The suppressive effect of continuous infusion of bilirubin on the immune response in mice.

Abstract:

:Mice (strains Balb/c and A/J) received an intravenous infusion of bilirubin for a 1 d period. The infusion was delivered at various phases of the primary reaction; the degree of the immune response was expressed as the number of antibody-forming cells against sheep erythrocytes. Bilirubin infusion during both the inductive and productive phase of the primary reaction decreased significantly the immune response. We assume that bilirubin influences the differentiation of immunocompetent cells immediately after their contact with the antigen; in addition it acts in the period of the quantitative increase of the number of antibody-producing cells.

journal_title

Folia microbiologica

authors

Síma P,Malá J,Miler I,Hodr R,Truxová E

doi

10.1007/BF02897214

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

483-90

issue

6

eissn

0015-5632

issn

1874-9356

journal_volume

25

pub_type

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