapatre K

更新日期：2003-06-01 00:00:00

abstract：:Laminins are heterotrimeric glycoproteins of the extracellular matrix that are secreted by epithelial cells and which are crucial for the normal structure and function of the basement membrane. We have generated a mouse harboring a conditional knockout of α3 laminin (Lama3(fl/fl)), one of the main laminin subunits in ...

journal_title：Journal of cell science

authors： Urich D,Eisenberg JL,Hamill KJ,Takawira D,Chiarella SE,Soberanes S,Gonzalez A,Koentgen F,Manghi T,Hopkinson SB,Misharin AV,Perlman H,Mutlu GM,Budinger GR,Jones JC

更新日期：2011-09-01 00:00:00

abstract：:A number of recent studies have highlighted the importance of autophagy and the ubiquitin-proteasome in the pathogenesis of muscle wasting in different types of inherited muscle disorders. Autophagy is crucial for the removal of dysfunctional organelles and protein aggregates, whereas the ubiquitin-proteasome is impor...

journal_title：Journal of cell science

authors： Sandri M,Coletto L,Grumati P,Bonaldo P

更新日期：2013-12-01 00:00:00

abstract：:Syndecan-4 is a ubiquitously expressed transmembrane heparan sulphate proteoglycan acting in concert with integrins in the formation of focal adhesions and stress fibres. Signalling events studied thus far suggest the formation of a ternary complex between syndecan-4, phosphatidylinositol 4,5-bisphosphate and protein ...

journal_title：Journal of cell science

authors： Dovas A,Yoneda A,Couchman JR

更新日期：2006-07-01 00:00:00

abstract：:To optimally perform the diversity of metabolic functions that occur within peroxisomes, cells must dynamically regulate peroxisome size, number and content in response to the cell state and the environment. Except for transcriptional regulation little is known about the mechanisms used to perform this complicated fea...

journal_title：Journal of cell science

authors： Yifrach E,Chuartzman SG,Dahan N,Maskit S,Zada L,Weill U,Yofe I,Olender T,Schuldiner M,Zalckvar E

更新日期：2016-11-01 00:00:00

abstract：:As chromosomes move polewards during anaphase in crane-fly spermatocytes, trailing arms commonly stretch backwards for a brief time, as if tethered to their partners. To test that notion, a laser microbeam was used to sever trailing arms and thereby release telomere-containing arm segments (called acentric fragments b...

journal_title：Journal of cell science

authors： LaFountain JR Jr,Cole RW,Rieder CL

更新日期：2002-04-01 00:00:00

abstract：:Glomerular basement membrane (GBM) and podocalyxin are essential for podocyte morphology. We provide evidence of functional interconnections between basement membrane components (collagen IV and laminin), the expression of podocalyxin and the morphology of human glomerular epithelial cells (podocytes). We demonstrated...

journal_title：Journal of cell science

authors： Economou CG,Kitsiou PV,Tzinia AK,Panagopoulou E,Marinos E,Kershaw DB,Kerjaschki D,Tsilibary EC

更新日期：2004-07-01 00:00:00

abstract：:The locomotion of single epidermis cells, grown out from Xenopus laevis tadpole tails has been investigated by time-lapse cinemicrography using phase-contrast and reflection-contrast optics. The cells develop a large, mostly 200-250 nm thick, lamella, which adheres homogeneously to the supporting coverglass and exceed...

journal_title：Journal of cell science

authors： Bereiter-Hahn J,Strohmeier R,Kunzenbacher I,Beck K,Vöth M

更新日期：1981-12-01 00:00:00

abstract：:HC11 is a normal mouse mammary epithelial cell line that requires certain growth factors, such as EGF or bFGF, to respond optimally to lactogenic hormones and produce the differentiation marker beta-casein. Growth in insulin (Ins) or PDGF does not produce cells competent to respond to lactogenic hormones. Here we show...

journal_title：Journal of cell science

authors： Chammas R,Taverna D,Cella N,Santos C,Hynes NE

更新日期：1994-04-01 00:00:00

abstract：:Pieces of small intestine from newborn, I- and 6-day-old piglets were incubated in vitro and ligated segments were incubated in vivo with polycationic ferritin (PCF) to determine the distribution and possible role in protein uptake of anionic sites on membranes at the luminal surfaces of the epithelial cells. Most PCF...

journal_title：Journal of cell science

authors： Chase CC,Munn EA

更新日期：1980-12-01 00:00:00

abstract：:In Rat-1 fibroblasts, v-Src causes a profound remodelling of cortical actin cytoskeleton. This transformation includes membrane ruffling, a hallmark of the leading edge in migrating cells, and results from activation of phosphoinositide 3-kinase (PI 3-kinase), phospholipase C (PLC) and phospholipase D (PLD). We theref...

journal_title：Journal of cell science

authors： Platek A,Mettlen M,Camby I,Kiss R,Amyere M,Courtoy PJ

更新日期：2004-09-15 00:00:00

abstract：:Gp78 (also known as AMFR), an endoplasmic-reticulum (ER)-associated protein degradation (ERAD) E3 ubiquitin ligase, localizes to mitochondria-associated ER and targets the mitofusin (Mfn1 and Mfn2) mitochondrial fusion proteins for degradation. Gp78 is also the cell surface receptor for autocrine motility factor (AMF)...

