BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation.

abstract：:Perilipin family proteins (Plins) coat the surface of intracellular neutral lipid storage droplets in various cell types. Studies across diverse species demonstrate that Plins regulate lipid storage metabolism through recruitment of lipases and other regulatory proteins to lipid droplet surfaces. Mammalian genomes hav...

journal_title：Journal of cell science

authors： Hsieh K,Lee YK,Londos C,Raaka BM,Dalen KT,Kimmel AR

更新日期：2012-09-01 00:00:00

abstract：:Planar cell polarity (PCP) has been demonstrated in the epithelium of organisms from flies to humans. Recent research has revealed that the planar organization of cells requires a conserved set of genes, known as the PCP genes. Tbe PCP proteins Frizzled (Fz) and Dishevelled (Dsh) function as key players in PCP signall...

journal_title：Journal of cell science

authors： Fanto M,McNeill H

更新日期：2004-02-01 00:00:00

abstract：:Start is the main decision point in the eukaryotic cell cycle at which cells commit to a new round of cell division. It involves the irreversible activation of a transcriptional programme through the inactivation of Start transcriptional repressors: the retinoblastoma family in mammals, or Whi5 and its recently identi...

journal_title：Journal of cell science

authors： Méndez E,Gomar-Alba M,Bañó MC,Mendoza M,Quilis I,Igual JC

更新日期：2020-12-21 00:00:00

abstract：:Axonemal dyneins are multisubunit molecular motors that provide the driving force for flagellar motility. Dynein light chain 1 (LC1) has been well studied in Chlamydomonas reinhardtii and is unique among all dynein components as the only protein known to bind directly to the catalytic motor domain of the dynein heavy ...

journal_title：Journal of cell science

authors： Baron DM,Kabututu ZP,Hill KL

更新日期：2007-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in the development of skeletal muscle. In our previous study, expression of miR-195 and miR-497 were shown to be upregulated during muscle development in pigs. In this study, we investigated the roles of these two miRNAs in myogenesis and analyzed their transcriptional regulatio...

journal_title：Journal of cell science

authors： Wei W,Zhang WY,Bai JB,Zhang HX,Zhao YY,Li XY,Zhao SH

更新日期：2016-01-01 00:00:00

abstract：:Cannabinoid receptors (CBRs) belong to the G protein-coupled receptor superfamily, and activation of CBRs in salivary cells inhibits agonist-stimulated salivation and modifies saliva content. However, the role of different CBR subtypes in acinar cell physiology and in intracellular signalling remains unclear. Here, we...

journal_title：Journal of cell science

authors： Kopach O,Vats J,Netsyk O,Voitenko N,Irving A,Fedirko N

更新日期：2012-04-15 00:00:00

abstract：:Eukaryotic cells replicate and partition their organelles between the mother cell and the daughter cell at cytokinesis. Polarized cells, notably the budding yeast Saccharomyces cerevisiae, are well suited for the study of organelle inheritance, as they facilitate an experimental dissection of organelle transport and r...

journal_title：Journal of cell science

authors： Knoblach B,Rachubinski RA

更新日期：2015-02-15 00:00:00

abstract：:Transcription factor E2F plays an important role in coordinating and integrating early cell cycle progression with the transcription apparatus. It is known that physiological E2F arises when a member of two families of proteins, E2F and DP, interact as E2F/DP heterodimers and that transcriptional activity is regulated...

journal_title：Journal of cell science

authors： Allen KE,de la Luna S,Kerkhoven RM,Bernards R,La Thangue NB

更新日期：1997-11-01 00:00:00

abstract：:The ribonucleoprotein enzyme RNase P catalyzes the 5' processing of pre-transfer RNA, and has also recently been implicated in pre-ribosomal RNA processing. In the present investigation, in situ hybridization revealed that RNase P RNA is present throughout the nucleus of mammalian cells. However, rhodamine-labeled hum...

journal_title：Journal of cell science

authors： Jacobson MR,Cao LG,Taneja K,Singer RH,Wang YL,Pederson T

更新日期：1997-04-01 00:00:00

abstract：:The protein import machinery of the peroxisome consists of many proteins, collectively called the peroxins. By applying the split-ubiquitin technique we systematically tested the pair-wise interactions between the Nub- and Cub-labeled peroxins for the first time in the living cells of the yeast Saccharomyces cerevisia...

journal_title：Journal of cell science

authors： Eckert JH,Johnsson N

更新日期：2003-09-01 00:00:00

abstract：:Recent studies suggest that cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) elicit cell proliferation and promote angiogenesis. The aim of this study was to determine the role of CYP 2C8/9-derived EETs in the process of angiogenesis under hypoxic conditions. In human endothelial cells, hypox...

