Intermicrotubular actin filaments in the transalar cytoskeletal arrays of Drosophila.

abstract：:Dynamic assembly and remodeling of actin is critical for many cellular processes during development and stress adaptation. In filamentous fungi and budding yeast, actin cables align in a polarized manner along the mother-to-daughter cell axis, and are essential for the establishment and maintenance of polarity; moreov...

journal_title：Journal of cell science

authors： Xie Y,Miao Y

更新日期：2021-01-08 00:00:00

abstract：:Transcription factor IIH (TFIIH) participates in transcription, nucleotide excision repair and the control of the cell cycle. In the present study, we demonstrate that the Dmp52 subunit of TFIIH in Drosophila physically interacts with the fly p53 homologue, Dp53. The depletion of Dmp52 in the wing disc generates chrom...

journal_title：Journal of cell science

authors： Villicaña C,Cruz G,Zurita M

更新日期：2013-06-01 00:00:00

abstract：:Protein kinases AKT and PKBR1 of Dictyostelium belong to the AGC protein kinase superfamily. AKT and PKBR1 are phosphorylated at similar sites by phosphoinositide-dependent kinase 1 (PDK1) and TORC2 kinases; however, they have different subcellular localizing domains. AKT has a phosphoinositide 3-kinase (PI3K)/phospha...

journal_title：Journal of cell science

authors： Liao XH,Buggey J,Kimmel AR

更新日期：2010-03-15 00:00:00

abstract：:Super-resolution fluorescence imaging by single-molecule photoactivation or photoswitching and position determination (localization microscopy) has the potential to fundamentally revolutionize our understanding of how cellular function is encoded at the molecular level. Among all powerful, high-resolution imaging tech...

journal_title：Journal of cell science

authors： Sauer M

更新日期：2013-08-15 00:00:00

abstract：:Vaccinia virus B1 kinase plays a key role in viral DNA replication. The homologous mammalian vaccinia-related kinases (VRKs) are also implicated in the regulation of DNA replication, although direct evidence remains elusive. Here we show that VRK1 regulates cell cycle progression in the DNA replication period by induc...

journal_title：Journal of cell science

authors： Kang TH,Park DY,Kim W,Kim KT

更新日期：2008-09-15 00:00:00

abstract：:The sensory functions of cilia are dependent on the enrichment of cilium-resident proteins. Although it is known that ciliary targeting signals (CTSs) specifically target ciliary proteins to cilia, it is still unclear how CTSs facilitate the entry and retention of cilium-resident proteins at the molecular level. We fo...

journal_title：Journal of cell science

authors： Madugula V,Lu L

更新日期：2016-10-15 00:00:00

abstract：:Nuclear calcium signalling has been a controversial battlefield for many years and the question of how permeable the nuclear pore complexes (NPCs) are to Ca2+ has been the subject of a particularly hot dispute. Recent data from isolated nuclei suggest that the NPCs are open even after depletion of the Ca2+ store in th...

journal_title：Journal of cell science

authors： Gerasimenko O,Gerasimenko J

更新日期：2004-07-01 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) plays an important role in development and maintenance of murine yolk sac vascular development. Targeted deletions of Tgfb1 and other components of this signaling pathway, such as Acvrl1, Tgfbr1 and Tgfbr2, result in abnormal vascular development especially of the yolk sac, le...

journal_title：Journal of cell science

authors： Poon E,Clermont F,Firpo MT,Akhurst RJ

更新日期：2006-02-15 00:00:00

abstract：:Agrin, a 200 kDa extracellular matrix protein, participates in the maturation of the postsynaptic target at the neuromuscular junction. Although agrin has also been detected in central neurons, little is known about its role in the formation of their synapses. In the present study, the pattern of expression, localizat...

journal_title：Journal of cell science

authors： Ferreira A

更新日期：1999-12-01 00:00:00

abstract：:Syndecan-4 is a ubiquitously expressed transmembrane heparan sulphate proteoglycan acting in concert with integrins in the formation of focal adhesions and stress fibres. Signalling events studied thus far suggest the formation of a ternary complex between syndecan-4, phosphatidylinositol 4,5-bisphosphate and protein ...

journal_title：Journal of cell science

authors： Dovas A,Yoneda A,Couchman JR

更新日期：2006-07-01 00:00:00

abstract：:Nearly all intermediate filament (IF) proteins share two sequence motifs located at the N- and the C-terminal ends of their helical rod domain ('coil 1a' and 'coil 2b', respectively). To examine the structural role of the coil 2b motif, we have performed in vitro assembly studies and in vivo microinjection experiments...

