Effects of 1,25- and 24,25-dihydroxyvitamin D3 on bone formation in the cichlid teleost Sarotherodon mossambicus.

Abstract:

:1,25-Dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 have antagonistic effects on the acellular bone of the tilapia Sarotherodon mossambicus. 1,25-Dihydroxyvitamin D3 inhibits the activity of the lining osteoblasts. Prolonged administration leads to demineralization of the bone matrix. Injection of 24,25-dihydroxyvitamin D3 induces structural signs of greatly enhanced appositional bone growth within three days. No effects were observed on the mineral content of pre-existing bone. Both 1,25- and 24,25-dihydroxyvitamin D3 may have distinct, but different physiological functions in fish.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Wendelaar Bonga SE,Lammers PI,van der Meij JC

doi

10.1007/BF00206270

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

117-26

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

228

pub_type

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