Loss of PPARγ in endothelial cells leads to impaired angiogenesis.

abstract：:The complex formed by Rad9, Rad1 and Hus1 (9-1-1) protects against genomic instability by activating DNA damage checkpoint and DNA damage repair pathways, mainly in response to replication fork collapse and UV lesions. Here we compare the role of Rad9A (also known as Rad9) with the human paralogue Rad9B. Unlike Rad9A,...

journal_title：Journal of cell science

authors： Pérez-Castro AJ,Freire R

更新日期：2012-03-01 00:00:00

abstract：:Serotonin receptors 5-HT(1A) and 5-HT(7) are highly coexpressed in brain regions implicated in depression. However, their functional interaction has not been established. In the present study we show that 5-HT(1A) and 5-HT(7) receptors form heterodimers both in vitro and in vivo. Foerster resonance energy transfer-bas...

journal_title：Journal of cell science

authors： Renner U,Zeug A,Woehler A,Niebert M,Dityatev A,Dityateva G,Gorinski N,Guseva D,Abdel-Galil D,Fröhlich M,Döring F,Wischmeyer E,Richter DW,Neher E,Ponimaskin EG

更新日期：2012-05-15 00:00:00

abstract：:end13-1 was isolated in a screen for endocytosis mutants and has been shown to have a post-internalisation defect in endocytic transport as well as a defect in vacuolar protein sorting (Vps(-) phenotype), leading to secretion of newly synthesised vacuolar proteins. Here we demonstrate that END13 is identical to VPS4, ...

journal_title：Journal of cell science

authors： Zahn R,Stevenson BJ,Schröder-Köhne S,Zanolari B,Riezman H,Munn AL

更新日期：2001-05-01 00:00:00

abstract：:The nuclear envelope is much more than a simple barrier between nucleoplasm and cytoplasm. Nuclear envelope bridging complexes are protein complexes spanning both the inner and outer nuclear envelope membranes, thus directly connecting the cytoplasm with the nucleoplasm. In metazoans, they are involved in connecting t...

journal_title：Journal of cell science

authors： Meier I

更新日期：2016-10-01 00:00:00

abstract：:Alpha-satellite (alphoid) DNA is necessary for de novo formation of human artificial chromosomes (HACs) in human cultured cells. To investigate the relationship among centromeric, transcriptionally permissive and non-permissive chromatin assemblies on de novo HAC formation, we constructed bacterial artificial chromoso...

journal_title：Journal of cell science

authors： Nakashima H,Nakano M,Ohnishi R,Hiraoka Y,Kaneda Y,Sugino A,Masumoto H

更新日期：2005-12-15 00:00:00

abstract：:The vacuolar H(+)-ATPase (V-ATPase) establishes pH gradients along secretory and endocytic pathways. Progressive acidification is essential for proteolytic processing of prohormones and aggregation of soluble content proteins. The V-ATPase V(0) subunit is thought to have a separate role in budding and fusion events. P...

journal_title：Journal of cell science

authors： Sobota JA,Bäck N,Eipper BA,Mains RE

更新日期：2009-10-01 00:00:00

abstract：:During the prometaphase stage of mitosis, the cell builds a bipolar spindle of microtubules that mechanically segregates sister chromatids between two daughter cells in anaphase. The spindle assembly checkpoint (SAC) is a quality control mechanism that monitors proper attachment of microtubules to chromosome kinetocho...

journal_title：Journal of cell science

authors： Courtheoux T,Diallo A,Damodaran AP,Reboutier D,Watrin E,Prigent C

更新日期：2018-04-12 00:00:00

abstract：:Embryonal rhabdomyosarcomas (ERMSs) show elevated levels of PAX7, a transcription factor that marks quiescent adult muscle stem (satellite) cells and is important for proliferation and survival of activated satellite cells and whose timely repression is required for myogenic differentiation. However, the mechanism of ...

journal_title：Journal of cell science

authors： Riuzzi F,Sorci G,Sagheddu R,Sidoni A,Alaggio R,Ninfo V,Donato R

更新日期：2014-04-15 00:00:00

abstract：:Recent studies using GFP-tagged markers and time-lapse microscopy have allowed direct visualisation of membrane traffic in the secretory pathway in living mammalian cells. This work shows that larger membrane structures, 300-500 nm in size, are the vehicles responsible for long distance, microtubule-dependent ER-to-Go...

journal_title：Journal of cell science

authors： Stephens DJ,Pepperkok R

更新日期：2001-03-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) establishes life-long latent infection in hematopoietic progenitor cells and circulating monocytes in infected individuals. Myeloid differentiation coupled with immune dysregulation leads to viral reactivation, which can cause severe disease and mortality. Reactivation of latent virus requ...

