Abstract:
:Atherosclerosis depends on risk factors such as hyperlipidemia, smoking, hypertension and diabetes. Although these risk factors are relatively constant throughout the arterial circulation, atherosclerotic plaques occur at specific sites where flow patterns are disturbed, with lower overall magnitude and complex changes in speed and direction. Research over the past few decades has provided new insights into the cellular mechanisms of force transduction and how mechanical effects act in concert with conventional risk factors to mediate plaque formation and progression. This Commentary summarizes our current understanding of how mechanotransduction pathways synergize with conventional risk factors in atherosclerosis. We attempt to integrate cellular studies with animal and clinical data, and highlight major questions that need to be answered to develop more effective therapies.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Conway DE,Schwartz MAdoi
10.1242/jcs.138313subject
Has Abstractpub_date
2013-11-15 00:00:00pages
5101-9issue
Pt 22eissn
0021-9533issn
1477-9137pii
jcs.138313journal_volume
126pub_type
杂志文章abstract::Angiogenesis is critical for vascular remodeling during development and contributes to the pathogenesis of diseases such as cancer. Targeted disruption of several EphB class receptor tyrosine kinases results in vascular remodeling defects during embryogenesis. The role of EphA class receptors in vascular remodeling, h...
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journal_title:Journal of cell science
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journal_title:Journal of cell science
pub_type: 杂志文章
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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doi:
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journal_title:Journal of cell science
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doi:
更新日期:1993-11-01 00:00:00
abstract::Natural killer (NK) cells eliminate abnormal cells through the release of cytolytic granule contents. In this process, NK cells must adhere to target cells through integrin-mediated adhesion, which is highly dependent on the generation of F-actin. Ena/VASP-like (EVL) is an actin regulatory protein previously shown to ...
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journal_title:Journal of cell science
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doi:
更新日期:1995-04-01 00:00:00
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更新日期:2015-07-15 00:00:00
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journal_title:Journal of cell science
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doi:
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