Abstract：
:Interactions between melanocytes and neighboring cells in the skin are important in regulating skin color in humans. We recently demonstrated that the less pigmented and thicker skin on the palms and soles is regulated by underlying fibroblasts in those areas, specifically via a secreted factor (DKK1) that modulates Wnt signaling. In this study, we tested the hypothesis that dermal fibroblasts regulate the constitutive skin color of individuals ranging from very light to very dark. We used microarray analysis to compare gene expression patterns in fibroblasts derived from lighter skin types compared to darker skin types, with a focus on secreted proteins. We identified a number of genes that differ dramatically in expression and, among the expressed proteins, neuregulin-1, which is secreted by fibroblasts derived from dark skin, effectively increases the pigmentation of melanocytes in tissue culture and in an artificial skin model and regulates their growth, suggesting that it is one of the major factors determining human skin color.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Choi W,Wolber R,Gerwat W,Mann T,Batzer J,Smuda C,Liu H,Kolbe L,Hearing VJdoi
10.1242/jcs.064774subject
Has Abstractpub_date
2010-09-15 00:00:00pages
3102-11issue
Pt 18eissn
0021-9533issn
1477-9137pii
jcs.064774journal_volume
123pub_type
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