journal_title：Journal of cell science

authors： Michaelis UR,Fisslthaler B,Barbosa-Sicard E,Falck JR,Fleming I,Busse R

更新日期：2005-12-01 00:00:00

abstract：:Previously, we demonstrated that proteolytic processing within the globular domain of the alpha3 subunit of laminin-5 (LN5) converts LN5 from a cell motility-inducing factor to a protein complex that can trigger the formation of hemidesmosomes, certain cell-matrix attachment sites found in epithelial cells. We have pr...

journal_title：Journal of cell science

authors： Goldfinger LE,Hopkinson SB,deHart GW,Collawn S,Couchman JR,Jones JC

更新日期：1999-08-01 00:00:00

abstract：:We report a fast method for the isolation of homogeneous C-protein from bovine skeletal muscle. In electron micrographs C-protein appears as short rods with a relatively uniform length of about 50 nm. Protein sequencing shows a single N-terminal sequence. Radio-labelled C-protein strongly decorates titin II and myosin...

journal_title：Journal of cell science

authors： Fürst DO,Vinkemeier U,Weber K

更新日期：1992-08-01 00:00:00

abstract：:Prion diseases are fatal neurodegenerative diseases characterised by the accumulation of misfolded prion protein (PrP(Sc)) in the brain. They are caused by the templated misfolding of normal cellular protein, PrP(C), by PrP(Sc). We have recently generated a unique cell system in which epitope-tagged PrP(C) competent t...

journal_title：Journal of cell science

authors： Goold R,McKinnon C,Rabbanian S,Collinge J,Schiavo G,Tabrizi SJ

更新日期：2013-08-15 00:00:00

abstract：:Meiotic cell cycles differ from mitotic cell cycles in that the former lack S-phase in the interphase between meiosis I and meiosis II. To obtain clues for mechanisms involved in the cell cycle regulation unique to meiosis, we have examined changes in chromosomal morphology and H1 kinase activity during a meiotic peri...

journal_title：Journal of cell science

authors： Ohsumi K,Sawada W,Kishimoto T

更新日期：1994-11-01 00:00:00

abstract：:Accumulation of adipocytes and collagen type-I-producing cells (fibrosis) is observed in muscular dystrophies. The origin of these cells had been largely unknown, but recently we identified mesenchymal progenitors positive for platelet-derived growth factor receptor alpha (PDGFRα) as the origin of adipocytes in skelet...

journal_title：Journal of cell science

authors： Uezumi A,Ito T,Morikawa D,Shimizu N,Yoneda T,Segawa M,Yamaguchi M,Ogawa R,Matev MM,Miyagoe-Suzuki Y,Takeda S,Tsujikawa K,Tsuchida K,Yamamoto H,Fukada S

更新日期：2011-11-01 00:00:00

abstract：:RINGO/Speedy proteins are direct activators of Cdk1 and Cdk2 that have no sequence homology to cyclins. We have characterized the role in cell-cycle progression of a new human member of this protein family referred to as RINGO C. We show that siRNA-mediated knockdown of RINGO C results in premature mitotic exit with m...

journal_title：Journal of cell science

authors： Mourón S,de Cárcer G,Seco E,Fernández-Miranda G,Malumbres M,Nebreda AR

更新日期：2010-08-01 00:00:00

abstract：:The polarized functions of epithelia require an intact tight junction (TJ) to restrict paracellular movement and to separate membrane proteins into specific domains. TJs contain scaffolding, integral membrane and signaling proteins, but the mechanisms that regulate TJs and their assembly are not well defined. Galpha12...

journal_title：Journal of cell science

authors： Sabath E,Negoro H,Beaudry S,Paniagua M,Angelow S,Shah J,Grammatikakis N,Yu AS,Denker BM

更新日期：2008-03-15 00:00:00

abstract：:The position of the nucleus is regulated in different developmental stages and cellular events. During polarization, the nucleus moves away from the future leading edge and this movement is required for proper cell migration. Nuclear movement requires the LINC complex components nesprin-2G and SUN2, which form transme...

journal_title：Journal of cell science

authors： Borrego-Pinto J,Jegou T,Osorio DS,Auradé F,Gorjánácz M,Koch B,Mattaj IW,Gomes ER

更新日期：2012-03-01 00:00:00

abstract：:The CCAAT/enhancer-binding protein beta (C/EBPbeta, also known as CEBPB) was first identified as a regulator of differentiation and inflammatory processes in adipose tissue and liver. Although C/EBPbeta was initially implicated in synaptic plasticity, its function in the brain remains largely unknown. We have previous...

journal_title：Journal of cell science

authors： Cortes-Canteli M,Luna-Medina R,Sanz-Sancristobal M,Alvarez-Barrientos A,Santos A,Perez-Castillo A

