Increased oxidative stress tolerance results in general stress tolerance in Candida albicans independently of stress-elicited morphological transitions.

Abstract:

:A selection of tert-butylhydroperoxide (tBOOH)-tolerant Candida albicans mutants showed increased tolerances to 19 different stress conditions. These mutants are characterized by a constitutively upregulated antioxidative defense system and, therefore, adaptation to oxidative stress may play an important role in gaining general stress tolerance in C. albicans. Although C. albicans cells may undergo morphological transitions under various stress treatments, this ability shows considerable stress-specific and strain-specific variability and, hence, it is independent of mounting stress cross protections.

journal_title

Folia microbiologica

authors

Jakab Á,Antal K,Kiss Á,Emri T,Pócsi I

doi

10.1007/s12223-014-0305-7

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

333-40

issue

4

eissn

0015-5632

issn

1874-9356

journal_volume

59

pub_type

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