journal_title：Journal of cell science

authors： Wang PT,Garcin PO,Fu M,Masoudi M,St-Pierre P,Panté N,Nabi IR

更新日期：2015-08-01 00:00:00

abstract：:We previously reported that, among the three connexins expressed in chick lens, overexpression of connexin (Cx) 45.6, not Cx43 or Cx56, stimulates lens cell differentiation; however, the underlying mechanism responsible for this effect is unclear. Here, we took advantage of naturally occurring loss-of-gap-junction fun...

journal_title：Journal of cell science

authors： Banks EA,Yu XS,Shi Q,Jiang JX

更新日期：2007-10-15 00:00:00

abstract：:The weak spindle integrity checkpoint in Drosophila spermatocytes has revealed a novel function of the gamma-tubulin ring complex (gammaTuRC) in maintaining spindle bipolarity throughout meiosis. Bipolar and bi-astral spindles could form in Drosophila mutants for dd4, the gene encoding the 91 kDa subunit of gammaTuRC....

journal_title：Journal of cell science

authors： Barbosa V,Gatt M,Rebollo E,Gonzalez C,Glover DM

更新日期：2003-03-01 00:00:00

abstract：:Caveolins are membrane proteins that are the major coat proteins of caveolae, specialized lipid rafts in the plasma membrane that serve as scaffolding sites for many signaling complexes. Among the many signaling molecules associated with caveolins are the Src tyrosine kinases, whose activation regulates numerous cellu...

journal_title：Journal of cell science

authors： Smythe GM,Eby JC,Disatnik MH,Rando TA

更新日期：2003-12-01 00:00:00

abstract：:Increases in cytosolic Ca(2+) concentration ([Ca(2+)](c)) mediated by inositol (1,4,5)-trisphosphate [Ins(1,4,5)P(3), hereafter InsP(3)] regulate activities that include division, contraction and cell death. InsP(3)-evoked Ca(2+) release often begins at a single site, then regeneratively propagates through the cell as...

journal_title：Journal of cell science

authors： Olson ML,Sandison ME,Chalmers S,McCarron JG

更新日期：2012-11-15 00:00:00

abstract：:Several lines of evidence indicate that increases in nuclear Ca(2+) have specific biological effects that differ from those of cytosolic Ca(2+), suggesting that they occur independently. The mechanisms involved in controlling nuclear Ca(2+) signaling are both controversial and still poorly understood. Using hypotonic ...

journal_title：Journal of cell science

authors： Cárdenas C,Liberona JL,Molgó J,Colasante C,Mignery GA,Jaimovich E

更新日期：2005-07-15 00:00:00

abstract：:Mesenchymal stromal progenitor cells (MSCs) are multipotent progenitors that can be isolated from numerous tissues. MSCs can undergo osteogenic differentiation under proper stimuli. We have recently demonstrated that bone morphogenetic protein 9 (BMP9) is one of the most osteogenic BMPs. As one of the least studied BM...

journal_title：Journal of cell science

authors： Hu N,Jiang D,Huang E,Liu X,Li R,Liang X,Kim SH,Chen X,Gao JL,Zhang H,Zhang W,Kong YH,Zhang J,Wang J,Shui W,Luo X,Liu B,Cui J,Rogers MR,Shen J,Zhao C,Wang N,Wu N,Luu HH,Haydon RC,He TC,Huang W

更新日期：2013-01-15 00:00:00

abstract：:Yeast Reb1 and its mammalian ortholog TTF1 are conserved Myb-type DNA-binding proteins that bind to specific sites near the 3'-end of rRNA genes (rDNA). Here, they participate in the termination of transcription driven by RNA polymerase I and block DNA replication forks approaching in the opposite direction. We found ...

journal_title：Journal of cell science

authors： Rodríguez-Sánchez L,Rodríguez-López M,García Z,Tenorio-Gómez M,Schvartzman JB,Krimer DB,Hernández P

更新日期：2011-01-01 00:00:00

abstract：:Phosphoinositides represent a major class of lipids specifically involved in the organization of signaling cascades, maintenance of the identity of organelles and regulation of multiple intracellular trafficking steps. We previously reported that phosphatidylinositol 5-monophosphate (PI5P), produced by the Shigella fl...

journal_title：Journal of cell science

authors： Boal F,Mansour R,Gayral M,Saland E,Chicanne G,Xuereb JM,Marcellin M,Burlet-Schiltz O,Sansonetti PJ,Payrastre B,Tronchère H

更新日期：2015-02-15 00:00:00

abstract：:Cells govern tissue shape by exerting highly regulated forces at sites of matrix adhesion. As the major force-bearing adhesion-receptor protein, integrins have a central role in how cells sense and respond to the mechanics of their surroundings. Recent studies have shown that a key aspect of mechanotransduction is the...

journal_title：Journal of cell science

authors： Puklin-Faucher E,Sheetz MP

更新日期：2009-01-15 00:00:00