更新日期：2008-04-15 00:00:00

abstract：:Primary cilia are conserved organelles that play crucial roles as mechano- and chemosensors, as well as transducing signaling cascades. Consequently, ciliary dysfunction results in a broad range of phenotypes: the ciliopathies. Bardet-Biedl syndrome (BBS), a model ciliopathy, is caused by mutations in 16 known genes. ...

journal_title：Journal of cell science

authors： Gascue C,Tan PL,Cardenas-Rodriguez M,Libisch G,Fernandez-Calero T,Liu YP,Astrada S,Robello C,Naya H,Katsanis N,Badano JL

更新日期：2012-01-15 00:00:00

abstract：:Sexual reproduction (conjugation) in protozoan ciliates is induced by specific cell-cell interactions between cells of complementary mating types. The ancestral ciliate Blepharisma japonicum has two mating types, I and II. The substances that act as signaling molecules in this extracellular interaction for conjugation...

journal_title：Journal of cell science

authors： Sugiura M,Kawahara S,Iio H,Harumoto T

更新日期：2005-06-15 00:00:00

abstract：:The translationally controlled tumor protein (TCTP; also known as TPT1 in mammals) is highly conserved and ubiquitously expressed in eukaryotes. It is involved in growth and development, cell cycle progression, protection against cellular stresses and apoptosis, indicating the multifunctional role of the protein. Here...

journal_title：Journal of cell science

authors： Jojic B,Amodeo S,Bregy I,Ochsenreiter T

更新日期：2018-05-10 00:00:00

abstract：:HT-29 cells selected by adaptation to 10(-5) M methotrexate (HT-29 MTX) are a homogeneous cell population producing high amounts of mucin. Intracellular mucins and proteoglycans were isolated from these cells by ultracentrifugation of cell lysates on a cesium bromide gradient and further separated by anion-exchange hi...

journal_title：Journal of cell science

authors： Huet G,Kim I,de Bolos C,Lo-Guidice JM,Moreau O,Hemon B,Richet C,Delannoy P,Real FX,Degand P

更新日期：1995-03-01 00:00:00

abstract：:The COP9 signalosome (CSN) is an evolutionarily conserved macromolecular complex that interacts with cullin-RING E3 ligases (CRLs) and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The CSN sequesters inactive CRL4(Ddb2), which rapidly dissociates from the CSN upon DNA damage. Here we systematically ...

journal_title：Journal of cell science

authors： Olma MH,Roy M,Le Bihan T,Sumara I,Maerki S,Larsen B,Quadroni M,Peter M,Tyers M,Pintard L

更新日期：2009-04-01 00:00:00

abstract：:Neutrophil extracellular traps (NETs) are one of the most intriguing discoveries in immunological research of the past few years. After their first description in 2004, the number of research articles on how NETs affect immunodefense, and also how they contribute to an ever-growing number of diseases, has skyrocketed....

journal_title：Journal of cell science

authors： Neubert E,Meyer D,Kruss S,Erpenbeck L

更新日期：2020-03-10 00:00:00

abstract：:The movement of cells in small groups, or clusters, was studied in vitro using epithelioid cells from Gordon-Kosswig melanomas (from poecelid fish) and time-lapse cinemicrography. Tumour explants cultured on glass yield cell sheets from which groups of cells separate and become independently motile clusters. These clu...

journal_title：Journal of cell science

authors： Kolega J

更新日期：1981-06-01 00:00:00

abstract：:Stages of meiosis from the bluebell Endymion non-scriptus (L.) were studied by electron microscopy. The nucleolus went through the process of segregation at the beginning of meiosis with the movement to its surface of a pale-staining region. This region was shown to be the same as that called the 'L zone' or lacunae o...

journal_title：Journal of cell science

authors： Jordan EG,Luck BT

更新日期：1976-10-01 00:00:00

abstract：:Poly(ADP-ribosyl)ation is a post-translational modification of proteins involved in the regulation of chromatin structure, DNA metabolism, cell division and cell death. Through the hydrolysis of poly(ADP-ribose) (PAR), Poly(ADP-ribose) glycohydrolase (PARG) has a crucial role in the control of life-and-death balance f...

journal_title：Journal of cell science

authors： Amé JC,Fouquerel E,Gauthier LR,Biard D,Boussin FD,Dantzer F,de Murcia G,Schreiber V

更新日期：2009-06-15 00:00:00

abstract：:Distinctive views of the tubulo-vesicular elements interposed between the endoplasmic reticulum (ER) and the Golgi apparatus were obtained in thin sections. The tubules that protrude from the transitional rough ER (tRER) are of dissimilar length. The numbers of tubules and of the nearby omega- and pear-shaped profiles...

journal_title：Journal of cell science

authors： Sesso A,de Faria FP,Iwamura ES,Corrêa H

更新日期：1994-03-01 00:00:00