journal_title：Journal of cell science

authors： Krishna BA,Wass AB,Dooley AL,O'Connor CM

更新日期：2021-01-25 00:00:00

abstract：:Candida albicans is a dimorphic fungus capable of growing as a budding yeast and as a filamentous hypha. We have used the technique of immunofluorescence to study the changes in the microtubule cytoskeleton during the cell cycle in both growth forms. This approach has revealed the presence of an extensive system of mi...

journal_title：Journal of cell science

authors： Barton R,Gull K

更新日期：1988-10-01 00:00:00

abstract：:Dynamin-related GTPase proteins (DRPs) are main players in membrane remodelling. Conserved DRPs called mitofusins (Mfn1/Mfn2/Fzo1) mediate the fusion of mitochondrial outer membranes (OM). OM fusion depends on self-assembly and GTPase activity of mitofusins as well as on two other proteins, Ugo1 and Mdm30. Here, we de...

journal_title：Journal of cell science

authors： Anton F,Fres JM,Schauss A,Pinson B,Praefcke GJ,Langer T,Escobar-Henriques M

更新日期：2011-04-01 00:00:00

abstract：:The extracellular matrix molecule tenascin-R (TN-R) and the proteoglycans of the lectican family show an overlapping distribution in the developing brain, have been implicated in similar cellular processes and form a complex network of interactions. Previously, we have demonstrated that TN-R induces microprocesses alo...

journal_title：Journal of cell science

authors： Zacharias U,Rauch U

更新日期：2006-08-15 00:00:00

abstract：:In fibroblasts, platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) stimulate the formation of actin-rich, circular dorsal ruffles (CDRs) and phosphatidylinositol 3-kinase (PI3K)-dependent phosphorylation of Akt. To test the hypothesis that CDRs increase synthesis of phosphorylated Akt1 (pAkt), we ...

journal_title：Journal of cell science

authors： Yoshida S,Pacitto R,Sesi C,Kotula L,Swanson JA

更新日期：2018-11-16 00:00:00

abstract：:What forces drive chromosome segregation remains one of the most challenging questions in cell division. Even though the duration of anaphase is short, it is of utmost importance for genome fidelity that no mistakes are made. Seminal studies in model organisms have revealed different mechanisms operating during chromo...

journal_title：Journal of cell science

authors： Vukušić K,Buđa R,Tolić IM

更新日期：2019-09-16 00:00:00

abstract：:During meiotic prophase in the ciliate Tetrahymena thermophila micronuclei dramatically elongate and form thread-like crescents. The arrangement of the chromosomes within the crescent as well as the timing of chromosome pairing and recombination with respect to the elongation process have been subjects of ongoing deba...

journal_title：Journal of cell science

authors： Loidl J,Scherthan H

更新日期：2004-11-15 00:00:00

abstract：:We have shown previously, by fluorescent antibody staining, that desmosomal antigens are widely distributed in the tissues of vertebrate animals. Furthermore, we have demonstrated mutual desmosome formation between cells derived from man, cow, dog, chicken and frog. In this paper we have studied the components of desm...

journal_title：Journal of cell science

authors： Suhrbier A,Garrod D

更新日期：1986-03-01 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) has been shown to induce skeletal muscle hypertrophy, to prevent the loss of muscle mass with ageing and to improve the muscle phenotype of dystrophic mice. We previously developed a model of IGF-1-induced hypertrophy of human myotubes, in which hypertrophy was not only characteriz...

journal_title：Journal of cell science

authors： Jacquemin V,Butler-Browne GS,Furling D,Mouly V

更新日期：2007-02-15 00:00:00

abstract：:In invertebrates, UNC-45 regulates myosin stability and functions. Vertebrates have two distinct isoforms of the protein: UNC-45B, expressed in muscle cells only, and UNC-45A, expressed in all cells and implicated in regulating both non-muscle myosin II (NMII)- and microtubule (MT)-associated functions. Here, we show ...

journal_title：Journal of cell science

authors： Habicht J,Mooneyham A,Hoshino A,Shetty M,Zhang X,Emmings E,Yang Q,Coombes C,Gardner MK,Bazzaro M

更新日期：2021-01-08 00:00:00

abstract：:Understanding the interactions between distinct epithelial cells would help us to understand the development of tissues. Drosophila imaginal discs, which are made up of two types of epithelial cells, provide good model systems for such studies. The disc proper or the columnar epithelial cells are apposed to a layer of...

journal_title：Journal of cell science

authors： Pallavi SK,Shashidhara LS

更新日期：2005-08-01 00:00:00

abstract：:We previously demonstrated that the aspartate protease cathepsin D is activated by ceramide derived from acid sphingomyelinase. Increased expression of cathepsin D in the skin has been reported in wound healing, psoriasis and skin tumors. We explored specific functions of cathepsin D during epidermal differentiation. ...

