Abstract：
:The Tec kinases represent the second largest family of mammalian non-receptor tyrosine kinases and are distinguished by the presence of distinct proline-rich regions and pleckstrin homology domains that are required for proper regulation and activation. Best studied in lymphocyte and mast cells, these kinases are critical for the full activation of phospholipase-C gamma (PLC-gamma) and Ca(2+) mobilization downstream of antigen receptors. However, it has become increasingly clear that these kinases are activated downstream of many cell-surface receptors, including receptor tyrosine kinases, cytokine receptors, integrins and G-protein-coupled receptors. Evidence suggests that the Tec kinases influence a wide range of signaling pathways controlling activation of MAP kinases, actin reorganization, transcriptional regulation, cell survival and cellular transformation. Their impact on cellular physiology suggests that the Tec kinases help regulate multiple cellular processes beyond Ca(2+) mobilization.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Takesono A,Finkelstein LD,Schwartzberg PLkeywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
3039-48issue
Pt 15eissn
0021-9533issn
1477-9137journal_volume
115pub_type
杂志文章,评审abstract：:Different isoforms of non-muscle myosin II have different distributions in vivo, even within individual cells. In order to understand how these different distributions arise, the distribution and dynamics of non-muscle myosins IIA and myosin IIB were examined in cultured cells using immunofluorescence staining and tim...
journal_title：Journal of cell science
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journal_title：Journal of cell science
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pub_type： 杂志文章
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更新日期：2011-11-01 00:00:00
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pub_type： 杂志文章
doi：
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of cell science
pub_type： 杂志文章,评审
doi：
更新日期：2002-06-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of cell science
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doi：
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journal_title：Journal of cell science
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journal_title：Journal of cell science
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journal_title：Journal of cell science
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journal_title：Journal of cell science
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