The polarization of the motile cell.

abstract：:The contractile vacuole of the chloromonadophycean alga Vacuolaria virescens is a permanent structure that possesses a specialized membrane: subunits of this membrane have a diameter of 21-24 nm and in places are arranged in a regular hexagonal pattern. The lateral walls of these subunits form regularly spaced bristle...

journal_title：Journal of cell science

authors： Heywood P

更新日期：1978-06-01 00:00:00

abstract：:Junction dynamics of endothelial cells are based on the integration of signal transduction, cytoskeletal remodeling and contraction, which are necessary for the formation and maintenance of monolayer integrity, but also enable repair and regeneration. The VE-cadherin-catenin complex forms the molecular basis of the ad...

journal_title：Journal of cell science

authors： Cao J,Schnittler H

更新日期：2019-01-03 00:00:00

abstract：:Rab GTPases regulate various membrane trafficking pathways but the mechanisms by which GTPase-activating proteins recognise specific Rabs are not clear. Rab8 is involved in controlling several trafficking processes, including the trafficking of transferrin receptor from the early endosome to the recycling endosome. He...

journal_title：Journal of cell science

authors： Vaibhava V,Nagabhushana A,Chalasani ML,Sudhakar C,Kumari A,Swarup G

更新日期：2012-11-01 00:00:00

abstract：:The transmembrane inner nuclear membrane (INM) protein Samp1 is required for anchoring centrosomes near the nuclei. Using high-resolution fluorescence microscopy we show that Samp1 is distributed in a distinct and characteristic pattern in the nuclear envelope (NE), where it partially colocalizes with the LINC complex...

journal_title：Journal of cell science

authors： Gudise S,Figueroa RA,Lindberg R,Larsson V,Hallberg E

更新日期：2011-06-15 00:00:00

abstract：:Endocytosis is a regulated physiological process by which membrane receptors and their extracellular ligands are internalized. After internalization, they enter the endosomal trafficking pathway for sorting and processing. Amphiphysins consist of a family of proteins conserved throughout evolution that are crucial ele...

journal_title：Journal of cell science

authors： Leprince C,Le Scolan E,Meunier B,Fraisier V,Brandon N,De Gunzburg J,Camonis J

更新日期：2003-05-15 00:00:00

abstract：:Hybrid cell lines between normal rat embryo fibroblasts and TA3B mouse tumour cells, or between TA3B and BI hamster sarcoma cells, have been examined for the expression of the cell surface large external-transformation-sensitive (LETS) protein and the organization of microfilament bundles. LETS protein was detected by...

journal_title：Journal of cell science

authors： Marshall CJ,Humphryes KC,Pollack RE

更新日期：1978-10-01 00:00:00

abstract：:We investigated at the electron microscope level the fate of the three intranuclear structures known to accumulate snRNPs, and which correspond to the punctuate immunofluorescent staining pattern (the coiled bodies, the clusters of interchromatin granules and the interchromatin granule-associated zones) after exposure...

journal_title：Journal of cell science

authors： Puvion-Dutilleul F,Besse S,Chan EK,Tan EM,Puvion E

更新日期：1995-03-01 00:00:00

abstract：:Non-coding RNAs (ncRNAs) are nucleotide sequences that are known to assume regulatory roles previously thought to be reserved for proteins. Their functions include the regulation of protein activity and localization and the organization of subcellular structures. Sequencing studies have now identified thousands of ncR...

journal_title：Journal of cell science

authors： Bensaoud C,Martins LA,Aounallah H,Hackenberg M,Kotsyfakis M

更新日期：2020-11-05 00:00:00

abstract：:An essential step in mammalian fertilisation is the sperm acrosome reaction (AR) - exocytosis of a single large vesicle (the acrosome) that surrounds the nucleus at the apical sperm head. The acrosomal and plasma membranes fuse, resulting in both the release of factors that might facilitate penetration of the zona pel...

journal_title：Journal of cell science

authors： Harper CV,Cummerson JA,White MR,Publicover SJ,Johnson PM

更新日期：2008-07-01 00:00:00

abstract：:Removal of interleukin-3 from murine IC.DP pre-mast cells results in irreversible commitment to apoptosis within 18 hours. To identify early events necessary for the engagement of apoptosis we examined the regulation of intracellular pH (pH(i)). IC.DP cells acidified 2 hours after removal of interleukin-3 (before disc...

journal_title：Journal of cell science

authors： Chen Q,Benson RS,Whetton AD,Brant SR,Donowitz M,Montrose MH,Dive C,Watson AJ

更新日期：1997-02-01 00:00:00

abstract：:Myofibroblasts, characterised by high expression of alpha-smooth muscle actin (alpha-SMA), are important and transient cells in normal wound healing but are found in increased number in various pathological conditions of the lung including asthma and pulmonary fibrosis. The mechanisms that regulate the myofibroblast p...

