Abstract：
:The complex formed by Rad9, Rad1 and Hus1 (9-1-1) protects against genomic instability by activating DNA damage checkpoint and DNA damage repair pathways, mainly in response to replication fork collapse and UV lesions. Here we compare the role of Rad9A (also known as Rad9) with the human paralogue Rad9B. Unlike Rad9A, overexpression of Rad9B delays cells in G1 phase. Moreover, Rad9B migrates to nucleoli after nucleolar stress in an ATR- and JNK-dependent manner, in a newly described nucleolar domain structure containing p21. Analysis of chimeras of Rad9A and Rad9B demonstrate that localisation to nucleoli and the block in G1 phase upon overexpression crucially depend on the Rad9B C-terminal tail. Taken together, data presented here show a relationship between Rad9B and pathways for checkpoints, stress response and nucleolar function.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Pérez-Castro AJ,Freire Rdoi
10.1242/jcs.091124subject
Has Abstractpub_date
2012-03-01 00:00:00pages
1152-64issue
Pt 5eissn
0021-9533issn
1477-9137pii
jcs.091124journal_volume
125pub_type
杂志文章abstract：:A comprehensive analysis of the molecular network of cellular factors establishing and maintaining pluripotency as well as self renewal of pluripotent stem cells is key for further progress in understanding basic stem cell biology. Nanog is necessary for the natural induction of pluripotency in early mammalian develop...
journal_title：Journal of cell science
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doi：10.1242/jcs.167932
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abstract：:We have performed a screening analysis of differential gene expression using a defined in vitro model of human capillary tube formation. Gene array, differential display and cDNA library screening were used to identify both known and novel differentially expressed genes. Major findings include: the upregulation and fu...
journal_title：Journal of cell science
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abstract：:Mammalian homologs of the Drosophila TRP protein have been shown to form cation-permeable channels in the plasma membrane but very little is known about the mechanisms that control their cell surface localization. Recently it has been demonstrated that the last three C-terminal amino acids (TRL) of TRPC4 comprise a PD...
journal_title：Journal of cell science
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更新日期：2002-09-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：10.1242/jcs.01122
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abstract：:Hematopoietic and vascular endothelial cells constitute the circulatory system and are both generated from the ventral mesoderm. However, the molecules and signaling pathways involved in ventral mesoderm formation and specification remain unclear. We found that zebrafish etv5a was expressed in the ventral mesoderm dur...
journal_title：Journal of cell science
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doi：10.1242/jcs.132613
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journal_title：Journal of cell science
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doi：10.1242/jcs.02769
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journal_title：Journal of cell science
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doi：
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journal_title：Journal of cell science
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doi：
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
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doi：
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journal_title：Journal of cell science
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doi：10.1242/jcs.030098
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journal_title：Journal of cell science
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doi：
更新日期：2001-02-01 00:00:00
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journal_title：Journal of cell science
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doi：
更新日期：2000-12-01 00:00:00
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doi：
更新日期：2000-03-01 00:00:00
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journal_title：Journal of cell science
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doi：
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journal_title：Journal of cell science
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doi：
更新日期：1997-02-01 00:00:00
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