journal_title：Journal of cell science

authors： Kouklis PD,Traub P,Georgatos SD

更新日期：1992-05-01 00:00:00

abstract：:Although the long-term effects of all-trans retinoic acid (RA) on neuronal growth and differentiation have been intensively studied, nothing is known about its effect on synaptic transmission. Here we show that RA rapidly and specifically enhances the spontaneous acetylcholine release at developing neuromuscular synap...

journal_title：Journal of cell science

authors： Liao YP,Ho SY,Liou JC

更新日期：2004-06-15 00:00:00

abstract：:The contractile vacuole complex (CVC) of Trypanosoma cruzi, the etiologic agent of Chagas disease, collects and expels excess water as a mechanism of regulatory volume decrease after hyposmotic stress; it also has a role in cell shrinking after hyperosmotic stress. Here, we report that, in addition to its role in osmo...

journal_title：Journal of cell science

authors： Niyogi S,Jimenez V,Girard-Dias W,de Souza W,Miranda K,Docampo R

更新日期：2015-06-15 00:00:00

abstract：:Podosomes, adhesion structures capable of matrix degradation, have been linked with the ability of cells to perform chemotaxis and invade tissues. Wiskott-Aldrich Syndrome protein (WASp), an effector of the RhoGTPase Cdc42 and a Src family kinase substrate, regulates macrophage podosome formation. In this study, we de...

journal_title：Journal of cell science

authors： Dovas A,Gevrey JC,Grossi A,Park H,Abou-Kheir W,Cox D

更新日期：2009-11-01 00:00:00

abstract：:Two monoclonal antibodies, BA16 and BA17, have been developed using a detergent-insoluble extract of human mammary epithelial organoids as immunogen. Indirect immunofluorescent staining of cultured cells showed that the component reacting with the antibodies was filamentous and the intensity of staining was stronger i...

journal_title：Journal of cell science

authors： Bartek J,Durban EM,Hallowes RC,Taylor-Papadimitriou J

更新日期：1985-04-01 00:00:00

abstract：:Although significant progress has recently been made in culturing mammalian urothelial cells, relatively little is known about their biochemical differentiation. In this paper, we assessed the differentiation state of cultured bovine urothelial cells by analyzing their keratins and a cell surface marker, uroplakin I. ...

journal_title：Journal of cell science

authors： Surya B,Yu J,Manabe M,Sun TT

更新日期：1990-11-01 00:00:00

abstract：:Molecular mechanisms of chemotactic response are highly conserved among many eukaryotic cells including human leukocytes and Dictyostelium discoideum cells. The cells can sense the differences in chemoattractant concentration across the cell body and respond by extending pseudopods from the cell side facing to a highe...

journal_title：Journal of cell science

authors： Matsuoka S,Iijima M,Watanabe TM,Kuwayama H,Yanagida T,Devreotes PN,Ueda M

更新日期：2006-03-15 00:00:00

abstract：:A dysregulation in the clearance of apoptotic material is considered a major pathogenetic factor for the emergence of autoimmune diseases. Apoptotic-cell-derived membrane microparticles (AdMPs), which are released from the cell surface during apoptosis, have been implicated in the pathogenesis of autoimmunity. Also of...

journal_title：Journal of cell science

authors： Niessen A,Heyder P,Krienke S,Blank N,Tykocinski LO,Lorenz HM,Schiller M

更新日期：2015-07-15 00:00:00

abstract：:Casein kinase 1 (CK1) plays central roles in various signal transduction pathways and performs many cellular activities. For many years CK1 was thought to act independently of modulatory subunits and in a constitutive manner. Recently, DEAD box RNA helicases, in particular DEAD box RNA helicase 3 X-linked (DDX3X), wer...

journal_title：Journal of cell science

authors： Dolde C,Bischof J,Grüter S,Montada A,Halekotte J,Peifer C,Kalbacher H,Baumann U,Knippschild U,Suter B

更新日期：2018-01-04 00:00:00

abstract：:Notch signalling is used throughout the animal kingdom to spatially and temporally regulate cell fate, proliferation and differentiation. Its importance is reflected in the dramatic effects produced on both development and health by small variations in the strength of the Notch signal. The Down-syndrome-associated kin...

journal_title：Journal of cell science

authors： Fernandez-Martinez J,Vela EM,Tora-Ponsioen M,Ocaña OH,Nieto MA,Galceran J

更新日期：2009-05-15 00:00:00

abstract：:Occludin and 18 distinct members of the claudin family are tetra-span transmembrane proteins that are localized in cell-specific tight junctions (TJs). A previous study showed that expression of chick occludin in Madin-Darby canine kidney (MDCK) cells raised transepithelial electrical resistance (TER) and, paradoxical...

