Bouquet formation in budding yeast: initiation of recombination is not required for meiotic telomere clustering.

abstract：:We have characterised the functional regulation of the type-3 ryanodine receptor by the 12 kDa FK506-binding protein. Wild-type type-3 ryanodine receptor and mutant type-3 ryanodine receptor in which the critical valine at position 2322 in the central 12 kDa FK506-binding protein binding site was substituted by aspart...

journal_title：Journal of cell science

authors： Van Acker K,Bultynck G,Rossi D,Sorrentino V,Boens N,Missiaen L,De Smedt H,Parys JB,Callewaert G

更新日期：2004-03-01 00:00:00

abstract：:In fission yeast, Mid1p, a major determinant for division plane position, defines a medial cortical compartment where it recruits myosin II at the onset of mitosis to initiate contractile ring assembly. How Mid1p is restricted to the medial cortex is unknown. We report here that in a pom1 polarity mutant, which displa...

journal_title：Journal of cell science

authors： Celton-Morizur S,Racine V,Sibarita JB,Paoletti A

更新日期：2006-11-15 00:00:00

abstract：:Several examples of direct interactions between helicases and topoisomerases have recently been described. The data suggest a possible cooperation between these enzymes in major DNA events such as the progression of a replication fork, segregation of newly replicated chromosomes, disruption of nucleosomal structure, D...

journal_title：Journal of cell science

authors： Duguet M

更新日期：1997-06-01 00:00:00

abstract：:Although it is well established that embryonic stem (ES) cells have the potential to differentiate into dopamine neurons, the molecular basis of this process, particularly the role of microRNAs (miRNAs), remains largely unknown. Here we report that miR-132 plays a key role in the differentiation of dopamine neurons by...

journal_title：Journal of cell science

authors： Yang D,Li T,Wang Y,Tang Y,Cui H,Tang Y,Zhang X,Chen D,Shen N,Le W

更新日期：2012-04-01 00:00:00

abstract：:Phagocytosis is an actin-based process used by macrophages to clear particles greater than 0.5 microm in diameter. In addition to its role in immunological responses, phagocytosis is also necessary for tissue remodeling and repair. To prevent catastrophic autoimmune reactions, phagocytosis must be tightly regulated. I...

journal_title：Journal of cell science

authors： Beningo KA,Wang YL

更新日期：2002-02-15 00:00:00

abstract：:The alpha6beta4 integrin is located at the basal surface of keratinocytes, in hemidesmosomal structures that mediate stable adhesion of epidermal cells to the underlying basement membrane component laminin-5. The absence of alpha6beta4 integrin causes junctional epidermolysis bullosa, a severe blistering disease of th...

journal_title：Journal of cell science

authors： Raymond K,Kreft M,Janssen H,Calafat J,Sonnenberg A

更新日期：2005-03-01 00:00:00

abstract：:Ryanodine receptor subtype 1 (RyR1) has been primarily characterized in skeletal muscle but several studies have revealed its expression in smooth muscle. Here, we used Ryr1-null mice to investigate the role of this isoform in Ca(2+) signaling in urinary bladder smooth muscle. We show that RyR1 is required for depolar...

journal_title：Journal of cell science

authors： Fritz N,Morel JL,Jeyakumar LH,Fleischer S,Allen PD,Mironneau J,Macrez N

更新日期：2007-11-01 00:00:00

abstract：:During angiogenesis, endothelial cells must coordinate matrix proteolysis with migration. Here, we tested whether the focal adhesion scaffold protein Hic-5 (also known as TGFB1I1) regulated endothelial sprouting in three dimensions. Hic-5 silencing reduced endothelial sprouting and lumen formation, and sprouting defec...

journal_title：Journal of cell science

authors： Dave JM,Abbey CA,Duran CL,Seo H,Johnson GA,Bayless KJ

更新日期：2016-02-15 00:00:00

abstract：:The monoclonal antibody AGF2.3 identifies a nuclear envelope protein that is restricted to certain cell types. In particular, this antigen shows a reduced level of expression during haemopoietic cell maturation. In this study, we have examined the relationship of this protein to known nuclear envelope proteins that ha...

journal_title：Journal of cell science

authors： Lord JM,Thick JA,Bunce CM,Taylor AM,Gallimore PH,Mills D,Brown G

更新日期：1988-06-01 00:00:00

abstract：:Glomerular basement membrane (GBM) and podocalyxin are essential for podocyte morphology. We provide evidence of functional interconnections between basement membrane components (collagen IV and laminin), the expression of podocalyxin and the morphology of human glomerular epithelial cells (podocytes). We demonstrated...

journal_title：Journal of cell science

authors： Economou CG,Kitsiou PV,Tzinia AK,Panagopoulou E,Marinos E,Kershaw DB,Kerjaschki D,Tsilibary EC