journal_title：Journal of cell science

authors： Egberts F,Heinrich M,Jensen JM,Winoto-Morbach S,Pfeiffer S,Wickel M,Schunck M,Steude J,Saftig P,Proksch E,Schütze S

更新日期：2004-05-01 00:00:00

abstract：:Atomic force microscopy (AFM) was used to probe topology, conformational changes and initial substrate-carrier interactions of Na+-glucose co-transporter (SGLT1) in living cells on a single-molecule level. By scanning SGLT1-transfected Chinese hamster ovary (CHO) cells with AFM tips carrying an epitope-specific antibo...

journal_title：Journal of cell science

authors： Puntheeranurak T,Wildling L,Gruber HJ,Kinne RK,Hinterdorfer P

更新日期：2006-07-15 00:00:00

abstract：:The contractile vacuole system is an osmoregulatory organelle composed of cisternae and interconnecting ducts. Large cisternae act as bladders that periodically fuse with the plasma membrane, forming pores to expel water. To visualize the entire network in vivo and to identify constituents of the vacuolar complex in c...

journal_title：Journal of cell science

authors： Gabriel D,Hacker U,Köhler J,Müller-Taubenberger A,Schwartz JM,Westphal M,Gerisch G

更新日期：1999-11-01 00:00:00

abstract：:Developing oral organelles of dividing Tetrahymena corlissi appear to be positioned by mechanisms which assess distances as a proportion of the organism's overall dimensions. In some respects, the cortex of this protozoan obeys the 'French flag' rule formulated by Wolpert for describing regulation of spatial proportio...

journal_title：Journal of cell science

authors： Lynn DH,Tucker JB

更新日期：1976-06-01 00:00:00

abstract：:The current model for hemoglobin ingestion and transport by intraerythrocytic Plasmodium falciparum malaria parasites shares similarities with endocytosis. However, the model is largely hypothetical, and the mechanisms responsible for the ingestion and transport of host cell hemoglobin to the lysosome-like food vacuol...

journal_title：Journal of cell science

authors： Lazarus MD,Schneider TG,Taraschi TF

更新日期：2008-06-01 00:00:00

abstract：:Using a series of chimeric and truncated N-acetylglucosaminyltransferase I (NAGT I) molecules we have shown that part of the lumenal stalk region is both necessary and sufficient for kin recognition of mannosidase II and retention in the Golgi stack. The membrane-spanning domain was not required for retention, but rep...

journal_title：Journal of cell science

authors： Nilsson T,Rabouille C,Hui N,Watson R,Warren G

更新日期：1996-07-01 00:00:00

abstract：:Nearly all intermediate filament (IF) proteins share two sequence motifs located at the N- and the C-terminal ends of their helical rod domain ('coil 1a' and 'coil 2b', respectively). To examine the structural role of the coil 2b motif, we have performed in vitro assembly studies and in vivo microinjection experiments...

journal_title：Journal of cell science

authors： Kouklis PD,Traub P,Georgatos SD

更新日期：1992-05-01 00:00:00

abstract：:Endothelial integrity relies on a mechanical crosstalk between intercellular and cell-matrix interactions. This crosstalk is compromised in hemorrhagic vascular lesions of patients carrying loss-of-function mutations in cerebral cavernous malformation (CCM) genes. RhoA/ROCK-dependent cytoskeletal remodeling is central...

journal_title：Journal of cell science

authors： Lisowska J,Rödel CJ,Manet S,Miroshnikova YA,Boyault C,Planus E,De Mets R,Lee HH,Destaing O,Mertani H,Boulday G,Tournier-Lasserve E,Balland M,Abdelilah-Seyfried S,Albiges-Rizo C,Faurobert E

更新日期：2018-08-13 00:00:00

abstract：:Tissues fixed in osmium tetroxide or in combined osmium and glutaraldehyde (Hinde), embedded in Spurr's medium, cut at 0-5-I mum and mounted in Farrants' gum medium containing ethyl gallate, show good staining of lipid-contaning structures (droplets of triglyceride, membranes, mitochondria, etc.) in the light microsco...

journal_title：Journal of cell science

authors： Wigglesworth VB

更新日期：1975-12-01 00:00:00

abstract：:Loss of tissue organization is a hallmark of the early stages of cancer, and there is considerable interest in proteins that maintain normal tissue architecture. Prostate epithelial cells cultured in Matrigel form three-dimensional acini that mimic aspects of prostate gland development. The organization of these struc...

journal_title：Journal of cell science

authors： Romero D,Kawano Y,Bengoa N,Walker MM,Maltry N,Niehrs C,Waxman J,Kypta R

更新日期：2013-04-15 00:00:00