journal_title：Journal of cell science

authors： Scaffidi AK,Moodley YP,Weichselbaum M,Thompson PJ,Knight DA

更新日期：2001-10-01 00:00:00

abstract：:Plectin, a cytolinker protein greater than 500 kDa in size, has an important role as a mechanical stabiliser of cells. It interlinks the various cytoskeletal filament systems and anchors intermediate filaments to peripheral junctional complexes. In addition, there is increasing evidence that plectin acts as a scaffold...

journal_title：Journal of cell science

authors： Gregor M,Zeöld A,Oehler S,Marobela KA,Fuchs P,Weigel G,Hardie DG,Wiche G

更新日期：2006-05-01 00:00:00

abstract：:Many of the cilia- and flagella-specific integral membrane proteins identified to date function to sense the extracellular milieu, and there is considerable interest in defining pathways for targeting such proteins to these sensory organelles. The flagellar glucose transporter of Leishmania mexicana, LmxGT1, is target...

journal_title：Journal of cell science

authors： Tran KD,Rodriguez-Contreras D,Shinde U,Landfear SM

更新日期：2012-07-15 00:00:00

abstract：:Loss-of-function mutations in the genes encoding PINK1 and Parkin (also known as PARK2) are the most common causes of recessive Parkinson's disease. Both together mediate the selective degradation of mitochondrial proteins and whole organelles via the proteasome and the autophagy-lysosome pathway (mitophagy). The mito...

journal_title：Journal of cell science

authors： Fiesel FC,Moussaud-Lamodière EL,Ando M,Springer W

更新日期：2014-08-15 00:00:00

abstract：:Rabbit muscle myosin subfragment S1 decorates 6 nm diameter filaments in Drosophila wing epidermal cells in the arrowhead fashion characteristic of the binding of subfragment S1 to actin filaments. The filaments in question are concentrated between microtubules that are mostly composed of 15 protofilaments and form ce...

journal_title：Journal of cell science

authors： Mogensen MM,Tucker JB

更新日期：1988-11-01 00:00:00

abstract：:Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) cause the ciliopathies known as Joubert and MORM syndromes; however, the role of INPP5E in ciliary biology is not well understood. Here, we describe an interaction between INPP5E and AURKA, a centrosomal kinase that regulates mitosis and ciliary disassembly,...

journal_title：Journal of cell science

authors： Plotnikova OV,Seo S,Cottle DL,Conduit S,Hakim S,Dyson JM,Mitchell CA,Smyth IM

更新日期：2015-01-15 00:00:00

abstract：:We have identified a novel mammalian protein, MIR1, with microtubule-binding activity. MIR1 is a relative of MID1/midin, the protein implicated in Opitz G/BBB syndrome. In tissue culture cells, MIR1 is enriched at the centrosome. MIR1 dissociates from centrosomes at the G2/M transition and is recruited back to spindle...

journal_title：Journal of cell science

authors： Stein PA,Toret CP,Salic AN,Rolls MM,Rapoport TA

更新日期：2002-09-01 00:00:00

abstract：:Integrins mediate cell adhesion and signal transduction at focal adhesions. Here we investigate the roles of integrin beta subunits in the regulation of actin cytoskeletal structure and the activities of Rho and Rac. The overexpression of beta3 integrin in Chinese hamster ovary cells enhances Rho activity and stress f...

journal_title：Journal of cell science

authors： Miao H,Li S,Hu YL,Yuan S,Zhao Y,Chen BP,Puzon-McLaughlin W,Tarui T,Shyy JY,Takada Y,Usami S,Chien S

更新日期：2002-05-15 00:00:00

abstract：:The plasma membrane Ca2+-ATPase-2 (PMCA2) is expressed in stereocilia of hair cells of the inner ear, whereas PMCA1 is expressed in the basolateral plasma membrane of hair cells. Both extrude excess Ca2+ from the cytosol. They are predicted to contain ten membrane-spanning segments, two large cytoplasmic loops as well...

journal_title：Journal of cell science

authors： Grati M,Aggarwal N,Strehler EE,Wenthold RJ

更新日期：2006-07-15 00:00:00

abstract：:Interactions between melanocytes and neighboring cells in the skin are important in regulating skin color in humans. We recently demonstrated that the less pigmented and thicker skin on the palms and soles is regulated by underlying fibroblasts in those areas, specifically via a secreted factor (DKK1) that modulates W...

journal_title：Journal of cell science

authors： Choi W,Wolber R,Gerwat W,Mann T,Batzer J,Smuda C,Liu H,Kolbe L,Hearing VJ