更新日期：2004-07-01 00:00:00

abstract：:By differential screening of a Xenopus laevis egg cDNA library, we have isolated a 2,111 bp cDNA which corresponds to a maternal mRNA specifically deadenylated after fertilisation. This cDNA, called Eg2, encodes a 407 amino acid protein kinase. The pEg2 sequence shows significant identity with members of a new protein...

journal_title：Journal of cell science

authors： Roghi C,Giet R,Uzbekov R,Morin N,Chartrain I,Le Guellec R,Couturier A,Dorée M,Philippe M,Prigent C

更新日期：1998-03-01 00:00:00

abstract：:Previously we cloned and characterized the hamster intermediate filament genes coding for vimentin and desmin. It was demonstrated that the cloned desmin gene was expressed after gene transfer and that the newly synthesized protein assembles into intermediate filaments. Here we present data on the transfection of modi...

journal_title：Journal of cell science

authors： van den Heuvel RM,van Eys GJ,Ramaekers FC,Quax WJ,Vree Egberts WT,Schaart G,Cuypers HT,Bloemendal H

更新日期：1987-11-01 00:00:00

abstract：:Changes in cellular behavior that cause epithelial cells to lose adhesiveness, acquire a motile invasive phenotype and metastasize to secondary sites are complex and poorly understood. Molecules that normally function to integrate adhesive spatial information with cytoskeleton dynamics and membrane trafficking probabl...

journal_title：Journal of cell science

authors： Spiczka KS,Yeaman C

更新日期：2008-09-01 00:00:00

abstract：:We have previously demonstrated that the subcellular distribution of the adhesion plaque protein, talin, changes dramatically in human platelets in response to platelet activation (Beckerle et al., J. Cell Biol. 109, 3333-3346, 1989). Talin is uniformly distributed throughout the cytoplasm of resting platelets. Howeve...

journal_title：Journal of cell science

authors： Bertagnolli ME,Locke SJ,Hensler ME,Bray PF,Beckerle MC

更新日期：1993-12-01 00:00:00

abstract：:Quantitative information about the range of influence of extracellular signaling molecules is critical for understanding their effects, but is difficult to determine in the complex and dynamic three-dimensional environment of a living embryo. Drosophila germ cells migrate during embryogenesis and use spatial informati...

journal_title：Journal of cell science

authors： Mukherjee A,Neher RA,Renault AD

更新日期：2013-12-01 00:00:00

abstract：:Cyclic stretch is an artificial model of mechanical force loading, which induces the reorientation of vascular endothelial cells and their stress fibers in a direction perpendicular to the stretch axis. Rho family GTPases are crucial for cyclic-stretch-induced endothelial cell reorientation; however, the mechanism und...

journal_title：Journal of cell science

authors： Abiko H,Fujiwara S,Ohashi K,Hiatari R,Mashiko T,Sakamoto N,Sato M,Mizuno K

更新日期：2015-05-01 00:00:00

abstract：:Using a reconstituted complex of profilin and skeletal muscle actin as an antigen, we generated a monoclonal mouse antibody against actin, termed 2G2. As revealed by immunoblots of proteolytic actin fragments and by pepscan analysis, the antibody recognises a nonsequential epitope on actin which is located within thre...

journal_title：Journal of cell science

authors： Gonsior SM,Platz S,Buchmeier S,Scheer U,Jockusch BM,Hinssen H

更新日期：1999-03-01 00:00:00

abstract：:During their development, mammalian oocytes acquire the ability to resume meiosis. We demonstrate that the concentration of p34cdc2 increases during the acquisition of meiotic competence, as determined by immunoblotting, whereas the concentration of cyclin B1 decreases. Laser-scanning confocal microscopy corroborated ...

journal_title：Journal of cell science

authors： Mitra J,Schultz RM

更新日期：1996-09-01 00:00:00

abstract：:RAS isoforms have been proposed to exhibit differing biological outputs due to differences in their relative occupancy of cellular organelles and signalling microdomains. The membrane binding and targeting motifs of RAS are encoded by the C-terminal hypervariable region (HVR), and the precise localisation depends upon...

journal_title：Journal of cell science

authors： Laude AJ,Prior IA

更新日期：2008-02-15 00:00:00

abstract：:Localization and translation of mRNAs within different subcellular domains provides an important mechanism to spatially and temporally introduce new proteins in polarized cells. Neurons make use of this localized protein synthesis during initial growth, regeneration and functional maintenance of their axons. Although ...