journal_title：Journal of cell science

authors： McCarthy KM,Francis SA,McCormack JM,Lai J,Rogers RA,Skare IB,Lynch RD,Schneeberger EE

更新日期：2000-10-01 00:00:00

abstract：:Neurite outgrowth is known as a slow (days) process occurring in nerve cells and neurons during neurotrophin treatment and upon transfer to culture, respectively. Using Y27632, a drug that induces activation of Rac1, a downstream step of the neurotrophin signaling cascade, we have identified a new form of outgrowth, w...

journal_title：Journal of cell science

authors： Racchetti G,Lorusso A,Schulte C,Gavello D,Carabelli V,D'Alessandro R,Meldolesi J

更新日期：2010-01-15 00:00:00

abstract：:The plasma membrane of cells is composed of lateral heterogeneities, patches and microdomains. These membrane microdomains or lipid rafts are enriched in glycosphingolipids and cholesterol and have been implicated in cellular processes such as membrane sorting and signal transduction. In this study we investigated the...

journal_title：Journal of cell science

authors： Triantafilou M,Miyake K,Golenbock DT,Triantafilou K

更新日期：2002-06-15 00:00:00

abstract：:Osh6 and Osh7 are lipid transfer proteins (LTPs) that move phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM). High PS levels at the PM are key for many cellular functions. Intriguingly, Osh6 and Osh7 localize to ER-PM contact sites, although they lack membrane-targeting motifs, in...

journal_title：Journal of cell science

authors： D'Ambrosio JM,Albanèse V,Lipp NF,Fleuriot L,Debayle D,Drin G,Čopič A

更新日期：2020-06-04 00:00:00

abstract：:In the cytoplasm of chlorenchyma cells in primary Origanum dictamnus leaves, rectangular prism-like crystals occur, which, as shown by pepsin digestion, are proteinaceous. In sections they usually show either a square lattice or striations running parallel to the short or long axis. In both cases the interspacings are...

journal_title：Journal of cell science

authors： Bosabalidis AM,Papadopoulos D

更新日期：1983-11-01 00:00:00

abstract：:Every two years, the French Society for Cell Biology (SBCF) organises an international meeting called 'Imaging the Cell'. This year, the 8th edition was held on 24-26 June 2015 at University of Bordeaux Campus Victoire in the city of Bordeaux, France, a UNESCO World Heritage site. Over the course of three days, the me...

journal_title：Journal of cell science

authors： Moreau V,Cordelières FP,Poujol C,Sagot I,Saltel F

更新日期：2015-11-01 00:00:00

abstract：:SNARE (Soluble N-ethyl-maleimide sensitive factor Attachment protein Receptor) proteins assemble in tight core complexes, which promote fusion of carrier vesicles with target compartments. Members of this class of proteins are expressed in all eukaryotic cells and are distributed in distinct subcellular compartments. ...

journal_title：Journal of cell science

authors： Rowe J,Calegari F,Taverna E,Longhi R,Rosa P

更新日期：2001-09-01 00:00:00

abstract：:Atomic force microscopy (AFM) was used to probe topology, conformational changes and initial substrate-carrier interactions of Na+-glucose co-transporter (SGLT1) in living cells on a single-molecule level. By scanning SGLT1-transfected Chinese hamster ovary (CHO) cells with AFM tips carrying an epitope-specific antibo...

journal_title：Journal of cell science

authors： Puntheeranurak T,Wildling L,Gruber HJ,Kinne RK,Hinterdorfer P

更新日期：2006-07-15 00:00:00

abstract：:Increases in cytosolic Ca(2+) concentration ([Ca(2+)](c)) mediated by inositol (1,4,5)-trisphosphate [Ins(1,4,5)P(3), hereafter InsP(3)] regulate activities that include division, contraction and cell death. InsP(3)-evoked Ca(2+) release often begins at a single site, then regeneratively propagates through the cell as...

journal_title：Journal of cell science

authors： Olson ML,Sandison ME,Chalmers S,McCarron JG

更新日期：2012-11-15 00:00:00

abstract：:Members of the PKC superfamily have been implicated in various migratory models and in particular in spatially restricted processes. However, defining the precise local events that underlie the PKC-dependent processes is constrained by the unspecific nature of interventions. Here we address this problem in relation to...

journal_title：Journal of cell science

authors： Boeckeler K,Rosse C,Howell M,Parker PJ

更新日期：2010-08-15 00:00:00