更新日期：2010-09-15 00:00:00

abstract：:Understanding the interactions between distinct epithelial cells would help us to understand the development of tissues. Drosophila imaginal discs, which are made up of two types of epithelial cells, provide good model systems for such studies. The disc proper or the columnar epithelial cells are apposed to a layer of...

journal_title：Journal of cell science

authors： Pallavi SK,Shashidhara LS

更新日期：2005-08-01 00:00:00

abstract：:During pre-mRNA splicing, introns are removed and exons are ligated to form an mRNA. Exon choice is determined by different nuclear protein concentrations varying among tissues and cell types or by developmental stage. These can be altered by different cellular circumstances such as physiological stimuli, environmenta...

journal_title：Journal of cell science

authors： Shomron N,Alberstein M,Reznik M,Ast G

更新日期：2005-03-15 00:00:00

abstract：:The mechanisms underlying stromal cell supportive functions are incompletely understood but probably implicate a mixture of cytokines, matrix components and cell adhesion molecules. Skeletal muscle uses recruited macrophages to support post-injury regeneration. We and others have previously shown that macrophages secr...

journal_title：Journal of cell science

authors： Sonnet C,Lafuste P,Arnold L,Brigitte M,Poron F,Authier FJ,Chrétien F,Gherardi RK,Chazaud B

更新日期：2006-06-15 00:00:00

abstract：:Actomyosin stress fibers (SFs) enable cells to exert traction on planar extracellular matrices (ECMs) by tensing focal adhesions (FAs) at the cell-ECM interface. Although it is widely appreciated that the spatial and temporal distribution of these tensile forces play key roles in polarity, motility, fate choice, and o...

journal_title：Journal of cell science

authors： Chang CW,Kumar S

更新日期：2013-07-15 00:00:00

abstract：:Pin1/Ess1p is a highly conserved WW domain-containing peptidyl-prolyl isomerase (PPIase); its WW domain binds specifically to phospho-Ser/Thr-Pro sequences and its catalytic domain isomerizes phospho-Ser/Thr-Pro bonds. Pin1 PPIase activity can alter protein conformation in a phosphorylation-dependent manner and/or pro...

journal_title：Journal of cell science

authors： Huang HK,Forsburg SL,John UP,O'Connell MJ,Hunter T

更新日期：2001-10-01 00:00:00

abstract：:The peroxin Pex11 has a recognized role in peroxisome division. Pex11p remodels and elongates peroxisomal membranes prior to the recruitment of dynamin-related GTPases that act in membrane scission to divide peroxisomes. We performed a comprehensive comparative genomics survey to understand the significance of the evo...

journal_title：Journal of cell science

authors： Chang J,Klute MJ,Tower RJ,Mast FD,Dacks JB,Rachubinski RA

更新日期：2015-04-01 00:00:00

abstract：:The metabolism of PI(3,5)P2 is regulated by the PIKfyve, VAC14 and FIG4 complex, mutations in which are associated with hypopigmentation in mice. These pigmentation defects indicate a key, but as yet unexplored, physiological relevance of this complex in the biogenesis of melanosomes. Here, we show that PIKfyve activi...

journal_title：Journal of cell science

authors： Bissig C,Croisé P,Heiligenstein X,Hurbain I,Lenk GM,Kaufman E,Sannerud R,Annaert W,Meisler MH,Weisman LS,Raposo G,van Niel G

更新日期：2019-02-28 00:00:00

abstract：:Reactive oxygen species (ROS) produced by the NADPH oxidase (NOX) complex play important physiological and pathological roles in neurotransmission and neurodegeneration, respectively. However, the contribution of ROS to the molecular mechanisms involved in neuronal polarity and axon elongation is not well understood. ...

journal_title：Journal of cell science

authors： Wilson C,Núñez MT,González-Billault C

更新日期：2015-08-15 00:00:00

abstract：:The translationally controlled protein P23 was discovered by the early induction of its rate of synthesis after mitogenic stimulation of mouse fibroblasts. P23 is expressed in almost all mammalian tissues and it is highly conserved between animals, plants and yeast. Based on its amino acid sequence, P23 cannot be attr...

journal_title：Journal of cell science

authors： Gachet Y,Tournier S,Lee M,Lazaris-Karatzas A,Poulton T,Bommer UA

更新日期：1999-04-01 00:00:00

abstract：:Cytoplasmic dynein-2 is a motor protein complex that drives the movement of cargoes along microtubules within cilia, facilitating the assembly of these organelles on the surface of nearly all mammalian cells. Dynein-2 is crucial for ciliary function, as evidenced by deleterious mutations in patients with skeletal abno...

journal_title：Journal of cell science

authors： Vuolo L,Stevenson NL,Mukhopadhyay AG,Roberts AJ,Stephens DJ

更新日期：2020-03-30 00:00:00