journal_title：Journal of cell science

authors： Sahoo PK,Smith DS,Perrone-Bizzozero N,Twiss JL

更新日期：2018-04-13 00:00:00

abstract：:Polarization of the motile cell is associated with the formation of a distinct plasma membrane domain, the pseudopod, whose stabilization determines the directionality of cell movement. The rapid movement of cells over a substrate requires that an essential aspect of cell motility must be the supply of the necessary m...

journal_title：Journal of cell science

authors： Nabi IR

更新日期：1999-06-01 00:00:00

abstract：:The marginal band microtubules of isolated Xenopus erythrocyte cytoskeletons possess the stability properties of non-steady-state microtubules. They are unperturbed by low temperatures, a variety of microtubule inhibitors, hypotonic treatment and the direct action of calcium. These microtubules can be rapidly depolyme...

journal_title：Journal of cell science

authors： Gambino J,Ross MJ,Weatherbee JA,Gavin RH,Eckhardt RA

更新日期：1985-11-01 00:00:00

abstract：:Hemidesmosomes are epithelial-specific attachment structures that maintain tissue integrity and resist tension. Despite their importance, how hemidesmosomes are regulated at the post-transcriptional level is poorly understood. Caenorhabditiselegans hemidesmosomes (CeHDs) have a similar structure and composition to the...

journal_title：Journal of cell science

authors： Fu R,Zhu Y,Jiang X,Li Y,Zhu M,Dong M,Huang Z,Wang C,Labouesse M,Zhang H

更新日期：2018-06-11 00:00:00

abstract：:Megasporogenesis in the heterosporous fern Marsilea (Hydropterideae) shows features intermediate between sporogenesis in homosporous ferns and that in heterosporous seed plants. The plastids in the dyads and young spores were associated with tubules 30-35 nm in diameter, probably a specialized form of endoplasmic reti...

journal_title：Journal of cell science

authors： Bell PR

更新日期：1981-10-01 00:00:00

abstract：:Cell migration is required during development of the nervous system. The regulatory mechanisms for this process, however, are poorly elucidated. We show here that expression of or exposure to the neural cell adhesion molecule (NCAM) strongly affected the motile behaviour of glioma cells independently of homophilic NCA...

journal_title：Journal of cell science

authors： Prag S,Lepekhin EA,Kolkova K,Hartmann-Petersen R,Kawa A,Walmod PS,Belman V,Gallagher HC,Berezin V,Bock E,Pedersen N

更新日期：2002-01-15 00:00:00

abstract：:In epithelial cells integrins are segregated on discrete domains of the plasma membrane. Redistribution may also occur during migration or differentiation. However, little is known about the mechanisms that control such redistribution. Receptor internalization may be a part of one such mechanism. We developed a quanti...

journal_title：Journal of cell science

authors： Gaietta G,Redelmeier TE,Jackson MR,Tamura RN,Quaranta V

更新日期：1994-12-01 00:00:00

abstract：:We use the fungus Ashbya gossypii to investigate how its polar growth machinery is organized to achieve sustained hyphal growth. In slowly elongating hyphae exocyst, cell polarity and polarisome proteins permanently localize as cortical cap at hyphal tips, thus defining the zone of secretory vesicle fusion. In tenfold...

journal_title：Journal of cell science

authors： Köhli M,Galati V,Boudier K,Roberson RW,Philippsen P

更新日期：2008-12-01 00:00:00

abstract：:Keratins 8 and 18 (K8 and K18) are regulated by site-specific phosphorylation in response to multiple stresses. We examined the effect and regulation of hyposmotic stress on keratin phosphorylation. K8 phospho-Ser431 (Ser431-P) becomes dephosphorylated in HT29 cells, but hyperphosphorylated on other K8 but not K18 sit...

journal_title：Journal of cell science

authors： Tao GZ,Toivola DM,Zhou Q,Strnad P,Xu B,Michie SA,Omary MB

更新日期：2006-04-01 00:00:00

abstract：:The effect of a synthetic peptide consisting of Arg-Gly-Asp-Ser (RGDS), the amino acid sequence representing the fibroblast attachment site in fibronectin (FN), was tested on migrating newt epidermal cells. In one approach, skin explants were placed on the bottom of plastic dishes coated with human FN, human fibrinoge...

journal_title：Journal of cell science

authors： Donaldson DJ,Mahan JT,Smith GN Jr

更新日期：1987-05-01 00:00:00

abstract：:p97 (CDC-48 in Caenorhabditis elegans) is a ubiquitin-selective AAA (ATPases associated with diverse cellular activities) chaperone and its key function is to disassemble protein complexes. p97 functions in diverse cellular processes including endoplasmic reticulum (ER)-associated degradation, membrane fusion, and mei...

journal_title：Journal of cell science

authors： Sasagawa Y,Otani M,Higashitani N,Higashitani A,Sato K,Ogura T,Yamanaka K

更新日期：2009-10-15 00:00:00